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NRXP vs ALTO vs AXSM vs REX vs GPRE

Revenue, margins, valuation, and 5-year total return — side by side.

Live fundamentals10-year financials5-year price chart
NRXP
NRx Pharmaceuticals, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$85M
5Y Perf.-97.2%
ALTO
Alto Ingredients, Inc.

Chemicals - Specialty

Basic MaterialsNASDAQ • US
Market Cap$351M
5Y Perf.+580.7%
AXSM
Axsome Therapeutics, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$11.33B
5Y Perf.+185.9%
REX
REX American Resources Corporation

Chemicals - Specialty

Basic MaterialsNYSE • US
Market Cap$1.60B
5Y Perf.+398.3%
GPRE
Green Plains Inc.

Chemicals - Specialty

Basic MaterialsNASDAQ • US
Market Cap$1.15B
5Y Perf.+92.5%

NRXP vs ALTO vs AXSM vs REX vs GPRE — Key Financials

Market cap, revenue, margins, and valuation side-by-side.

Company Snapshot
NRXP logoNRXP
ALTO logoALTO
AXSM logoAXSM
REX logoREX
GPRE logoGPRE
IndustryBiotechnologyChemicals - SpecialtyBiotechnologyChemicals - SpecialtyChemicals - Specialty
Market Cap$85M$351M$11.33B$1.60B$1.15B
Revenue (TTM)$242K$918M$708M$651M$1.94B
Net Income (TTM)$-38M$13M$-188M$50M$-15M
Gross Margin59.5%3.8%92.6%12.7%1.8%
Operating Margin-63.0%0.8%-24.8%8.6%1.2%
Forward P/E15.4x62.8x46.6x
Total Debt$631K$98M$241M$21M$508M
Cash & Equiv.$8M$26M$323M$196M$182M

NRXP vs ALTO vs AXSM vs REX vs GPRELong-Term Stock Performance

Price return indexed to 100 at period start. Dividends excluded.

NRXP
ALTO
AXSM
REX
GPRE
StockMay 20May 26Return
NRx Pharmaceuticals… (NRXP)1002.8-97.2%
Alto Ingredients, I… (ALTO)100680.7+580.7%
Axsome Therapeutics… (AXSM)100285.9+185.9%
REX American Resour… (REX)100498.3+398.3%
Green Plains Inc. (GPRE)100192.5+92.5%

Price return only. Dividends and distributions are not included.

Quick Verdict: NRXP vs ALTO vs AXSM vs REX vs GPRE

Each card shows where this stock fits in a portfolio — not just who wins on paper.

Bottom line: ALTO leads in 4 of 7 categories (5-stock set), making it the strongest pick for valuation and capital efficiency and capital preservation and lower volatility. REX American Resources Corporation is the stronger pick specifically for profitability and margin quality and operational efficiency and capital deployment. NRXP also leads in specific categories worth noting. This set spans 2 sectors — these stocks serve different portfolio roles, not just different price points.
NRXP
NRx Pharmaceuticals, Inc.
The Growth Leader

NRXP ranks third and is worth considering specifically for growth.

  • 101.1% revenue growth vs REX's -22.9%
Best for: growth
ALTO
Alto Ingredients, Inc.
The Income Pick

ALTO carries the broadest edge in this set and is the clearest fit for income & stability and defensive.

  • Dividend streak 0 yrs, beta 0.30, yield 0.4%
  • Beta 0.30, yield 0.4%, current ratio 2.64x
  • Lower P/E (15.4x vs 62.8x)
  • Beta 0.30 vs NRXP's 1.91
Best for: income & stability and defensive
AXSM
Axsome Therapeutics, Inc.
The Growth Play

AXSM is the clearest fit if your priority is growth exposure and long-term compounding.

  • Rev growth 65.5%, EPS growth 38.6%, 3Y rev CAGR 133.7%
  • 18.9% 10Y total return vs REX's 464.7%
Best for: growth exposure and long-term compounding
REX
REX American Resources Corporation
The Defensive Pick

REX is the #2 pick in this set and the best alternative if sleep-well-at-night is your priority.

  • Lower volatility, beta 0.36, Low D/E 3.3%, current ratio 8.64x
  • 7.7% margin vs NRXP's -157.3%
  • 6.7% ROA vs NRXP's -489.9%
Best for: sleep-well-at-night
GPRE
Green Plains Inc.
The Basic Materials Pick

Among these 5 stocks, GPRE doesn't own a clear edge in any measured category.

Best for: basic materials exposure
See the full category breakdown
CategoryWinnerWhy
GrowthNRXP logoNRXP101.1% revenue growth vs REX's -22.9%
ValueALTO logoALTOLower P/E (15.4x vs 62.8x)
Quality / MarginsREX logoREX7.7% margin vs NRXP's -157.3%
Stability / SafetyALTO logoALTOBeta 0.30 vs NRXP's 1.91
DividendsALTO logoALTO0.4% yield; the other 4 pay no meaningful dividend
Momentum (1Y)ALTO logoALTO+427.8% vs NRXP's +55.3%
Efficiency (ROA)REX logoREX6.7% ROA vs NRXP's -489.9%

NRXP vs ALTO vs AXSM vs REX vs GPRE — Revenue Breakdown by Segment

How each company's revenue is distributed across its business units

NRXPNRx Pharmaceuticals, Inc.
FY 2025
Therapy
100.0%$854,000
ALTOAlto Ingredients, Inc.
FY 2025
Intersegment Eliminations Member
0.0%$-12,612,000
AXSMAxsome Therapeutics, Inc.
FY 2025
Product
100.0%$634M
REXREX American Resources Corporation
FY 2024
Other Member
100.0%$329,000
GPREGreen Plains Inc.
FY 2025
Products And Services Other
101.2%$94M
Intersegment Revenues
-1.2%$-1,119,000

NRXP vs ALTO vs AXSM vs REX vs GPRE — Financial Metrics

Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.

BEST OVERALLALTOLAGGINGGPRE

Income & Cash Flow (Last 12 Months)

Evenly matched — AXSM and REX each lead in 2 of 6 comparable metrics.

GPRE is the larger business by revenue, generating $1.9B annually — 7999.9x NRXP's $242,000. REX is the more profitable business, keeping 7.7% of every revenue dollar as net income compared to NRXP's -157.3%. On growth, AXSM holds the edge at +57.4% YoY revenue growth, suggesting stronger near-term business momentum.

MetricNRXP logoNRXPNRx Pharmaceutica…ALTO logoALTOAlto Ingredients,…AXSM logoAXSMAxsome Therapeuti…REX logoREXREX American Reso…GPRE logoGPREGreen Plains Inc.
RevenueTrailing 12 months$242,000$918M$708M$651M$1.9B
EBITDAEarnings before interest/tax-$31M$33M-$167M$67M$122M
Net IncomeAfter-tax profit-$38M$13M-$188M$50M-$15M
Free Cash FlowCash after capex-$12M$9M-$71M$18M$90M
Gross MarginGross profit ÷ Revenue+59.5%+3.8%+92.6%+12.7%+1.8%
Operating MarginEBIT ÷ Revenue-63.0%+0.8%-24.8%+8.6%+1.2%
Net MarginNet income ÷ Revenue-157.3%+1.5%-26.6%+7.7%-0.8%
FCF MarginFCF ÷ Revenue-49.0%+0.9%-10.0%+2.7%+4.7%
Rev. Growth (YoY)Latest quarter vs prior year-1.9%+57.4%+0.4%-25.9%
EPS Growth (YoY)Latest quarter vs prior year-80.0%+149.1%-3.3%+2.9%+134.2%
Evenly matched — AXSM and REX each lead in 2 of 6 comparable metrics.

Valuation Metrics

ALTO leads this category, winning 4 of 6 comparable metrics.

At 28.4x trailing earnings, ALTO trades at a 4% valuation discount to REX's 29.5x P/E. On an enterprise value basis, ALTO's 12.8x EV/EBITDA is more attractive than GPRE's 103.8x.

MetricNRXP logoNRXPNRx Pharmaceutica…ALTO logoALTOAlto Ingredients,…AXSM logoAXSMAxsome Therapeuti…REX logoREXREX American Reso…GPRE logoGPREGreen Plains Inc.
Market CapShares × price$85M$351M$11.3B$1.6B$1.1B
Enterprise ValueMkt cap + debt − cash$78M$423M$11.2B$1.4B$1.5B
Trailing P/EPrice ÷ TTM EPS-2.28x28.38x-59.81x29.50x-9.14x
Forward P/EPrice ÷ next-FY EPS est.15.39x62.81x46.62x
PEG RatioP/E ÷ EPS growth rate0.55x
EV / EBITDAEnterprise value multiple12.84x16.60x103.82x
Price / SalesMarket cap ÷ Revenue69.15x0.38x17.74x2.50x0.55x
Price / BookPrice ÷ Book value/share1.40x124.01x2.67x1.44x
Price / FCFMarket cap ÷ FCF40.58x17.84x
ALTO leads this category, winning 4 of 6 comparable metrics.

Profitability & Efficiency

REX leads this category, winning 7 of 9 comparable metrics.

REX delivers a 7.7% return on equity — every $100 of shareholder capital generates $8 in annual profit, vs $-3 for AXSM. REX carries lower financial leverage with a 0.03x debt-to-equity ratio, signaling a more conservative balance sheet compared to AXSM's 2.73x. On the Piotroski fundamental quality scale (0–9), NRXP scores 5/9 vs GPRE's 4/9, reflecting solid financial health.

MetricNRXP logoNRXPNRx Pharmaceutica…ALTO logoALTOAlto Ingredients,…AXSM logoAXSMAxsome Therapeuti…REX logoREXREX American Reso…GPRE logoGPREGreen Plains Inc.
ROE (TTM)Return on equity+6.0%-2.6%+7.7%-2.0%
ROA (TTM)Return on assets-4.9%+3.4%-27.8%+6.7%-1.0%
ROICReturn on invested capital+1.9%-19.1%+11.4%-5.2%
ROCEReturn on capital employed+2.3%-52.1%+10.1%-6.2%
Piotroski ScoreFundamental quality 0–955454
Debt / EquityFinancial leverage0.40x2.73x0.03x0.66x
Net DebtTotal debt minus cash-$7M$72M-$82M-$175M$326M
Cash & Equiv.Liquid assets$8M$26M$323M$196M$182M
Total DebtShort + long-term debt$631,000$98M$241M$21M$508M
Interest CoverageEBIT ÷ Interest expense-24.18x-0.93x-34.13x-0.08x
REX leads this category, winning 7 of 9 comparable metrics.

Total Returns (Dividends Reinvested)

Evenly matched — ALTO and AXSM and REX each lead in 2 of 6 comparable metrics.

A $10,000 investment in AXSM five years ago would be worth $38,641 today (with dividends reinvested), compared to $92 for NRXP. Over the past 12 months, ALTO leads with a +427.8% total return vs NRXP's +55.3%. The 3-year compound annual growth rate (CAGR) favors REX at 50.8% vs NRXP's -21.0% — a key indicator of consistent wealth creation.

MetricNRXP logoNRXPNRx Pharmaceutica…ALTO logoALTOAlto Ingredients,…AXSM logoAXSMAxsome Therapeuti…REX logoREXREX American Reso…GPRE logoGPREGreen Plains Inc.
YTD ReturnYear-to-date+16.8%+70.7%+23.2%+50.2%+60.1%
1-Year ReturnPast 12 months+55.3%+427.8%+98.5%+147.6%+336.6%
3-Year ReturnCumulative with dividends-50.6%+233.8%+183.2%+243.1%-46.8%
5-Year ReturnCumulative with dividends-99.1%-21.2%+286.4%+250.0%-48.5%
10-Year ReturnCumulative with dividends-96.8%+6.8%+1886.5%+464.7%+21.3%
CAGR (3Y)Annualised 3-year return-21.0%+49.5%+41.5%+50.8%-19.0%
Evenly matched — ALTO and AXSM and REX each lead in 2 of 6 comparable metrics.

Risk & Volatility

Evenly matched — ALTO and AXSM each lead in 1 of 2 comparable metrics.

ALTO is the less volatile stock with a 0.30 beta — it tends to amplify market swings less than NRXP's 1.91 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. AXSM currently trades 94.2% from its 52-week high vs ALTO's 75.8% drawdown — a narrower gap to the peak suggests stronger recent price momentum.

MetricNRXP logoNRXPNRx Pharmaceutica…ALTO logoALTOAlto Ingredients,…AXSM logoAXSMAxsome Therapeuti…REX logoREXREX American Reso…GPRE logoGPREGreen Plains Inc.
Beta (5Y)Sensitivity to S&P 5001.91x0.30x0.69x0.36x1.22x
52-Week HighHighest price in past year$3.84$5.99$233.75$53.36$18.94
52-Week LowLowest price in past year$1.62$0.80$96.09$19.44$3.39
% of 52W HighCurrent price vs 52-week peak+79.7%+75.8%+94.2%+91.2%+86.9%
RSI (14)Momentum oscillator 0–10064.761.178.859.154.3
Avg Volume (50D)Average daily shares traded913K2.1M667K204K1.5M
Evenly matched — ALTO and AXSM each lead in 1 of 2 comparable metrics.

Analyst Outlook

Insufficient data to determine a leader in this category.

Analyst consensus: ALTO as "Buy", AXSM as "Buy", REX as "Buy", GPRE as "Buy". Consensus price targets imply 23.3% upside for REX (target: $60) vs -22.9% for ALTO (target: $4). ALTO is the only dividend payer here at 0.37% yield — a key consideration for income-focused portfolios.

MetricNRXP logoNRXPNRx Pharmaceutica…ALTO logoALTOAlto Ingredients,…AXSM logoAXSMAxsome Therapeuti…REX logoREXREX American Reso…GPRE logoGPREGreen Plains Inc.
Analyst RatingConsensus buy/hold/sellBuyBuyBuyBuy
Price TargetConsensus 12-month target$3.50$225.86$60.00$13.80
# AnalystsCovering analysts225320
Dividend YieldAnnual dividend ÷ price+0.4%
Dividend StreakConsecutive years of raises00
Dividend / ShareAnnual DPS$0.02
Buyback YieldShare repurchases ÷ mkt cap0.0%0.0%0.0%+0.9%+2.6%
Insufficient data to determine a leader in this category.
Key Takeaway

ALTO leads in 1 of 6 categories (Valuation Metrics). REX leads in 1 (Profitability & Efficiency). 3 tied.

Best OverallAlto Ingredients, Inc. (ALTO)Leads 1 of 6 categories
Loading custom metrics...

NRXP vs ALTO vs AXSM vs REX vs GPRE: Key Questions Answered

10 questions · data-driven answers · updated daily

01

Is NRXP or ALTO or AXSM or REX or GPRE a better buy right now?

For growth investors, Axsome Therapeutics, Inc.

(AXSM) is the stronger pick with 65. 5% revenue growth year-over-year, versus -22. 9% for REX American Resources Corporation (REX). Alto Ingredients, Inc. (ALTO) offers the better valuation at 28. 4x trailing P/E (15. 4x forward), making it the more compelling value choice. Analysts rate Alto Ingredients, Inc. (ALTO) a "Buy" — based on 2 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

02

Which has the better valuation — NRXP or ALTO or AXSM or REX or GPRE?

On trailing P/E, Alto Ingredients, Inc.

(ALTO) is the cheapest at 28. 4x versus REX American Resources Corporation at 29. 5x. On forward P/E, Alto Ingredients, Inc. is actually cheaper at 15. 4x.

03

Which is the better long-term investment — NRXP or ALTO or AXSM or REX or GPRE?

Over the past 5 years, Axsome Therapeutics, Inc.

(AXSM) delivered a total return of +286. 4%, compared to -99. 1% for NRx Pharmaceuticals, Inc. (NRXP). Over 10 years, the gap is even starker: AXSM returned +1886% versus NRXP's -96. 8%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

04

Which is safer — NRXP or ALTO or AXSM or REX or GPRE?

By beta (market sensitivity over 5 years), Alto Ingredients, Inc.

(ALTO) is the lower-risk stock at 0. 30β versus NRx Pharmaceuticals, Inc. 's 1. 91β — meaning NRXP is approximately 529% more volatile than ALTO relative to the S&P 500. On balance sheet safety, REX American Resources Corporation (REX) carries a lower debt/equity ratio of 3% versus 3% for Axsome Therapeutics, Inc. — giving it more financial flexibility in a downturn.

05

Which is growing faster — NRXP or ALTO or AXSM or REX or GPRE?

By revenue growth (latest reported year), Axsome Therapeutics, Inc.

(AXSM) is pulling ahead at 65. 5% versus -22. 9% for REX American Resources Corporation (REX). On earnings-per-share growth, the picture is similar: Alto Ingredients, Inc. grew EPS 119. 5% year-over-year, compared to -39. 5% for Green Plains Inc.. Over a 3-year CAGR, AXSM leads at 133. 7% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

06

Which has better profit margins — NRXP or ALTO or AXSM or REX or GPRE?

REX American Resources Corporation (REX) is the more profitable company, earning 9.

1% net margin versus -23. 4% for NRx Pharmaceuticals, Inc. — meaning it keeps 9. 1% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: REX leads at 10. 0% versus -1324. 4% for NRXP. At the gross margin level — before operating expenses — AXSM leads at 92. 6%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

07

Is NRXP or ALTO or AXSM or REX or GPRE more undervalued right now?

On forward earnings alone, Alto Ingredients, Inc.

(ALTO) trades at 15. 4x forward P/E versus 62. 8x for REX American Resources Corporation — 47. 4x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for REX: 23. 3% to $60. 00.

08

Which pays a better dividend — NRXP or ALTO or AXSM or REX or GPRE?

In this comparison, ALTO (0.

4% yield) pays a dividend. NRXP, AXSM, REX, GPRE do not pay a meaningful dividend and should not be held primarily for income.

09

Is NRXP or ALTO or AXSM or REX or GPRE better for a retirement portfolio?

For long-horizon retirement investors, Axsome Therapeutics, Inc.

(AXSM) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0. 69), +1886% 10Y return). NRx Pharmaceuticals, Inc. (NRXP) carries a higher beta of 1. 91 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (AXSM: +1886%, NRXP: -96. 8%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

10

What are the main differences between NRXP and ALTO and AXSM and REX and GPRE?

These companies operate in different sectors (NRXP (Healthcare) and ALTO (Basic Materials) and AXSM (Healthcare) and REX (Basic Materials) and GPRE (Basic Materials)), which means they face different economic cycles, regulatory environments, and macro sensitivities — making direct comparison nuanced.

In terms of investment character: NRXP is a small-cap quality compounder stock; ALTO is a small-cap quality compounder stock; AXSM is a mid-cap high-growth stock; REX is a small-cap quality compounder stock; GPRE is a small-cap quality compounder stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.

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