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PLRX logoPliant Therapeutics, Inc.(PLRX)Earnings, Financials & Key Ratios

PLRX•NASDAQ
Price updated Jun 13, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryImmunology and Inflammation Therapies
AboutPliant Therapeutics, Inc., a clinical stage biopharmaceutical company, discovers, develops, and commercializes novel therapies for the treatment of fibrosis and related diseases in the United States. Its lead product candidate is PLN-74809, an oral small-molecule dual selective inhibitor of avß6 and avß1 integrins, which is in three Phase 2a trials. The company also develops PLN-1474, a small-molecule selective inhibitor of avß1, which completed Phase 1 clinical trial for the treatment of liver fibrosis associated with nonalcoholic steatohepatitis. In addition, it is developing two additional preclinical integrin-based programs, which include an oncology program, as well as a program for an allosteric agonistic monoclonal antibody against an undisclosed integrin receptor for treatment of muscular dystrophies, including duchenne muscular dystrophy. Pliant Therapeutics, Inc. was incorporated in 2015 and is based in South San Francisco, California.Show more
  • Revenue$0
  • EBITDA-$148M+34.4%
  • Net Income-$149M+29.0%
  • EPS (Diluted)-2.43+30.0%
  • ROE-61.55%-13.8%
  • ROIC-49.16%-2.6%
  • Debt/Equity0.16-18.9%
  • Interest Coverage-58.65+14.4%

PLRX Key Insights

Pliant Therapeutics, Inc. (PLRX) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Trading at only 0.4x book value

✗Weaknesses

  • ✗Profits declining 29.2% over 5 years
  • ✗Weak Piotroski F-Score: 3/9
  • ✗Trading more than 30% below 52-week high
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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PLRX Price & Volume

Pliant Therapeutics, Inc. (PLRX) stock price & volume — 10-year historical chart

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PLRX Growth Metrics

Pliant Therapeutics, Inc. (PLRX) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM48.42%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM49.03%

Return on Capital

10 Years-100.31%
5 Years-47.92%
3 Years-50.59%
Last Year-52.42%

PLRX Recent Earnings

Pliant Therapeutics, Inc. (PLRX) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 8/12 qtrs (67%)●Beat Revenue 1/12 qtrs (50%)
Q2 2026Latest
May 11, 2026
EPS
$0.32
Est $0.36
+11.1%
Revenue
—
Q2 2026
Mar 11, 2026
EPS
$0.35
Est $0.42
+16.7%
Revenue
—
Est $5M
Q4 2025
Nov 6, 2025
EPS
$0.43
Est $0.53
+18.9%
Revenue
—
Q3 2025
Aug 7, 2025
EPS
$0.71
Est $0.62
-14.5%
Revenue
—
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 11, 2026
$0.32vs $0.36+11.1%
—
Q2 2026Mar 11, 2026
$0.35vs $0.42+16.7%
—vs $5M
Q4 2025Nov 6, 2025
$0.43vs $0.53+18.9%
—
Q3 2025Aug 7, 2025
$0.71vs $0.62-14.5%
—
Based on last 12 quarters of dataView full earnings history →

PLRX Peer Comparison

Pliant Therapeutics, Inc. (PLRX) competitors in Immunology and Inflammation Therapies — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
GILD logoGILDGilead Sciences, Inc.Direct Competitor155.93B125.5918.522.39%30.99%42.33%1.09
IDYA logoIDYAIDEAYA Biosciences, Inc.Direct Competitor2.55B28.98-22.6430.24%-62.17%-13.96%0.03
HALO logoHALOHalozyme Therapeutics, Inc.Direct Competitor8.24B69.5027.1537.55%23.13%126.27%43.89
AKBA logoAKBAAkebia Therapeutics, Inc.Direct Competitor248M0.92-44.4547.46%-8.83%-62.72%6.63
INVA logoINVAInnoviva, Inc.Direct Competitor1.68B22.746.8918.52%118.91%47.59%0.23
MDGL logoMDGLMadrigal Pharmaceuticals, Inc.Product Competitor11.08B480.77-37.41432.05%-27.32%-50.15%0.59
AKRO logoAKROAkero Therapeutics, Inc.Product Competitor4.5B54.65-14.57-30.58%0.05
HIMS logoHIMSHims & Hers Health, Inc.Product Competitor5.89B26.8252.5959%-0.56%-2.48%2.34

Compare PLRX vs Peers

Pliant Therapeutics, Inc. (PLRX) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs GILD

Most directly comparable listed peer for PLRX.

Scale Benchmark

vs ALNY

Larger-name benchmark to compare PLRX against a more recognizable public peer.

Peer Set

Compare Top 5

vs GILD, IDYA, HALO, AKBA

PLRX Income Statement

Pliant Therapeutics, Inc. (PLRX) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
0057.05M41.82M7.57M9.69M1.58M000
Revenue Growth %
----26.7%-81.89%27.91%-83.69%-100%--
Cost of Goods Sold
0666K0000001.7M711K
COGS % of Revenue
----------
Gross Profit
0▲ 0%
-666K▲ 0%
57.05M▲ 8666.4%
41.82M▼ 26.7%
7.57M▼ 81.9%
9.69M▲ 27.9%
1.58M▼ 83.7%
0▼ 100.0%
-1.7M▲ 0%
-711K▲ 0%
Gross Margin %
--100%100%100%100%100%---
Gross Profit Growth %
--8666.37%-26.7%-81.89%27.91%-83.69%-100%--
Operating Expenses
18.35M30.91M58.28M83.46M105.11M136.88M185.72M228.37M148.38M118.5M
OpEx % of Revenue
--102.16%199.59%1388.1%1413.37%11754.75%---
Selling, General & Admin
3.82M6.5M10.93M17.27M27.56M39.95M57.93M59.05M47.22M39.91M
SG&A % of Revenue
--19.16%41.3%363.95%412.48%3666.33%---
Research & Development
14.53M24.41M47.35M66.19M77.55M96.94M127.8M169.31M109.16M79.04M
R&D % of Revenue
--83%158.29%1024.15%1000.89%8088.42%---
Other Operating Expenses
0-49K000000-8M-447K
Operating Income
-18.35M▲ 0%
-30.91M▼ 68.5%
-1.23M▲ 96.0%
-41.65M▼ 3283.0%
-97.53M▼ 134.2%
-127.2M▼ 30.4%
-184.15M▼ 44.8%
-228.37M▼ 24.0%
-150.07M▲ 34.3%
-119.21M▲ 0%
Operating Margin %
---2.16%-99.59%-1288.1%-1313.37%-11654.75%---
Operating Income Growth %
--68.48%96.02%-3283.02%-134.21%-30.41%-44.77%-24.01%34.28%-
EBITDA
-18.06M-30.25M-118K-40.34M-96M-123.52M-182.3M-226.24M-148.38M-117.7M
EBITDA Margin %
---0.21%-96.46%-1267.83%-1275.36%-11538.23%---
EBITDA Growth %
--67.52%99.61%-34082.2%-138.01%-28.67%-47.59%-24.1%34.42%49.45%
D&A (Non-Cash Add-back)
292K666K1.11M1.31M1.53M3.68M1.84M2.13M1.7M1.51M
EBIT
-18.35M-30.91M-1.23M-41.65M-97.26M-122.53M-160.07M-207.28M-150.07M-111.22M
Net Interest Income
00600K112K272K3.88M22.81M18.06M-2.56M1.34M
Interest Income
16K688K816K478K272K4.67M24.08M21.09M05.07M
Interest Expense
00216K366K0791K1.27M3.02M2.56M3.73M
Other Income/Expense
16K639K600K112K272K3.88M22.81M18.06M729K5.99M
Pretax Income
-18.33M▲ 0%
-30.28M▼ 65.1%
-631K▲ 97.9%
-41.53M▼ 6482.1%
-97.26M▼ 134.2%
-123.32M▼ 26.8%
-161.34M▼ 30.8%
-210.3M▼ 30.4%
-149.34M▲ 29.0%
-113.22M▲ 0%
Pretax Margin %
---1.11%-99.32%-1284.51%-1273.32%-10211.14%---
Income Tax
0000000000
Effective Tax Rate %
0%0%0%0%0%0%0%0%0%0%
Net Income
-20.62M▲ 0%
-30.28M▼ 46.8%
-631K▲ 97.9%
-41.53M▼ 6482.1%
-97.26M▼ 134.2%
-123.32M▼ 26.8%
-161.34M▼ 30.8%
-210.3M▼ 30.4%
-149.34M▲ 29.0%
-113.22M▲ 0%
Net Margin %
---1.11%-99.32%-1284.51%-1273.32%-10211.14%---
Net Income Growth %
--46.81%97.92%-6482.09%-134.18%-26.79%-30.83%-30.35%28.99%48.42%
Net Income (Continuing)
-18.33M-30.28M-631K-41.53M-97.26M-123.32M-161.34M-210.3M-149.34M-113.22M
Discontinued Operations
0000000000
Minority Interest
0000000000
EPS (Diluted)
-25.67▲ 0%
-1.83▲ 92.9%
0.01▲ 100.3%
-1.17▼ 22600.0%
-2.71▼ 131.6%
-2.94▼ 8.5%
-2.75▲ 6.5%
-3.47▼ 26.2%
-2.43▲ 30.0%
-1.83▲ 0%
EPS Growth %
-92.87%100.28%--131.62%-8.49%6.46%-26.18%29.97%49.03%
EPS (Basic)
-25.67-1.830.01-1.17-2.71-2.94-2.75-3.47-2.43-
Diluted Shares Outstanding
803.5K16.51M35.55M35.55M35.85M42.02M58.72M60.54M61.37M61.8M
Basic Shares Outstanding
803.5K16.51M35.55M35.55M35.85M42.02M58.72M60.54M61.37M61.8M
Dividend Payout Ratio
----------

PLRX Balance Sheet

Pliant Therapeutics, Inc. (PLRX) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
4.71M61.73M111.9M290.75M209.44M340.31M505.5M362.26M196.45M174.93M
Cash & Short-Term Investments
4.25M60.95M102.77M276.89M200.6M331.19M494.25M355.72M190.94M170.89M
Cash Only
4.25M60.95M85.81M50.88M51.66M33.69M63.23M71.19M45.45M22.19M
Short-Term Investments
0016.97M226.01M148.93M297.5M431.01M284.54M145.5M148.7M
Accounts Receivable
0500K7.38M9.36M2.47M3.14M3M2.3M823K914K
Days Sales Outstanding
--47.2581.72118.87118.49692.34---
Inventory
0000000000
Days Inventory Outstanding
----------
Other Current Assets
250K000156K173K1.27M163K4.68M3.12M
Total Non-Current Assets
1.85M4.8M7.16M4.77M11.77M10.3M6.65M34.69M28.78M27.67M
Property, Plant & Equipment
1.85M4.26M4.08M4.32M10.94M9.91M4.78M32.77M25.01M24.04M
Fixed Asset Turnover
--13.99x9.68x0.69x0.98x0.33x--0.00x
Goodwill
0000000000
Intangible Assets
0000000000
Long-Term Investments
0000000000
Other Non-Current Assets
0536K3.08M451K838K394K1.87M1.92M3.77M3.63M
Total Assets
6.55M▲ 0%
66.53M▲ 915.2%
119.06M▲ 79.0%
295.53M▲ 148.2%
221.22M▼ 25.1%
350.61M▲ 58.5%
512.15M▲ 46.1%
396.95M▼ 22.5%
225.23M▼ 43.3%
202.6M▲ 0%
Asset Turnover
--0.48x0.14x0.03x0.03x0.00x--0.00x
Asset Growth %
-915.24%78.97%148.21%-25.15%58.49%46.07%-22.49%-43.26%-160.45%
Total Current Liabilities
3.19M5.08M8.17M11.6M16.83M23.91M28.52M33.22M16.36M10.36M
Accounts Payable
1.59M2.58M1.25M2.02M2.97M1.58M4.53M5.96M480K362K
Days Payables Outstanding
-1.41K------103.3347.93
Short-Term Debt
0000000000
Deferred Revenue (Current)
0000000000
Other Current Liabilities
0130K3.04M4.63M5.22M7.2M9.04M014.44M8.28M
Current Ratio
1.48x12.14x13.69x25.07x12.44x14.23x17.72x10.91x12.00x16.89x
Quick Ratio
1.48x12.14x13.69x25.07x12.44x14.23x17.72x10.91x12.00x16.89x
Cash Conversion Cycle
----------
Total Non-Current Liabilities
062.33M111.33M866K5.33M13.36M10.05M59.65M27.66M27.07M
Long-Term Debt
0525K0009.93M10.05M30.21M00
Capital Lease Obligations
0525K444K05.33M3.43M029.44M27.66M111.75M
Deferred Tax Liabilities
0000000000
Other Non-Current Liabilities
061.28M110.88M866K000000
Total Liabilities
3.19M67.41M119.5M12.46M22.16M37.27M38.58M92.87M44.02M37.43M
Total Debt
0525K444K07.19M15.81M11.37M60.19M29.11M28.78M
Net Debt
-4.25M-60.42M-85.36M-50.88M-44.47M-17.87M-51.86M-11M-16.34M6.59M
Debt / Equity
----0.04x0.05x0.02x0.20x0.16x0.17x
Debt / EBITDA
----------0.24x
Net Debt / EBITDA
----------0.06x
Interest Coverage
---5.70x-113.78x--154.91x-126.34x-68.54x-58.65x-29.83x
Total Equity
3.35M▲ 0%
-882K▼ 126.4%
-435K▲ 50.7%
283.06M▲ 65171.5%
199.06M▼ 29.7%
313.34M▲ 57.4%
473.58M▲ 51.1%
304.08M▼ 35.8%
181.21M▼ 40.4%
165.17M▲ 0%
Equity Growth %
--126.37%50.68%65171.49%-29.68%57.41%51.14%-35.79%-40.41%-162.22%
Book Value per Share
4.16-0.05-0.017.965.557.468.075.022.952.67
Total Shareholders' Equity
3.35M-882K-435K283.06M199.06M313.34M473.58M304.08M181.21M165.17M
Common Stock
1K1K1K3K3K5K6K6K6K6K
Retained Earnings
-36.57M-71.47M-76.3M-117.83M-215.09M-338.41M-499.75M-710.05M-859.4M-879.44M
Treasury Stock
0000000000
Accumulated OCI
0-1.07M-1K-32K-201K-1.96M345K321K-15K-341K
Minority Interest
0000000000

PLRX Cash Flow Statement

Pliant Therapeutics, Inc. (PLRX) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-16.92M-28.33M-2.75M-37.27M-75.44M-94.63M-116.36M-155.5M-128.34M-98.7M
Operating CF Margin %
---4.82%-89.13%-996.34%-977.09%-7364.62%---
Operating CF Growth %
--67.38%90.29%-1255.31%-102.42%-25.43%-22.96%-33.64%17.47%168.37%
Net Income
-18.33M-30.28M-631K-41.53M-97.26M-123.32M-161.34M-210.3M-149.34M-113.22M
Depreciation & Amortization
292K666K1.11M1.31M1.53M1.82M1.84M2.13M1.7M1.51M
Stock-Based Compensation
33K228K1.83M3.9M10.44M22.6M44.48M37.63M26.23M10.9M
Deferred Taxes
00-12.2M0000000
Other Non-Cash Items
191K1.05M12.2M266K2.93M52K-2.6M5.96M9.02M18.67M
Working Capital Changes
893K1.05M-5.06M-1.21M6.92M4.22M1.25M9.09M-15.94M-16.57M
Change in Receivables
0-250K-7.05M-2.23M7.28M15K1.98M000
Change in Inventory
003.2M113K000000
Change in Payables
0760K-1.25M922K891K-1.35M2.97M1.43M-5.48M-5.26M
Cash from Investing
-1.41M-2.32M-17.93M-210.87M73.7M-150.2M-127.01M140.34M134.29M61.08M
Capital Expenditures
-1.41M-2.32M-964K-1.53M-1.95M-1.76M-921K-3.85M-374K44K
CapEx % of Revenue
--1.69%3.66%25.79%18.17%58.29%---
Acquisitions
00254K209.33M-75.65M148.44M00155K102K
Investments
----------
Other Investing
00-254K-209.33M75.65M-148.44M000-1K
Cash from Financing
20.01M87.35M45.54M213.21M2.53M226.85M274.4M23.12M-31.7M-32.12M
Debt Issued (Net)
0000010M019.91M-32.27M-32.27M
Equity Issued (Net)
-12K048.12M213.21M2.98M215.64M269.4M3.21M570K146K
Dividends Paid
0000000000
Share Repurchases
-12K000000000
Other Financing
20.02M87.35M-2.58M0-457K1.21M5M000
Net Change in Cash
1.68M▲ 0%
56.7M▲ 3280.9%
24.86M▼ 56.2%
-34.92M▼ 240.5%
783K▲ 102.2%
-17.98M▼ 2396.4%
31.03M▲ 272.6%
7.95M▼ 74.4%
-25.74M▼ 423.6%
-69.75M▲ 0%
Free Cash Flow
-18.33M▲ 0%
-30.65M▼ 67.2%
-3.71M▲ 87.9%
-38.8M▼ 944.8%
-77.4M▼ 99.5%
-96.39M▼ 24.5%
-117.28M▼ 21.7%
-159.35M▼ 35.9%
-128.71M▲ 19.2%
-98.81M▲ 0%
FCF Margin %
---6.51%-92.79%-1022.13%-995.26%-7422.91%---
FCF Growth %
--67.23%87.88%-944.78%-99.46%-24.54%-21.67%-35.87%19.23%44.08%
FCF per Share
-22.81-1.86-0.10-1.09-2.16-2.29-2.00-2.63-2.10-1.60
FCF Conversion (FCF/Net Income)
0.82x0.94x4.36x0.90x0.78x0.77x0.72x0.74x0.86x0.87x
Interest Paid
0000000001.47M
Taxes Paid
0000000000

PLRX Key Ratios

Pliant Therapeutics, Inc. (PLRX) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric20182019202020212022202320242025TTM
Return on Equity (ROE)-2458.47%--29.39%-40.35%-48.13%-41%-54.09%-61.55%-59.06%
Return on Invested Capital (ROIC)---42.67%-37.83%-42.39%-38.51%-47.92%-49.16%-51.33%
Gross Margin-100%100%100%100%100%---
Net Margin--1.11%-99.32%-1284.51%-1273.32%-10211.14%---
Debt / Equity---0.04x0.05x0.02x0.20x0.16x0.17x
Interest Coverage--5.70x-113.78x--154.91x-126.34x-68.54x-58.65x-29.83x
FCF Conversion0.94x4.36x0.90x0.78x0.77x0.72x0.74x0.86x0.87x
Revenue Growth---26.7%-81.89%27.91%-83.69%-100%--
Related:PLRX Dividend History·PLRX Revenue History·PLRX Price History·PLRX P/E History·PLRX Financial Ratios·PLRX Institutional Holders

PLRX SEC Filings & Documents

Pliant Therapeutics, Inc. (PLRX) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 11, 2026·SEC

Material company update

Apr 17, 2026·SEC

Material company update

Mar 30, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 11, 2026·SEC

FY 2025

Mar 3, 2025·SEC

FY 2024

Feb 27, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 11, 2026·SEC

FY 2025

Nov 6, 2025·SEC

FY 2025

Aug 7, 2025·SEC

PLRX Frequently Asked Questions

Pliant Therapeutics, Inc. (PLRX) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Pliant Therapeutics, Inc. (PLRX) grew revenue by 0.0% over the past year. Growth has been modest.

Pliant Therapeutics, Inc. (PLRX) reported a net loss of $113.2M for fiscal year 2025.

Dividend & Returns

Pliant Therapeutics, Inc. (PLRX) has a return on equity (ROE) of -61.5%. Negative ROE indicates the company is unprofitable.

Pliant Therapeutics, Inc. (PLRX) had negative free cash flow of $98.8M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in PLRX back in 2017?

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