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LYELLyell Immunopharma, Inc.
$11.97$279M
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LYEL logoLyell Immunopharma, Inc.(LYEL)Earnings, Financials & Key Ratios

LYEL•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCell and Gene Therapy Developers
AboutLyell Immunopharma, Inc., a T cell reprogramming company, engages in developing T cell therapies for patients with solid tumors. The company develops therapies using technology platforms, such as Gen-R, an ex vivo genetic reprogramming technology to overcome T cell exhaustion; and Epi-R, an ex vivo epigenetic reprogramming technology to generate population of T cells with durable stemness. Its pipeline includes LYL797, a T cell product candidate for the treatment of non-small cell lung cancer and triple negative breast cancers; LYL845, that targets multiple solid tumors; and NY-ESO-1 for synovial sarcoma and other solid tumor indications. The company entered into research and development collaboration and license agreement with GlaxoSmithKline for NY-ESO-1 program. Lyell Immunopharma, Inc. was incorporated in 2018 and is headquartered in South San Francisco, California.Show more
  • Revenue$36K-41.0%
  • EBITDA-$192M+43.3%
  • Net Income-$274M+20.0%
  • EPS (Diluted)-16.06-1126.0%
  • Gross Margin-31952.78%-32052.8%
  • EBITDA Margin-533986.11%+3.9%
  • Operating Margin-566038.89%+3.8%
  • Net Margin-762355.56%-35.6%
  • ROE-86.98%-31.6%

LYEL Key Insights

Lyell Immunopharma, Inc. (LYEL) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Trading at only 0.9x book value

✗Weaknesses

  • ✗Weak Piotroski F-Score: 1/9
  • ✗Negative free cash flow
  • ✗Weak momentum: RS Rating 7 (bottom 7%)
  • ✗Sales declining 65.9% over 5 years
  • ✗Shares diluted 30.7% in last year
  • ✗Trading more than 30% below 52-week high

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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LYEL Price & Volume

Lyell Immunopharma, Inc. (LYEL) stock price & volume — 10-year historical chart

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LYEL Growth Metrics

Lyell Immunopharma, Inc. (LYEL) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-65.85%
3 Years-92.48%
TTM-52.31%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM26.34%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-919.69%

Return on Capital

10 Years-34.2%
5 Years-37.97%
3 Years-49.61%
Last Year-56%

LYEL Recent Earnings

Lyell Immunopharma, Inc. (LYEL) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 9/12 qtrs (75%)●Beat Revenue 6/12 qtrs (75%)
Q2 2026Latest
May 6, 2026
Metric
Actual
Est
EPS
$1.10+60.4%
$2.78
Rev
$2,000-33.3%
$3,000
Q2 2026
Mar 12, 2026
Metric
Actual
Est
EPS
$7.68-257.2%
$2.15
Rev
$6,000-60.7%
$15,250
Q4 2025
Nov 12, 2025
Metric
Actual
Est
EPS
$2.13+24.2%
$2.81
Rev
$15,000
—
Q3 2025
Aug 12, 2025
Metric
Actual
Est
EPS
$2.89+23.9%
$3.80
Rev
$8,000+100.0%
$4,000
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 6, 2026
$1.10vs $2.78+60.4%
$2,000vs $3,000-33.3%
Q2 2026Mar 12, 2026
$7.68vs $2.15-257.2%
$6,000vs $15,250-60.7%
Q4 2025Nov 12, 2025
$2.13vs $2.81+24.2%
$15,000
Q3 2025Aug 12, 2025
$2.89vs $3.80+23.9%
$8,000vs $4,000+100.0%
Based on last 12 quarters of dataView full earnings history →

LYEL Peer Comparison

Lyell Immunopharma, Inc. (LYEL) competitors in Cell and Gene Therapy Developers — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
FATE logoFATEFate Therapeutics, Inc.Direct Competitor243.61M2.09-1.82-51.24%-20.57%-58.89%0.38
ADCT logoADCTADC Therapeutics S.A.Direct Competitor138.64M1.09-0.9714.85%-173.02%
CABA logoCABACabaletta Bio, Inc.Direct Competitor463.08M2.84-1.73-131.58%0.24
TGTX logoTGTXTG Therapeutics, Inc.Direct Competitor8.15B53.2219.2187.32%65.95%87.36%0.40
KYMR logoKYMRKymera Therapeutics, Inc.Product Competitor7.38B90.43-24.51-16.72%-6.12%-25.02%0.05
ALKT logoALKTAlkami Technology, Inc.Product Competitor1.57B14.68-31.9132.89%-10.55%-13.96%0.98
NKTR logoNKTRNektar TherapeuticsProduct Competitor1.19B60.98-6.27-43.89%-284.18%-87%1.66
IMVT logoIMVTImmunovant, Inc.Product Competitor7.26B35.34-12.76-68.16%0.00

Compare LYEL vs Peers

Lyell Immunopharma, Inc. (LYEL) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs FATE

Most directly comparable listed peer for LYEL.

Scale Benchmark

vs TMO

Larger-name benchmark to compare LYEL against a more recognizable public peer.

Peer Set

Compare Top 5

vs FATE, ADCT, CABA, TGTX

LYEL Income Statement

Lyell Immunopharma, Inc. (LYEL) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
657K7.76M10.65M84.68M130K61K36K31K
Revenue Growth %
-1080.52%37.31%695.15%-99.85%-53.08%-40.98%-52.31%
Cost of Goods Sold
00000011.54M2.33M
COGS % of Revenue
------32052.78%-
Gross Profit
657K▲ 0%
7.76M▲ 1080.5%
10.65M▲ 37.3%
84.68M▲ 695.1%
130K▼ 99.8%
61K▼ 53.1%
-11.5M▼ 18957.4%
-2.3M▲ 0%
Gross Margin %
100%100%100%100%100%100%-31952.78%-7422.58%
Gross Profit Growth %
-1080.52%37.31%695.15%-99.85%-53.08%-18957.38%-
Operating Expenses
102.75M219.69M225.43M271.74M247.14M358.82M192.27M189.56M
OpEx % of Revenue
15638.66%2832.56%2116.68%320.89%190106.15%588222.95%534086.11%-
Selling, General & Admin
39.15M46.88M89.06M117.31M66.98M52.04M45.13M40.64M
SG&A % of Revenue
5959.06%604.45%836.22%138.52%51525.38%85313.11%125375%-
Research & Development
63.59M182.24M138.69M159.19M182.94M171.6M158.68M151.83M
R&D % of Revenue
9679.6%2349.7%1302.28%187.98%140726.92%281316.39%440763.89%-
Other Operating Expenses
0-9.43M-2.32M-4.75M-2.79M135.17M-11.54M-2M
Operating Income
-102.09M▲ 0%
-211.94M▼ 107.6%
-214.78M▼ 1.3%
-187.06M▲ 12.9%
-247.01M▼ 32.0%
-358.75M▼ 45.2%
-203.77M▲ 43.2%
-191.86M▲ 0%
Operating Margin %
-15538.66%-2732.56%-2016.68%-220.89%-190006.15%-588122.95%-566038.89%-618909.68%
Operating Income Growth %
--107.6%-1.34%12.91%-32.05%-45.24%43.2%-
EBITDA
-100.83M-207.64M-201.15M-169.04M-226.76M-339.12M-192.24M-181.43M
EBITDA Margin %
-15347.49%-2677.19%-1888.75%-199.61%-174429.23%-555940.98%-533986.11%-585264.52%
EBITDA Growth %
--105.93%3.13%15.96%-34.15%-49.55%43.31%47.03%
D&A (Non-Cash Add-back)
1.26M4.29M13.62M18.02M20.25M19.63M11.54M10.43M
EBIT
-102.09M-219.72M-214.78M-187.06M-247.01M-220.27M-203.77M-192.01M
Net Interest Income
8.12M5.94M1.17M7.05M23.45M24.07M13.08M11.41M
Interest Income
8.12M5.94M1.17M7.05M23.45M24.07M13.08M11.41M
Interest Expense
00000000
Other Income/Expense
-27.29M7.46M-35.44M3.94M12.38M15.76M-70.67M-54.54M
Pretax Income
-129.38M▲ 0%
-204.47M▼ 58.0%
-250.22M▼ 22.4%
-183.12M▲ 26.8%
-234.63M▼ 28.1%
-342.99M▼ 46.2%
-274.45M▲ 20.0%
-246.41M▲ 0%
Pretax Margin %
-19692.09%-2636.31%-2349.47%-216.24%-180486.15%-562285.25%-762355.56%-794858.06%
Income Tax
00000000
Effective Tax Rate %
0%0%0%0%0%0%0%0%
Net Income
-129.38M▲ 0%
-204.47M▼ 58.0%
-250.22M▼ 22.4%
-183.12M▲ 26.8%
-234.63M▼ 28.1%
-342.99M▼ 46.2%
-274.45M▲ 20.0%
-246.41M▲ 0%
Net Margin %
-19692.09%-2636.31%-2349.47%-216.24%-180486.15%-562285.25%-762355.56%-794858.06%
Net Income Growth %
--58.04%-22.37%26.82%-28.13%-46.18%19.98%26.34%
Net Income (Continuing)
-129.38M-204.47M-250.22M-183.12M-234.63M-342.99M-274.45M-246.41M
Discontinued Operations
00000000
Minority Interest
00000000
EPS (Diluted)
-0.53▲ 0%
-0.84▼ 59.4%
-1.03▼ 22.2%
-0.74▲ 28.1%
-0.93▼ 26.1%
-1.31▼ 40.1%
-16.06▼ 1126.0%
-11.26▲ 0%
EPS Growth %
--59.42%-22.16%28.1%-26.14%-40.14%-1125.95%-919.69%
EPS (Basic)
-0.53-0.84-1.03-0.74-0.93-1.31-16.06-
Diluted Shares Outstanding
12.33M12.33M12.14M12.35M12.55M13.07M17.09M21.88M
Basic Shares Outstanding
12.33M12.33M12.14M12.35M12.55M13.07M17.09M21.88M
Dividend Payout Ratio
--------

LYEL Balance Sheet

Lyell Immunopharma, Inc. (LYEL) balance sheet — assets, liabilities & shareholders' equity

MetricDec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
440.26M617.55M626.29M651.29M554.69M379.59M260.94M267.3M
Cash & Short-Term Investments
436.05M612.62M614.79M640.15M546.22M370.53M247.22M254.02M
Cash Only
96.67M140.41M293.83M123.55M145.65M105.6M60.18M90.77M
Short-Term Investments
339.38M472.21M320.97M516.6M400.58M264.93M187.04M163.25M
Accounts Receivable
00000000
Days Sales Outstanding
--------
Inventory
00000000
Days Inventory Outstanding
--------
Other Current Assets
00011.14M8.46M9.07M13.72M13.28M
Total Non-Current Assets
115.37M290.73M501.12M286.27M195.34M111.27M79.11M83.32M
Property, Plant & Equipment
43.7M124.06M166.64M166.26M142.32M72.94M53.64M50.55M
Fixed Asset Turnover
0.02x0.06x0.06x0.51x0.00x0.00x0.00x0.00x
Goodwill
00000000
Intangible Assets
00000000
Long-Term Investments
68.98M163.44M330.53M115.04M48.51M32.01M19M96.06M
Other Non-Current Assets
2.68M3.23M3.95M4.96M4.52M6.31M6.47M13.77M
Total Assets
555.63M▲ 0%
908.28M▲ 63.5%
1.13B▲ 24.1%
937.56M▼ 16.8%
750.03M▼ 20.0%
490.86M▼ 34.6%
340.05M▼ 30.7%
350.63M▲ 0%
Asset Turnover
0.00x0.01x0.01x0.09x0.00x0.00x0.00x0.00x
Asset Growth %
-63.47%24.13%-16.84%-20%-34.55%-30.72%-124.33%
Total Current Liabilities
22.05M49.28M46.74M37.03M34.52M53.79M49.41M36.95M
Accounts Payable
2.84M9.4M3.21M3.92M4.82M5.37M2.89M5.47M
Days Payables Outstanding
------91.51559.86
Short-Term Debt
00000000
Deferred Revenue (Current)
4.51M6.09M4.99M00000
Other Current Liabilities
10.58M15.33M28.25M22.16M8.79M22.72M46.52M31.48M
Current Ratio
19.97x12.53x13.40x17.59x16.07x7.06x5.28x7.23x
Quick Ratio
19.97x12.53x13.40x17.59x16.07x7.06x5.28x7.23x
Cash Conversion Cycle
--------
Total Non-Current Liabilities
125.53M140.56M150.88M67.28M60.56M54.25M42.44M40.01M
Long-Term Debt
000000039.49M
Capital Lease Obligations
27.13M50.96M66.65M63.17M56.89M50.99M41.92M132.8M
Deferred Tax Liabilities
00000000
Other Non-Current Liabilities
0532K4.57M4.11M3.66M3.25M517K527K
Total Liabilities
147.58M189.84M197.62M104.31M95.08M108.03M91.85M76.96M
Total Debt
27.47M54.57M67.82M67.7M63.17M58.97M41.92M39.49M
Net Debt
-69.2M-85.83M-226.01M-55.85M-82.48M-46.63M-18.26M-51.28M
Debt / Equity
0.07x0.08x0.07x0.08x0.10x0.15x0.17x0.14x
Debt / EBITDA
--------0.22x
Net Debt / EBITDA
-------0.28x
Interest Coverage
--------
Total Equity
408.06M▲ 0%
718.44M▲ 76.1%
929.79M▲ 29.4%
833.25M▼ 10.4%
654.95M▼ 21.4%
382.82M▼ 41.5%
248.2M▼ 35.2%
273.67M▲ 0%
Equity Growth %
-76.06%29.42%-10.38%-21.4%-41.55%-35.17%-139.06%
Book Value per Share
33.1058.2776.6167.4552.1929.2814.5212.51
Total Shareholders' Equity
408.06M718.44M929.79M833.25M654.95M382.82M248.2M273.67M
Common Stock
1K2K24K25K25K29K2K2K
Retained Earnings
-129.67M-334.14M-584.36M-767.48M-1B-1.35B-1.62B-1.64B
Treasury Stock
00000000
Accumulated OCI
454K256K-1.62M-7.6M-94K291K242K-9K
Minority Interest
00000000

LYEL Cash Flow Statement

Lyell Immunopharma, Inc. (LYEL) cash flow — operating, investing & free cash flow history

MetricDec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
39.47M-160.87M-126.25M-169.56M-163.69M-162.39M-150.02M-133.8M
Operating CF Margin %
6008.22%-2074.19%-1185.44%-200.22%-125918.46%-266219.67%-416733.33%-
Operating CF Growth %
--507.54%21.52%-34.3%3.46%0.79%7.62%89.37%
Net Income
-129.38M-204.47M-250.22M-183.12M-234.63M-342.99M-274.45M-246.41M
Depreciation & Amortization
1.26M4.29M13.62M16.47M20.25M19.63M11.54M10.43M
Stock-Based Compensation
15.73M33.26M62.2M047.08M33.14M41.83M35.8M
Deferred Taxes
-1.52M039.51M00000
Other Non-Cash Items
42.57M6.38M4.62M79.11M183K130.94M80.95M67.8M
Working Capital Changes
110.81M-336K4.01M-82.02M3.42M-3.12M-9.89M-1.42M
Change in Receivables
00000000
Change in Inventory
00000000
Change in Payables
1.71M-278K91K667K1.46M-3.23M-2.34M1.7M
Cash from Investing
-422.43M-273.52M-121.57M-11.54M184.05M122.42M54.1M2.01M
Capital Expenditures
-16.05M-51.48M-65.5M-24.28M-2.69M-464K-780K-623K
CapEx % of Revenue
2442.47%663.76%615.06%28.67%2066.15%760.66%2166.67%2009.68%
Acquisitions
00673.47M00-31.35M-41.2M263K
Investments
--------
Other Investing
-610.84M0-673.47M000-18.9M-41.17M
Cash from Financing
351.16M476.79M401.24M10.63M1.74M1.33M50.41M102.13M
Debt Issued (Net)
00000000
Equity Issued (Net)
351.16M476.42M391.8M11.1M2.2M1.4M50.41M102.13M
Dividends Paid
00000000
Share Repurchases
-185K-11.81M000000
Other Financing
0373K9.44M-461K-457K-76K-1K-2K
Net Change in Cash
-31.8M▲ 0%
42.4M▲ 233.3%
153.42M▲ 261.8%
-170.27M▼ 211.0%
22.09M▲ 113.0%
-38.64M▼ 274.9%
-45.52M▼ 17.8%
-29.66M▲ 0%
Free Cash Flow
23.43M▲ 0%
-212.35M▼ 1006.5%
-191.75M▲ 9.7%
-193.83M▼ 1.1%
-166.38M▲ 14.2%
-162.86M▲ 2.1%
-150.8M▲ 7.4%
-134.42M▲ 0%
FCF Margin %
3565.75%-2737.94%-1800.5%-228.89%-127984.62%-266980.33%-418900%-433609.68%
FCF Growth %
--1006.45%9.7%-1.08%14.16%2.12%7.4%23.54%
FCF per Share
1.90-17.22-15.80-15.69-13.26-12.46-8.82-6.14
FCF Conversion (FCF/Net Income)
-0.31x0.79x0.50x0.93x0.70x0.47x0.55x0.55x
Interest Paid
00000000
Taxes Paid
00000000

LYEL Key Ratios

Lyell Immunopharma, Inc. (LYEL) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric202020212022202320242025TTM
Return on Equity (ROE)
-36.3%-30.36%-20.77%-31.53%-66.1%-86.98%-85.71%
Return on Invested Capital (ROIC)
-32.72%-24.11%-18.94%-27.45%-59.22%-53.99%-60.12%
Gross Margin
100%100%100%100%100%-31952.78%-7422.58%
Net Margin
-2636.31%-2349.47%-216.24%-180486.15%-562285.25%-762355.56%-794858.06%
Debt / Equity
0.08x0.07x0.08x0.10x0.15x0.17x0.14x
FCF Conversion
0.79x0.50x0.93x0.70x0.47x0.55x0.55x
Revenue Growth
1080.52%37.31%695.15%-99.85%-53.08%-40.98%-52.31%
Related:LYEL Dividend History·LYEL Revenue History·LYEL Price History·LYEL P/E History·LYEL Financial Ratios·LYEL Institutional Holders

LYEL SEC Filings & Documents

Lyell Immunopharma, Inc. (LYEL) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 6, 2026·SEC

Material company update

Mar 12, 2026·SEC

Material company update

Mar 9, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 12, 2026·SEC

FY 2025

Mar 11, 2025·SEC

FY 2024

Feb 28, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 6, 2026·SEC

FY 2025

Nov 12, 2025·SEC

FY 2025

Aug 12, 2025·SEC

LYEL Frequently Asked Questions

Lyell Immunopharma, Inc. (LYEL) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Lyell Immunopharma, Inc. (LYEL) reported $0.0M in revenue for fiscal year 2025. This represents a 95% decrease from $0.7M in 2019.

Lyell Immunopharma, Inc. (LYEL) saw revenue decline by 41.0% over the past year.

Lyell Immunopharma, Inc. (LYEL) reported a net loss of $246.4M for fiscal year 2025.

Dividend & Returns

Lyell Immunopharma, Inc. (LYEL) has a return on equity (ROE) of -87.0%. Negative ROE indicates the company is unprofitable.

Lyell Immunopharma, Inc. (LYEL) had negative free cash flow of $134.4M in fiscal year 2025, likely due to heavy capital investments.

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