Revenue growth remains highly erratic, swinging from a 49.9% decline in 2025Q4 to a 2.3% increase in 2026Q1, while gross margins have fluctuated wildly between 15.5% and 87.8% due to batch timing.
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 | Dec'08 | Dec'07 | Dec'06 | Dec'05 | Dec'04 | Dec'03 | Dec'02 | Dec'01 | Dec'00 | Dec'99 | Dec'98 | Dec'97 | Dec'96 |
|---|
| Sales/Revenue | 76.38M | 52.74M | 53.4M | 65.49M | 47.64M | 38.35M | 62.9M | 54.69M | 34.24M | 21.08M | 9.2M | 4.36M | 15.16M | 11.51M | 34.42M | 8.39M | 11.24M | 388K | 0 | 0 | 150K | 150K | 430K | 0 | 0 | 0 | 0 | 3.56M | 8.04M | 0 | 0 |
| Revenue Growth % | 27.8% | -1.23% | -18.47% | 37.48% | 24.22% | -39.03% | 15% | 59.73% | 62.44% | 129.13% | 110.79% | -71.21% | 31.68% | -66.56% | 310.49% | -25.42% | 2797.94% | - | - | -100% | 0% | -65.12% | - | - | - | - | -100% | -55.76% | - | - | - |
| Cost of Goods Sold | 22.94M | 27.51M | 24.32M | 22.98M | 19.59M | 16.35M | 10.87M | 10.89M | 9.3M | 15.23M | 8.4M | 730K | 9.05M | 5.43M | 8.14M | 1.52M | 4.38M | 3.58M | 0 | 2.25M | 35K | 35K | 0 | 0 | 0 | 0 | 0 | 2.68M | 6.31M | 0 | 0 |
| COGS % of Revenue | - | 52.15% | 45.54% | 35.09% | 41.13% | 42.63% | 17.29% | 19.92% | 27.17% | 72.26% | 91.29% | 16.73% | 59.72% | 47.15% | 23.66% | 18.19% | 38.98% | 921.39% | - | - | 23.33% | 23.33% | - | - | - | - | - | 75.5% | 78.47% | - | - |
| Gross Profit | 53.44M | 25.24M | 29.08M | 42.51M | 28.05M | 22M | 52.02M | 43.8M | 24.94M | 5.85M | 801K | 3.63M | 6.11M | 6.08M | 26.28M | 1.44M | 6.86M | -3.19M | 0 | 0 | 115K | 115K | 310K | 0 | 0 | 0 | 0 | 871.16K | 1.73M | 0 | 0 |
| Gross Margin % | 69.97% | 47.85% | 54.46% | 64.91% | 58.87% | 57.37% | 82.71% | 80.08% | 72.83% | 27.74% | 8.71% | 83.27% | 40.28% | 52.85% | 76.34% | 17.21% | 61.02% | -821.39% | - | - | 76.67% | 76.67% | 72.09% | - | - | - | - | 24.51% | 21.53% | - | - |
| Gross Profit Growth % | - | -13.22% | -31.6% | 51.58% | 27.48% | -57.71% | 18.78% | 75.63% | 326.51% | 629.96% | -77.96% | -40.49% | 0.36% | -76.85% | 1721.21% | -78.97% | 315.28% | - | - | -100% | 0% | -62.9% | - | - | - | - | -100% | -49.64% | - | - | - |
| Operating Expenses | 33.65M | 30.74M | 25.16M | 32.05M | 41.06M | 42.46M | 49.31M | 54.52M | 44.25M | 40.36M | 33.96M | 27.3M | 31.31M | 34.06M | 38.45M | 37.97M | 36.83M | 28.78M | 24.17M | 22.25M | 9.77M | 93.3K | 2.73M | 147.38K | 165.79K | 385.79K | 381.85K | 1.69M | 2.9M | 164.38K | 44.06K |
| OpEx % of Revenue | - | 58.27% | 47.12% | 48.94% | 86.19% | 110.72% | 78.4% | 99.67% | 129.22% | 191.5% | 369.21% | 625.66% | 206.54% | 295.87% | 111.7% | 452.83% | 327.53% | 7418.04% | - | - | 6514% | 62.2% | 634.19% | - | - | - | - | 47.45% | 36.14% | - | - |
| Selling, General & Admin | 12.13M | 11.68M | 12.19M | 14.96M | 11.71M | 12.73M | 11.15M | 9.9M | 10.92M | 11.53M | 9.36M | 7.28M | 9.23M | 8.38M | 9.76M | 6.93M | 6.88M | 7.14M | 6.77M | 11.71M | 4.53M | 93.3K | 807K | 147.38K | 165.79K | 291.79K | 381.85K | 1.52M | 2.09M | 164.38K | 44.06K |
| SG&A % of Revenue | - | 22.15% | 22.83% | 22.84% | 24.58% | 33.19% | 17.72% | 18.1% | 31.88% | 54.7% | 101.71% | 166.8% | 60.87% | 72.83% | 28.36% | 82.65% | 61.15% | 1841.24% | - | - | 3016.67% | 62.2% | 187.67% | - | - | - | - | 42.87% | 25.96% | - | - |
| Research & Development | 21.52M | 19.05M | 12.97M | 17.09M | 29.35M | 29.73M | 38.17M | 44.62M | 33.33M | 28.83M | 30.41M | 20.02M | 27.35M | 29.23M | 28.69M | 31.04M | 29.95M | 21.64M | 17.4M | 12.86M | 5.25M | 3.52M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| R&D % of Revenue | - | 36.13% | 24.29% | 26.1% | 61.61% | 77.53% | 60.68% | 81.58% | 97.34% | 136.8% | 330.6% | 458.87% | 180.42% | 253.84% | 83.34% | 370.18% | 266.37% | 5576.8% | - | - | 3497.33% | 2349.33% | - | - | - | - | - | - | - | - | - |
| Other Operating Expenses | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -6.8M | 0 | -6.13M | -4.35M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 94K | 0 | 163.2K | 817.93K | 0 | 0 |
| Operating Income | 19.79M | -5.5M | 3.92M | 10.46M | -13.01M | -20.46M | 2.71M | -10.72M | -19.31M | -34.52M | -33.16M | -23.67M | -28.56M | -27.12M | -12.17M | -36.53M | -29.97M | -31.97M | -24.17M | -24.57M | -9.7M | -5.79M | -2.42M | -147K | -166K | -386K | -382K | -816K | -1.17M | -164K | -44.06K |
| Operating Margin % | 25.91% | -10.43% | 7.34% | 15.97% | -27.32% | -53.36% | 4.31% | -19.59% | -56.39% | -163.76% | -360.51% | -542.39% | -188.38% | -235.53% | -35.36% | -435.62% | -266.51% | -8239.43% | - | - | -6469.33% | -3859.33% | -562.09% | - | - | - | - | -22.95% | -14.61% | - | - |
| Operating Income Growth % | - | -240.41% | -62.55% | 180.38% | 36.4% | -855.06% | 125.29% | 44.49% | 44.06% | -4.08% | -40.11% | 17.12% | -5.32% | -122.77% | 66.68% | -21.91% | 6.27% | -32.26% | 1.61% | -153.16% | -67.63% | -139.51% | -1544.22% | 11.45% | 56.99% | -1.05% | 53.19% | 30.49% | -615.85% | -272.24% | - |
| EBITDA | 21.31M | -4.04M | 5.22M | 11.65M | -11.93M | -19.34M | 4.01M | -9.1M | -17.64M | -32.6M | -31.18M | -21.3M | -25.42M | -23.58M | -8.48M | -32.9M | -26.88M | -29.98M | -22.94M | -23.88M | -9.27M | -5.48M | -2.29M | -147K | -166.31K | -292K | -532K | -652.8K | -971.79K | -164K | -44.06K |
| EBITDA Margin % | 27.9% | -7.65% | 9.78% | 17.79% | -25.04% | -50.44% | 6.38% | -16.64% | -51.51% | -154.65% | -338.95% | -488.08% | -167.67% | -204.79% | -24.63% | -392.32% | -239.03% | -7726.55% | - | - | -6179.33% | -3652% | -533.49% | - | - | - | - | -18.36% | -12.09% | - | - |
| EBITDA Growth % | 257.86% | -177.28% | -55.19% | 197.68% | 38.34% | -582.15% | 144.09% | 48.4% | 45.89% | -4.54% | -46.38% | 16.2% | -7.81% | -178.03% | 74.22% | -22.41% | 10.35% | -30.7% | 3.93% | -157.58% | -69.2% | -138.8% | -1460.54% | 11.61% | 43.04% | 45.11% | 18.5% | 32.83% | -492.56% | -272.24% | - |
| D&A (Non-Cash Add-back) | 1.52M | 1.47M | 1.3M | 1.19M | 1.09M | 1.12M | 1.3M | 1.62M | 1.67M | 1.92M | 1.98M | 2.37M | 3.14M | 3.54M | 3.69M | 3.63M | 3.09M | 1.99M | 1.23M | 692K | 435K | 311K | 123K | 0 | -312 | 94K | -150K | 163.2K | 202.21K | 0 | 0 |
| EBIT | 19.79M | -5.5M | 5.22M | 11.75M | -11.87M | -20.06M | 3.15M | -10.31M | -18.77M | -73.72M | -24.98M | -23.55M | -28.56M | -27.12M | -11.58M | -36.53M | -29.97M | -31.97M | -22.41M | -22.48M | -9.43M | -5.79M | -2.42M | 0 | -166K | -386K | -382K | -816K | -1.17M | 0 | 0 |
| Net Interest Income | -526K | -108K | 237K | -1.89M | -1.38M | -7.12M | -9.23M | -7.56M | -7.15M | -9.54M | -3.6M | -3.61M | -4.74M | 0 | 554K | 2K | 968K | 529K | 0 | 0 | 0 | 14.15K | 5.51K | 0 | 0 | 0 | 126.01K | 0 | 27.27K | 0 | 0 |
| Interest Income | 1.01M | 1.08M | 1.3M | 1.29M | 1.15M | 401K | 438K | 407K | 536K | 188K | 589K | 123K | 196K | 0 | 588K | 0 | 0 | 462K | 1.76M | 2.08M | 344K | 14.15K | 5.51K | 6.67K | 15.72K | 56.62K | 126.01K | 0 | 78.84K | 0 | 243.74K |
| Interest Expense | 1.54M | 1.19M | 1.06M | 3.18M | 2.53M | 7.52M | 9.67M | 7.97M | 7.68M | 9.72M | 4.19M | 3.73M | 4.93M | 0 | 34K | 2K | 968K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 51.57K | 0 | 0 |
| Other Income/Expense | -526K | -108K | 237K | -1.89M | -1.38M | -7.12M | -9.23M | -7.56M | -7.15M | -48.92M | 3.99M | -3.61M | -4.74M | 6.82M | 554K | 36.53M | 58.96M | 63.41M | 46.59M | 2.09M | 9.43M | 5.79M | -4K | 0 | 312 | -94K | 150.23K | -254K | 0 | 343.84K | 243.74K |
| Pretax Income | 19.27M | -5.61M | 4.15M | 8.57M | -14.4M | -27.58M | -6.52M | -18.28M | -26.46M | -83.44M | -29.18M | -27.28M | -33.3M | -27.79M | -11.62M | 2K | 29M | 31.44M | 22.41M | -22.48M | -344K | -5.75M | -2.42M | 0 | -165K | -480K | -232K | -1.07M | 0 | 179.46K | 199.69K |
| Pretax Margin % | 25.22% | -10.63% | 7.78% | 13.08% | -30.22% | -71.92% | -10.37% | -33.42% | -77.27% | -395.86% | -317.16% | -625.16% | -219.64% | -241.38% | -33.75% | 0.02% | 257.9% | 8103.09% | - | - | -229.33% | -3830.67% | -563.02% | - | - | - | - | -30.13% | - | - | - |
| Income Tax | 3.93M | 996K | 1.22M | 254K | 530K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2.94M | 0 | 0 | 43.31M | 48.79M | 62.88M | 44.83M | 0 | 11.15M | -14.15K | 0 | 140.71K | -15.72K | -151K | -126K | 181.65K | -27.27K | 61.02K | 68K |
| Effective Tax Rate % | 20.42% | -17.76% | 29.42% | 2.97% | -3.68% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 8.84% | 0% | 0% | 2165300% | 168.26% | 200% | 200% | 0% | -3242.44% | 0.25% | 0% | - | 9.52% | 31.46% | 54.31% | -16.96% | - | 34% | 34.06% |
| Net Income | 15.33M | -6.6M | 2.93M | 8.31M | -14.93M | -27.58M | -6.52M | -18.28M | -26.46M | -83.44M | -29.36M | 58.04M | -29.94M | -27.79M | -11.62M | -36.53M | -29M | -31.44M | -22.41M | -22.48M | -9.43M | -5.75M | -2.42M | -141K | -150K | -329K | -106K | -998K | -1.15M | 118.44K | 131.68K |
| Net Margin % | 20.07% | -12.52% | 5.49% | 12.69% | -31.33% | -71.92% | -10.37% | -33.42% | -77.27% | -395.86% | -319.22% | 1329.9% | -197.51% | -241.38% | -33.75% | -435.6% | -257.9% | -8103.09% | - | - | -6284.67% | -3830.67% | -563.02% | - | - | - | - | -28.07% | -14.27% | - | - |
| Net Income Growth % | 292.32% | -325.24% | -64.73% | 155.68% | 45.88% | -322.84% | 64.31% | 30.92% | 68.29% | -184.15% | -150.6% | 293.82% | -7.75% | -139.2% | 68.2% | -25.97% | 7.77% | -40.27% | 0.3% | -138.47% | -64.06% | -137.34% | -1617.02% | 6% | 54.41% | -210.38% | 89.38% | 12.99% | -1068.38% | -10.05% | - |
| Net Income (Continuing) | 15.33M | -6.6M | 2.93M | 8.31M | -14.93M | -27.58M | -6.52M | -18.28M | -26.46M | -83.44M | -29.18M | -27.28M | -29.94M | -34.74M | -11.62M | -36.53M | -29M | -31.44M | -22.41M | -22.48M | -9.43M | -5.75M | -2.42M | -141K | -150K | -329K | -106K | -998K | -1.15M | 118.44K | 131.68K |
| Discontinued Operations | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -189K | 85.32M | 0 | 6.95M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| EPS (Diluted) | 0.18 | -0.08 | 0.04 | 0.10 | -0.31 | -0.62 | -0.22 | -1.23 | -1.80 | -6.50 | -0.29 | 0.61 | -0.32 | -0.30 | -1.30 | -4.30 | -3.60 | -4.10 | -0.30 | -3.35 | -0.32 | -3.10 | -1.30 | -0.48 | -0.51 | -1.02 | -3.00 | -19.00 | -25.00 | 0.47 | 0.61 |
| EPS Growth % | 334.92% | -329.78% | -63.4% | 132.26% | 50% | -181.82% | 82.11% | 31.67% | 72.31% | -2141.38% | -147.54% | 290.63% | -6.67% | 76.92% | 69.77% | -19.44% | 12.2% | -1266.67% | 91.04% | -946.88% | 89.68% | -138.46% | -170.83% | 5.88% | 50% | 66% | 84.21% | 24% | -5419.15% | -22.95% | - |
| EPS (Basic) | - | -0.08 | 0.04 | 0.12 | -0.31 | -0.62 | -0.22 | -1.23 | -1.80 | -6.50 | -0.29 | 0.61 | -0.32 | -0.30 | -1.30 | -4.30 | -0.36 | -0.41 | -0.30 | -3.35 | -0.32 | -3.10 | -1.30 | -0.48 | -0.51 | -1.02 | -0.26 | -19.00 | -25.00 | 0.47 | 0.61 |
| Diluted Shares Outstanding | 83.05M | 78.55M | 81.06M | 82.42M | 48.47M | 44.14M | 29.15M | 14.84M | 14.71M | 13.11M | 101.39M | 94.92M | 92.89M | 92.37M | 9.09M | 84.64M | 80.96M | 76.94M | 75.89M | 6.72M | 29.3M | 18.8M | 30.78K | 291.54K | 291.54K | 322.85K | 401.46K | 521.73K | 456.37K | 254.29K | 216.47K |
| Basic Shares Outstanding | 79.85M | 78.55M | 72.53M | 67.51M | 48.47M | 44.14M | 29.15M | 14.84M | 14.71M | 13.11M | 101.39M | 94.92M | 92.89M | 92.37M | 9.09M | 84.64M | 8.1M | 7.69M | 75.89M | 6.72M | 29.3M | 18.8M | 30.78K | 291.54K | 291.54K | 322.85K | 401.46K | 521.73K | 456.37K | 254K | 216.47K |
| Dividend Payout Ratio | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Revenue concentration and liquidity
According to the company's quarterly financial disclosures, revenue growth has exhibited extreme volatility, swinging from a 49.9% decline in 2025Q4 to a 2.3% increase in 2026Q1, highlighting the inherent unpredictability of milestone-driven income and bulk international shipments that characterize the firm's current commercial model.
The erratic revenue trajectory suggests that Protalix remains heavily dependent on the timing of specific contract deliveries rather than a steady, predictable patient-demand curve. Investors should monitor whether the recent revenue spike in 2026Q1 represents a sustainable shift or merely a temporary recognition of deferred milestones.
As reported in recent income statements, gross margins have fluctuated wildly between 15.5% and 87.8%, reflecting the significant impact of manufacturing batch timing and the variable cost structure associated with the ProCellEx platform's current utilization levels across different international supply agreements.
The wide variance in gross margins indicates that the company has not yet achieved the economies of scale necessary to stabilize its production costs. This volatility suggests that the underlying manufacturing process remains sensitive to volume fluctuations, which may continue to pressure profitability until commercial adoption of Elfabrio reaches a more consistent threshold.
Based on the provided financial data, operating income has oscillated between a $4.9M loss and a $21.1M profit, demonstrating that the company's current operating structure lacks the consistent scalability required to reliably convert gross profit into sustained positive operating cash flow for shareholders.
The lack of a clear, linear relationship between gross profit and operating income suggests that fixed overhead costs remain a significant burden on the bottom line. Future performance will likely depend on whether management can maintain SG&A discipline while scaling commercial operations, as current figures indicate high sensitivity to operational expenses.
Data from the most recent quarterly filings indicate that while net income reached $18.3M in 2026Q1, the historical pattern of frequent losses and reliance on non-recurring items warrants skepticism regarding the durability of this earnings inflection point in the absence of sustained commercial volume.
Short-term profitability improvements may be masking underlying structural challenges, particularly given the company's history of negative operating margins. Investors should investigate whether the recent earnings strength is driven by core product demand or one-time accounting adjustments, as the latter would imply a higher risk of future margin compression.
Quick answers to the most common questions about buying PLX stock.
For fiscal year 2025, Protalix BioTherapeutics, Inc. (PLX) reported total revenue of $52.7M.
Protalix BioTherapeutics, Inc. (PLX) reported a net loss of $6.6M for the fiscal year ending 2025.
Protalix BioTherapeutics, Inc. (PLX) reported an operating income of $-5.5M, resulting in an operating profit margin of -10.4%. This margin reflects the operational efficiency of the business before interest and taxes.
Protalix BioTherapeutics, Inc. (PLX) generated $25.2M in gross profit for the year, representing a gross profit margin of 47.8%. This demonstrates the company's core pricing power and production efficiency.