Last 48 quarters of trend data · Healthcare · Biotechnology
Quarterly valuation ratios — annualised for comparability. YoY Δ shows same-quarter-prior-year change.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P/E Ratio → | -3.28 | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| P/S Ratio | 8.59 | 20.65 | 11.20 | 20.11 | 14.08 | 7.75 | 12.56 | 9.67 | 5.38 | 10.49 | 11.83 | 19.22 | 26.37 |
| — | +166.5% | -10.8% | +107.9% | +161.9% | -26.2% | +6.2% | -49.7% | -79.6% | -83.0% | -80.0% | +28.5% | +95.5% | |
| P/B Ratio | 2.66 | 4.54 | 4.22 | 4.11 | 3.21 | 1.64 | 2.44 | 5.95 | 4.13 | 4.97 | 3.40 | 2.15 | 2.55 |
| — | +176.1% | +72.5% | -31.0% | -22.2% | -66.9% | -28.1% | +177.2% | +62.1% | +69.2% | -20.9% | +160.8% | +298.8% | |
| P/FCF | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBITDA | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBIT | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Quarterly margins and returns. Watch for margin compression across consecutive quarters.
ProQR Therapeutics N.V.'s operating margin was -671.4% in Q1 2026, down 476.7 pp QoQ and down 432.0 pp YoY. The trailing four-quarter average of -393.5% exceeds the current quarter, suggesting the latest result may reflect seasonal weakness or a one-off headwind. Gross margin contracted 34.1% YoY, suggesting cost inflation or competitive pricing pressure.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 83.0% | 65.9% | 85.5% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% |
| — | -34.1% | -14.5% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | |
| Operating Margin | -275.9% | -671.4% | -194.6% | -387.1% | -320.9% | -239.3% | -234.1% | -226.8% | -57.1% | -181.5% | -190.9% | -539.5% | -708.8% |
| — | -180.5% | +16.8% | -70.7% | -462.0% | -31.9% | -22.6% | +58.0% | +91.9% | +86.5% | +81.4% | +75.8% | +53.9% | |
| Net Margin | -265.2% | -658.3% | -190.3% | -377.6% | -319.1% | -223.0% | -216.0% | -211.0% | -42.7% | -172.1% | -167.0% | -416.8% | -643.0% |
| — | -195.1% | +11.9% | -79.0% | -647.3% | -29.6% | -29.4% | +49.4% | +93.4% | +86.6% | +84.8% | +84.1% | +51.7% |
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | -58.8% | -31.3% | -16.6% | -17.7% | -16.0% | -11.6% | -16.4% | -28.0% | -7.6% | -18.4% | -11.6% | -11.4% | -14.5% |
| — | -169.7% | -1.3% | +36.7% | -109.4% | +36.9% | -41.7% | -146.9% | +47.3% | -29.0% | +42.9% | +63.1% | +0.9% | |
| ROA | -28.9% | -12.8% | -7.5% | -8.4% | -8.1% | -6.1% | -6.8% | -7.2% | -2.1% | -5.4% | -3.6% | -3.8% | -5.2% |
| — | -111.4% | -10.1% | -16.6% | -278.0% | -13.5% | -86.9% | -88.4% | +59.1% | +1.3% | +60.1% | +75.3% | +29.6% | |
| ROIC | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Quarterly solvency trend — watch for debt spikes or covenant pressure.
The current ratio has weakened 39.4% YoY to 2.48x, tightening the short-term liquidity position.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 0.28 | 0.36 | 0.28 | 0.29 | 0.25 | 0.19 | 0.19 | 0.70 | 0.58 | 0.51 | 0.48 | 0.46 | 0.42 |
| — | +90.3% | +45.8% | -58.5% | -56.9% | -62.5% | -59.2% | +51.7% | +39.7% | +39.8% | +44.7% | +33.3% | -40.3% | |
| Debt / EBITDA | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| Current Ratio | 3.09 | 2.48 | 3.09 | 3.36 | 3.76 | 4.10 | 3.95 | 2.33 | 2.73 | 3.11 | 3.54 | 4.68 | 5.71 |
| — | -39.4% | -22.0% | +44.1% | +37.6% | +31.5% | +11.8% | -50.2% | -52.2% | -62.3% | -51.9% | +21.2% | -3.8% | |
| Quick Ratio | 3.09 | 2.48 | 3.09 | 3.36 | 3.76 | 4.10 | 3.95 | 2.33 | 2.73 | 3.11 | 3.54 | 4.68 | 5.71 |
| — | -39.4% | -22.0% | +44.1% | +37.6% | +31.5% | +11.8% | -50.2% | -52.2% | -62.3% | -51.9% | +21.2% | -3.8% | |
| Interest Coverage | -48.66 | — | — | — | — | — | — | — | -1387.82 | -2811.63 | -3.68 | -700.04 | -8521.28 |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Includes 30+ ratios · 48 years · Updated daily
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ProQR Therapeutics N.V.'s current P/E is -3.3x. Quarterly P/E ratios can vary due to seasonal revenue patterns and one-time charges.
ProQR Therapeutics N.V.'s current operating margin is -275.9%. Margins have been compressing over recent quarters. Quarterly margins are particularly useful for identifying trend inflections that annual data smooths over.
Quarterly financial ratios reveal short-term trend shifts — margin compression, debt spikes, or valuation re-ratings — that annual figures smooth over. They're essential for active investors tracking ProQR Therapeutics N.V.'s business trajectory between earnings reports.