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LNTH vs EXAS vs RMD vs GH vs NTRA

Revenue, margins, valuation, and 5-year total return — side by side.

Live fundamentals10-year financials5-year price chart
LNTH
Lantheus Holdings, Inc.

Drug Manufacturers - Specialty & Generic

HealthcareNASDAQ • US
Market Cap$5.92B
5Y Perf.+562.8%
EXAS
Exact Sciences Corporation

Medical - Diagnostics & Research

HealthcareNASDAQ • US
Market Cap$20.02B
5Y Perf.+20.4%
RMD
ResMed Inc.

Medical - Instruments & Supplies

HealthcareNYSE • US
Market Cap$30.15B
5Y Perf.+28.7%
GH
Guardant Health, Inc.

Medical - Diagnostics & Research

HealthcareNASDAQ • US
Market Cap$12.10B
5Y Perf.+2.1%
NTRA
Natera, Inc.

Medical - Diagnostics & Research

HealthcareNASDAQ • US
Market Cap$31.16B
5Y Perf.+401.3%

LNTH vs EXAS vs RMD vs GH vs NTRA — Key Financials

Market cap, revenue, margins, and valuation side-by-side.

Company Snapshot
LNTH logoLNTH
EXAS logoEXAS
RMD logoRMD
GH logoGH
NTRA logoNTRA
IndustryDrug Manufacturers - Specialty & GenericMedical - Diagnostics & ResearchMedical - Instruments & SuppliesMedical - Diagnostics & ResearchMedical - Diagnostics & Research
Market Cap$5.92B$20.02B$30.15B$12.10B$31.16B
Revenue (TTM)$1.55B$3.25B$5.54B$1.08B$2.31B
Net Income (TTM)$279M$-208M$1.52B$-433M$-208M
Gross Margin60.5%69.7%61.7%64.9%64.8%
Operating Margin18.8%-6.4%34.3%-41.4%-13.4%
Forward P/E17.5x582.8x18.8x
Total Debt$738K$2.52B$852M$1.68B$214M
Cash & Equiv.$359M$956M$1.21B$378M$1.08B

LNTH vs EXAS vs RMD vs GH vs NTRALong-Term Stock Performance

Price return indexed to 100 at period start. Dividends excluded.

LNTH
EXAS
RMD
GH
NTRA
StockMay 20May 26Return
Lantheus Holdings, … (LNTH)100662.8+562.8%
Exact Sciences Corp… (EXAS)100120.4+20.4%
ResMed Inc. (RMD)100128.7+28.7%
Guardant Health, In… (GH)100102.1+2.1%
Natera, Inc. (NTRA)100501.3+401.3%

Price return only. Dividends and distributions are not included.

Quick Verdict: LNTH vs EXAS vs RMD vs GH vs NTRA

Each card shows where this stock fits in a portfolio — not just who wins on paper.

Bottom line: RMD leads in 3 of 7 categories (5-stock set), making it the strongest pick for profitability and margin quality and dividend income and shareholder returns. Lantheus Holdings, Inc. is the stronger pick specifically for valuation and capital efficiency. EXAS, GH, and NTRA also each lead in at least one category. As sector peers, any of these can serve as alternatives in the same allocation.
LNTH
Lantheus Holdings, Inc.
The Long-Run Compounder

LNTH is the #2 pick in this set and the best alternative if long-term compounding and sleep-well-at-night is your priority.

  • 41.9% 10Y total return vs NTRA's 20.9%
  • Lower volatility, beta 0.47, Low D/E 0.1%, current ratio 2.70x
  • Better valuation composite
Best for: long-term compounding and sleep-well-at-night
EXAS
Exact Sciences Corporation
The Defensive Choice

EXAS ranks third and is worth considering specifically for stability.

  • Beta 0.12 vs NTRA's 1.26
Best for: stability
RMD
ResMed Inc.
The Income Pick

RMD carries the broadest edge in this set and is the clearest fit for income & stability and defensive.

  • Dividend streak 14 yrs, beta 0.66, yield 1.0%
  • Beta 0.66, yield 1.0%, current ratio 3.44x
  • 27.4% margin vs GH's -40.1%
  • 1.0% yield; 14-year raise streak; the other 4 pay no meaningful dividend
Best for: income & stability and defensive
GH
Guardant Health, Inc.
The Momentum Pick

GH is the clearest fit if your priority is momentum.

  • +132.2% vs RMD's -14.5%
Best for: momentum
NTRA
Natera, Inc.
The Growth Play

NTRA is the clearest fit if your priority is growth exposure.

  • Rev growth 35.9%, EPS growth 0.7%, 3Y rev CAGR 41.1%
  • 35.9% revenue growth vs LNTH's 0.5%
Best for: growth exposure
See the full category breakdown
CategoryWinnerWhy
GrowthNTRA logoNTRA35.9% revenue growth vs LNTH's 0.5%
ValueLNTH logoLNTHBetter valuation composite
Quality / MarginsRMD logoRMD27.4% margin vs GH's -40.1%
Stability / SafetyEXAS logoEXASBeta 0.12 vs NTRA's 1.26
DividendsRMD logoRMD1.0% yield; 14-year raise streak; the other 4 pay no meaningful dividend
Momentum (1Y)GH logoGH+132.2% vs RMD's -14.5%
Efficiency (ROA)RMD logoRMD18.0% ROA vs GH's -26.5%, ROIC 22.8% vs -34.9%

LNTH vs EXAS vs RMD vs GH vs NTRA — Revenue Breakdown by Segment

How each company's revenue is distributed across its business units

LNTHLantheus Holdings, Inc.
FY 2025
Product
33.4%$1.5B
Radiopharmaceutical Oncology
21.9%$989M
PYLARIFY
21.9%$989M
Total Precision Diagnostics
10.9%$493M
DEFINITY
7.3%$330M
Techne Lite
1.9%$87M
Strategic Partnerships And Other
1.3%$59M
Other (2)
1.3%$59M
EXASExact Sciences Corporation
FY 2025
Screening
77.9%$2.5B
Precision Oncology
22.1%$717M
RMDResMed Inc.
FY 2024
Sleep And Respiratory
87.5%$4.1B
Software As Service
12.5%$584M
GHGuardant Health, Inc.
FY 2025
Oncology
69.6%$684M
Biopharma & Data
21.4%$210M
Screening
8.1%$80M
Licensing & Other
0.9%$9M
NTRANatera, Inc.
FY 2025
Product
99.6%$2.3B
Licensing and other
0.4%$10M

LNTH vs EXAS vs RMD vs GH vs NTRA — Financial Metrics

Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.

BEST OVERALLRMDLAGGINGNTRA

Income & Cash Flow (Last 12 Months)

RMD leads this category, winning 3 of 6 comparable metrics.

RMD is the larger business by revenue, generating $5.5B annually — 5.1x GH's $1.1B. RMD is the more profitable business, keeping 27.4% of every revenue dollar as net income compared to GH's -40.1%. On growth, GH holds the edge at +48.3% YoY revenue growth, suggesting stronger near-term business momentum.

MetricLNTH logoLNTHLantheus Holdings…EXAS logoEXASExact Sciences Co…RMD logoRMDResMed Inc.GH logoGHGuardant Health, …NTRA logoNTRANatera, Inc.
RevenueTrailing 12 months$1.5B$3.2B$5.5B$1.1B$2.3B
EBITDAEarnings before interest/tax$347M-$41M$2.1B-$418M-$310M
Net IncomeAfter-tax profit$279M-$208M$1.5B-$433M-$208M
Free Cash FlowCash after capex$372M$357M$1.8B-$225M$97M
Gross MarginGross profit ÷ Revenue+60.5%+69.7%+61.7%+64.9%+64.8%
Operating MarginEBIT ÷ Revenue+18.8%-6.4%+34.3%-41.4%-13.4%
Net MarginNet income ÷ Revenue+18.0%-6.4%+27.4%-40.1%-9.0%
FCF MarginFCF ÷ Revenue+24.0%+11.0%+31.7%-20.8%+4.2%
Rev. Growth (YoY)Latest quarter vs prior year+1.2%+23.1%+10.8%+48.3%+39.8%
EPS Growth (YoY)Latest quarter vs prior year+76.5%+90.4%+9.3%-10.4%+185.4%
RMD leads this category, winning 3 of 6 comparable metrics.

Valuation Metrics

LNTH leads this category, winning 4 of 6 comparable metrics.

At 21.8x trailing earnings, RMD trades at a 18% valuation discount to LNTH's 26.7x P/E. On an enterprise value basis, LNTH's 14.6x EV/EBITDA is more attractive than RMD's 15.5x.

MetricLNTH logoLNTHLantheus Holdings…EXAS logoEXASExact Sciences Co…RMD logoRMDResMed Inc.GH logoGHGuardant Health, …NTRA logoNTRANatera, Inc.
Market CapShares × price$5.9B$20.0B$30.1B$12.1B$31.2B
Enterprise ValueMkt cap + debt − cash$5.6B$21.6B$29.8B$13.4B$30.3B
Trailing P/EPrice ÷ TTM EPS26.69x-95.37x21.76x-27.79x-144.62x
Forward P/EPrice ÷ next-FY EPS est.17.52x582.83x18.78x
PEG RatioP/E ÷ EPS growth rate1.25x
EV / EBITDAEnterprise value multiple14.61x15.51x
Price / SalesMarket cap ÷ Revenue3.84x6.16x5.86x12.32x13.51x
Price / BookPrice ÷ Book value/share5.72x8.24x5.11x17.55x
Price / FCFMarket cap ÷ FCF16.73x56.10x18.14x285.53x
LNTH leads this category, winning 4 of 6 comparable metrics.

Profitability & Efficiency

RMD leads this category, winning 5 of 9 comparable metrics.

RMD delivers a 24.4% return on equity — every $100 of shareholder capital generates $24 in annual profit, vs $-15 for NTRA. LNTH carries lower financial leverage with a 0.00x debt-to-equity ratio, signaling a more conservative balance sheet compared to EXAS's 1.05x. On the Piotroski fundamental quality scale (0–9), RMD scores 8/9 vs NTRA's 5/9, reflecting strong financial health.

MetricLNTH logoLNTHLantheus Holdings…EXAS logoEXASExact Sciences Co…RMD logoRMDResMed Inc.GH logoGHGuardant Health, …NTRA logoNTRANatera, Inc.
ROE (TTM)Return on equity+24.3%-8.7%+24.4%-15.3%
ROA (TTM)Return on assets+12.4%-3.5%+18.0%-26.5%-10.6%
ROICReturn on invested capital+30.6%-3.6%+22.8%-34.9%-36.1%
ROCEReturn on capital employed+17.1%-4.0%+25.7%-29.4%-18.3%
Piotroski ScoreFundamental quality 0–957855
Debt / EquityFinancial leverage0.00x1.05x0.14x0.13x
Net DebtTotal debt minus cash-$358M$1.6B-$358M$1.3B-$862M
Cash & Equiv.Liquid assets$359M$956M$1.2B$378M$1.1B
Total DebtShort + long-term debt$738,000$2.5B$852M$1.7B$214M
Interest CoverageEBIT ÷ Interest expense11.72x-5.47x66.06x-181.67x-25.21x
RMD leads this category, winning 5 of 9 comparable metrics.

Total Returns (Dividends Reinvested)

LNTH leads this category, winning 3 of 6 comparable metrics.

A $10,000 investment in LNTH five years ago would be worth $41,420 today (with dividends reinvested), compared to $6,814 for GH. Over the past 12 months, GH leads with a +132.2% total return vs RMD's -14.5%. The 3-year compound annual growth rate (CAGR) favors NTRA at 60.6% vs RMD's -2.9% — a key indicator of consistent wealth creation.

MetricLNTH logoLNTHLantheus Holdings…EXAS logoEXASExact Sciences Co…RMD logoRMDResMed Inc.GH logoGHGuardant Health, …NTRA logoNTRANatera, Inc.
YTD ReturnYear-to-date+35.3%+3.1%-15.2%-9.3%-3.9%
1-Year ReturnPast 12 months+13.1%+96.9%-14.5%+132.2%+37.3%
3-Year ReturnCumulative with dividends-4.0%+53.0%-8.4%+292.1%+314.0%
5-Year ReturnCumulative with dividends+314.2%+0.4%+11.0%-31.9%+115.9%
10-Year ReturnCumulative with dividends+4192.5%+1669.1%+293.8%+186.5%+2089.4%
CAGR (3Y)Annualised 3-year return-1.4%+15.2%-2.9%+57.7%+60.6%
LNTH leads this category, winning 3 of 6 comparable metrics.

Risk & Volatility

EXAS leads this category, winning 2 of 2 comparable metrics.

EXAS is the less volatile stock with a 0.12 beta — it tends to amplify market swings less than NTRA's 1.26 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. EXAS currently trades 99.9% from its 52-week high vs RMD's 70.4% drawdown — a narrower gap to the peak suggests stronger recent price momentum.

MetricLNTH logoLNTHLantheus Holdings…EXAS logoEXASExact Sciences Co…RMD logoRMDResMed Inc.GH logoGHGuardant Health, …NTRA logoNTRANatera, Inc.
Beta (5Y)Sensitivity to S&P 5000.47x0.12x0.66x0.86x1.26x
52-Week HighHighest price in past year$93.00$104.98$293.81$120.74$256.36
52-Week LowLowest price in past year$47.25$38.81$198.64$36.36$131.81
% of 52W HighCurrent price vs 52-week peak+97.8%+99.9%+70.4%+76.4%+85.7%
RSI (14)Momentum oscillator 0–10061.276.435.655.957.1
Avg Volume (50D)Average daily shares traded886K4.2M1.1M1.9M1.3M
EXAS leads this category, winning 2 of 2 comparable metrics.

Analyst Outlook

RMD leads this category, winning 1 of 1 comparable metric.

Analyst consensus: LNTH as "Buy", EXAS as "Buy", RMD as "Buy", GH as "Buy", NTRA as "Buy". Consensus price targets imply 44.3% upside for GH (target: $133) vs -1.6% for EXAS (target: $103). RMD is the only dividend payer here at 1.02% yield — a key consideration for income-focused portfolios.

MetricLNTH logoLNTHLantheus Holdings…EXAS logoEXASExact Sciences Co…RMD logoRMDResMed Inc.GH logoGHGuardant Health, …NTRA logoNTRANatera, Inc.
Analyst RatingConsensus buy/hold/sellBuyBuyBuyBuyBuy
Price TargetConsensus 12-month target$101.00$103.18$281.29$133.14$262.50
# AnalystsCovering analysts1741353027
Dividend YieldAnnual dividend ÷ price+1.0%
Dividend StreakConsecutive years of raises014
Dividend / ShareAnnual DPS$2.11
Buyback YieldShare repurchases ÷ mkt cap+5.1%+0.1%+1.0%+0.1%0.0%
RMD leads this category, winning 1 of 1 comparable metric.
Key Takeaway

RMD leads in 3 of 6 categories (Income & Cash Flow, Profitability & Efficiency). LNTH leads in 2 (Valuation Metrics, Total Returns).

Best OverallResMed Inc. (RMD)Leads 3 of 6 categories
Loading custom metrics...

LNTH vs EXAS vs RMD vs GH vs NTRA: Key Questions Answered

10 questions · data-driven answers · updated daily

01

Is LNTH or EXAS or RMD or GH or NTRA a better buy right now?

For growth investors, Natera, Inc.

(NTRA) is the stronger pick with 35. 9% revenue growth year-over-year, versus 0. 5% for Lantheus Holdings, Inc. (LNTH). ResMed Inc. (RMD) offers the better valuation at 21. 8x trailing P/E (18. 8x forward), making it the more compelling value choice. Analysts rate Lantheus Holdings, Inc. (LNTH) a "Buy" — based on 17 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

02

Which has the better valuation — LNTH or EXAS or RMD or GH or NTRA?

On trailing P/E, ResMed Inc.

(RMD) is the cheapest at 21. 8x versus Lantheus Holdings, Inc. at 26. 7x. On forward P/E, Lantheus Holdings, Inc. is actually cheaper at 17. 5x — notably different from the trailing picture, reflecting expected earnings growth.

03

Which is the better long-term investment — LNTH or EXAS or RMD or GH or NTRA?

Over the past 5 years, Lantheus Holdings, Inc.

(LNTH) delivered a total return of +314. 2%, compared to -31. 9% for Guardant Health, Inc. (GH). Over 10 years, the gap is even starker: LNTH returned +41. 9% versus GH's +186. 5%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

04

Which is safer — LNTH or EXAS or RMD or GH or NTRA?

By beta (market sensitivity over 5 years), Exact Sciences Corporation (EXAS) is the lower-risk stock at 0.

12β versus Natera, Inc. 's 1. 26β — meaning NTRA is approximately 943% more volatile than EXAS relative to the S&P 500. On balance sheet safety, Lantheus Holdings, Inc. (LNTH) carries a lower debt/equity ratio of 0% versus 105% for Exact Sciences Corporation — giving it more financial flexibility in a downturn.

05

Which is growing faster — LNTH or EXAS or RMD or GH or NTRA?

By revenue growth (latest reported year), Natera, Inc.

(NTRA) is pulling ahead at 35. 9% versus 0. 5% for Lantheus Holdings, Inc. (LNTH). On earnings-per-share growth, the picture is similar: Exact Sciences Corporation grew EPS 80. 3% year-over-year, compared to -21. 8% for Lantheus Holdings, Inc.. Over a 3-year CAGR, NTRA leads at 41. 1% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

06

Which has better profit margins — LNTH or EXAS or RMD or GH or NTRA?

ResMed Inc.

(RMD) is the more profitable company, earning 27. 2% net margin versus -42. 4% for Guardant Health, Inc. — meaning it keeps 27. 2% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: RMD leads at 32. 7% versus -44. 4% for GH. At the gross margin level — before operating expenses — EXAS leads at 69. 7%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

07

Is LNTH or EXAS or RMD or GH or NTRA more undervalued right now?

On forward earnings alone, Lantheus Holdings, Inc.

(LNTH) trades at 17. 5x forward P/E versus 582. 8x for Exact Sciences Corporation — 565. 3x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for GH: 44. 3% to $133. 14.

08

Which pays a better dividend — LNTH or EXAS or RMD or GH or NTRA?

In this comparison, RMD (1.

0% yield) pays a dividend. LNTH, EXAS, GH, NTRA do not pay a meaningful dividend and should not be held primarily for income.

09

Is LNTH or EXAS or RMD or GH or NTRA better for a retirement portfolio?

For long-horizon retirement investors, Exact Sciences Corporation (EXAS) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.

12), +1669% 10Y return). Both have compounded well over 10 years (EXAS: +1669%, NTRA: +20. 9%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

10

What are the main differences between LNTH and EXAS and RMD and GH and NTRA?

Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.

In terms of investment character: LNTH is a small-cap quality compounder stock; EXAS is a mid-cap high-growth stock; RMD is a mid-cap quality compounder stock; GH is a mid-cap high-growth stock; NTRA is a mid-cap high-growth stock. RMD pays a dividend while LNTH, EXAS, GH, NTRA do not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.

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LNTH

Quality Business

  • Sector: Healthcare
  • Market Cap > $100B
  • Net Margin > 10%
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EXAS

High-Growth Disruptor

  • Sector: Healthcare
  • Market Cap > $100B
  • Revenue Growth > 11%
  • Gross Margin > 41%
Run This Screen
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RMD

Quality Mega-Cap Compounder

  • Sector: Healthcare
  • Market Cap > $100B
  • Revenue Growth > 5%
  • Net Margin > 16%
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GH

High-Growth Disruptor

  • Sector: Healthcare
  • Market Cap > $100B
  • Revenue Growth > 24%
  • Gross Margin > 38%
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NTRA

High-Growth Disruptor

  • Sector: Healthcare
  • Market Cap > $100B
  • Revenue Growth > 19%
  • Gross Margin > 38%
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Beat Both

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Revenue Growth>
%
(LNTH: 1.2% · EXAS: 23.1%)

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