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STOK logoStoke Therapeutics, Inc.(STOK)Earnings, Financials & Key Ratios

STOK•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryRNA and Genome Editing Developers
AboutStoke Therapeutics, Inc., an early-stage biopharmaceutical company, develops novel antisense oligonucleotide (ASO) medicines to treat the underlying causes of severe genetic diseases in the United States. The company utilizes its proprietary Targeted Augmentation of Nuclear Gene Output to design ASOs to precisely upregulate protein expression. Its lead clinical candidate is STK-001, which is in phase I/IIa clinical trial to treat Dravet syndrome, a severe and progressive genetic epilepsy; and STK-002, which is in preclinical stage for the treatment of autosomal dominant optic atrophy. It had entered into a license and collaboration agreement with Acadia Pharmaceuticals Inc. for the discovery, development, and commercialization of novel RNA-based medicines for the treatment of severe and rare genetic neurodevelopmental diseases of the central nervous system. The company was formerly known as ASOthera Pharmaceuticals, Inc. and changed its name to Stoke Therapeutics, Inc. in May 2016. Stoke Therapeutics, Inc. was incorporated in 2014 and is headquartered in Bedford, Massachusetts.Show more
  • Revenue$184M+404.5%
  • EBITDA-$19M+81.0%
  • Net Income-$7M+92.3%
  • EPS (Diluted)-0.12+92.7%
  • Gross Margin100%
  • EBITDA Margin-10.21%+96.2%
  • Operating Margin-11.16%+96.0%
  • Net Margin-3.73%+98.5%
  • ROE-2.37%+94.8%

STOK Key Insights

Stoke Therapeutics, Inc. (STOK) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Strong 5Y profit CAGR of 33.3%
  • ✓FCF machine: 24.4% free cash flow margin

✗Weaknesses

No significant weaknesses identified

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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STOK Price & Volume

Stoke Therapeutics, Inc. (STOK) stock price & volume — 10-year historical chart

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STOK Growth Metrics

Stoke Therapeutics, Inc. (STOK) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years145.89%
TTM-83.2%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-437.7%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-458.23%

Return on Capital

10 Years-32.03%
5 Years-37.84%
3 Years-36.19%
Last Year-6.96%

STOK Recent Earnings

Stoke Therapeutics, Inc. (STOK) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 9/12 qtrs (75%)●Beat Revenue 8/12 qtrs (67%)
Q2 2026Latest
May 7, 2026
Metric
Actual
Est
EPS
$0.79+1.3%
$0.80
Rev
$6M-3.9%
$6M
Q2 2026
Mar 17, 2026
Metric
Actual
Est
EPS
$0.99-8.1%
$0.92
Rev
$1M-77.5%
$6M
Q2 2026
Mar 16, 2026
Metric
Actual
Est
EPS
$0.97-29.3%
$0.75
Rev
$1M-76.0%
$6M
Q4 2025
Nov 4, 2025
Metric
Actual
Est
EPS
$0.65-20.4%
$0.54
Rev
$11M+133.4%
$5M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 7, 2026
$0.79vs $0.80+1.3%
$6Mvs $6M-3.9%
Q2 2026Mar 17, 2026
$0.99vs $0.92-8.1%
$1Mvs $6M-77.5%
Q2 2026Mar 16, 2026
$0.97vs $0.75-29.3%
$1Mvs $6M-76.0%
Q4 2025Nov 4, 2025
$0.65vs $0.54-20.4%
$11Mvs $5M+133.4%
Based on last 12 quarters of dataView full earnings history →

STOK Peer Comparison

Stoke Therapeutics, Inc. (STOK) competitors in RNA and Genome Editing Developers — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
ACAD logoACADACADIA Pharmaceuticals Inc.Direct Competitor3.7B21.629.4411.87%34.3%35.65%0.04
PRAX logoPRAXPraxis Precision Medicines, Inc.Direct Competitor8.15B282.31-20.94-100%-43.02%0.00
ARVN logoARVNArvinas, Inc.Direct Competitor494.88M7.67-5.99-0.3%-247.54%-44.39%0.02
IONS logoIONSIonis Pharmaceuticals, Inc.Product Competitor12.25B74.12-31.1433.87%-30.87%-58.57%5.35
SRPT logoSRPTSarepta Therapeutics, Inc.Product Competitor1.85B17.53-2.4615.58%2.98%4.89%0.91
ALNY logoALNYAlnylam Pharmaceuticals, Inc.Product Competitor37.1B278.09119.3565.19%13.46%98.29%1.62
ARWR logoARWRArrowhead Pharmaceuticals, Inc.Product Competitor11.52B81.82-6706.56232.58%-48.38%-55.09%0.73
NTLA logoNTLAIntellia Therapeutics, Inc.Product Competitor1.76B15.67-4.1116.92%-5.97%-57.27%0.14

Compare STOK vs Peers

Stoke Therapeutics, Inc. (STOK) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs ACAD

Most directly comparable listed peer for STOK.

Scale Benchmark

vs TMO

Larger-name benchmark to compare STOK against a more recognizable public peer.

Peer Set

Compare Top 5

vs ACAD, PRAX, ARVN, IONS

STOK Income Statement

Stoke Therapeutics, Inc. (STOK) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
0000012.4M8.78M36.55M184.42M32.08M
Revenue Growth %
-------29.22%316.34%404.5%-83.2%
Cost of Goods Sold
113K214K450K1.93M000003.09M
COGS % of Revenue
----------
Gross Profit
-113K▲ 0%
-214K▼ 89.4%
-450K▼ 110.3%
-1.93M▼ 328.0%
0▲ 100.0%
12.4M▲ 0%
8.78M▼ 29.2%
36.55M▲ 316.3%
184.42M▲ 404.5%
28.99M▲ 0%
Gross Margin %
-----100%100%100%100%90.36%
Gross Profit Growth %
--89.38%-110.28%-328%100%--29.22%316.34%404.5%-
Operating Expenses
5.55M12.78M35.23M51.12M86.06M116.76M123.55M137.93M205.01M214.24M
OpEx % of Revenue
-----941.24%1407.21%377.31%111.16%-
Selling, General & Admin
1.96M4.41M11.91M20.85M31.9M38.92M41.32M48.79M67.09M71.21M
SG&A % of Revenue
-----313.78%470.64%133.48%36.38%-
Research & Development
3.6M8.37M23.31M32.2M54.17M77.84M82.23M89.13M137.92M144.07M
R&D % of Revenue
-----627.46%936.57%243.83%74.79%-
Other Operating Expenses
-4K-10K0-1.93M00000-1000K
Operating Income
-5.55M▲ 0%
-12.78M▼ 130.1%
-35.68M▼ 179.1%
-53.04M▼ 48.7%
-86.06M▼ 62.3%
-104.36M▼ 21.3%
-114.77M▼ 10.0%
-101.37M▲ 11.7%
-20.59M▲ 79.7%
-185.25M▲ 0%
Operating Margin %
------841.24%-1307.21%-277.31%-11.16%-577.46%
Operating Income Growth %
--130.12%-179.15%-48.67%-62.25%-21.25%-9.98%11.68%79.69%-
EBITDA
-5.44M-12.57M-35.23M-51.12M-85.09M-102.81M-112.3M-99.19M-18.82M-181.71M
EBITDA Margin %
------828.78%-1279.09%-271.36%-10.21%-566.43%
EBITDA Growth %
--130.97%-180.32%-45.11%-66.46%-20.82%-9.23%11.67%81.03%-550.53%
D&A (Non-Cash Add-back)
113K214K450K1.93M974K1.55M2.47M2.18M1.77M3.54M
EBIT
-5.55M-12.78M-32.33M-52.24M-86.06M-104.36M-114.77M-101.37M-20.59M-181.78M
Net Interest Income
003.35M744K120K00003.68M
Interest Income
0270K3.35M744K120K00007.08M
Interest Expense
0000000003.4M
Other Income/Expense
-4K260K3.35M801K260K3.29M10.07M12.39M13.71M14.2M
Pretax Income
-5.56M▲ 0%
-12.52M▼ 125.3%
-32.33M▼ 158.2%
-52.24M▼ 61.6%
-85.81M▼ 64.2%
-101.07M▼ 17.8%
-104.7M▼ 3.6%
-88.98M▲ 15.0%
-6.88M▲ 92.3%
-171.04M▲ 0%
Pretax Margin %
------814.73%-1192.47%-243.42%-3.73%-533.18%
Income Tax
000000000-1.28M
Effective Tax Rate %
0%0%0%0%0%0%0%0%0%0.75%
Net Income
-5.56M▲ 0%
-12.52M▼ 125.3%
-32.33M▼ 158.2%
-52.24M▼ 61.6%
-85.81M▼ 64.2%
-101.07M▼ 17.8%
-104.7M▼ 3.6%
-88.98M▲ 15.0%
-6.88M▲ 92.3%
-169.77M▲ 0%
Net Margin %
------814.73%-1192.47%-243.42%-3.73%-529.2%
Net Income Growth %
--125.28%-158.17%-61.62%-64.24%-17.79%-3.59%15.01%92.26%-437.7%
Net Income (Continuing)
-5.56M-12.52M-32.33M-52.24M-85.81M-101.07M-104.7M-88.98M-6.88M-169.77M
Discontinued Operations
0000000000
Minority Interest
0000000000
EPS (Diluted)
-0.24▲ 0%
-0.53▼ 120.8%
-1.59▼ 200.0%
-1.56▲ 1.9%
-2.34▼ 50.0%
-2.60▼ 11.1%
-2.38▲ 8.5%
-1.65▲ 30.7%
-0.12▲ 92.7%
-2.69▲ 0%
EPS Growth %
--120.83%-200%1.89%-50%-11.11%8.46%30.67%92.73%-458.23%
EPS (Basic)
-0.24-0.53-1.59-1.56-2.34-2.60-2.38-1.65-0.12-
Diluted Shares Outstanding
23.51M23.51M17.97M33.49M36.74M38.9M43.99M54.01M59.22M63.06M
Basic Shares Outstanding
23.51M23.51M17.97M33.49M36.74M38.9M43.99M54.01M59.22M63.06M
Dividend Payout Ratio
----------

STOK Balance Sheet

Stoke Therapeutics, Inc. (STOK) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
1.91M106.14M226.03M293.93M229.22M244.07M215.34M232.76M305.7M366.68M
Cash & Short-Term Investments
1.8M105.4M222.47M287.31M219.81M229.59M201.39M216.9M284.67M343.55M
Cash Only
1.8M105.4M222.47M287.31M144.9M113.56M191.44M127.98M84.22M155.66M
Short-Term Investments
000074.92M116.04M9.95M88.92M200.45M187.89M
Accounts Receivable
0196K281K6K132K588K64K700K7.91M6.14M
Days Sales Outstanding
-----17.32.666.9915.6575.39
Inventory
0000000000
Days Inventory Outstanding
----------
Other Current Assets
000181K2.33M2.96M2.56M4.04M13.13M6.88M
Total Non-Current Assets
529K1.4M2.72M4M9.65M12M13M38.8M112.73M76.6M
Property, Plant & Equipment
473K1.19M2.51M3.79M9.08M11.43M12.43M8.25M6.25M5.89M
Fixed Asset Turnover
-----1.09x0.71x4.43x29.52x5.03x
Goodwill
0000000000
Intangible Assets
0000000000
Long-Term Investments
56K204K0000029.82M0258.28M
Other Non-Current Assets
00205K205K569K569K569K721K106.49M0
Total Assets
2.44M▲ 0%
107.54M▲ 4309.1%
228.75M▲ 112.7%
297.93M▲ 30.2%
238.87M▼ 19.8%
256.07M▲ 7.2%
228.34M▼ 10.8%
271.56M▲ 18.9%
418.43M▲ 54.1%
443.28M▲ 0%
Asset Turnover
-----0.05x0.04x0.13x0.44x0.08x
Asset Growth %
-4309.14%112.71%30.24%-19.82%7.2%-10.83%18.92%54.09%110.79%
Total Current Liabilities
3.71M2.47M4.1M11.43M17.14M31.39M30.82M40.06M57.88M40.81M
Accounts Payable
141K1.07M751K1.5M2.38M766K1.7M2.5M4.94M6.84M
Days Payables Outstanding
455.441.83K609.14283.32-----648.34
Short-Term Debt
3M000000002.43M
Deferred Revenue (Current)
-3M000014.88M15.31M18.99M11.9M36.48M
Other Current Liabilities
002.11M4.58M5.92M6.26M6.47M8.44M41.03M18.39M
Current Ratio
0.51x43.03x55.12x25.73x13.37x7.77x6.99x5.81x5.28x8.99x
Quick Ratio
0.51x43.03x55.12x25.73x13.37x7.77x6.99x5.81x5.28x8.99x
Cash Conversion Cycle
----------572.95
Total Non-Current Liabilities
16K4K221K422K3.95M39.82M37.96M2.48M8.1M7.59M
Long-Term Debt
0000000000
Capital Lease Obligations
000000000990K
Deferred Tax Liabilities
0000000000
Other Non-Current Liabilities
16K4K221K422K3.95M2.97M4.88M2.48M8.1M1K
Total Liabilities
3.73M2.47M4.32M11.85M21.09M71.22M68.78M42.53M65.98M48.4M
Total Debt
3M001.07M1.51M2.36M2.06M2.32M03.42M
Net Debt
1.2M-105.4M-222.47M-286.24M-143.39M-111.2M-189.38M-125.66M-84.22M-152.24M
Debt / Equity
---0.00x0.01x0.01x0.01x0.01x-0.01x
Debt / EBITDA
----------0.02x
Net Debt / EBITDA
---------0.84x
Interest Coverage
----------53.42x
Total Equity
-1.29M▲ 0%
105.07M▲ 8232.2%
224.43M▲ 113.6%
286.08M▲ 27.5%
217.78M▼ 23.9%
184.85M▼ 15.1%
159.56M▼ 13.7%
229.02M▲ 43.5%
352.46M▲ 53.9%
394.88M▲ 0%
Equity Growth %
-8232.2%113.6%27.47%-23.88%-15.12%-13.68%43.53%53.9%137.44%
Book Value per Share
-0.054.4712.498.545.934.753.634.245.956.26
Total Shareholders' Equity
-1.29M105.07M224.43M286.08M217.78M184.85M159.56M229.02M352.46M394.88M
Common Stock
1K1K3K4K4K4K5K5K5K6K
Retained Earnings
-13.19M-25.71M-58.03M-110.28M-196.08M-297.15M-401.85M-490.83M-497.71M-547.72M
Treasury Stock
0000000000
Accumulated OCI
-172K-379K00-168K-1.18M-24K-151K543K-115K
Minority Interest
0000000000

STOK Cash Flow Statement

Stoke Therapeutics, Inc. (STOK) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-5.38M-10.96M-31.05M-42.22M-66.91M-31.87M-81.07M-86.85M45.59M-146.82M
Operating CF Margin %
------256.88%-923.31%-237.59%24.72%-
Operating CF Growth %
--103.64%-183.25%-35.96%-58.47%52.37%-154.4%-7.13%152.49%-263.21%
Net Income
-5.56M-12.52M-32.33M-52.24M-85.81M-101.07M-104.7M-88.98M-6.88M-169.77M
Depreciation & Amortization
113K214K450K888K974K1.55M2.47M2.18M1.77M2.28M
Stock-Based Compensation
26K240K1.92M5.77M16.45M22.85M25.26M27.47M32.24M26.2M
Deferred Taxes
0003K172K00000
Other Non-Cash Items
4K10K3K1.04M1.26M1.78M1.94M623K2.12M9.74M
Working Capital Changes
31K1.09M-1.1M2.33M46K43.02M-6.03M-28.14M16.35M-15.28M
Change in Receivables
00000000-4.27M4.8M
Change in Inventory
0000000000
Change in Payables
100K1.74M891K5.2M2.9M121K-3.21M3.09M21.29M829K
Cash from Investing
-113K-925K-1.63M-1.05M-76.43M-45.88M105.95M-107.47M-186.81M-149.75M
Capital Expenditures
-113K-935K-1.64M-1.05M-1.2M-3.96M-1.62M-203K-670K-871K
CapEx % of Revenue
-----31.94%18.41%0.56%0.36%2.72%
Acquisitions
010K1K075.23M45.34M0000
Investments
----------
Other Investing
010K00-75.23M-45.34M0000
Cash from Financing
5.97M115.64M149.76M108.11M1.28M46.41M53.01M131.09M97.39M180.34M
Debt Issued (Net)
0000000000
Equity Issued (Net)
3M116M151.91M105.4M1.29M45.34M52.08M128.84M97.39M180.34M
Dividends Paid
0000000000
Share Repurchases
0000000000
Other Financing
2.97M-361K-2.15M2.71M-2K1.06M926K2.25M00
Net Change in Cash
477K▲ 0%
103.75M▲ 21650.5%
117.07M▲ 12.8%
64.84M▼ 44.6%
-142.05M▼ 319.1%
-31.34M▲ 77.9%
77.89M▲ 348.5%
-63.23M▼ 181.2%
-43.84M▲ 30.7%
-116.23M▲ 0%
Free Cash Flow
-5.5M▲ 0%
-11.9M▼ 116.5%
-32.69M▼ 174.7%
-43.27M▼ 32.4%
-68.11M▼ 57.4%
-35.83M▲ 47.4%
-82.68M▼ 130.8%
-87.05M▼ 5.3%
44.91M▲ 151.6%
-147.69M▲ 0%
FCF Margin %
------288.82%-941.72%-238.15%24.35%-460.4%
FCF Growth %
--116.46%-174.73%-32.37%-57.4%47.39%-130.78%-5.29%151.59%-313.44%
FCF per Share
-0.23-0.51-1.82-1.29-1.85-0.92-1.88-1.610.76-2.34
FCF Conversion (FCF/Net Income)
0.97x0.88x0.96x0.81x0.78x0.32x0.77x0.98x-6.62x0.87x
Interest Paid
0000000000
Taxes Paid
0000000000

STOK Key Ratios

Stoke Therapeutics, Inc. (STOK) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric20182019202020212022202320242025TTM
Return on Equity (ROE)
-24.13%-19.62%-20.47%-34.06%-50.2%-60.8%-45.8%-2.37%-48.84%
Return on Invested Capital (ROIC)
--3291.33%-4437.59%-173.93%-105.74%-392.73%-206.76%-8.31%-57.04%
Gross Margin
----100%100%100%100%90.36%
Net Margin
-----814.73%-1192.47%-243.42%-3.73%-529.2%
Debt / Equity
--0.00x0.01x0.01x0.01x0.01x-0.01x
Interest Coverage
---------53.42x
FCF Conversion
0.88x0.96x0.81x0.78x0.32x0.77x0.98x-6.62x0.87x
Revenue Growth
------29.22%316.34%404.5%-83.2%
Related:STOK Dividend History·STOK Revenue History·STOK Price History·STOK P/E History·STOK Financial Ratios·STOK Institutional Holders

STOK SEC Filings & Documents

Stoke Therapeutics, Inc. (STOK) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 7, 2026·SEC

Material company update

Apr 7, 2026·SEC

Material company update

Mar 27, 2026·SEC

10-K Annual Reports

2
FY 2026

Mar 16, 2026·SEC

FY 2025

Mar 18, 2025·SEC

10-Q Quarterly Reports

6
FY 2026

May 7, 2026·SEC

FY 2025

Nov 4, 2025·SEC

FY 2025

Aug 12, 2025·SEC

STOK Frequently Asked Questions

Stoke Therapeutics, Inc. (STOK) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Stoke Therapeutics, Inc. (STOK) reported $32.1M in revenue for fiscal year 2025.

Stoke Therapeutics, Inc. (STOK) grew revenue by 404.5% over the past year. This is strong growth.

Stoke Therapeutics, Inc. (STOK) reported a net loss of $169.8M for fiscal year 2025.

Dividend & Returns

Stoke Therapeutics, Inc. (STOK) has a return on equity (ROE) of -2.4%. Negative ROE indicates the company is unprofitable.

Stoke Therapeutics, Inc. (STOK) had negative free cash flow of $147.7M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in STOK back in 2017?

Total return calculator · dividends reinvested · 9+ years of data

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How much would $100/month in STOK be worth today?

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