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PRLD logoPrelude Therapeutics Incorporated(PRLD)Earnings, Financials & Key Ratios

PRLD•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryOncology Therapeutics Developers
AboutPrelude Therapeutics Incorporated, a clinical-stage precision oncology company, focuses on the discovery and development of novel precision cancer medicines to underserved patients. It is developing PRT543 that is in Phase 1 clinical trials in select solid tumors and myeloid malignancies; and PRT811, which is in Phase 1 clinical trials in solid tumors, including glioblastoma multiforme. The company is also developing PRT1419, a potent and selective inhibitor of the anti-apoptotic protein; PRT2527, a potent inhibitor of CDK9 that exhibits high kinome selectivity; PRT-SCA2, which is in preclinical stage for multiple genomically selected cancers; PRT3645, a brain penetrant molecule that potently and selectively targets CDK4/6; and PRT-K4 that is in preclinical stage for solid tumors. The company was incorporated in 2016 and is headquartered in Wilmington, Delaware.Show more
  • Revenue$12M+73.4%
  • EBITDA-$103M+25.4%
  • Net Income-$99M+21.8%
  • EPS (Diluted)-1.29+23.2%
  • Gross Margin85.91%-14.1%
  • EBITDA Margin-847.24%+57.0%
  • Operating Margin-861.33%+56.8%
  • Net Margin-819.59%+54.9%
  • ROE-99.45%-44.1%

PRLD Key Insights

Prelude Therapeutics Incorporated (PRLD) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Momentum leader: RS Rating 96 (top 4%)

✗Weaknesses

  • ✗Profits declining 11.8% over 5 years
  • ✗Weak Piotroski F-Score: 2/9
  • ✗Negative free cash flow
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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PRLD Price & Volume

Prelude Therapeutics Incorporated (PRLD) stock price & volume — 10-year historical chart

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PRLD Growth Metrics

Prelude Therapeutics Incorporated (PRLD) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM138.86%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM39.14%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM37.28%

Return on Capital

10 Years-81.43%
5 Years-62.3%
3 Years-71.62%
Last Year-87.8%

PRLD Recent Earnings

Prelude Therapeutics Incorporated (PRLD) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 11/12 qtrs (92%)●Beat Revenue 0/12 qtrs (0%)
Q2 2026Latest
May 12, 2026
Metric
Actual
Est
EPS
$0.13+51.9%
$0.27
Rev
$5M+0.0%
$5M
Q2 2026
Mar 10, 2026
Metric
Actual
Est
EPS
$0.20+39.4%
$0.33
Rev
$6M-72.7%
$21M
Q4 2025
Nov 12, 2025
Metric
Actual
Est
EPS
$0.26+25.7%
$0.35
Rev
$7M-68.3%
$21M
Q3 2025
Aug 14, 2025
Metric
Actual
Est
EPS
$0.41+8.9%
$0.45
Rev
—
—
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 12, 2026
$0.13vs $0.27+51.9%
$5Mvs $5M+0.0%
Q2 2026Mar 10, 2026
$0.20vs $0.33+39.4%
$6Mvs $21M-72.7%
Q4 2025Nov 12, 2025
$0.26vs $0.35+25.7%
$7Mvs $21M-68.3%
Q3 2025Aug 14, 2025
$0.41vs $0.45+8.9%
—
Based on last 12 quarters of dataView full earnings history →

PRLD Peer Comparison

Prelude Therapeutics Incorporated (PRLD) competitors in Oncology Therapeutics Developers — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
RVMD logoRVMDRevolution Medicines, Inc.Direct Competitor34.65B162.99-27.39-83.22%0.10
KYMR logoKYMRKymera Therapeutics, Inc.Direct Competitor7.38B90.43-24.51-16.72%-6.12%-25.02%0.05
ARVN logoARVNArvinas, Inc.Direct Competitor494.88M7.67-5.99-0.3%-247.54%-44.39%0.02
VKTX logoVKTXViking Therapeutics, Inc.Direct Competitor3.52B30.38-9.52-71.31%0.00
AUPH logoAUPHAurinia Pharmaceuticals Inc.Product Competitor2.12B16.467.9520.38%99.97%64.48%0.13
IMVT logoIMVTImmunovant, Inc.Product Competitor7.26B35.34-12.76-68.16%0.00
TGTX logoTGTXTG Therapeutics, Inc.Product Competitor8.15B53.2219.2187.32%65.95%87.36%0.40
PTCT logoPTCTPTC Therapeutics, Inc.Product Competitor6.55B78.9810.15114.51%-22.58%

Compare PRLD vs Peers

Prelude Therapeutics Incorporated (PRLD) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs RVMD

Most directly comparable listed peer for PRLD.

Scale Benchmark

vs IQV

Larger-name benchmark to compare PRLD against a more recognizable public peer.

Peer Set

Compare Top 5

vs RVMD, KYMR, ARVN, VKTX

PRLD Income Statement

Prelude Therapeutics Incorporated (PRLD) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
0000007M12.14M16.72M
Revenue Growth %
-------73.43%138.86%
Cost of Goods Sold
149K0000001.71M391K
COGS % of Revenue
-------14.09%-
Gross Profit
-149K▲ 0%
0▲ 100.0%
0▲ 0%
0▲ 0%
0▲ 0%
0▲ 0%
7M▲ 0%
10.43M▲ 49.0%
16.33M▲ 0%
Gross Margin %
------100%85.91%97.66%
Gross Profit Growth %
-100%-----48.99%-
Operating Expenses
14.97M28.11M58.76M113.73M123.54M132.28M146.71M115M100.47M
OpEx % of Revenue
------2095.91%947.24%-
Selling, General & Admin
2.35M3.83M10.59M26.96M30.65M28.88M28.72M22.41M21.38M
SG&A % of Revenue
------410.27%184.56%-
Research & Development
12.62M24.28M48.18M86.78M92.89M103.39M118M94.3M79.08M
R&D % of Revenue
------1685.64%776.77%-
Other Operating Expenses
00000-10-1.71M0
Operating Income
-14.97M▲ 0%
-28.11M▼ 87.7%
-58.76M▼ 109.1%
-113.73M▼ 93.5%
-123.54M▼ 8.6%
-132.28M▼ 7.1%
-139.71M▼ 5.6%
-104.57M▲ 25.2%
-84.14M▲ 0%
Operating Margin %
-------1995.91%-861.33%-503.21%
Operating Income Growth %
--87.71%-109.05%-93.55%-8.62%-7.07%-5.62%25.16%-
EBITDA
-14.83M-27.73M-58.22M-112.82M-122.22M-131.11M-137.94M-102.86M-82.47M
EBITDA Margin %
-------1970.6%-847.24%-493.24%
EBITDA Growth %
--87.02%-109.98%-93.78%-8.33%-7.28%-5.21%25.44%40.32%
D&A (Non-Cash Add-back)
149K382K542K915K1.32M1.17M1.77M1.71M1.67M
EBIT
-14.97M-28.11M-58.76M-113.73M-123.54M-132.28M-139.71M-104.57M-84.14M
Net Interest Income
000000000
Interest Income
000000000
Interest Expense
000000000
Other Income/Expense
295K539K1.83M2.04M8.1M10.44M12.54M5.07M6.34M
Pretax Income
-14.68M▲ 0%
-27.57M▼ 87.8%
-56.93M▼ 106.5%
-111.69M▼ 96.2%
-115.44M▼ 3.4%
-121.83M▼ 5.5%
-127.17M▼ 4.4%
-99.5M▲ 21.8%
-77.8M▲ 0%
Pretax Margin %
-------1816.76%-819.59%-465.3%
Income Tax
000000000
Effective Tax Rate %
0%0%0%0%0%0%0%0%0%
Net Income
-14.68M▲ 0%
-27.57M▼ 87.8%
-56.93M▼ 106.5%
-111.69M▼ 96.2%
-115.44M▼ 3.4%
-121.83M▼ 5.5%
-127.17M▼ 4.4%
-99.5M▲ 21.8%
-77.8M▲ 0%
Net Margin %
-------1816.76%-819.59%-465.3%
Net Income Growth %
--87.81%-106.49%-96.2%-3.35%-5.54%-4.38%21.76%39.14%
Net Income (Continuing)
-14.68M-27.57M-56.93M-111.69M-115.44M-121.83M-127.17M-99.5M-77.8M
Discontinued Operations
000000000
Minority Interest
000000000
EPS (Diluted)
-9.31▲ 0%
-0.85▲ 90.9%
-1.30▼ 52.9%
-2.33▼ 79.2%
-2.27▲ 2.6%
-2.02▲ 11.0%
-1.68▲ 16.8%
-1.29▲ 23.2%
-0.94▲ 0%
EPS Growth %
-90.87%-52.94%-79.23%2.58%11.01%16.83%23.21%37.28%
EPS (Basic)
-9.31-0.85-1.30-2.33-2.27-2.02-1.68-1.29-
Diluted Shares Outstanding
1.58M32.4M43.71M47.6M47.37M60.36M75.81M76.96M82.52M
Basic Shares Outstanding
1.58M32.4M43.71M47.6M47.37M60.36M75.81M76.96M82.52M
Dividend Payout Ratio
---------

PRLD Balance Sheet

Prelude Therapeutics Incorporated (PRLD) balance sheet — assets, liabilities & shareholders' equity

MetricDec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
15.6M20.22M220.81M295.12M204.38M235.59M135.9M105.69M84.59M
Cash & Short-Term Investments
15.6M18.88M218.31M291.23M201.73M232.94M133.61M103.21M81.55M
Cash Only
15.6M18.88M218.31M31.83M30.61M25.29M12.47M35.26M21.76M
Short-Term Investments
000259.4M171.12M207.64M121.14M67.96M59.8M
Accounts Receivable
000000000
Days Sales Outstanding
---------
Inventory
000000000
Days Inventory Outstanding
---------
Other Current Assets
002.5M02.65M2.65M2.28M2.48M3.04M
Total Non-Current Assets
811K1.65M2.78M9.98M16.12M42.08M39.62M35.62M35.05M
Property, Plant & Equipment
811K1.65M2.48M5.64M6.7M37.74M35.47M32.28M31.5M
Fixed Asset Turnover
------0.20x0.38x0.51x
Goodwill
000000000
Intangible Assets
000000000
Long-Term Investments
000000003.23M
Other Non-Current Assets
00301K4.35M9.42M4.34M4.15M3.35M3.55M
Total Assets
16.41M▲ 0%
21.87M▲ 33.3%
223.59M▲ 922.3%
305.1M▲ 36.5%
220.5M▼ 27.7%
277.67M▲ 25.9%
175.51M▼ 36.8%
141.31M▼ 19.5%
119.64M▲ 0%
Asset Turnover
------0.04x0.09x0.14x
Asset Growth %
-33.31%922.31%36.45%-27.73%25.93%-36.79%-19.49%-135.51%
Total Current Liabilities
2.45M4.83M11.38M19.2M21.7M21.83M25.64M52.99M41.72M
Accounts Payable
1.36M1.97M3.92M7.84M6.78M4.58M7.73M3.98M2.07M
Days Payables Outstanding
3.34K------849.683.16K
Short-Term Debt
00000002.74M2.76M
Deferred Revenue (Current)
000000033.73M64.69M
Other Current Liabilities
01.63M420K5.01M6.21M6.61M9.79M12.53M5.94M
Current Ratio
6.37x4.18x19.41x15.37x9.42x10.79x5.30x1.99x2.03x
Quick Ratio
6.37x4.18x19.41x15.37x9.42x10.79x5.30x1.99x2.03x
Cash Conversion Cycle
---------
Total Non-Current Liabilities
36.65M66.45M32K03.36M18.75M18.41M19.68M17.74M
Long-Term Debt
000000015.04M14.96M
Capital Lease Obligations
0000015.41M15.32M045.38M
Deferred Tax Liabilities
000000000
Other Non-Current Liabilities
36.65M66.45M32K03.36M3.34M3.09M4.64M2.78M
Total Liabilities
39.1M71.28M11.41M19.2M25.06M40.58M44.06M72.68M59.46M
Total Debt
0258K01.74M1.83M16.89M18.02M17.79M17.72M
Net Debt
-15.6M-18.62M-218.31M-30.09M-28.77M-8.4M5.55M-17.47M-4.04M
Debt / Equity
---0.01x0.01x0.07x0.14x0.26x0.29x
Debt / EBITDA
---------0.21x
Net Debt / EBITDA
--------0.05x
Interest Coverage
---------
Total Equity
-22.69M▲ 0%
-49.41M▼ 117.7%
212.18M▲ 529.4%
285.9M▲ 34.7%
195.44M▼ 31.6%
237.09M▲ 21.3%
131.46M▼ 44.6%
68.64M▼ 47.8%
60.18M▲ 0%
Equity Growth %
--117.74%529.42%34.74%-31.64%21.31%-44.55%-47.79%-210.43%
Book Value per Share
-14.40-1.524.856.014.133.931.730.890.73
Total Shareholders' Equity
-22.69M-49.41M212.18M285.9M195.44M237.09M131.46M68.64M60.18M
Common Stock
004K5K5K5K5K5K5K
Retained Earnings
-22.93M-50.5M-107.43M-219.12M-334.56M-456.39M-583.56M-683.06M-693.45M
Treasury Stock
000000000
Accumulated OCI
-191K0-223.59M-711K-1.69M223K35K8K-41K
Minority Interest
000000000

PRLD Cash Flow Statement

Prelude Therapeutics Incorporated (PRLD) cash flow — operating, investing & free cash flow history

MetricDec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-12.95M-25.66M-46.18M-83.53M-83.73M-107.06M-102.89M-56.3M-43.76M
Operating CF Margin %
-------1469.83%-463.77%-
Operating CF Growth %
--98.12%-79.92%-80.89%-0.24%-27.87%3.9%45.28%264.98%
Net Income
-14.68M-27.57M-56.93M-111.69M-115.44M-121.83M-127.17M-99.5M-77.8M
Depreciation & Amortization
149K382K542K915K1.32M1.17M1.77M1.34M1.53M
Stock-Based Compensation
180K846K5.58M20.93M25.14M25.62M21.34M11.91M8.08M
Deferred Taxes
000000000
Other Non-Cash Items
15K10K11K2.69M4.31M-1.54M-3.05M1.53M2.83M
Working Capital Changes
1.38M667K4.62M3.63M932K-10.48M4.22M28.41M21.59M
Change in Receivables
000000000
Change in Inventory
000000000
Change in Payables
721K546K1.16M3.9M-347K-2.27M3.31M-3.92M-3.89M
Cash from Investing
-529K-780K-621K-263.8M81.69M-34.65M90.19M53.46M-228K
Capital Expenditures
-529K-780K-621K-2.32M-3.02M-3.51M-764K-67K-20K
CapEx % of Revenue
------10.91%0.55%0.12%
Acquisitions
000000000
Investments
---------
Other Investing
000000000
Cash from Financing
17.94M29.73M246.23M164.9M815K136.4M-120K24.82M24.66M
Debt Issued (Net)
0-124K-258K000-395K-208K-53K
Equity Issued (Net)
17.94M29.85M246.4M161.42M0135.73M329K25.04M24.78M
Dividends Paid
000000000
Share Repurchases
000000000
Other Financing
05K88K3.47M815K664K-54K-17K-63K
Net Change in Cash
4.45M▲ 0%
3.28M▼ 26.3%
199.43M▲ 5972.8%
-182.44M▼ 191.5%
-1.22M▲ 99.3%
-5.31M▼ 334.5%
-12.82M▼ 141.2%
21.97M▲ 271.4%
-19.32M▲ 0%
Free Cash Flow
-13.48M▲ 0%
-26.45M▼ 96.1%
-46.8M▼ 77.0%
-85.85M▼ 83.5%
-86.75M▼ 1.0%
-110.58M▼ 27.5%
-103.65M▲ 6.3%
-56.37M▲ 45.6%
-43.78M▲ 0%
FCF Margin %
-------1480.74%-464.32%-261.82%
FCF Growth %
--96.14%-76.96%-83.46%-1.04%-27.47%6.26%45.62%58.64%
FCF per Share
-8.55-0.82-1.07-1.80-1.83-1.83-1.37-0.73-0.53
FCF Conversion (FCF/Net Income)
0.88x0.93x0.81x0.75x0.73x0.88x0.81x0.57x0.56x
Interest Paid
000000000
Taxes Paid
000000000

PRLD Key Ratios

Prelude Therapeutics Incorporated (PRLD) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric2019202020212022202320242025TTM
Return on Equity (ROE)
--69.95%-44.85%-47.97%-56.34%-69.01%-99.45%-118.24%
Return on Invested Capital (ROIC)
---68.33%-43.86%-50.19%-57.31%-83.35%-123.62%
Gross Margin
-----100%85.91%97.66%
Net Margin
------1816.76%-819.59%-465.3%
Debt / Equity
--0.01x0.01x0.07x0.14x0.26x0.29x
FCF Conversion
0.93x0.81x0.75x0.73x0.88x0.81x0.57x0.56x
Revenue Growth
------73.43%138.86%
Related:PRLD Dividend History·PRLD Revenue History·PRLD Price History·PRLD P/E History·PRLD Financial Ratios·PRLD Institutional Holders

PRLD SEC Filings & Documents

Prelude Therapeutics Incorporated (PRLD) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 12, 2026·SEC

Material company update

Apr 21, 2026·SEC

Material company update

Apr 20, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 10, 2026·SEC

FY 2025

Mar 10, 2025·SEC

FY 2024

Feb 15, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 12, 2026·SEC

FY 2025

Nov 12, 2025·SEC

FY 2025

Aug 14, 2025·SEC

PRLD Frequently Asked Questions

Prelude Therapeutics Incorporated (PRLD) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Prelude Therapeutics Incorporated (PRLD) reported $16.7M in revenue for fiscal year 2025.

Prelude Therapeutics Incorporated (PRLD) grew revenue by 73.4% over the past year. This is strong growth.

Prelude Therapeutics Incorporated (PRLD) reported a net loss of $77.8M for fiscal year 2025.

Dividend & Returns

Prelude Therapeutics Incorporated (PRLD) has a return on equity (ROE) of -99.5%. Negative ROE indicates the company is unprofitable.

Prelude Therapeutics Incorporated (PRLD) had negative free cash flow of $43.8M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in PRLD back in 2018?

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