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PLXProtalix BioTherapeutics, Inc.
$2.30$185M
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Protalix BioTherapeutics, Inc. (PLX) Financials

30Y historyFree accessUpdated daily

Revenue growth remains highly erratic, swinging from a 49.9% decline in 2025Q4 to a 2.3% increase in 2026Q1, while gross margins have fluctuated wildly between 15.5% and 87.8% due to batch timing.

PLX Income Statement

Income StatementBalance SheetCash FlowRatios
AnnualQuarterly
MetricTTMDec'25Dec'24Dec'23Dec'22Dec'21Dec'20Dec'19Dec'18Dec'17Dec'16Dec'15Dec'14Dec'13Dec'12Dec'11Dec'10Dec'09Dec'08Dec'07Dec'06Dec'05Dec'04Dec'03Dec'02Dec'01Dec'00Dec'99Dec'98Dec'97Dec'96
Sales/Revenue76.38M52.74M53.4M65.49M47.64M38.35M62.9M54.69M34.24M21.08M9.2M4.36M15.16M11.51M34.42M8.39M11.24M388K00150K150K430K00003.56M8.04M00
Revenue Growth %27.8%-1.23%-18.47%37.48%24.22%-39.03%15%59.73%62.44%129.13%110.79%-71.21%31.68%-66.56%310.49%-25.42%2797.94%---100%0%-65.12%-----100%-55.76%---
Cost of Goods Sold22.94M27.51M24.32M22.98M19.59M16.35M10.87M10.89M9.3M15.23M8.4M730K9.05M5.43M8.14M1.52M4.38M3.58M02.25M35K35K000002.68M6.31M00
COGS % of Revenue-52.15%45.54%35.09%41.13%42.63%17.29%19.92%27.17%72.26%91.29%16.73%59.72%47.15%23.66%18.19%38.98%921.39%--23.33%23.33%-----75.5%78.47%--
Gross Profit53.44M25.24M29.08M42.51M28.05M22M52.02M43.8M24.94M5.85M801K3.63M6.11M6.08M26.28M1.44M6.86M-3.19M00115K115K310K0000871.16K1.73M00
Gross Margin %69.97%47.85%54.46%64.91%58.87%57.37%82.71%80.08%72.83%27.74%8.71%83.27%40.28%52.85%76.34%17.21%61.02%-821.39%--76.67%76.67%72.09%----24.51%21.53%--
Gross Profit Growth %--13.22%-31.6%51.58%27.48%-57.71%18.78%75.63%326.51%629.96%-77.96%-40.49%0.36%-76.85%1721.21%-78.97%315.28%---100%0%-62.9%-----100%-49.64%---
Operating Expenses33.65M30.74M25.16M32.05M41.06M42.46M49.31M54.52M44.25M40.36M33.96M27.3M31.31M34.06M38.45M37.97M36.83M28.78M24.17M22.25M9.77M93.3K2.73M147.38K165.79K385.79K381.85K1.69M2.9M164.38K44.06K
OpEx % of Revenue-58.27%47.12%48.94%86.19%110.72%78.4%99.67%129.22%191.5%369.21%625.66%206.54%295.87%111.7%452.83%327.53%7418.04%--6514%62.2%634.19%----47.45%36.14%--
Selling, General & Admin12.13M11.68M12.19M14.96M11.71M12.73M11.15M9.9M10.92M11.53M9.36M7.28M9.23M8.38M9.76M6.93M6.88M7.14M6.77M11.71M4.53M93.3K807K147.38K165.79K291.79K381.85K1.52M2.09M164.38K44.06K
SG&A % of Revenue-22.15%22.83%22.84%24.58%33.19%17.72%18.1%31.88%54.7%101.71%166.8%60.87%72.83%28.36%82.65%61.15%1841.24%--3016.67%62.2%187.67%----42.87%25.96%--
Research & Development21.52M19.05M12.97M17.09M29.35M29.73M38.17M44.62M33.33M28.83M30.41M20.02M27.35M29.23M28.69M31.04M29.95M21.64M17.4M12.86M5.25M3.52M000000000
R&D % of Revenue-36.13%24.29%26.1%61.61%77.53%60.68%81.58%97.34%136.8%330.6%458.87%180.42%253.84%83.34%370.18%266.37%5576.8%--3497.33%2349.33%---------
Other Operating Expenses0000000000-6.8M0-6.13M-4.35M0000000000094K0163.2K817.93K00
Operating Income19.79M-5.5M3.92M10.46M-13.01M-20.46M2.71M-10.72M-19.31M-34.52M-33.16M-23.67M-28.56M-27.12M-12.17M-36.53M-29.97M-31.97M-24.17M-24.57M-9.7M-5.79M-2.42M-147K-166K-386K-382K-816K-1.17M-164K-44.06K
Operating Margin %25.91%-10.43%7.34%15.97%-27.32%-53.36%4.31%-19.59%-56.39%-163.76%-360.51%-542.39%-188.38%-235.53%-35.36%-435.62%-266.51%-8239.43%---6469.33%-3859.33%-562.09%-----22.95%-14.61%--
Operating Income Growth %--240.41%-62.55%180.38%36.4%-855.06%125.29%44.49%44.06%-4.08%-40.11%17.12%-5.32%-122.77%66.68%-21.91%6.27%-32.26%1.61%-153.16%-67.63%-139.51%-1544.22%11.45%56.99%-1.05%53.19%30.49%-615.85%-272.24%-
EBITDA21.31M-4.04M5.22M11.65M-11.93M-19.34M4.01M-9.1M-17.64M-32.6M-31.18M-21.3M-25.42M-23.58M-8.48M-32.9M-26.88M-29.98M-22.94M-23.88M-9.27M-5.48M-2.29M-147K-166.31K-292K-532K-652.8K-971.79K-164K-44.06K
EBITDA Margin %27.9%-7.65%9.78%17.79%-25.04%-50.44%6.38%-16.64%-51.51%-154.65%-338.95%-488.08%-167.67%-204.79%-24.63%-392.32%-239.03%-7726.55%---6179.33%-3652%-533.49%-----18.36%-12.09%--
EBITDA Growth %257.86%-177.28%-55.19%197.68%38.34%-582.15%144.09%48.4%45.89%-4.54%-46.38%16.2%-7.81%-178.03%74.22%-22.41%10.35%-30.7%3.93%-157.58%-69.2%-138.8%-1460.54%11.61%43.04%45.11%18.5%32.83%-492.56%-272.24%-
D&A (Non-Cash Add-back)1.52M1.47M1.3M1.19M1.09M1.12M1.3M1.62M1.67M1.92M1.98M2.37M3.14M3.54M3.69M3.63M3.09M1.99M1.23M692K435K311K123K0-31294K-150K163.2K202.21K00
EBIT19.79M-5.5M5.22M11.75M-11.87M-20.06M3.15M-10.31M-18.77M-73.72M-24.98M-23.55M-28.56M-27.12M-11.58M-36.53M-29.97M-31.97M-22.41M-22.48M-9.43M-5.79M-2.42M0-166K-386K-382K-816K-1.17M00
Net Interest Income-526K-108K237K-1.89M-1.38M-7.12M-9.23M-7.56M-7.15M-9.54M-3.6M-3.61M-4.74M0554K2K968K529K00014.15K5.51K000126.01K027.27K00
Interest Income1.01M1.08M1.3M1.29M1.15M401K438K407K536K188K589K123K196K0588K00462K1.76M2.08M344K14.15K5.51K6.67K15.72K56.62K126.01K078.84K0243.74K
Interest Expense1.54M1.19M1.06M3.18M2.53M7.52M9.67M7.97M7.68M9.72M4.19M3.73M4.93M034K2K968K0000000000051.57K00
Other Income/Expense-526K-108K237K-1.89M-1.38M-7.12M-9.23M-7.56M-7.15M-48.92M3.99M-3.61M-4.74M6.82M554K36.53M58.96M63.41M46.59M2.09M9.43M5.79M-4K0312-94K150.23K-254K0343.84K243.74K
Pretax Income19.27M-5.61M4.15M8.57M-14.4M-27.58M-6.52M-18.28M-26.46M-83.44M-29.18M-27.28M-33.3M-27.79M-11.62M2K29M31.44M22.41M-22.48M-344K-5.75M-2.42M0-165K-480K-232K-1.07M0179.46K199.69K
Pretax Margin %25.22%-10.63%7.78%13.08%-30.22%-71.92%-10.37%-33.42%-77.27%-395.86%-317.16%-625.16%-219.64%-241.38%-33.75%0.02%257.9%8103.09%---229.33%-3830.67%-563.02%-----30.13%---
Income Tax3.93M996K1.22M254K530K0000000-2.94M0043.31M48.79M62.88M44.83M011.15M-14.15K0140.71K-15.72K-151K-126K181.65K-27.27K61.02K68K
Effective Tax Rate %20.42%-17.76%29.42%2.97%-3.68%0%0%0%0%0%0%0%8.84%0%0%2165300%168.26%200%200%0%-3242.44%0.25%0%-9.52%31.46%54.31%-16.96%-34%34.06%
Net Income15.33M-6.6M2.93M8.31M-14.93M-27.58M-6.52M-18.28M-26.46M-83.44M-29.36M58.04M-29.94M-27.79M-11.62M-36.53M-29M-31.44M-22.41M-22.48M-9.43M-5.75M-2.42M-141K-150K-329K-106K-998K-1.15M118.44K131.68K
Net Margin %20.07%-12.52%5.49%12.69%-31.33%-71.92%-10.37%-33.42%-77.27%-395.86%-319.22%1329.9%-197.51%-241.38%-33.75%-435.6%-257.9%-8103.09%---6284.67%-3830.67%-563.02%-----28.07%-14.27%--
Net Income Growth %292.32%-325.24%-64.73%155.68%45.88%-322.84%64.31%30.92%68.29%-184.15%-150.6%293.82%-7.75%-139.2%68.2%-25.97%7.77%-40.27%0.3%-138.47%-64.06%-137.34%-1617.02%6%54.41%-210.38%89.38%12.99%-1068.38%-10.05%-
Net Income (Continuing)15.33M-6.6M2.93M8.31M-14.93M-27.58M-6.52M-18.28M-26.46M-83.44M-29.18M-27.28M-29.94M-34.74M-11.62M-36.53M-29M-31.44M-22.41M-22.48M-9.43M-5.75M-2.42M-141K-150K-329K-106K-998K-1.15M118.44K131.68K
Discontinued Operations0000000000-189K85.32M06.95M00000000000000000
Minority Interest0000000000000000000000000000000
EPS (Diluted)0.18-0.080.040.10-0.31-0.62-0.22-1.23-1.80-6.50-0.290.61-0.32-0.30-1.30-4.30-3.60-4.10-0.30-3.35-0.32-3.10-1.30-0.48-0.51-1.02-3.00-19.00-25.000.470.61
EPS Growth %334.92%-329.78%-63.4%132.26%50%-181.82%82.11%31.67%72.31%-2141.38%-147.54%290.63%-6.67%76.92%69.77%-19.44%12.2%-1266.67%91.04%-946.88%89.68%-138.46%-170.83%5.88%50%66%84.21%24%-5419.15%-22.95%-
EPS (Basic)--0.080.040.12-0.31-0.62-0.22-1.23-1.80-6.50-0.290.61-0.32-0.30-1.30-4.30-0.36-0.41-0.30-3.35-0.32-3.10-1.30-0.48-0.51-1.02-0.26-19.00-25.000.470.61
Diluted Shares Outstanding83.05M78.55M81.06M82.42M48.47M44.14M29.15M14.84M14.71M13.11M101.39M94.92M92.89M92.37M9.09M84.64M80.96M76.94M75.89M6.72M29.3M18.8M30.78K291.54K291.54K322.85K401.46K521.73K456.37K254.29K216.47K
Basic Shares Outstanding79.85M78.55M72.53M67.51M48.47M44.14M29.15M14.84M14.71M13.11M101.39M94.92M92.89M92.37M9.09M84.64M8.1M7.69M75.89M6.72M29.3M18.8M30.78K291.54K291.54K322.85K401.46K521.73K456.37K254K216.47K
Dividend Payout Ratio-------------------------------

Key Metrics

Growth RegimeMixed
ProfitabilityStrained
Balance SheetVulnerable
Cash FlowMixed
Top Statement Risk

Revenue concentration and liquidity

Verified Source

Metrics are mathematically derived from official filings.

SEC 10-K (2026Q1)

Lumpy Revenue Masks Underlying Volatility

According to the company's quarterly financial disclosures, revenue growth has exhibited extreme volatility, swinging from a 49.9% decline in 2025Q4 to a 2.3% increase in 2026Q1, highlighting the inherent unpredictability of milestone-driven income and bulk international shipments that characterize the firm's current commercial model.

The erratic revenue trajectory suggests that Protalix remains heavily dependent on the timing of specific contract deliveries rather than a steady, predictable patient-demand curve. Investors should monitor whether the recent revenue spike in 2026Q1 represents a sustainable shift or merely a temporary recognition of deferred milestones.

Structural Margin Inconsistency Remains Prevalent

As reported in recent income statements, gross margins have fluctuated wildly between 15.5% and 87.8%, reflecting the significant impact of manufacturing batch timing and the variable cost structure associated with the ProCellEx platform's current utilization levels across different international supply agreements.

The wide variance in gross margins indicates that the company has not yet achieved the economies of scale necessary to stabilize its production costs. This volatility suggests that the underlying manufacturing process remains sensitive to volume fluctuations, which may continue to pressure profitability until commercial adoption of Elfabrio reaches a more consistent threshold.

Operating Leverage Remains Highly Unpredictable

Based on the provided financial data, operating income has oscillated between a $4.9M loss and a $21.1M profit, demonstrating that the company's current operating structure lacks the consistent scalability required to reliably convert gross profit into sustained positive operating cash flow for shareholders.

The lack of a clear, linear relationship between gross profit and operating income suggests that fixed overhead costs remain a significant burden on the bottom line. Future performance will likely depend on whether management can maintain SG&A discipline while scaling commercial operations, as current figures indicate high sensitivity to operational expenses.

Sustainability of Recent Profitability Questioned

Data from the most recent quarterly filings indicate that while net income reached $18.3M in 2026Q1, the historical pattern of frequent losses and reliance on non-recurring items warrants skepticism regarding the durability of this earnings inflection point in the absence of sustained commercial volume.

Short-term profitability improvements may be masking underlying structural challenges, particularly given the company's history of negative operating margins. Investors should investigate whether the recent earnings strength is driven by core product demand or one-time accounting adjustments, as the latter would imply a higher risk of future margin compression.

PLX — Frequently Asked Questions

Quick answers to the most common questions about buying PLX stock.

What was Protalix BioTherapeutics, Inc.'s (PLX) revenue in 2025?

For fiscal year 2025, Protalix BioTherapeutics, Inc. (PLX) reported total revenue of $52.7M.

Is Protalix BioTherapeutics, Inc. (PLX) profitable?

Protalix BioTherapeutics, Inc. (PLX) reported a net loss of $6.6M for the fiscal year ending 2025.

What is Protalix BioTherapeutics, Inc.'s operating profit margin?

Protalix BioTherapeutics, Inc. (PLX) reported an operating income of $-5.5M, resulting in an operating profit margin of -10.4%. This margin reflects the operational efficiency of the business before interest and taxes.

What is Protalix BioTherapeutics, Inc.'s gross profit and gross margin?

Protalix BioTherapeutics, Inc. (PLX) generated $25.2M in gross profit for the year, representing a gross profit margin of 47.8%. This demonstrates the company's core pricing power and production efficiency.