ITRM
Iterum Therapeutics plc
Biotechnology
Market Cap$2M
5Y Perf.-99.6%
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Stock Comparison
ITRM vs PRAX
Revenue, margins, valuation, and 5-year total return — side by side.
PRAX
Praxis Precision Medicines, Inc.
Biotechnology
Market Cap$7.61B
5Y Perf.-38.6%
ITRM vs PRAX — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | ITRM | PRAX |
|---|---|---|
| Industry | Biotechnology | Biotechnology |
| Market Cap | $2M | $7.61B |
| Revenue (TTM) | $390K | $0.00 |
| Net Income (TTM) | $-27M | $-303M |
| Gross Margin | -171.3% | — |
| Operating Margin | -52.0% | — |
| Total Debt | $46M | $110K |
| Cash & Equiv. | $24M | $357M |
ITRM vs PRAX — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
ITRM
PRAX
| Stock | Oct 20 | Mar 26 | Return |
|---|---|---|---|
| Iterum Therapeutics… (ITRM) | 100 | 0.4 | -99.6% |
| Praxis Precision Me… (PRAX) | 100 | 61.4 | -38.6% |
Price return only. Dividends and distributions are not included.
Quick Verdict: ITRM vs PRAX
Each card shows where this stock fits in a portfolio — not just who wins on paper.
Bottom line: PRAX leads in 3 of 6 categories, making it the strongest pick for profitability and margin quality and recent price momentum and sentiment. Iterum Therapeutics plc is the stronger pick specifically for growth and revenue expansion and capital preservation and lower volatility. As sector peers, any of these can serve as alternatives in the same allocation.
ITRM
Iterum Therapeutics plc
The Income Pick
ITRM is the clearest fit if your priority is income & stability and growth exposure.
- beta 1.49
- EPS growth 57.4%
- Lower volatility, beta 1.49, current ratio 1.41x
Best for: income & stability and growth exposure
PRAX
Praxis Precision Medicines, Inc.
The Long-Run Compounder
PRAX carries the broadest edge in this set and is the clearest fit for long-term compounding.
- -19.0% 10Y total return vs ITRM's -100.0%
- 2.4% margin vs ITRM's -69.1%
- +8.6% vs ITRM's -96.9%
Best for: long-term compounding
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | ITRM | 14.8% revenue growth vs PRAX's -100.0% |
| Quality / Margins | PRAX | 2.4% margin vs ITRM's -69.1% |
| Stability / Safety | ITRM | Beta 1.49 vs PRAX's 1.55 |
| Dividends | Tie | Neither stock pays a meaningful dividend |
| Momentum (1Y) | PRAX | +8.6% vs ITRM's -96.9% |
| Efficiency (ROA) | PRAX | -53.5% ROA vs ITRM's -74.8%, ROIC -65.0% vs -117.8% |
ITRM vs PRAX — Revenue Breakdown by Segment
How each company's revenue is distributed across its business units
Segment breakdown not available.
FY 2024
ITRM vs PRAX — Financial Metrics
Side-by-side numbers across 2 stocks — who leads on profitability, valuation, growth, and risk.
BEST OVERALLPRAXLAGGINGITRM
ITRMIterum Therapeutics p…
1leads
PRAXPraxis Precision Medi…
3leads
6 Total Categories
CATEGORYLEADERvs ITRMMETRICS WON
Income & Cash FlowRevenue, margins, and cash flow strength
ITRM1/1
Valuation MetricsMultiples, price ratios, and targets
PRAX1/1
Profitability & EfficiencyROE, ROIC, leverage, and quality scores
PRAX6/6
Total Returns1Y, 3Y, 5Y total returns with dividends
PRAX6/6
Risk & VolatilityBeta, volatility, and downside exposure
Tied
—
Analyst OutlookRatings, price targets, and dividends
—
—
Income & Cash Flow (Last 12 Months)
ITRM leads this category, winning 1 of 1 comparable metric.
Income & Cash Flow (Last 12 Months)
ITRM and PRAX operate at a comparable scale, with $390,000 and $0 in trailing revenue.
| Metric | ITRMIterum Therapeuti… | PRAXPraxis Precision … |
|---|---|---|
| RevenueTrailing 12 months | $390,000 | $0 |
| EBITDAEarnings before interest/tax | -$19M | -$326M |
| Net IncomeAfter-tax profit | -$27M | -$303M |
| Free Cash FlowCash after capex | -$20M | -$249M |
| Gross MarginGross profit ÷ Revenue | -171.3% | — |
| Operating MarginEBIT ÷ Revenue | -52.0% | — |
| Net MarginNet income ÷ Revenue | -69.1% | — |
| FCF MarginFCF ÷ Revenue | -51.1% | — |
| Rev. Growth (YoY)Latest quarter vs prior year | — | -100.0% |
| EPS Growth (YoY)Latest quarter vs prior year | +33.3% | -19.0% |
ITRM leads this category, winning 1 of 1 comparable metric.
Valuation Metrics
PRAX leads this category, winning 1 of 1 comparable metric.
Valuation Metrics
| Metric | ITRMIterum Therapeuti… | PRAXPraxis Precision … |
|---|---|---|
| Market CapShares × price | $2M | $7.6B |
| Enterprise ValueMkt cap + debt − cash | $23M | $7.2B |
| Trailing P/EPrice ÷ TTM EPS | -0.02x | -25.07x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | — |
| Price / SalesMarket cap ÷ Revenue | — | — |
| Price / BookPrice ÷ Book value/share | — | 8.66x |
| Price / FCFMarket cap ÷ FCF | — | — |
PRAX leads this category, winning 1 of 1 comparable metric.
Profitability & Efficiency
PRAX leads this category, winning 6 of 6 comparable metrics.
Profitability & Efficiency
On the Piotroski fundamental quality scale (0–9), PRAX scores 3/9 vs ITRM's 1/9, reflecting mixed financial health.
| Metric | ITRMIterum Therapeuti… | PRAXPraxis Precision … |
|---|---|---|
| ROE (TTM)Return on equity | — | -58.7% |
| ROA (TTM)Return on assets | -74.8% | -53.5% |
| ROICReturn on invested capital | -117.8% | -65.0% |
| ROCEReturn on capital employed | -94.1% | -49.3% |
| Piotroski ScoreFundamental quality 0–9 | 1 | 3 |
| Debt / EquityFinancial leverage | — | 0.00x |
| Net DebtTotal debt minus cash | $21M | -$357M |
| Cash & Equiv.Liquid assets | $24M | $357M |
| Total DebtShort + long-term debt | $46M | $110,000 |
| Interest CoverageEBIT ÷ Interest expense | -10.61x | — |
PRAX leads this category, winning 6 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
PRAX leads this category, winning 6 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in PRAX five years ago would be worth $8,157 today (with dividends reinvested), compared to $20 for ITRM. Over the past 12 months, PRAX leads with a +860.9% total return vs ITRM's -96.9%. The 3-year compound annual growth rate (CAGR) favors PRAX at 176.1% vs ITRM's -69.7% — a key indicator of consistent wealth creation.
| Metric | ITRMIterum Therapeuti… | PRAXPraxis Precision … |
|---|---|---|
| YTD ReturnYear-to-date | -90.2% | +18.0% |
| 1-Year ReturnPast 12 months | -96.9% | +860.9% |
| 3-Year ReturnCumulative with dividends | -97.2% | +2005.6% |
| 5-Year ReturnCumulative with dividends | -99.8% | -18.4% |
| 10-Year ReturnCumulative with dividends | -100.0% | -19.0% |
| CAGR (3Y)Annualised 3-year return | -69.7% | +176.1% |
PRAX leads this category, winning 6 of 6 comparable metrics.
Risk & Volatility
Evenly matched — ITRM and PRAX each lead in 1 of 2 comparable metrics.
Risk & Volatility
ITRM is the less volatile stock with a 1.49 beta — it tends to amplify market swings less than PRAX's 1.55 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. PRAX currently trades 94.9% from its 52-week high vs ITRM's 2.4% drawdown — a narrower gap to the peak suggests stronger recent price momentum.
| Metric | ITRMIterum Therapeuti… | PRAXPraxis Precision … |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.49x | 1.55x |
| 52-Week HighHighest price in past year | $1.28 | $356.00 |
| 52-Week LowLowest price in past year | $0.03 | $34.89 |
| % of 52W HighCurrent price vs 52-week peak | +2.4% | +94.9% |
| RSI (14)Momentum oscillator 0–100 | 29.6 | 53.7 |
| Avg Volume (50D)Average daily shares traded | 35.4M | 376K |
Evenly matched — ITRM and PRAX each lead in 1 of 2 comparable metrics.
Analyst Outlook
Insufficient data to determine a leader in this category.
Analyst Outlook
| Metric | ITRMIterum Therapeuti… | PRAXPraxis Precision … |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | — | Buy |
| Price TargetConsensus 12-month target | — | $544.40 |
| # AnalystsCovering analysts | — | 16 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | — |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | 0.0% | 0.0% |
Insufficient data to determine a leader in this category.
Key Takeaway
PRAX leads in 3 of 6 categories (Valuation Metrics, Profitability & Efficiency). ITRM leads in 1 (Income & Cash Flow). 1 tied.
Best OverallPraxis Precision Medicines,… (PRAX)Leads 3 of 6 categories
Loading custom metrics...
ITRM vs PRAX: Frequently Asked Questions
8 questions · data-driven answers · updated daily
01Is ITRM or PRAX a better buy right now?
Analysts rate Praxis Precision Medicines, Inc.
(PRAX) a "Buy" — based on 16 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — ITRM or PRAX?
Over the past 5 years, Praxis Precision Medicines, Inc.
(PRAX) delivered a total return of -18. 4%, compared to -99. 8% for Iterum Therapeutics plc (ITRM). Over 10 years, the gap is even starker: PRAX returned -19. 0% versus ITRM's -100. 0%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — ITRM or PRAX?
By beta (market sensitivity over 5 years), Iterum Therapeutics plc (ITRM) is the lower-risk stock at 1.
49β versus Praxis Precision Medicines, Inc. 's 1. 55β — meaning PRAX is approximately 4% more volatile than ITRM relative to the S&P 500.
04Which is growing faster — ITRM or PRAX?
On earnings-per-share growth, the picture is similar: Iterum Therapeutics plc grew EPS 57.
4% year-over-year, compared to -32. 0% for Praxis Precision Medicines, Inc.. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
05Which has better profit margins — ITRM or PRAX?
Praxis Precision Medicines, Inc.
(PRAX) is the more profitable company, earning 0. 0% net margin versus -69. 1% for Iterum Therapeutics plc — meaning it keeps 0. 0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: PRAX leads at 0. 0% versus -52. 0% for ITRM. At the gross margin level — before operating expenses — PRAX leads at 0. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Which pays a better dividend — ITRM or PRAX?
None of the stocks in this comparison currently pay a material dividend.
All are effectively zero-yield and should be held for capital appreciation rather than income.
07Is ITRM or PRAX better for a retirement portfolio?
For long-horizon retirement investors, Praxis Precision Medicines, Inc.
(PRAX) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding. Both have compounded well over 10 years (PRAX: -19. 0%, ITRM: -100. 0%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between ITRM and PRAX?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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