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SLNSilence Therapeutics plc
$6.93$327M
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SLN logoSilence Therapeutics plc(SLN)Earnings, Financials & Key Ratios

SLN•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryRNA and Genome Editing Developers
AboutSilence Therapeutics plc, a biotechnology company, focuses on the discovery and development of novel ribonucleic acid (RNA) therapeutics in hematology, cardiovascular, and other rare and metabolic indications. The company's platform includes mRNAi GalNAc Oligonucleotide Discovery platform designed to accurately target specific disease-associated genes in the liver. It designs short interfering RNA molecules to harness the body's natural mechanism of RNA interference, and degrading messenger RNA molecules that encode specific targeted disease-associated proteins in a cell. The company is developing various product candidates, including SLN360, which is Phase I clinical trials for the treatment of cardiovascular disease with high lipoprotein; SLN124 that is in Phase I clinical trials for the treatment of non-transfusion dependent thalassemia, and Phase I clinical trials for the treatment of myelodysplastic syndrome; and SLN124 for the treatment of polycythemia vera. It has collaboration agreements with AstraZeneca PLC to discover, develop, and commercialize small interfering RNA therapeutics for the treatment of cardiovascular, renal, metabolic, and respiratory diseases; and Mallinckrodt Pharma IP Trading DAC to develop and commercialize RNAi drug targets designed to silence the complement cascade in complement-mediated disorders. The company also has a collaboration with Hansoh Pharmaceutical Group Company Limited to develop siRNAs for three undisclosed targets leveraging Silence's mRNAi GOLD platform. The company was formerly known as SR Pharma plc and changed its name to Silence Therapeutics plc in May 2007. Silence Therapeutics plc is headquartered in London, the United Kingdom.Show more
  • Revenue$559K-98.7%
  • EBITDA-$89M-42.2%
  • Net Income-$89M-95.6%
  • EPS (Diluted)-1.89+20.3%
  • Gross Margin61.54%-15.4%
  • EBITDA Margin-15956.71%-10904.3%
  • Operating Margin-16055.99%-10869.1%
  • Net Margin-15851.88%-15034.3%
  • ROE-90.27%-55.4%

SLN Key Insights

Silence Therapeutics plc (SLN) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Company is almost debt free

✗Weaknesses

  • ✗Profits declining 22.2% over 5 years
  • ✗Weak Piotroski F-Score: 1/9
  • ✗Negative free cash flow
  • ✗Sales declining 36.7% over 5 years
  • ✗Shares diluted 100.0% in last year
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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SLN Price & Volume

Silence Therapeutics plc (SLN) stock price & volume — 10-year historical chart

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SLN Growth Metrics

Silence Therapeutics plc (SLN) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-36.65%
3 Years-68.36%
TTM-96.8%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-31.77%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-1.67%

Return on Capital

10 Years-51.52%
5 Years-56.54%
3 Years-52.73%
Last Year-59.12%

SLN Recent Earnings

Silence Therapeutics plc (SLN) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 7/12 qtrs (64%)●Beat Revenue 4/12 qtrs (36%)
Q2 2026Latest
May 7, 2026
Metric
Actual
Est
EPS
$0.32+3.0%
$0.33
Rev
$422,000-66.4%
$1M
Q2 2026
Mar 5, 2026
Metric
Actual
Est
EPS
$0.25+21.9%
$0.32
Rev
$39,000-98.7%
$3M
Q4 2025
Nov 6, 2025
Metric
Actual
Est
EPS
$0.45-12.5%
$0.40
Rev
$159,000-94.9%
$3M
Q3 2025
Aug 7, 2025
Metric
Actual
Est
EPS
$0.54-100.0%
$0.27
Rev
$224,000-93.1%
$3M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 7, 2026
$0.32vs $0.33+3.0%
$422,000vs $1M-66.4%
Q2 2026Mar 5, 2026
$0.25vs $0.32+21.9%
$39,000vs $3M-98.7%
Q4 2025Nov 6, 2025
$0.45vs $0.40-12.5%
$159,000vs $3M-94.9%
Q3 2025Aug 7, 2025
$0.54vs $0.27-100.0%
$224,000vs $3M-93.1%
Based on last 12 quarters of dataView full earnings history →

SLN Peer Comparison

Silence Therapeutics plc (SLN) competitors in RNA and Genome Editing Developers — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
ALNY logoALNYAlnylam Pharmaceuticals, Inc.Direct Competitor37.1B278.09119.3565.19%13.46%98.29%1.62
ARWR logoARWRArrowhead Pharmaceuticals, Inc.Direct Competitor11.52B81.82-6706.56232.58%-48.38%-55.09%0.73
SRPT logoSRPTSarepta Therapeutics, Inc.Direct Competitor1.85B17.53-2.4615.58%2.98%4.89%0.91
NTLA logoNTLAIntellia Therapeutics, Inc.Direct Competitor1.76B15.67-4.1116.92%-5.97%-57.27%0.14
IONS logoIONSIonis Pharmaceuticals, Inc.Product Competitor12.25B74.12-31.1433.87%-30.87%-58.57%5.35
REGN logoREGNRegeneron Pharmaceuticals, Inc.Product Competitor63.37B609.9414.700.99%29.65%14.32%0.09
MDGL logoMDGLMadrigal Pharmaceuticals, Inc.Product Competitor11.66B505.75-39.36432.05%-27.32%-50.15%0.59
AKRO logoAKROAkero Therapeutics, Inc.Product Competitor4.5B54.65-14.57-30.58%0.05

Compare SLN vs Peers

Silence Therapeutics plc (SLN) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs ALNY

Most directly comparable listed peer for SLN.

Scale Benchmark

vs MRK

Larger-name benchmark to compare SLN against a more recognizable public peer.

Peer Set

Compare Top 5

vs ALNY, ARWR, SRPT, NTLA

SLN Income Statement

Silence Therapeutics plc (SLN) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
16K0244K5.48M12.41M17.65M25.38M43.26M559K838.29K
Revenue Growth %
-97.92%-100%-2145.49%126.59%42.19%43.74%70.47%-98.71%-96.8%
Cost of Goods Sold
7.94M9.74M03.76M7.46M10.97M10.32M11.81M215K277.8K
COGS % of Revenue
49643.75%--68.66%60.06%62.17%40.66%27.3%38.46%-
Gross Profit
-7.93M▲ 0%
-9.74M▼ 22.9%
244K▲ 102.5%
1.72M▲ 603.7%
4.96M▲ 188.8%
6.68M▲ 34.7%
15.06M▲ 125.5%
31.45M▲ 108.9%
344K▼ 98.9%
560.49K▲ 0%
Gross Margin %
-49543.75%-100%31.34%39.94%37.83%59.34%72.7%61.54%66.86%
Gross Profit Growth %
0.18%-22.91%102.5%603.69%188.82%34.67%125.47%108.86%-98.91%-
Operating Expenses
14.41M20.57M22.98M37.56M50.77M56.44M64.66M94.77M90.1M78.25M
OpEx % of Revenue
90043.75%-9417.21%685.6%408.96%319.7%254.82%219.07%16117.53%-
Selling, General & Admin
6.46M10.83M9.64M13.98M20.01M20.94M20.64M26.88M22.34M21.69M
SG&A % of Revenue
40400%-3951.64%255.21%161.16%118.6%81.32%62.15%3997.14%-
Research & Development
7.94M9.74M13.34M20.21M30.77M35.5M44.02M67.88M67.75M55.28M
R&D % of Revenue
49643.75%-5465.57%368.84%247.81%201.11%173.5%156.93%12120.39%-
Other Operating Expenses
0003.37M00000954.28K
Operating Income
-14.39M▲ 0%
-20.57M▼ 42.9%
-22.73M▼ 10.5%
-35.85M▼ 57.7%
-45.81M▼ 27.8%
-49.76M▼ 8.6%
-49.6M▲ 0.3%
-63.32M▼ 27.6%
-89.75M▼ 41.7%
-77.69M▲ 0%
Operating Margin %
-89943.75%--9317.21%-654.26%-369.02%-281.87%-195.48%-146.38%-16055.99%-9267.51%
Operating Income Growth %
-20.87%-42.94%-10.51%-57.68%-27.8%-8.61%0.31%-27.65%-41.75%-
EBITDA
-13.96M-20.17M-22.25M-35.35M-45.39M-49.27M-49.11M-62.73M-89.2M-77.17M
EBITDA Margin %
-87237.5%--9119.67%-645.21%-365.58%-279.12%-193.52%-145%-15956.71%-9205.14%
EBITDA Growth %
-20.37%-44.52%-10.31%-58.87%-28.39%-8.56%0.34%-27.74%-42.2%-7.39%
D&A (Non-Cash Add-back)
433K399K482K496K427K485.86K498K593K555K522.82K
EBIT
-3.76M-20.57M-22.84M-36.02M-45.85M-49.76M-50.28M-49.58M-89.75M-71.08M
Net Interest Income
-15K39K-6K113K2K179K1.41M4.47M3.48M0
Interest Income
039K27K129K10K226K1.45M4.47M3.48M0
Interest Expense
15K033K16K8K47K34K000
Other Income/Expense
10.62M45K-136K-194K-42K9.29M-706K18.86M1.15M2.69M
Pretax Income
-3.77M▲ 0%
-20.53M▼ 443.7%
-22.87M▼ 11.4%
-36.04M▼ 57.6%
-45.86M▼ 27.2%
-40.47M▲ 11.7%
-50.31M▼ 24.3%
-44.46M▲ 11.6%
-88.6M▼ 99.3%
-75M▲ 0%
Pretax Margin %
-23593.75%--9372.95%-657.8%-369.36%-229.26%-198.27%-102.79%-15849.91%-8947.11%
Income Tax
-2.16M-2.12M-3.29M-3.49M-6.45M560.85K-7.04M845K11K11K
Effective Tax Rate %
57.14%10.3%14.38%9.69%14.06%-1.39%14%-1.9%-0.01%-0.01%
Net Income
-1.62M▲ 0%
-18.41M▼ 1037.9%
-19.58M▼ 6.4%
-32.55M▼ 66.2%
-39.41M▼ 21.1%
-41.03M▼ 4.1%
-43.27M▼ 5.4%
-45.31M▼ 4.7%
-88.61M▼ 95.6%
-75.01M▲ 0%
Net Margin %
-10112.5%--8025.41%-594.03%-317.44%-232.44%-170.51%-104.74%-15851.88%-8948.43%
Net Income Growth %
80.83%-1037.89%-6.36%-66.21%-21.09%-4.12%-5.45%-4.72%-95.57%-31.77%
Net Income (Continuing)
-1.62M-18.41M-19.58M-32.55M-39.41M-41.03M-43.27M-45.31M-88.61M-75.01M
Discontinued Operations
0000000000
Minority Interest
0000000000
EPS (Diluted)
-0.07▲ 0%
-0.83▼ 1138.8%
-0.78▲ 6.0%
-1.11▼ 42.3%
-1.35▼ 21.6%
-3.78▼ 180.0%
-3.48▲ 7.9%
-2.37▲ 31.9%
-1.89▲ 20.3%
-1.59▲ 0%
EPS Growth %
83.25%-1138.81%6.02%-42.31%-21.62%-180%7.94%31.9%20.25%-1.67%
EPS (Basic)
-0.07-0.83-0.78-1.11-1.35-3.78-3.48-2.37-1.89-
Diluted Shares Outstanding
23.31M23.44M25.04M27.26M29.65M10.73M12.36M15.42M47.23M47.23M
Basic Shares Outstanding
23.31M23.44M25.04M27.26M29.65M10.73M12.36M15.42M47.23M47.23M
Dividend Payout Ratio
----------

SLN Balance Sheet

Silence Therapeutics plc (SLN) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
45.55M29.5M37.47M76.4M86.33M96.69M103.15M187.37M118.66M102.85M
Cash & Short-Term Investments
43.06M26.54M33.52M37.45M73.54M71.14M68.79M147.33M85.11M70.08M
Cash Only
42.74M21.49M13.52M27.45M73.54M54.82M68.79M121.33M11.28M5.66M
Short-Term Investments
319K5.04M20M10M016.33M026M73.84M64.42M
Accounts Receivable
004K29.31M331K915K23.98M26.91M24.61M22.22M
Days Sales Outstanding
--5.981.95K9.7318.92344.89227.0416.07K9.69K
Inventory
-2.48M-2.45M00000000
Days Inventory Outstanding
----------
Other Current Assets
003.51M5.7M8.16M16.43M00010.56M
Total Non-Current Assets
9.46M9.39M8.61M9.57M9.86M10.81M16.3M15.27M12.78M12.27M
Property, Plant & Equipment
1.17M921K611K1.13M1.94M2.2M2.31M1.98M1.75M1.54M
Fixed Asset Turnover
0.01x-0.40x4.86x6.39x8.02x10.99x21.90x0.32x0.48x
Goodwill
8.03M8.13M7.69M8.13M7.59M8.01M9.98M9.39M10.62M10.36M
Intangible Assets
28K64K34K17K24K320K362K312K288K248K
Long-Term Investments
0-4.77M275K303K301K284K0000
Other Non-Current Assets
233K5.04M00003.65M3.59M127K127K
Total Assets
55.01M▲ 0%
38.88M▼ 29.3%
46.08M▲ 18.5%
85.97M▲ 86.6%
96.19M▲ 11.9%
107.5M▲ 11.8%
119.45M▲ 11.1%
202.63M▲ 69.6%
131.44M▼ 35.1%
115.12M▲ 0%
Asset Turnover
0.00x-0.01x0.06x0.13x0.16x0.21x0.21x0.00x0.01x
Asset Growth %
-1.41%-29.31%18.5%86.58%11.89%11.75%11.11%69.64%-35.13%-98.75%
Total Current Liabilities
2.66M3.83M9.65M25.57M15.17M21.94M22.34M16.82M13.61M10.46M
Accounts Payable
462K1.15M1.79M2.29M4.07M3.19M3.35M3.7M4.41M10.37M
Days Payables Outstanding
21.2342.97-221.7199105.96118.44114.267.49K18.07K
Short-Term Debt
000000228K089K93K
Deferred Revenue (Current)
0000006.57M306K168K926K
Other Current Liabilities
027K2.48M17.04M4.43M9.45M8.58M3.44M5.94M0
Current Ratio
17.14x7.70x3.88x2.99x5.69x4.41x4.62x11.14x8.72x9.83x
Quick Ratio
18.08x8.34x3.88x2.99x5.69x4.41x4.62x11.14x8.72x9.83x
Cash Conversion Cycle
----------8.38K
Total Non-Current Liabilities
462K1.15M15.52M51.34M72.5M63.48M75.12M51.79M55.52M55.26M
Long-Term Debt
0000000000
Capital Lease Obligations
000000118K071K211K
Deferred Tax Liabilities
0000000000
Other Non-Current Liabilities
0015.52M51.34M72.5M63.48M0000
Total Liabilities
2.66M3.83M25.17M76.91M87.67M85.43M97.45M68.61M69.14M65.72M
Total Debt
00287K341K137K446K346K117K160K136K
Net Debt
-42.74M-21.49M-13.23M-27.11M-73.4M-54.37M-68.44M-121.21M-11.12M-5.52M
Debt / Equity
--0.01x0.04x0.02x0.02x0.02x0.00x0.00x0.00x
Debt / EBITDA
----------0.00x
Net Debt / EBITDA
---------0.07x
Interest Coverage
-250.67x--692.03x-2251.56x-5731.00x-1058.71x-1478.71x---
Total Equity
52.35M▲ 0%
35.05M▼ 33.0%
20.91M▼ 40.4%
9.06M▼ 56.7%
8.53M▼ 5.9%
22.07M▲ 158.9%
21.99M▼ 0.4%
134.02M▲ 509.4%
62.3M▼ 53.5%
49.4M▲ 0%
Equity Growth %
-3.38%-33.04%-40.35%-56.67%-5.88%158.88%-0.36%509.39%-53.51%52.35%
Book Value per Share
2.251.500.830.330.292.061.788.691.321.05
Total Shareholders' Equity
52.35M35.05M20.91M9.06M8.53M22.07M21.99M134.02M62.3M49.4M
Common Stock
3.5M3.55M3.92M4.17M4.49M5.39M8.85M10.29M10.29M10.29M
Retained Earnings
-116.43M-133.78M-152M-184.22M-222.97M-263.26M-431.89M-474.04M-562.57M-577.53M
Treasury Stock
0000000000
Accumulated OCI
165.28M165.28M30.84M35.38M42.67M53.27M40.36M-11.78M-2.98M-3.37M
Minority Interest
0000000000

SLN Cash Flow Statement

Silence Therapeutics plc (SLN) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-9.6M-16.76M1.73M-10.78M9.19M-57.04M-39.35M-67.64M-62.27M-65.56M
Operating CF Margin %
-59993.75%-707.79%-196.68%73.99%-323.14%-155.07%-156.36%-11139.71%-
Operating CF Growth %
4.64%-74.6%110.3%-723.97%185.24%-721.01%31.02%-71.89%7.94%-263.26%
Net Income
-3.77M-20.53M-22.87M-36.04M-61.89M-50.33M-50.31M-36.19M-88.61M-75.01M
Depreciation & Amortization
433K399K482K496K576.29K596K498K593K555K885K
Stock-Based Compensation
638K681K584K4.39M11.65M12.69M13.05M13.03M8.07M14.34M
Deferred Taxes
-8.4M1.82M2.31M3.02M5.95M688K0845K11K21K
Other Non-Cash Items
-206K-45K136K-1.3M468.32K-1.28M9.07M-12.89M7.54M70.22M
Working Capital Changes
1.71M913K21.09M18.66M52.43M-19.4M-11.66M-33.02M10.16M-5.6M
Change in Receivables
664K691K-4K-29.3M37.09M-10.54M314K-904K5.07M-8.33M
Change in Inventory
0000000000
Change in Payables
000000000-5.6M
Cash from Investing
13.01M-4.83M-15.02M9.62M11.71M-20.5M16.43M-21.97M-47.99M6.39M
Capital Expenditures
-173K-188K-9K-511K-1.77M-173K-45K-211K-55K-106K
CapEx % of Revenue
1081.25%-3.69%9.33%14.25%0.98%0.18%0.49%9.84%12.64%
Acquisitions
-13.22M-58K00000000
Investments
----------
Other Investing
13.2M97K-6K129K-17.55K-372K958K117.41M0137.99M
Cash from Financing
48K341K5.27M15.43M41.45M52.58M25.16M142.09M15K986
Debt Issued (Net)
000-402K-284.77K0-174K000
Equity Issued (Net)
48K341K5.27M15.83M41.73M52.58M25.33M142.09M15K986
Dividends Paid
0000000000
Share Repurchases
0000000000
Other Financing
0000000000
Net Change in Cash
3.73M▲ 0%
-21.25M▼ 669.3%
-7.98M▲ 62.5%
13.93M▲ 274.6%
62.2M▲ 346.4%
-33.08M▼ 153.2%
-785K▲ 97.6%
52.54M▲ 6793.1%
-110.05M▼ 309.5%
-59.21M▲ 0%
Free Cash Flow
-9.77M▲ 0%
-16.95M▼ 73.4%
1.72M▲ 110.1%
-11.29M▼ 757.2%
7.39M▲ 165.4%
-57.59M▼ 879.8%
-39.4M▲ 31.6%
-67.85M▼ 72.2%
-62.33M▲ 8.1%
-65.67M▲ 0%
FCF Margin %
-61075%-704.1%-206.06%59.49%-326.23%-155.25%-156.85%-11149.55%-7833.91%
FCF Growth %
7.84%-73.43%110.14%-757.16%165.41%-879.79%31.59%-72.23%8.14%-5.19%
FCF per Share
-0.42-0.720.07-0.410.25-5.37-3.19-4.40-1.32-1.39
FCF Conversion (FCF/Net Income)
5.93x0.91x-0.09x0.33x-0.23x1.39x0.91x1.49x0.70x0.88x
Interest Paid
0000000000
Taxes Paid
0000000433K637K561K

SLN Key Ratios

Silence Therapeutics plc (SLN) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025TTM
Return on Equity (ROE)
-3.04%-42.13%-69.98%-217.21%-448.22%-268.2%-196.38%-58.08%-90.27%-107.19%
Return on Invested Capital (ROIC)
-87.12%-133.2%-160.54%-----370.72%-210.37%-166.84%
Gross Margin
-49543.75%-100%31.34%39.94%37.83%59.34%72.7%61.54%66.86%
Net Margin
-10112.5%--8025.41%-594.03%-317.44%-232.44%-170.51%-104.74%-15851.88%-8948.43%
Debt / Equity
--0.01x0.04x0.02x0.02x0.02x0.00x0.00x0.00x
Interest Coverage
-250.67x--692.03x-2251.56x-5731.00x-1058.71x-1478.71x---
FCF Conversion
5.93x0.91x-0.09x0.33x-0.23x1.39x0.91x1.49x0.70x0.88x
Revenue Growth
-97.92%-100%-2145.49%126.59%42.19%43.74%70.47%-98.71%-96.8%
Related:SLN Dividend History·SLN Revenue History·SLN Price History·SLN P/E History·SLN Financial Ratios·SLN Institutional Holders

SLN SEC Filings & Documents

Silence Therapeutics plc (SLN) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 18, 2026·SEC

Material company update

May 7, 2026·SEC

Material company update

Mar 5, 2026·SEC

10-K Annual Reports

2
FY 2026

Mar 5, 2026·SEC

FY 2025

Feb 27, 2025·SEC

10-Q Quarterly Reports

4
FY 2026

May 7, 2026·SEC

FY 2025

Nov 6, 2025·SEC

FY 2025

Aug 7, 2025·SEC

SLN Frequently Asked Questions

Silence Therapeutics plc (SLN) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Silence Therapeutics plc (SLN) reported $0.8M in revenue for fiscal year 2025.

Silence Therapeutics plc (SLN) saw revenue decline by 98.7% over the past year.

Silence Therapeutics plc (SLN) reported a net loss of $75.0M for fiscal year 2025.

Dividend & Returns

Silence Therapeutics plc (SLN) has a return on equity (ROE) of -90.3%. Negative ROE indicates the company is unprofitable.

Silence Therapeutics plc (SLN) had negative free cash flow of $65.7M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in SLN back in 1996?

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