Drug Manufacturers - Specialty & Generic
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GELS vs NUVB vs PRAX vs KYMR vs ARVN
Revenue, margins, valuation, and 5-year total return — side by side.
Biotechnology
Biotechnology
Biotechnology
Biotechnology
GELS vs NUVB vs PRAX vs KYMR vs ARVN — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | |||||
|---|---|---|---|---|---|
| Industry | Drug Manufacturers - Specialty & Generic | Biotechnology | Biotechnology | Biotechnology | Biotechnology |
| Market Cap | $5M | $1.67B | $9.63B | $6.91B | $652M |
| Revenue (TTM) | $148K | $143M | $-92K | $51M | $263M |
| Net Income (TTM) | $-4M | $-146M | $-327M | $-315M | $-81M |
| Gross Margin | 100.0% | 91.6% | — | 33.2% | 99.5% |
| Operating Margin | -87.7% | -105.0% | — | -7.0% | -44.0% |
| Total Debt | $4M | $10M | $110K | $82M | $9M |
| Cash & Equiv. | $25K | $164M | $357M | $357M | $143M |
GELS vs NUVB vs PRAX vs KYMR vs ARVN — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
| Stock | Oct 24 | May 26 | Return |
|---|---|---|---|
| Gelteq Limited Ordi… (GELS) | 100 | 18.4 | -81.6% |
| Nuvation Bio Inc. (NUVB) | 100 | 216.7 | +116.7% |
| Praxis Precision Me… (PRAX) | 100 | 471.5 | +371.5% |
| Kymera Therapeutics… (KYMR) | 100 | 186.4 | +86.4% |
| Arvinas, Inc. (ARVN) | 100 | 38.3 | -61.7% |
Price return only. Dividends and distributions are not included.
Quick Verdict: GELS vs NUVB vs PRAX vs KYMR vs ARVN
Each card shows where this stock fits in a portfolio — not just who wins on paper.
GELS lags the leaders in this set but could rank higher in a more targeted comparison.
NUVB ranks third and is worth considering specifically for growth.
- 7.0% revenue growth vs PRAX's -100.0%
PRAX carries the broadest edge in this set and is the clearest fit for quality and momentum.
- 2.4% margin vs GELS's -27.4%
- +7.7% vs GELS's -66.5%
KYMR is the clearest fit if your priority is long-term compounding and defensive.
- 154.4% 10Y total return vs PRAX's -20.1%
- Beta 1.15, current ratio 10.47x
ARVN is the #2 pick in this set and the best alternative if income & stability and growth exposure is your priority.
- beta 1.15
- Rev growth -0.3%, EPS growth 53.8%, 3Y rev CAGR 26.0%
- Lower volatility, beta 1.15, Low D/E 2.0%, current ratio 4.92x
- Beta 1.15 vs NUVB's 2.04, lower leverage
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | 7.0% revenue growth vs PRAX's -100.0% | |
| Quality / Margins | 2.4% margin vs GELS's -27.4% | |
| Stability / Safety | Beta 1.15 vs NUVB's 2.04, lower leverage | |
| Dividends | Tie | None of these 5 stocks pay a meaningful dividend |
| Momentum (1Y) | +7.7% vs GELS's -66.5% | |
| Efficiency (ROA) | -9.3% ROA vs PRAX's -40.2%, ROIC -22.4% vs -65.0% |
GELS vs NUVB vs PRAX vs KYMR vs ARVN — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
Segment breakdown not available.
GELS vs NUVB vs PRAX vs KYMR vs ARVN — Financial Metrics
Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.
Who Leads Where
NUVB leads in 1 of 6 categories
ARVN leads 1 • PRAX leads 1 • GELS leads 0 • KYMR leads 0 • 2 tied
Explore the data ↓Income & Cash Flow (Last 12 Months)
NUVB leads this category, winning 3 of 6 comparable metrics.
Income & Cash Flow (Last 12 Months)
ARVN and PRAX operate at a comparable scale, with $263M and -$92,000 in trailing revenue. Profitability is closely matched — net margins range from -30.8% (ARVN) to -27.4% (GELS). On growth, NUVB holds the edge at +26.0% YoY revenue growth, suggesting stronger near-term business momentum.
| Metric | |||||
|---|---|---|---|---|---|
| RevenueTrailing 12 months | $147,535 | $143M | -$92,000 | $51M | $263M |
| EBITDAEarnings before interest/tax | -$12M | -$145M | -$357M | -$352M | -$111M |
| Net IncomeAfter-tax profit | -$4M | -$146M | -$327M | -$315M | -$81M |
| Free Cash FlowCash after capex | -$2M | -$126M | -$283M | -$244M | -$276M |
| Gross MarginGross profit ÷ Revenue | +100.0% | +91.6% | — | +33.2% | +99.5% |
| Operating MarginEBIT ÷ Revenue | -87.7% | -105.0% | — | -7.0% | -44.0% |
| Net MarginNet income ÷ Revenue | -27.4% | -102.1% | — | -6.1% | -30.8% |
| FCF MarginFCF ÷ Revenue | -12.4% | -88.1% | — | -4.7% | -105.0% |
| Rev. Growth (YoY)Latest quarter vs prior year | +100.0% | +26.0% | — | +55.5% | -84.0% |
| EPS Growth (YoY)Latest quarter vs prior year | — | +106.3% | +2.7% | +13.4% | -65.1% |
Valuation Metrics
ARVN leads this category, winning 2 of 3 comparable metrics.
Valuation Metrics
| Metric | |||||
|---|---|---|---|---|---|
| Market CapShares × price | $5M | $1.7B | $9.6B | $6.9B | $652M |
| Enterprise ValueMkt cap + debt − cash | $8M | $1.5B | $9.3B | $6.6B | $517M |
| Trailing P/EPrice ÷ TTM EPS | — | -8.03x | -24.72x | -22.93x | -7.96x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — | — | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — | — | — | — |
| EV / EBITDAEnterprise value multiple | — | — | — | — | — |
| Price / SalesMarket cap ÷ Revenue | — | 26.61x | — | 176.26x | 2.48x |
| Price / BookPrice ÷ Book value/share | — | 5.38x | 8.54x | 4.52x | 1.52x |
| Price / FCFMarket cap ÷ FCF | — | — | — | — | — |
Profitability & Efficiency
Evenly matched — GELS and PRAX and ARVN each lead in 3 of 9 comparable metrics.
Profitability & Efficiency
ARVN delivers a -14.3% return on equity — every $100 of shareholder capital generates $-14 in annual profit, vs $-44 for NUVB. PRAX carries lower financial leverage with a 0.00x debt-to-equity ratio, signaling a more conservative balance sheet compared to GELS's 0.25x. On the Piotroski fundamental quality scale (0–9), NUVB scores 4/9 vs GELS's 2/9, reflecting mixed financial health.
| Metric | |||||
|---|---|---|---|---|---|
| ROE (TTM)Return on equity | -26.8% | -44.1% | -43.0% | -25.0% | -14.3% |
| ROA (TTM)Return on assets | -19.5% | -23.8% | -40.2% | -22.3% | -9.3% |
| ROICReturn on invested capital | -11.1% | -54.3% | -65.0% | -24.9% | -22.4% |
| ROCEReturn on capital employed | -15.5% | -42.8% | -49.3% | -27.2% | -16.0% |
| Piotroski ScoreFundamental quality 0–9 | 2 | 4 | 3 | 4 | 4 |
| Debt / EquityFinancial leverage | 0.25x | 0.03x | 0.00x | 0.05x | 0.02x |
| Net DebtTotal debt minus cash | $4M | -$154M | -$357M | -$275M | -$134M |
| Cash & Equiv.Liquid assets | $24,522 | $164M | $357M | $357M | $143M |
| Total DebtShort + long-term debt | $4M | $10M | $110,000 | $82M | $9M |
| Interest CoverageEBIT ÷ Interest expense | -6.89x | -162.11x | — | -2119.53x | — |
Total Returns (Dividends Reinvested)
PRAX leads this category, winning 4 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in KYMR five years ago would be worth $19,212 today (with dividends reinvested), compared to $1,585 for GELS. Over the past 12 months, PRAX leads with a +775.0% total return vs GELS's -66.5%. The 3-year compound annual growth rate (CAGR) favors PRAX at 174.9% vs GELS's -45.9% — a key indicator of consistent wealth creation.
| Metric | |||||
|---|---|---|---|---|---|
| YTD ReturnYear-to-date | -44.4% | -43.8% | +16.4% | +16.3% | -11.2% |
| 1-Year ReturnPast 12 months | -66.5% | +136.3% | +775.0% | +190.7% | +52.8% |
| 3-Year ReturnCumulative with dividends | -84.1% | +197.5% | +1976.5% | +205.1% | -58.7% |
| 5-Year ReturnCumulative with dividends | -84.1% | -58.3% | -20.8% | +92.1% | -84.0% |
| 10-Year ReturnCumulative with dividends | -84.1% | -51.8% | -20.1% | +154.4% | -36.5% |
| CAGR (3Y)Annualised 3-year return | -45.9% | +43.8% | +174.9% | +45.0% | -25.5% |
Risk & Volatility
Evenly matched — GELS and PRAX each lead in 1 of 2 comparable metrics.
Risk & Volatility
ARVN is the less volatile stock with a 1.15 beta — it tends to amplify market swings less than NUVB's 2.04 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. PRAX currently trades 93.6% from its 52-week high vs GELS's 13.3% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | |||||
|---|---|---|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 0.91x | 1.97x | 1.40x | 1.03x | 0.99x |
| 52-Week HighHighest price in past year | $3.51 | $9.75 | $356.00 | $103.00 | $14.51 |
| 52-Week LowLowest price in past year | $0.44 | $1.57 | $35.18 | $28.06 | $5.90 |
| % of 52W HighCurrent price vs 52-week peak | +13.3% | +49.4% | +93.6% | +82.2% | +70.2% |
| RSI (14)Momentum oscillator 0–100 | 24.0 | 59.1 | 55.6 | 54.1 | 42.6 |
| Avg Volume (50D)Average daily shares traded | 18K | 4.3M | 378K | 602K | 808K |
Analyst Outlook
Insufficient data to determine a leader in this category.
Analyst Outlook
Analyst consensus: NUVB as "Buy", PRAX as "Buy", KYMR as "Buy", ARVN as "Buy". Consensus price targets imply 157.3% upside for NUVB (target: $12) vs 27.6% for ARVN (target: $13).
| Metric | |||||
|---|---|---|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy | Buy | Buy | Buy |
| Price TargetConsensus 12-month target | — | $12.40 | $548.80 | $118.06 | $13.00 |
| # AnalystsCovering analysts | — | 9 | 16 | 26 | 26 |
| Dividend YieldAnnual dividend ÷ price | — | — | — | — | — |
| Dividend StreakConsecutive years of raises | — | — | — | — | — |
| Dividend / ShareAnnual DPS | — | — | — | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% | 0.0% | 0.0% | +14.1% |
NUVB leads in 1 of 6 categories (Income & Cash Flow). ARVN leads in 1 (Valuation Metrics). 2 tied.
GELS vs NUVB vs PRAX vs KYMR vs ARVN: Key Questions Answered
8 questions · data-driven answers · updated daily
01Is GELS or NUVB or PRAX or KYMR or ARVN a better buy right now?
For growth investors, Nuvation Bio Inc.
(NUVB) is the stronger pick with 699. 0% revenue growth year-over-year, versus -100. 0% for Praxis Precision Medicines, Inc. (PRAX). Analysts rate Nuvation Bio Inc. (NUVB) a "Buy" — based on 9 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — GELS or NUVB or PRAX or KYMR or ARVN?
Over the past 5 years, Kymera Therapeutics, Inc.
(KYMR) delivered a total return of +92. 1%, compared to -84. 1% for Gelteq Limited Ordinary Shares (GELS). Over 10 years, the gap is even starker: KYMR returned +158. 8% versus GELS's -84. 0%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — GELS or NUVB or PRAX or KYMR or ARVN?
By beta (market sensitivity over 5 years), Gelteq Limited Ordinary Shares (GELS) is the lower-risk stock at 0.
91β versus Nuvation Bio Inc. 's 1. 97β — meaning NUVB is approximately 115% more volatile than GELS relative to the S&P 500. On balance sheet safety, Praxis Precision Medicines, Inc. (PRAX) carries a lower debt/equity ratio of 0% versus 25% for Gelteq Limited Ordinary Shares — giving it more financial flexibility in a downturn.
04Which is growing faster — GELS or NUVB or PRAX or KYMR or ARVN?
By revenue growth (latest reported year), Nuvation Bio Inc.
(NUVB) is pulling ahead at 699. 0% versus -100. 0% for Praxis Precision Medicines, Inc. (PRAX). On earnings-per-share growth, the picture is similar: Gelteq Limited Ordinary Shares grew EPS 100. 0% year-over-year, compared to -32. 0% for Praxis Precision Medicines, Inc.. Over a 3-year CAGR, ARVN leads at 26. 0% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
05Which has better profit margins — GELS or NUVB or PRAX or KYMR or ARVN?
Praxis Precision Medicines, Inc.
(PRAX) is the more profitable company, earning 0. 0% net margin versus -27. 4% for Gelteq Limited Ordinary Shares — meaning it keeps 0. 0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: PRAX leads at 0. 0% versus -87. 7% for GELS. At the gross margin level — before operating expenses — GELS leads at 100. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Which pays a better dividend — GELS or NUVB or PRAX or KYMR or ARVN?
None of the stocks in this comparison currently pay a material dividend.
All are effectively zero-yield and should be held for capital appreciation rather than income.
07Is GELS or NUVB or PRAX or KYMR or ARVN better for a retirement portfolio?
For long-horizon retirement investors, Kymera Therapeutics, Inc.
(KYMR) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 1. 03), +158. 8% 10Y return). Nuvation Bio Inc. (NUVB) carries a higher beta of 1. 97 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (KYMR: +158. 8%, NUVB: -52. 1%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between GELS and NUVB and PRAX and KYMR and ARVN?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
In terms of investment character: GELS is a small-cap quality compounder stock; NUVB is a small-cap high-growth stock; PRAX is a small-cap quality compounder stock; KYMR is a small-cap quality compounder stock; ARVN is a small-cap quality compounder stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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