IMTX vs CRIS vs TGTX vs AGEN

For growth investors, Immatics N.

V. (IMTX) is the stronger pick with 188. 6% revenue growth year-over-year, versus -13. 4% for Curis, Inc. (CRIS). TG Therapeutics, Inc. (TGTX) offers the better valuation at 15. 5x trailing P/E (32. 9x forward), making it the more compelling value choice. Analysts rate Immatics N. V. (IMTX) a "Buy" — based on 8 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

On trailing P/E, TG Therapeutics, Inc.

(TGTX) is the cheapest at 15. 5x versus Immatics N. V. at 69. 2x. On forward P/E, Agenus Inc. is actually cheaper at 2. 9x — notably different from the trailing picture, reflecting expected earnings growth.

Over the past 5 years, TG Therapeutics, Inc.

(TGTX) delivered a total return of +13. 1%, compared to -99. 7% for Curis, Inc. (CRIS). Over 10 years, the gap is even starker: TGTX returned +434. 4% versus CRIS's -99. 7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

By beta (market sensitivity over 5 years), TG Therapeutics, Inc.

(TGTX) is the lower-risk stock at 0. 84β versus Agenus Inc. 's 2. 58β — meaning AGEN is approximately 209% more volatile than TGTX relative to the S&P 500. On balance sheet safety, Immatics N. V. (IMTX) carries a lower debt/equity ratio of 3% versus 40% for TG Therapeutics, Inc. — giving it more financial flexibility in a downturn.

By revenue growth (latest reported year), Immatics N.

V. (IMTX) is pulling ahead at 188. 6% versus -13. 4% for Curis, Inc. (CRIS). On earnings-per-share growth, the picture is similar: TG Therapeutics, Inc. grew EPS 1747% year-over-year, compared to 91. 6% for Curis, Inc.. Over a 3-year CAGR, TGTX leads at 504. 9% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

TG Therapeutics, Inc.

(TGTX) is the more profitable company, earning 72. 6% net margin versus -80. 3% for Curis, Inc. — meaning it keeps 72. 6% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: TGTX leads at 20. 0% versus -348. 4% for CRIS. At the gross margin level — before operating expenses — IMTX leads at 100. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

On forward earnings alone, Agenus Inc.

(AGEN) trades at 2. 9x forward P/E versus 32. 9x for TG Therapeutics, Inc. — 29. 9x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for AGEN: 91. 9% to $7. 33.

None of the stocks in this comparison currently pay a material dividend.

All are effectively zero-yield and should be held for capital appreciation rather than income.

For long-horizon retirement investors, TG Therapeutics, Inc.

(TGTX) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0. 84), +434. 4% 10Y return). Agenus Inc. (AGEN) carries a higher beta of 2. 58 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (TGTX: +434. 4%, AGEN: -94. 2%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.

In terms of investment character: IMTX is a small-cap high-growth stock; CRIS is a small-cap quality compounder stock; TGTX is a small-cap high-growth stock; AGEN is a small-cap quality compounder stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.