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AXSM logoAxsome Therapeutics, Inc.(AXSM)Earnings, Financials & Key Ratios

AXSM•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryNeuroscience and Psychiatry Therapies
AboutAxsome Therapeutics, Inc., a biopharmaceutical company, engages in the development of novel therapies for central nervous system (CNS) disorders in the United States. The company's product pipeline includes AXS-05, a therapeutic for the treatment of major depressive disorder and resistant depression disorders; and that is in the Phase III clinical trial to treat Alzheimer's disease agitation, as well as that has completed phase II clinical trial for the treatment of smoking cessation. It is also developing AXS-07, a novel, oral, rapidly absorbed, multi-mechanistic, and investigational medicine that has completed two Phase III trials for the acute treatment of migraine; AXS-12, a selective and potent norepinephrine reuptake inhibitor, which is in Phase III trial to treat narcolepsy; and AXS-14, a novel, oral, and investigational medicine that is in Phase III trial for the treatment of fibromyalgia. Axsome Therapeutics, Inc. has a research collaboration agreement with Duke University for evaluating AXS-05 in smoking cessation. The company was incorporated in 2012 and is based in New York, New York.Show more
  • Revenue$638M+65.5%
  • EBITDA-$160M+41.2%
  • Net Income-$183M+36.2%
  • EPS (Diluted)-3.68+38.6%
  • Gross Margin92.56%+1.3%
  • EBITDA Margin-25.09%+64.5%
  • Operating Margin-26.51%+63.6%
  • Net Margin-28.69%+61.5%
  • ROE-252.11%-8.8%

AXSM Key Insights

Axsome Therapeutics, Inc. (AXSM) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Momentum leader: RS Rating 92 (top 8%)
  • ✓Trading near 52-week high

✗Weaknesses

  • ✗High debt to equity ratio of 2.7x
  • ✗Profits declining 12.2% over 5 years
  • ✗Negative free cash flow
  • ✗Expensive at 141.1x book value

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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AXSM Price & Volume

Axsome Therapeutics, Inc. (AXSM) stock price & volume — 10-year historical chart

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AXSM Growth Metrics

Axsome Therapeutics, Inc. (AXSM) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years133.68%
TTM63.88%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM32.33%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM35.36%

Return on Capital

10 Years-94.92%
5 Years-84.16%
3 Years-63.7%
Last Year-52.12%

AXSM Recent Earnings

Axsome Therapeutics, Inc. (AXSM) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 8/12 qtrs (67%)●Beat Revenue 7/12 qtrs (58%)
Q2 2026Latest
May 4, 2026
Metric
Actual
Est
EPS
$1.26-48.2%
$0.85
Rev
$189M-0.8%
$191M
Q1 2026
Feb 23, 2026
Metric
Actual
Est
EPS
$0.71-1.4%
$0.70
Rev
$195M+0.7%
$193M
Q4 2025
Nov 3, 2025
Metric
Actual
Est
EPS
$0.94-14.6%
$0.82
Rev
$171M-10.6%
$191M
Q3 2025
Aug 4, 2025
Metric
Actual
Est
EPS
$0.92+8.0%
$1.00
Rev
$150M+7.2%
$140M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 4, 2026
$1.26vs $0.85-48.2%
$189Mvs $191M-0.8%
Q1 2026Feb 23, 2026
$0.71vs $0.70-1.4%
$195Mvs $193M+0.7%
Q4 2025Nov 3, 2025
$0.94vs $0.82-14.6%
$171Mvs $191M-10.6%
Q3 2025Aug 4, 2025
$0.92vs $1.00+8.0%
$150Mvs $140M+7.2%
Based on last 12 quarters of dataView full earnings history →

AXSM Peer Comparison

Axsome Therapeutics, Inc. (AXSM) competitors in Neuroscience and Psychiatry Therapies — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
INVA logoINVAInnoviva, Inc.Direct Competitor1.66B22.496.8218.52%118.91%47.59%0.23
SUPN logoSUPNSupernus Pharmaceuticals, Inc.Direct Competitor2.56B44.38-65.268.63%-3.74%-2.73%0.04
ACAD logoACADACADIA Pharmaceuticals Inc.Direct Competitor3.7B21.629.4411.87%34.3%35.65%0.04
INTR logoINTRInter & Co, Inc.Direct Competitor2.4B5.449.6150.54%8.99%14.24%2.85
PRAX logoPRAXPraxis Precision Medicines, Inc.Direct Competitor8.15B282.31-20.94-100%-43.02%0.00
ALKS logoALKSAlkermes plcProduct Competitor7.5B44.9931.46-5.25%9.78%8.82%0.04
JAZZ logoJAZZJazz Pharmaceuticals plcProduct Competitor14.09B224.66-38.474.88%0.66%0.71%1.26
NKTR logoNKTRNektar TherapeuticsProduct Competitor1.19B60.98-6.27-43.89%-284.18%-87%1.66

Compare AXSM vs Peers

Axsome Therapeutics, Inc. (AXSM) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs INVA

Most directly comparable listed peer for AXSM.

Scale Benchmark

vs MCK

Larger-name benchmark to compare AXSM against a more recognizable public peer.

Peer Set

Compare Top 5

vs INVA, SUPN, ACAD, INTR

AXSM Income Statement

Axsome Therapeutics, Inc. (AXSM) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
0000050.04M270.6M385.69M638.5M708.24M
Revenue Growth %
------440.8%42.53%65.55%63.88%
Cost of Goods Sold
42.56K48.94K37.33K005.2M26.07M33.3M47.48M52.41M
COGS % of Revenue
-----10.39%9.63%8.63%7.44%-
Gross Profit
-42.56K▲ 0%
-48.94K▼ 15.0%
-37.33K▲ 23.7%
0▲ 100.0%
0▲ 0%
44.84M▲ 0%
244.53M▲ 445.4%
352.39M▲ 44.1%
591.02M▲ 67.7%
655.82M▲ 0%
Gross Margin %
-----89.61%90.37%91.37%92.56%92.6%
Gross Profit Growth %
-107.76%-14.99%23.72%100%--445.36%44.11%67.72%-
Operating Expenses
27.16M32.85M67.11M99.14M124.71M224.64M476.36M632.95M760.25M831.43M
OpEx % of Revenue
-----448.94%176.04%164.11%119.07%-
Selling, General & Admin
7.21M9.35M13.6M28.9M66.65M159.25M323.12M411.36M570.6M634.81M
SG&A % of Revenue
-----318.27%119.41%106.65%89.37%-
Research & Development
19.96M23.5M53.65M70.24M58.06M57.95M97.94M187.08M183.28M191.17M
R&D % of Revenue
-----115.81%36.2%48.5%28.7%-
Other Operating Expenses
00-139.45K-53.58K07.44M55.29M34.52M6.38M0
Operating Income
-27.16M▲ 0%
-32.85M▼ 20.9%
-67.25M▼ 104.7%
-99.14M▼ 47.4%
-124.71M▼ 25.8%
-179.8M▼ 44.2%
-231.82M▼ 28.9%
-280.56M▼ 21.0%
-169.24M▲ 39.7%
-175.61M▲ 0%
Operating Margin %
------359.33%-85.67%-72.74%-26.51%-24.8%
Operating Income Growth %
1.38%-20.92%-104.72%-47.43%-25.79%-44.18%-28.94%-21.02%39.68%-
EBITDA
-27.12M-32.8M-67.21M-99.06M-124.63M-175.4M-224.99M-272.6M-160.17M-167.09M
EBITDA Margin %
------350.53%-83.15%-70.68%-25.09%-23.59%
EBITDA Growth %
1.46%-20.93%-104.92%-47.4%-25.81%-40.73%-28.28%-21.16%41.24%36.23%
D&A (Non-Cash Add-back)
42.56K48.94K37.33K77.72K76K4.4M6.83M7.96M9.06M8.52M
EBIT
-27.81M-32.63M-67.25M-100.39M-124.71M-179.8M-231.82M-280.56M-177.15M-181.24M
Net Interest Income
-1.34M-1.13M00-5.7M-7.33M-6.45M-6.57M2.81M-3.27M
Interest Income
001.24M2.57M00009.37M2.04M
Interest Expense
1.34M1.13M1.24M2.57M5.7M7.33M6.45M6.57M6.56M5.31M
Other Income/Expense
-1.78M1.66M-1.1M-3.76M-5.7M-7.33M-6.45M-6.57M-14.47M-13.22M
Pretax Income
-28.94M▲ 0%
-30.97M▼ 7.0%
-68.35M▼ 120.7%
-102.9M▼ 50.6%
-130.4M▼ 26.7%
-187.13M▼ 43.5%
-238.28M▼ 27.3%
-287.13M▼ 20.5%
-183.7M▲ 36.0%
-188.83M▲ 0%
Pretax Margin %
------373.99%-88.06%-74.45%-28.77%-26.66%
Income Tax
000000960K85K-530K-530K
Effective Tax Rate %
0%0%0%0%0%0%-0.4%-0.03%0.29%0.28%
Net Income
-28.94M▲ 0%
-30.97M▼ 7.0%
-68.35M▼ 120.7%
-102.9M▼ 50.6%
-130.4M▼ 26.7%
-187.13M▼ 43.5%
-239.24M▼ 27.8%
-287.22M▼ 20.1%
-183.17M▲ 36.2%
-188.3M▲ 0%
Net Margin %
------373.99%-88.41%-74.47%-28.69%-26.59%
Net Income Growth %
-6.4%-6.99%-120.71%-50.56%-26.73%-43.5%-27.84%-20.05%36.22%32.33%
Net Income (Continuing)
-28.94M-30.97M-68.35M-102.9M-130.4M-187.13M-239.24M-287.22M-183.17M-188.3M
Discontinued Operations
0000000000
Minority Interest
0000000000
EPS (Diluted)
-1.27▲ 0%
-1.15▲ 9.4%
-2.05▼ 78.3%
-2.83▼ 38.0%
-3.47▼ 22.6%
-4.60▼ 32.6%
-5.27▼ 14.6%
-5.99▼ 13.7%
-3.68▲ 38.6%
-3.68▲ 0%
EPS Growth %
10.56%9.45%-78.26%-38.05%-22.61%-32.56%-14.57%-13.66%38.56%35.36%
EPS (Basic)
-1.27-1.15-2.05-2.83-3.47-4.60-5.27-5.99-3.68-
Diluted Shares Outstanding
22.76M26.88M34.02M37.21M37.62M40.66M45.43M47.91M49.75M51.2M
Basic Shares Outstanding
22.76M26.88M34.02M37.21M37.62M40.66M45.43M47.91M49.75M51.2M
Dividend Payout Ratio
----------

AXSM Balance Sheet

Axsome Therapeutics, Inc. (AXSM) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
35.3M15.22M220.38M184.02M86.52M245.64M504.26M485.06M588.99M611.21M
Cash & Short-Term Investments
34.02M13.97M219.97M183.88M86.47M200.84M386.19M315.35M322.93M305.11M
Cash Only
34.02M13.97M219.97M183.88M86.47M200.84M386.19M315.35M322.93M305.11M
Short-Term Investments
0000000000
Accounts Receivable
0000037.7M94.82M142M224.46M251.06M
Days Sales Outstanding
-----275127.9134.38128.32112.2
Inventory
000004.32M15.13M15.73M27.94M31.52M
Days Inventory Outstanding
-----303.35211.94172.42214.78177
Other Current Assets
000002.78M8.12M11.98M13.65M23.52M
Total Non-Current Assets
256.02K164.18K170.5K2.11M1.27M85.83M83.97M83.43M100.82M102.4M
Property, Plant & Equipment
68.07K51.83K30.62K1.79M944.01K1.14M7.62M5.97M20.86M20.01M
Fixed Asset Turnover
-----43.82x35.52x64.64x30.61x31.25x
Goodwill
0000010.31M12.04M12.04M12.04M12.04M
Intangible Assets
0000059.66M53.29M46.89M40.52M38.95M
Long-Term Investments
0000000000
Other Non-Current Assets
187.95K112.34K139.88K317.38K322.91K14.72M11.03M18.53M27.4M31.4M
Total Assets
35.56M▲ 0%
15.38M▼ 56.7%
220.55M▲ 1334.1%
186.13M▼ 15.6%
87.79M▼ 52.8%
331.48M▲ 277.6%
588.24M▲ 77.5%
568.5M▼ 3.4%
689.8M▲ 21.3%
713.61M▲ 0%
Asset Turnover
-----0.15x0.46x0.68x0.93x1.04x
Asset Growth %
-6.95%-56.75%1334.07%-15.6%-52.84%277.6%77.46%-3.36%21.34%76.84%
Total Current Liabilities
12.18M10.82M24.49M23.44M23.07M96.56M138.85M230.1M378.84M439.21M
Accounts Payable
3.44M3.69M10.94M13.5M13.15M38.6M40.68M72M65.54M106.7M
Days Payables Outstanding
29.46K27.5K107K--2.71K569.65789.09503.83553.78
Short-Term Debt
3.27M3.29M2.6M0000072.98M70.63M
Deferred Revenue (Current)
2.35M000000000
Other Current Liabilities
444.29K0004.05M17.18M76.45M36.51M203.28M261.88M
Current Ratio
2.90x1.41x9.00x7.85x3.75x2.54x3.63x2.11x1.55x1.39x
Quick Ratio
2.90x1.41x9.00x7.85x3.75x2.50x3.52x2.04x1.48x1.32x
Cash Conversion Cycle
------2.13K-229.81-482.28-160.74-264.58
Total Non-Current Liabilities
6.66M3.62M17.33M48.9M49.09M125.36M258.4M281.38M222.67M219.81M
Long-Term Debt
6.66M3.62M17.33M48.32M49.09M94.26M178.07M180.71M140.93M146.08M
Capital Lease Obligations
000581.71K007.04M8.99M27.39M82.53M
Deferred Tax Liabilities
0000000000
Other Non-Current Liabilities
0000031.1M73.3M91.68M54.36M73.73M
Total Liabilities
18.84M14.44M41.83M72.34M72.15M221.92M397.26M511.48M601.51M659.02M
Total Debt
9.93M6.91M19.93M50.12M49.71M94.68M186.37M192.96M241.29M216.71M
Net Debt
-24.09M-7.06M-200.03M-133.75M-36.76M-106.16M-199.82M-122.4M-81.64M-88.4M
Debt / Equity
0.59x7.37x0.11x0.44x3.18x0.86x0.98x3.38x2.73x3.97x
Debt / EBITDA
----------1.30x
Net Debt / EBITDA
---------0.53x
Interest Coverage
-20.75x-28.94x-54.25x-39.12x-21.89x-24.51x-35.93x-42.71x-27.02x-34.13x
Total Equity
16.72M▲ 0%
937.92K▼ 94.4%
178.72M▲ 18955.2%
113.79M▼ 36.3%
15.63M▼ 86.3%
109.56M▲ 600.9%
190.98M▲ 74.3%
57.02M▼ 70.1%
88.3M▲ 54.9%
54.59M▲ 0%
Equity Growth %
-22.5%-94.39%18955.16%-36.33%-86.26%600.92%74.32%-70.15%54.86%7.87%
Book Value per Share
0.730.035.253.060.422.694.201.191.771.07
Total Shareholders' Equity
16.72M937.92K178.72M113.79M15.63M109.56M190.98M57.02M88.3M54.59M
Common Stock
2.55K3.01K3.69K3.74K3.78K4K5K5K5K5K
Retained Earnings
-76.58M-107.55M-175.9M-278.8M-409.2M-596.33M-835.57M-1.12B-1.31B-1.37B
Treasury Stock
0000000000
Accumulated OCI
0000000000
Minority Interest
0000000000

AXSM Cash Flow Statement

Axsome Therapeutics, Inc. (AXSM) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-26.47M-30.05M-46.38M-78.46M-108.23M-116.51M-145.08M-128.41M-93.41M-70.73M
Operating CF Margin %
------232.85%-53.61%-33.29%-14.63%-
Operating CF Growth %
-24.39%-13.53%-54.31%-69.18%-37.94%-7.66%-24.52%11.49%27.26%179.02%
Net Income
-28.94M-30.97M-68.35M-102.9M-130.4M-187.13M-239.24M-287.22M-183.17M-188.3M
Depreciation & Amortization
42.56K48.94K37.33K77.72K76K4.4M6.83M7.96M9.06M8.76M
Stock-Based Compensation
2.07M1.75M6.12M14.76M20.8M37.73M62.62M093.75M70.44M
Deferred Taxes
646K-2.79M01.25M000000
Other Non-Cash Items
470.52K375.63K649.99K7.95M974K4.83M53.1M116.95M9.48M34.3M
Working Capital Changes
-759.55K1.52M15.17M412.04K324K23.67M-28.39M33.9M-22.52M4.07M
Change in Receivables
000177.5K0-37.7M-57.12M-47.18M-82.46M-89.67M
Change in Inventory
000-177.5K-6K-5.28M-8.16M744K-15.67M-13.37M
Change in Payables
-645.72K251.79K7.26M2.56M-355K25.46M2.07M31.32M-6.46M21.04M
Cash from Investing
-9.9K-32.7K-16.12K-45.89K-308K-53.7M-582K-270K-480K-263K
Capital Expenditures
-9.9K-32.7K-16.12K-45.89K-308K-702K-582K-270K-480K-263K
CapEx % of Revenue
-----1.4%0.22%0.07%0.08%0.04%
Acquisitions
00000-53M0000
Investments
----------
Other Investing
0000000000
Cash from Financing
23.88M10.03M252.39M42.41M11.13M284.58M331.01M57.84M101.47M75.19M
Debt Issued (Net)
-277.78K-3.33M12.76M28.34M045M85M-990K-7.75M-8.02M
Equity Issued (Net)
23.68M12.88M238.23M14.13M7.44M243.76M258.75M40.78M126.27M106.2M
Dividends Paid
0000000000
Share Repurchases
0000000000
Other Financing
484.61K486.03K1.39M-52.76K3.69M-4.18M-12.74M18.05M-17.05M-22.99M
Net Change in Cash
-2.6M▲ 0%
-20.05M▼ 672.0%
206M▲ 1127.3%
-36.09M▼ 117.5%
-97.4M▼ 169.9%
114.37M▲ 217.4%
185.35M▲ 62.1%
-70.84M▼ 138.2%
7.58M▲ 110.7%
4.2M▲ 0%
Free Cash Flow
-26.48M▲ 0%
-30.09M▼ 13.6%
-46.39M▼ 54.2%
-78.5M▼ 69.2%
-108.53M▼ 38.3%
-117.21M▼ 8.0%
-145.66M▼ 24.3%
-128.68M▲ 11.7%
-93.89M▲ 27.0%
-70.99M▲ 0%
FCF Margin %
------234.25%-53.83%-33.36%-14.7%-10.02%
FCF Growth %
-23.83%-13.61%-54.19%-69.22%-38.26%-8%-24.27%11.66%27.04%40.13%
FCF per Share
-1.16-1.12-1.36-2.11-2.89-2.88-3.21-2.69-1.89-1.39
FCF Conversion (FCF/Net Income)
0.91x0.97x0.68x0.76x0.83x0.62x0.61x0.45x0.51x0.38x
Interest Paid
865.28K771.97K1.29M2.1M4.63M7.69M16.73M19.69M14.63M10.04M
Taxes Paid
0000000000

AXSM Key Ratios

Axsome Therapeutics, Inc. (AXSM) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025TTM
Return on Equity (ROE)
-151.19%-350.78%-76.08%-70.36%-201.51%-298.97%-159.21%-231.63%-252.11%-260.01%
Return on Invested Capital (ROIC)
---------1906.66%724.28%
Gross Margin
-----89.61%90.37%91.37%92.56%92.6%
Net Margin
------373.99%-88.41%-74.47%-28.69%-26.59%
Debt / Equity
0.59x7.37x0.11x0.44x3.18x0.86x0.98x3.38x2.73x3.97x
Interest Coverage
-20.75x-28.94x-54.25x-39.12x-21.89x-24.51x-35.93x-42.71x-27.02x-34.13x
FCF Conversion
0.91x0.97x0.68x0.76x0.83x0.62x0.61x0.45x0.51x0.38x
Revenue Growth
------440.8%42.53%65.55%63.88%
Related:AXSM Dividend History·AXSM Revenue History·AXSM Price History·AXSM P/E History·AXSM Financial Ratios·AXSM Institutional Holders

AXSM SEC Filings & Documents

Axsome Therapeutics, Inc. (AXSM) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 4, 2026·SEC

Material company update

Apr 30, 2026·SEC

Material company update

Apr 1, 2026·SEC

10-K Annual Reports

3
FY 2026

Feb 23, 2026·SEC

FY 2025

Feb 18, 2025·SEC

FY 2024

Feb 23, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 4, 2026·SEC

FY 2025

Nov 3, 2025·SEC

FY 2025

Aug 4, 2025·SEC

AXSM Frequently Asked Questions

Axsome Therapeutics, Inc. (AXSM) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Axsome Therapeutics, Inc. (AXSM) reported $708.2M in revenue for fiscal year 2025.

Axsome Therapeutics, Inc. (AXSM) grew revenue by 65.5% over the past year. This is strong growth.

Axsome Therapeutics, Inc. (AXSM) reported a net loss of $188.3M for fiscal year 2025.

Dividend & Returns

Axsome Therapeutics, Inc. (AXSM) has a return on equity (ROE) of -252.1%. Negative ROE indicates the company is unprofitable.

Axsome Therapeutics, Inc. (AXSM) had negative free cash flow of $71.0M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in AXSM back in 2013?

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How much would $100/month in AXSM be worth today?

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