ITRM
Iterum Therapeutics plc
Biotechnology
Market Cap$2M
5Y Perf.-99.8%
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Stock Comparison
ITRM vs CMPX
Revenue, margins, valuation, and 5-year total return — side by side.
CMPX
Compass Therapeutics, Inc.
Biotechnology
Market Cap$250M
5Y Perf.-24.4%
ITRM vs CMPX — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | ITRM | CMPX |
|---|---|---|
| Industry | Biotechnology | Biotechnology |
| Market Cap | $2M | $250M |
| Revenue (TTM) | $390K | $0.00 |
| Net Income (TTM) | $-27M | $-68M |
| Gross Margin | -171.3% | — |
| Operating Margin | -52.0% | — |
| Total Debt | $46M | $10M |
| Cash & Equiv. | $24M | $31M |
ITRM vs CMPX — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
ITRM
CMPX
| Stock | Apr 21 | Mar 26 | Return |
|---|---|---|---|
| Iterum Therapeutics… (ITRM) | 100 | 0.2 | -99.8% |
| Compass Therapeutic… (CMPX) | 100 | 75.6 | -24.4% |
Price return only. Dividends and distributions are not included.
Quick Verdict: ITRM vs CMPX
Each card shows where this stock fits in a portfolio — not just who wins on paper.
Bottom line: CMPX leads in 4 of 6 categories, making it the strongest pick for profitability and margin quality and capital preservation and lower volatility. Iterum Therapeutics plc is the stronger pick specifically for growth and revenue expansion. As sector peers, any of these can serve as alternatives in the same allocation.
ITRM
Iterum Therapeutics plc
The Growth Play
ITRM is the clearest fit if your priority is growth exposure.
- EPS growth 57.4%
- 14.8% revenue growth vs CMPX's -100.0%
Best for: growth exposure
CMPX
Compass Therapeutics, Inc.
The Income Pick
CMPX carries the broadest edge in this set and is the clearest fit for income & stability and long-term compounding.
- beta 1.35
- -78.7% 10Y total return vs ITRM's -100.0%
- Lower volatility, beta 1.35, Low D/E 5.0%, current ratio 15.02x
Best for: income & stability and long-term compounding
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | ITRM | 14.8% revenue growth vs CMPX's -100.0% |
| Quality / Margins | CMPX | 2.9% margin vs ITRM's -69.1% |
| Stability / Safety | CMPX | Beta 1.35 vs ITRM's 1.49 |
| Dividends | Tie | Neither stock pays a meaningful dividend |
| Momentum (1Y) | CMPX | +2.8% vs ITRM's -96.6% |
| Efficiency (ROA) | CMPX | -35.3% ROA vs ITRM's -74.8%, ROIC -41.3% vs -117.8% |
ITRM vs CMPX — Financial Metrics
Side-by-side numbers across 2 stocks — who leads on profitability, valuation, growth, and risk.
BEST OVERALLCMPXLAGGINGITRM
ITRMIterum Therapeutics p…
1leads
CMPXCompass Therapeutics,…
4leads
6 Total Categories
CATEGORYLEADERvs ITRMMETRICS WON
Income & Cash FlowRevenue, margins, and cash flow strength
ITRM1/1
Valuation MetricsMultiples, price ratios, and targets
CMPX1/1
Profitability & EfficiencyROE, ROIC, leverage, and quality scores
CMPX6/6
Total Returns1Y, 3Y, 5Y total returns with dividends
CMPX6/6
Risk & VolatilityBeta, volatility, and downside exposure
CMPX2/2
Analyst OutlookRatings, price targets, and dividends
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Income & Cash Flow (Last 12 Months)
ITRM leads this category, winning 1 of 1 comparable metric.
Income & Cash Flow (Last 12 Months)
ITRM and CMPX operate at a comparable scale, with $390,000 and $0 in trailing revenue.
| Metric | ITRMIterum Therapeuti… | CMPXCompass Therapeut… |
|---|---|---|
| RevenueTrailing 12 months | $390,000 | $0 |
| EBITDAEarnings before interest/tax | -$19M | -$74M |
| Net IncomeAfter-tax profit | -$27M | -$68M |
| Free Cash FlowCash after capex | -$20M | -$53M |
| Gross MarginGross profit ÷ Revenue | -171.3% | — |
| Operating MarginEBIT ÷ Revenue | -52.0% | — |
| Net MarginNet income ÷ Revenue | -69.1% | — |
| FCF MarginFCF ÷ Revenue | -51.1% | — |
| Rev. Growth (YoY)Latest quarter vs prior year | — | — |
| EPS Growth (YoY)Latest quarter vs prior year | +33.3% | +16.7% |
ITRM leads this category, winning 1 of 1 comparable metric.
Valuation Metrics
CMPX leads this category, winning 1 of 1 comparable metric.
Valuation Metrics
| Metric | ITRMIterum Therapeuti… | CMPXCompass Therapeut… |
|---|---|---|
| Market CapShares × price | $2M | $250M |
| Enterprise ValueMkt cap + debt − cash | $23M | $229M |
| Trailing P/EPrice ÷ TTM EPS | -0.02x | -4.31x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | — |
| Price / SalesMarket cap ÷ Revenue | — | — |
| Price / BookPrice ÷ Book value/share | — | 1.45x |
| Price / FCFMarket cap ÷ FCF | — | — |
CMPX leads this category, winning 1 of 1 comparable metric.
Profitability & Efficiency
CMPX leads this category, winning 6 of 6 comparable metrics.
Profitability & Efficiency
On the Piotroski fundamental quality scale (0–9), CMPX scores 3/9 vs ITRM's 1/9, reflecting mixed financial health.
| Metric | ITRMIterum Therapeuti… | CMPXCompass Therapeut… |
|---|---|---|
| ROE (TTM)Return on equity | — | -39.7% |
| ROA (TTM)Return on assets | -74.8% | -35.3% |
| ROICReturn on invested capital | -117.8% | -41.3% |
| ROCEReturn on capital employed | -94.1% | -43.2% |
| Piotroski ScoreFundamental quality 0–9 | 1 | 3 |
| Debt / EquityFinancial leverage | — | 0.05x |
| Net DebtTotal debt minus cash | $21M | -$21M |
| Cash & Equiv.Liquid assets | $24M | $31M |
| Total DebtShort + long-term debt | $46M | $10M |
| Interest CoverageEBIT ÷ Interest expense | -10.61x | — |
CMPX leads this category, winning 6 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
CMPX leads this category, winning 6 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in CMPX five years ago would be worth $3,876 today (with dividends reinvested), compared to $19 for ITRM. Over the past 12 months, CMPX leads with a +2.8% total return vs ITRM's -96.6%. The 3-year compound annual growth rate (CAGR) favors CMPX at -19.6% vs ITRM's -69.7% — a key indicator of consistent wealth creation.
| Metric | ITRMIterum Therapeuti… | CMPXCompass Therapeut… |
|---|---|---|
| YTD ReturnYear-to-date | -90.2% | -65.0% |
| 1-Year ReturnPast 12 months | -96.6% | +2.8% |
| 3-Year ReturnCumulative with dividends | -97.2% | -48.0% |
| 5-Year ReturnCumulative with dividends | -99.8% | -61.2% |
| 10-Year ReturnCumulative with dividends | -100.0% | -78.7% |
| CAGR (3Y)Annualised 3-year return | -69.7% | -19.6% |
CMPX leads this category, winning 6 of 6 comparable metrics.
Risk & Volatility
CMPX leads this category, winning 2 of 2 comparable metrics.
Risk & Volatility
CMPX is the less volatile stock with a 1.35 beta — it tends to amplify market swings less than ITRM's 1.49 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. CMPX currently trades 26.3% from its 52-week high vs ITRM's 2.4% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | ITRMIterum Therapeuti… | CMPXCompass Therapeut… |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.49x | 1.35x |
| 52-Week HighHighest price in past year | $1.28 | $6.88 |
| 52-Week LowLowest price in past year | $0.03 | $1.61 |
| % of 52W HighCurrent price vs 52-week peak | +2.4% | +26.3% |
| RSI (14)Momentum oscillator 0–100 | 29.6 | 23.8 |
| Avg Volume (50D)Average daily shares traded | 36.8M | 7.6M |
CMPX leads this category, winning 2 of 2 comparable metrics.
Analyst Outlook
Insufficient data to determine a leader in this category.
Analyst Outlook
| Metric | ITRMIterum Therapeuti… | CMPXCompass Therapeut… |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy |
| Price TargetConsensus 12-month target | — | $11.20 |
| # AnalystsCovering analysts | — | 15 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% |
Insufficient data to determine a leader in this category.
Key Takeaway
CMPX leads in 4 of 6 categories (Valuation Metrics, Profitability & Efficiency). ITRM leads in 1 (Income & Cash Flow).
Best OverallCompass Therapeutics, Inc. (CMPX)Leads 4 of 6 categories
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ITRM vs CMPX: Frequently Asked Questions
8 questions · data-driven answers · updated daily
01Is ITRM or CMPX a better buy right now?
Analysts rate Compass Therapeutics, Inc.
(CMPX) a "Buy" — based on 15 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — ITRM or CMPX?
Over the past 5 years, Compass Therapeutics, Inc.
(CMPX) delivered a total return of -61. 2%, compared to -99. 8% for Iterum Therapeutics plc (ITRM). Over 10 years, the gap is even starker: CMPX returned -78. 7% versus ITRM's -100. 0%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — ITRM or CMPX?
By beta (market sensitivity over 5 years), Compass Therapeutics, Inc.
(CMPX) is the lower-risk stock at 1. 35β versus Iterum Therapeutics plc's 1. 49β — meaning ITRM is approximately 10% more volatile than CMPX relative to the S&P 500.
04Which is growing faster — ITRM or CMPX?
On earnings-per-share growth, the picture is similar: Iterum Therapeutics plc grew EPS 57.
4% year-over-year, compared to -16. 7% for Compass Therapeutics, Inc.. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
05Which has better profit margins — ITRM or CMPX?
Compass Therapeutics, Inc.
(CMPX) is the more profitable company, earning 0. 0% net margin versus -69. 1% for Iterum Therapeutics plc — meaning it keeps 0. 0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: CMPX leads at 0. 0% versus -52. 0% for ITRM. At the gross margin level — before operating expenses — CMPX leads at 0. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Which pays a better dividend — ITRM or CMPX?
None of the stocks in this comparison currently pay a material dividend.
All are effectively zero-yield and should be held for capital appreciation rather than income.
07Is ITRM or CMPX better for a retirement portfolio?
For long-horizon retirement investors, Compass Therapeutics, Inc.
(CMPX) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding. Both have compounded well over 10 years (CMPX: -78. 7%, ITRM: -100. 0%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between ITRM and CMPX?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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