Biotechnology
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ATXS vs BCAB vs IMVT vs ALNY vs REGN
Revenue, margins, valuation, and 5-year total return — side by side.
Biotechnology
Biotechnology
Biotechnology
Biotechnology
ATXS vs BCAB vs IMVT vs ALNY vs REGN — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | |||||
|---|---|---|---|---|---|
| Industry | Biotechnology | Biotechnology | Biotechnology | Biotechnology | Biotechnology |
| Market Cap | $718M | $5M | $5.53B | $39.48B | $73.68B |
| Revenue (TTM) | $706K | $2M | $0.00 | $4.29B | $14.92B |
| Net Income (TTM) | $-124M | $-60M | $-464M | $577M | $4.42B |
| Gross Margin | 100.0% | 100.0% | — | 80.9% | 84.5% |
| Operating Margin | -193.4% | -29.7% | — | 17.5% | 24.3% |
| Forward P/E | — | — | — | 44.2x | 15.3x |
| Total Debt | $5M | $6M | $98K | $1.28B | $2.71B |
| Cash & Equiv. | $60M | $7M | $714M | $1.66B | $3.12B |
ATXS vs BCAB vs IMVT vs ALNY vs REGN — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
| Stock | Dec 20 | Jan 26 | Return |
|---|---|---|---|
| Astria Therapeutics… (ATXS) | 100 | 98.0 | -2.0% |
| BioAtla, Inc. (BCAB) | 100 | 1.7 | -98.3% |
| Immunovant, Inc. (IMVT) | 100 | 55.0 | -45.0% |
| Alnylam Pharmaceuti… (ALNY) | 100 | 306.0 | +206.0% |
| Regeneron Pharmaceu… (REGN) | 100 | 159.8 | +59.8% |
Price return only. Dividends and distributions are not included.
Quick Verdict: ATXS vs BCAB vs IMVT vs ALNY vs REGN
Each card shows where this stock fits in a portfolio — not just who wins on paper.
ATXS ranks third and is worth considering specifically for sleep-well-at-night and defensive.
- Lower volatility, beta 1.32, Low D/E 1.7%, current ratio 17.49x
- Beta 1.32, current ratio 17.49x
- +184.6% vs BCAB's -80.6%
BCAB is the clearest fit if your priority is income & stability.
- beta 0.51
- Beta 0.51 vs IMVT's 1.37
Among these 5 stocks, IMVT doesn't own a clear edge in any measured category.
ALNY is the #2 pick in this set and the best alternative if growth exposure and long-term compounding is your priority.
- Rev growth 65.2%, EPS growth 206.9%, 3Y rev CAGR 53.0%
- 411.9% 10Y total return vs IMVT's 173.6%
- 65.2% revenue growth vs BCAB's -81.8%
- 11.8% ROA vs BCAB's -250.6%
REGN carries the broadest edge in this set and is the clearest fit for value and quality.
- Lower P/E (15.3x vs 44.2x)
- 29.6% margin vs ATXS's -175.7%
- 0.5% yield; 1-year raise streak; the other 4 pay no meaningful dividend
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | 65.2% revenue growth vs BCAB's -81.8% | |
| Value | Lower P/E (15.3x vs 44.2x) | |
| Quality / Margins | 29.6% margin vs ATXS's -175.7% | |
| Stability / Safety | Beta 0.51 vs IMVT's 1.37 | |
| Dividends | 0.5% yield; 1-year raise streak; the other 4 pay no meaningful dividend | |
| Momentum (1Y) | +184.6% vs BCAB's -80.6% | |
| Efficiency (ROA) | 11.8% ROA vs BCAB's -250.6% |
ATXS vs BCAB vs IMVT vs ALNY vs REGN — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Segment breakdown not available.
Segment breakdown not available.
ATXS vs BCAB vs IMVT vs ALNY vs REGN — Financial Metrics
Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.
Who Leads Where
REGN leads in 2 of 6 categories
ALNY leads 2 • ATXS leads 0 • BCAB leads 0 • IMVT leads 0 • 1 tied
Explore the data ↓Income & Cash Flow (Last 12 Months)
REGN leads this category, winning 3 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
REGN and IMVT operate at a comparable scale, with $14.9B and $0 in trailing revenue. REGN is the more profitable business, keeping 29.6% of every revenue dollar as net income compared to ATXS's -175.7%. On growth, ALNY holds the edge at +96.4% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | |||||
|---|---|---|---|---|---|
| RevenueTrailing 12 months | $706,000 | $2M | $0 | $4.3B | $14.9B |
| EBITDAEarnings before interest/tax | -$134M | -$59M | -$487M | $677M | $4.2B |
| Net IncomeAfter-tax profit | -$124M | -$60M | -$464M | $577M | $4.4B |
| Free Cash FlowCash after capex | -$120M | -$34M | -$423M | $641M | $4.2B |
| Gross MarginGross profit ÷ Revenue | +100.0% | +100.0% | — | +80.9% | +84.5% |
| Operating MarginEBIT ÷ Revenue | -193.4% | -29.7% | — | +17.5% | +24.3% |
| Net MarginNet income ÷ Revenue | -175.7% | -29.8% | — | +13.5% | +29.6% |
| FCF MarginFCF ÷ Revenue | -170.4% | -17.0% | — | +15.0% | +27.9% |
| Rev. Growth (YoY)Latest quarter vs prior year | — | — | — | +96.4% | +19.0% |
| EPS Growth (YoY)Latest quarter vs prior year | -27.9% | +46.7% | +19.7% | +4.4% | -7.2% |
Valuation Metrics
REGN leads this category, winning 3 of 6 comparable metrics.
Valuation Metrics
At 17.1x trailing earnings, REGN trades at a 87% valuation discount to ALNY's 127.0x P/E. On an enterprise value basis, REGN's 17.8x EV/EBITDA is more attractive than ALNY's 70.2x.
| Metric | |||||
|---|---|---|---|---|---|
| Market CapShares × price | $718M | $5M | $5.5B | $39.5B | $73.7B |
| Enterprise ValueMkt cap + debt − cash | $664M | $4M | $4.8B | $39.1B | $73.3B |
| Trailing P/EPrice ÷ TTM EPS | -7.49x | -0.09x | -9.97x | 127.00x | 17.09x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — | — | 44.18x | 15.35x |
| PEG RatioP/E ÷ EPS growth rate | — | — | — | — | 2.70x |
| EV / EBITDAEnterprise value multiple | — | — | — | 70.17x | 17.78x |
| Price / SalesMarket cap ÷ Revenue | — | 2.56x | — | 10.63x | 5.14x |
| Price / BookPrice ÷ Book value/share | 2.21x | — | 5.83x | 50.50x | 2.46x |
| Price / FCFMarket cap ÷ FCF | — | — | — | 84.84x | 18.06x |
Profitability & Efficiency
ALNY leads this category, winning 5 of 9 comparable metrics.
Profitability & Efficiency
ALNY delivers a 98.3% return on equity — every $100 of shareholder capital generates $98 in annual profit, vs $-53 for ATXS. IMVT carries lower financial leverage with a 0.00x debt-to-equity ratio, signaling a more conservative balance sheet compared to ALNY's 1.62x. On the Piotroski fundamental quality scale (0–9), ALNY scores 6/9 vs ATXS's 1/9, reflecting solid financial health.
| Metric | |||||
|---|---|---|---|---|---|
| ROE (TTM)Return on equity | -53.2% | — | -47.1% | +98.3% | +14.3% |
| ROA (TTM)Return on assets | -45.6% | -2.5% | -44.1% | +11.8% | +11.1% |
| ROICReturn on invested capital | -50.3% | — | — | +33.4% | +8.9% |
| ROCEReturn on capital employed | -39.4% | -4.0% | -66.1% | +15.3% | +10.2% |
| Piotroski ScoreFundamental quality 0–9 | 1 | 2 | 2 | 6 | 5 |
| Debt / EquityFinancial leverage | 0.02x | — | 0.00x | 1.62x | 0.09x |
| Net DebtTotal debt minus cash | -$54M | -$918,000 | -$714M | -$379M | -$412M |
| Cash & Equiv.Liquid assets | $60M | $7M | $714M | $1.7B | $3.1B |
| Total DebtShort + long-term debt | $5M | $6M | $98,000 | $1.3B | $2.7B |
| Interest CoverageEBIT ÷ Interest expense | — | — | — | 2.02x | 108.44x |
Total Returns (Dividends Reinvested)
ALNY leads this category, winning 4 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in ALNY five years ago would be worth $22,537 today (with dividends reinvested), compared to $19 for BCAB. Over the past 12 months, ATXS leads with a +184.6% total return vs BCAB's -80.6%. The 3-year compound annual growth rate (CAGR) favors ALNY at 12.1% vs BCAB's -70.1% — a key indicator of consistent wealth creation.
| Metric | |||||
|---|---|---|---|---|---|
| YTD ReturnYear-to-date | -2.4% | -83.7% | +5.1% | -26.1% | -8.5% |
| 1-Year ReturnPast 12 months | +184.6% | -80.6% | +96.1% | +7.0% | +27.1% |
| 3-Year ReturnCumulative with dividends | -0.4% | -97.3% | +40.9% | +40.9% | -5.1% |
| 5-Year ReturnCumulative with dividends | +7.0% | -99.8% | +62.4% | +125.4% | +43.6% |
| 10-Year ReturnCumulative with dividends | -95.5% | -99.7% | +173.6% | +411.9% | +90.0% |
| CAGR (3Y)Annualised 3-year return | -0.1% | -70.1% | +12.1% | +12.1% | -1.7% |
Risk & Volatility
Evenly matched — ATXS and BCAB each lead in 1 of 2 comparable metrics.
Risk & Volatility
BCAB is the less volatile stock with a 0.51 beta — it tends to amplify market swings less than IMVT's 1.37 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. ATXS currently trades 94.7% from its 52-week high vs BCAB's 6.1% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | |||||
|---|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.32x | 0.51x | 1.37x | 0.71x | 0.81x |
| 52-Week HighHighest price in past year | $13.29 | $71.50 | $30.09 | $495.55 | $821.11 |
| 52-Week LowLowest price in past year | $3.69 | $0.33 | $13.36 | $245.96 | $476.49 |
| % of 52W HighCurrent price vs 52-week peak | +94.7% | +6.1% | +90.5% | +59.7% | +86.4% |
| RSI (14)Momentum oscillator 0–100 | 46.1 | 40.5 | 60.2 | 43.8 | 44.9 |
| Avg Volume (50D)Average daily shares traded | 1.6M | 40K | 1.4M | 1.1M | 631K |
Analyst Outlook
Insufficient data to determine a leader in this category.
Analyst Outlook
Analyst consensus: ATXS as "Hold", BCAB as "Buy", IMVT as "Buy", ALNY as "Buy", REGN as "Buy". Consensus price targets imply 5647.1% upside for BCAB (target: $250) vs 22.1% for REGN (target: $866). REGN is the only dividend payer here at 0.48% yield — a key consideration for income-focused portfolios.
| Metric | |||||
|---|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Hold | Buy | Buy | Buy | Buy |
| Price TargetConsensus 12-month target | $19.40 | $250.00 | $45.50 | $445.67 | $865.68 |
| # AnalystsCovering analysts | 8 | 9 | 23 | 52 | 48 |
| Dividend YieldAnnual dividend ÷ price | — | — | — | — | +0.5% |
| Dividend StreakConsecutive years of raises | — | — | — | — | 1 |
| Dividend / ShareAnnual DPS | — | — | — | — | $3.41 |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% | 0.0% | 0.0% | +5.4% |
REGN leads in 2 of 6 categories (Income & Cash Flow, Valuation Metrics). ALNY leads in 2 (Profitability & Efficiency, Total Returns). 1 tied.
ATXS vs BCAB vs IMVT vs ALNY vs REGN: Key Questions Answered
10 questions · data-driven answers · updated daily
01Is ATXS or BCAB or IMVT or ALNY or REGN a better buy right now?
For growth investors, Alnylam Pharmaceuticals, Inc.
(ALNY) is the stronger pick with 65. 2% revenue growth year-over-year, versus -81. 8% for BioAtla, Inc. (BCAB). Regeneron Pharmaceuticals, Inc. (REGN) offers the better valuation at 17. 1x trailing P/E (15. 3x forward), making it the more compelling value choice. Analysts rate BioAtla, Inc. (BCAB) a "Buy" — based on 9 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which has the better valuation — ATXS or BCAB or IMVT or ALNY or REGN?
On trailing P/E, Regeneron Pharmaceuticals, Inc.
(REGN) is the cheapest at 17. 1x versus Alnylam Pharmaceuticals, Inc. at 127. 0x. On forward P/E, Regeneron Pharmaceuticals, Inc. is actually cheaper at 15. 3x.
03Which is the better long-term investment — ATXS or BCAB or IMVT or ALNY or REGN?
Over the past 5 years, Alnylam Pharmaceuticals, Inc.
(ALNY) delivered a total return of +125. 4%, compared to -99. 8% for BioAtla, Inc. (BCAB). Over 10 years, the gap is even starker: ALNY returned +411. 9% versus BCAB's -99. 7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
04Which is safer — ATXS or BCAB or IMVT or ALNY or REGN?
By beta (market sensitivity over 5 years), BioAtla, Inc.
(BCAB) is the lower-risk stock at 0. 51β versus Immunovant, Inc. 's 1. 37β — meaning IMVT is approximately 169% more volatile than BCAB relative to the S&P 500. On balance sheet safety, Immunovant, Inc. (IMVT) carries a lower debt/equity ratio of 0% versus 162% for Alnylam Pharmaceuticals, Inc. — giving it more financial flexibility in a downturn.
05Which is growing faster — ATXS or BCAB or IMVT or ALNY or REGN?
By revenue growth (latest reported year), Alnylam Pharmaceuticals, Inc.
(ALNY) is pulling ahead at 65. 2% versus -81. 8% for BioAtla, Inc. (BCAB). On earnings-per-share growth, the picture is similar: Alnylam Pharmaceuticals, Inc. grew EPS 206. 9% year-over-year, compared to -45. 2% for Immunovant, Inc.. Over a 3-year CAGR, ALNY leads at 53. 0% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
06Which has better profit margins — ATXS or BCAB or IMVT or ALNY or REGN?
Regeneron Pharmaceuticals, Inc.
(REGN) is the more profitable company, earning 31. 4% net margin versus -175. 7% for Astria Therapeutics, Inc. — meaning it keeps 31. 4% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: REGN leads at 24. 9% versus -193. 4% for ATXS. At the gross margin level — before operating expenses — ATXS leads at 100. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
07Is ATXS or BCAB or IMVT or ALNY or REGN more undervalued right now?
On forward earnings alone, Regeneron Pharmaceuticals, Inc.
(REGN) trades at 15. 3x forward P/E versus 44. 2x for Alnylam Pharmaceuticals, Inc. — 28. 8x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for BCAB: 5647. 1% to $250. 00.
08Which pays a better dividend — ATXS or BCAB or IMVT or ALNY or REGN?
In this comparison, REGN (0.
5% yield) pays a dividend. ATXS, BCAB, IMVT, ALNY do not pay a meaningful dividend and should not be held primarily for income.
09Is ATXS or BCAB or IMVT or ALNY or REGN better for a retirement portfolio?
For long-horizon retirement investors, Alnylam Pharmaceuticals, Inc.
(ALNY) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0. 71), +411. 9% 10Y return). Both have compounded well over 10 years (ALNY: +411. 9%, ATXS: -95. 5%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
10What are the main differences between ATXS and BCAB and IMVT and ALNY and REGN?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
In terms of investment character: ATXS is a small-cap quality compounder stock; BCAB is a small-cap quality compounder stock; IMVT is a small-cap quality compounder stock; ALNY is a mid-cap high-growth stock; REGN is a mid-cap deep-value stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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