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STOK logoStoke Therapeutics, Inc.(STOK)Earnings, Financials & Key Ratios

STOK•NASDAQ
$33.28
$1.96B mkt cap·Price updated May 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryRNA and Genome Editing Developers
AboutStoke Therapeutics, Inc., an early-stage biopharmaceutical company, develops novel antisense oligonucleotide (ASO) medicines to treat the underlying causes of severe genetic diseases in the United States. The company utilizes its proprietary Targeted Augmentation of Nuclear Gene Output to design ASOs to precisely upregulate protein expression. Its lead clinical candidate is STK-001, which is in phase I/IIa clinical trial to treat Dravet syndrome, a severe and progressive genetic epilepsy; and STK-002, which is in preclinical stage for the treatment of autosomal dominant optic atrophy. It had entered into a license and collaboration agreement with Acadia Pharmaceuticals Inc. for the discovery, development, and commercialization of novel RNA-based medicines for the treatment of severe and rare genetic neurodevelopmental diseases of the central nervous system. The company was formerly known as ASOthera Pharmaceuticals, Inc. and changed its name to Stoke Therapeutics, Inc. in May 2016. Stoke Therapeutics, Inc. was incorporated in 2014 and is headquartered in Bedford, Massachusetts.Show more
  • Revenue$184M+404.5%
  • EBITDA-$19M+81.0%
  • Net Income-$7M+92.3%
  • EPS (Diluted)-0.12+92.7%
  • Gross Margin100%
  • EBITDA Margin-10.21%+96.2%
  • Operating Margin-11.16%+96.0%
  • Net Margin-3.73%+98.5%
  • ROE-2.37%+94.8%
  • ROIC-8.31%+96.0%
  • Interest Coverage-1.50
Technical→

STOK Key Insights

Stoke Therapeutics, Inc. (STOK) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓FCF machine: 24.4% free cash flow margin

✗Weaknesses

No significant weaknesses identified

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

STOK Price & Volume

Stoke Therapeutics, Inc. (STOK) stock price & volume — 10-year historical chart

Loading chart...

STOK Growth Metrics

Stoke Therapeutics, Inc. (STOK) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years145.89%
TTM404.5%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM92.26%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM91.67%

Return on Capital

10 Years-32.03%
5 Years-37.84%
3 Years-36.19%
Last Year-6.96%

STOK Recent Earnings

Stoke Therapeutics, Inc. (STOK) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 8/12 qtrs (67%)●Beat Revenue 8/12 qtrs (67%)
Q2 2026Latest
Mar 17, 2026
EPS
$0.99
Est $0.92
-8.1%
Revenue
$1M
Est $6M
-77.5%
Q2 2026
Mar 16, 2026
EPS
$0.97
Est $0.75
-29.3%
Revenue
$1M
Est $6M
-76.0%
Q4 2025
Nov 4, 2025
EPS
$0.65
Est $0.54
-20.4%
Revenue
$11M
Est $5M
+133.4%
Q3 2025
Aug 12, 2025
EPS
$0.40
Est $0.57
+29.8%
Revenue
$14M
Est $5M
+158.0%
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMar 17, 2026
$0.99vs $0.92-8.1%
$1Mvs $6M-77.5%
Q2 2026Mar 16, 2026
$0.97vs $0.75-29.3%
$1Mvs $6M-76.0%
Q4 2025Nov 4, 2025
$0.65vs $0.54-20.4%
$11Mvs $5M+133.4%
Q3 2025Aug 12, 2025
$0.40vs $0.57+29.8%
$14Mvs $5M+158.0%
Based on last 12 quarters of dataView full earnings history →

STOK Peer Comparison

Stoke Therapeutics, Inc. (STOK) competitors in RNA and Genome Editing Developers — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
ACAD logoACADACADIA Pharmaceuticals Inc.Direct Competitor3.68B21.489.3811.87%36.49%41.9%0.04
PRAX logoPRAXPraxis Precision Medicines, Inc.Direct Competitor7.61B337.95-25.07-100%-58.74%0.00
ARVN logoARVNArvinas, Inc.Direct Competitor656.24M10.26-8.02-0.3%-30.77%-14.25%0.02
IONS logoIONSIonis Pharmaceuticals, Inc.Product Competitor12.7B76.85-32.2933.87%-30.87%-58.57%5.35
SRPT logoSRPTSarepta Therapeutics, Inc.Product Competitor2.42B23.03-3.2315.58%2.98%4.89%0.91
ALNY logoALNYAlnylam Pharmaceuticals, Inc.Product Competitor40.43B303.00130.0465.19%13.46%98.29%1.62
ARWR logoARWRArrowhead Pharmaceuticals, Inc.Product Competitor11.08B79.14-6486.89232.58%18.54%35.64%0.73
NTLA logoNTLAIntellia Therapeutics, Inc.Product Competitor1.61B13.85-3.64-100%-61.47%0.14

Compare STOK vs Peers

Stoke Therapeutics, Inc. (STOK) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs ACAD

Most directly comparable listed peer for STOK.

Scale Benchmark

vs TMO

Larger-name benchmark to compare STOK against a more recognizable public peer.

Peer Set

Compare Top 5

vs ACAD, PRAX, ARVN, IONS

STOK Income Statement

Stoke Therapeutics, Inc. (STOK) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Sales/Revenue0000012.4M8.78M36.55M184.42M
Revenue Growth %-------29.22%316.34%404.5%
Cost of Goods Sold113K214K450K1.93M00000
COGS % of Revenue---------
Gross Profit
-113K▲ 0%
-214K▼ 89.4%
-450K▼ 110.3%
-1.93M▼ 328.0%
0▲ 100.0%
12.4M▲ 0%
8.78M▼ 29.2%
36.55M▲ 316.3%
184.42M▲ 404.5%
Gross Margin %-----100%100%100%100%
Gross Profit Growth %--89.38%-110.28%-328%100%--29.22%316.34%404.5%
Operating Expenses5.55M12.78M35.23M51.12M86.06M116.76M123.55M137.93M205.01M
OpEx % of Revenue-----941.24%1407.21%377.31%111.16%
Selling, General & Admin1.96M4.41M11.91M20.85M31.9M38.92M41.32M48.79M67.09M
SG&A % of Revenue-----313.78%470.64%133.48%36.38%
Research & Development3.6M8.37M23.31M32.2M54.17M77.84M82.23M89.13M137.92M
R&D % of Revenue-----627.46%936.57%243.83%74.79%
Other Operating Expenses-4K-10K0-1.93M00000
Operating Income
-5.55M▲ 0%
-12.78M▼ 130.1%
-35.68M▼ 179.1%
-53.04M▼ 48.7%
-86.06M▼ 62.3%
-104.36M▼ 21.3%
-114.77M▼ 10.0%
-101.37M▲ 11.7%
-20.59M▲ 79.7%
Operating Margin %------841.24%-1307.21%-277.31%-11.16%
Operating Income Growth %--130.12%-179.15%-48.67%-62.25%-21.25%-9.98%11.68%79.69%
EBITDA-5.44M-12.57M-35.23M-51.12M-85.09M-102.81M-112.3M-99.19M-18.82M
EBITDA Margin %------828.78%-1279.09%-271.36%-10.21%
EBITDA Growth %--130.97%-180.32%-45.11%-66.46%-20.82%-9.23%11.67%81.03%
D&A (Non-Cash Add-back)113K214K450K1.93M974K1.55M2.47M2.18M1.77M
EBIT-5.55M-12.78M-32.33M-52.24M-86.06M-104.36M-114.77M-101.37M-20.59M
Net Interest Income003.35M744K120K000-13.76M
Interest Income0270K3.35M744K120K0000
Interest Expense0000000013.76M
Other Income/Expense-4K260K3.35M801K260K3.29M10.07M12.39M13.71M
Pretax Income
-5.56M▲ 0%
-12.52M▼ 125.3%
-32.33M▼ 158.2%
-52.24M▼ 61.6%
-85.81M▼ 64.2%
-101.07M▼ 17.8%
-104.7M▼ 3.6%
-88.98M▲ 15.0%
-6.88M▲ 92.3%
Pretax Margin %------814.73%-1192.47%-243.42%-3.73%
Income Tax000000000
Effective Tax Rate %0%0%0%0%0%0%0%0%0%
Net Income
-5.56M▲ 0%
-12.52M▼ 125.3%
-32.33M▼ 158.2%
-52.24M▼ 61.6%
-85.81M▼ 64.2%
-101.07M▼ 17.8%
-104.7M▼ 3.6%
-88.98M▲ 15.0%
-6.88M▲ 92.3%
Net Margin %------814.73%-1192.47%-243.42%-3.73%
Net Income Growth %--125.28%-158.17%-61.62%-64.24%-17.79%-3.59%15.01%92.26%
Net Income (Continuing)-5.56M-12.52M-32.33M-52.24M-85.81M-101.07M-104.7M-88.98M-6.88M
Discontinued Operations000000000
Minority Interest000000000
EPS (Diluted)
-0.24▲ 0%
-0.53▼ 120.8%
-1.59▼ 200.0%
-1.56▲ 1.9%
-2.34▼ 50.0%
-2.60▼ 11.1%
-2.38▲ 8.5%
-1.65▲ 30.7%
-0.12▲ 92.7%
EPS Growth %--120.83%-200%1.89%-50%-11.11%8.46%30.67%92.73%
EPS (Basic)-0.24-0.53-1.59-1.56-2.34-2.60-2.38-1.65-0.12
Diluted Shares Outstanding23.51M23.51M17.97M33.49M36.74M38.9M43.99M54.01M59.22M
Basic Shares Outstanding23.51M23.51M17.97M33.49M36.74M38.9M43.99M54.01M59.22M
Dividend Payout Ratio---------

STOK Balance Sheet

Stoke Therapeutics, Inc. (STOK) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Total Current Assets1.91M106.14M226.03M293.93M229.22M244.07M215.34M232.76M305.7M
Cash & Short-Term Investments1.8M105.4M222.47M287.31M219.81M229.59M201.39M216.9M284.67M
Cash Only1.8M105.4M222.47M287.31M144.9M113.56M191.44M127.98M84.22M
Short-Term Investments000074.92M116.04M9.95M88.92M200.45M
Accounts Receivable0196K281K6K132K588K64K700K7.91M
Days Sales Outstanding-----17.32.666.9915.65
Inventory000000000
Days Inventory Outstanding---------
Other Current Assets000181K2.33M2.96M2.56M4.04M13.13M
Total Non-Current Assets529K1.4M2.72M4M9.65M12M13M38.8M112.73M
Property, Plant & Equipment473K1.19M2.51M3.79M9.08M11.43M12.43M8.25M6.25M
Fixed Asset Turnover-----1.09x0.71x4.43x29.52x
Goodwill000000000
Intangible Assets000000000
Long-Term Investments56K204K0000029.82M0
Other Non-Current Assets00205K205K569K569K569K721K106.49M
Total Assets
2.44M▲ 0%
107.54M▲ 4309.1%
228.75M▲ 112.7%
297.93M▲ 30.2%
238.87M▼ 19.8%
256.07M▲ 7.2%
228.34M▼ 10.8%
271.56M▲ 18.9%
418.43M▲ 54.1%
Asset Turnover-----0.05x0.04x0.13x0.44x
Asset Growth %-4309.14%112.71%30.24%-19.82%7.2%-10.83%18.92%54.09%
Total Current Liabilities3.71M2.47M4.1M11.43M17.14M31.39M30.82M40.06M57.88M
Accounts Payable141K1.07M751K1.5M2.38M766K1.7M2.5M4.94M
Days Payables Outstanding455.441.83K609.14283.32-----
Short-Term Debt3M00000000
Deferred Revenue (Current)-3M000014.88M15.31M18.99M11.9M
Other Current Liabilities002.11M4.58M5.92M6.26M6.47M8.44M41.03M
Current Ratio0.51x43.03x55.12x25.73x13.37x7.77x6.99x5.81x5.28x
Quick Ratio0.51x43.03x55.12x25.73x13.37x7.77x6.99x5.81x5.28x
Cash Conversion Cycle---------
Total Non-Current Liabilities16K4K221K422K3.95M39.82M37.96M2.48M8.1M
Long-Term Debt000000000
Capital Lease Obligations000000000
Deferred Tax Liabilities000000000
Other Non-Current Liabilities16K4K221K422K3.95M2.97M4.88M2.48M8.1M
Total Liabilities3.73M2.47M4.32M11.85M21.09M71.22M68.78M42.53M65.98M
Total Debt3M001.07M1.51M2.36M2.06M2.32M0
Net Debt1.2M-105.4M-222.47M-286.24M-143.39M-111.2M-189.38M-125.66M-84.22M
Debt / Equity---0.00x0.01x0.01x0.01x0.01x-
Debt / EBITDA---------
Net Debt / EBITDA---------
Interest Coverage---------1.50x
Total Equity
-1.29M▲ 0%
105.07M▲ 8232.2%
224.43M▲ 113.6%
286.08M▲ 27.5%
217.78M▼ 23.9%
184.85M▼ 15.1%
159.56M▼ 13.7%
229.02M▲ 43.5%
352.46M▲ 53.9%
Equity Growth %-8232.2%113.6%27.47%-23.88%-15.12%-13.68%43.53%53.9%
Book Value per Share-0.054.4712.498.545.934.753.634.245.95
Total Shareholders' Equity-1.29M105.07M224.43M286.08M217.78M184.85M159.56M229.02M352.46M
Common Stock1K1K3K4K4K4K5K5K5K
Retained Earnings-13.19M-25.71M-58.03M-110.28M-196.08M-297.15M-401.85M-490.83M-497.71M
Treasury Stock000000000
Accumulated OCI-172K-379K00-168K-1.18M-24K-151K543K
Minority Interest000000000

STOK Cash Flow Statement

Stoke Therapeutics, Inc. (STOK) cash flow — operating, investing & free cash flow history

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Cash from Operations-5.38M-10.96M-31.05M-42.22M-66.91M-31.87M-81.07M-86.85M45.59M
Operating CF Margin %------256.88%-923.31%-237.59%24.72%
Operating CF Growth %--103.64%-183.25%-35.96%-58.47%52.37%-154.4%-7.13%152.49%
Net Income-5.56M-12.52M-32.33M-52.24M-85.81M-101.07M-104.7M-88.98M-6.88M
Depreciation & Amortization113K214K450K888K974K1.55M2.47M2.18M1.77M
Stock-Based Compensation26K240K1.92M5.77M16.45M22.85M25.26M27.47M32.24M
Deferred Taxes0003K172K0000
Other Non-Cash Items4K10K3K1.04M1.26M1.78M1.94M623K2.12M
Working Capital Changes31K1.09M-1.1M2.33M46K43.02M-6.03M-28.14M16.35M
Change in Receivables00000000-4.27M
Change in Inventory000000000
Change in Payables100K1.74M891K5.2M2.9M121K-3.21M3.09M21.29M
Cash from Investing-113K-925K-1.63M-1.05M-76.43M-45.88M105.95M-107.47M-186.81M
Capital Expenditures-113K-935K-1.64M-1.05M-1.2M-3.96M-1.62M-203K-670K
CapEx % of Revenue-----31.94%18.41%0.56%0.36%
Acquisitions010K1K075.23M45.34M000
Investments---------
Other Investing010K00-75.23M-45.34M000
Cash from Financing5.97M115.64M149.76M108.11M1.28M46.41M53.01M131.09M97.39M
Debt Issued (Net)000000000
Equity Issued (Net)1000K1000K1000K1000K1000K1000K1000K1000K1000K
Dividends Paid000000000
Share Repurchases000000000
Other Financing2.97M-361K-2.15M2.71M-2K1.06M926K2.25M0
Net Change in Cash
477K▲ 0%
103.75M▲ 21650.5%
117.07M▲ 12.8%
64.84M▼ 44.6%
-142.05M▼ 319.1%
-31.34M▲ 77.9%
77.89M▲ 348.5%
-63.23M▼ 181.2%
-43.84M▲ 30.7%
Free Cash Flow
-5.5M▲ 0%
-11.9M▼ 116.5%
-32.69M▼ 174.7%
-43.27M▼ 32.4%
-68.11M▼ 57.4%
-35.83M▲ 47.4%
-82.68M▼ 130.8%
-87.05M▼ 5.3%
44.91M▲ 151.6%
FCF Margin %------288.82%-941.72%-238.15%24.35%
FCF Growth %--116.46%-174.73%-32.37%-57.4%47.39%-130.78%-5.29%151.59%
FCF per Share-0.23-0.51-1.82-1.29-1.85-0.92-1.88-1.610.76
FCF Conversion (FCF/Net Income)0.97x0.88x0.96x0.81x0.78x0.32x0.77x0.98x-6.62x
Interest Paid000000000
Taxes Paid000000000

STOK Key Ratios

Stoke Therapeutics, Inc. (STOK) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025
Return on Equity (ROE)--24.13%-19.62%-20.47%-34.06%-50.2%-60.8%-45.8%-2.37%
Return on Invested Capital (ROIC)---3291.33%-4437.59%-173.93%-105.74%-392.73%-206.76%-8.31%
Gross Margin-----100%100%100%100%
Net Margin------814.73%-1192.47%-243.42%-3.73%
Debt / Equity---0.00x0.01x0.01x0.01x0.01x-
Interest Coverage---------1.50x
FCF Conversion0.97x0.88x0.96x0.81x0.78x0.32x0.77x0.98x-6.62x
Revenue Growth-------29.22%316.34%404.5%

STOK SEC Filings & Documents

Stoke Therapeutics, Inc. (STOK) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Apr 7, 2026·SEC

Material company update

Mar 27, 2026·SEC

Material company update

Mar 3, 2026·SEC

10-K Annual Reports

2
FY 2026

Mar 16, 2026·SEC

FY 2025

Mar 18, 2025·SEC

10-Q Quarterly Reports

6
FY 2025

Nov 4, 2025·SEC

FY 2025

Aug 12, 2025·SEC

FY 2025

May 13, 2025·SEC

STOK Frequently Asked Questions

Stoke Therapeutics, Inc. (STOK) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Stoke Therapeutics, Inc. (STOK) reported $184.4M in revenue for fiscal year 2025.

Stoke Therapeutics, Inc. (STOK) grew revenue by 404.5% over the past year. This is strong growth.

Stoke Therapeutics, Inc. (STOK) reported a net loss of $6.9M for fiscal year 2025.

Dividend & Returns

Stoke Therapeutics, Inc. (STOK) has a return on equity (ROE) of -2.4%. Negative ROE indicates the company is unprofitable.

Stoke Therapeutics, Inc. (STOK) generated $44.9M in free cash flow for fiscal year 2025. Positive FCF indicates the company can fund dividends, buybacks, or reinvestment.

Explore More STOK

Stoke Therapeutics, Inc. (STOK) financial analysis — history, returns, DCA and operating performance tools

Total Return Calculator

Historical returns with dividends reinvested

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DCA Calculator

Dollar cost averaging vs lump sum

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Dividend History

Yield, growth, payout safety & DRIP

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Earnings History

EPS trends, net income & profitability

→

Price History

Long-term charts & historical price data

→

Revenue History

Sales growth patterns & revenue breakdown

→

Financial Ratios

30 years of market, efficiency and balance-sheet ratios

→

Valuation

DCF intrinsic value, peer multiples & estimates

→
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