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ONMD vs PHVS vs NVCR vs KALV vs PRAX

Revenue, margins, valuation, and 5-year total return — side by side.

Live fundamentals10-year financials5-year price chart
ONMD
OneMedNet Corporation

Medical - Healthcare Information Services

HealthcareNASDAQ • US
Market Cap$32M
5Y Perf.-90.1%
PHVS
Pharvaris N.V.

Biotechnology

HealthcareNASDAQ • NL
Market Cap$1.93B
5Y Perf.+59.3%
NVCR
NovoCure Limited

Medical - Instruments & Supplies

HealthcareNASDAQ • JE
Market Cap$1.92B
5Y Perf.-92.4%
KALV
KalVista Pharmaceuticals, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$1.37B
5Y Perf.+11.5%
PRAX
Praxis Precision Medicines, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$9.63B
5Y Perf.+21.5%

ONMD vs PHVS vs NVCR vs KALV vs PRAX — Key Financials

Market cap, revenue, margins, and valuation side-by-side.

Company Snapshot
ONMD logoONMD
PHVS logoPHVS
NVCR logoNVCR
KALV logoKALV
PRAX logoPRAX
IndustryMedical - Healthcare Information ServicesBiotechnologyMedical - Instruments & SuppliesBiotechnologyBiotechnology
Market Cap$32M$1.93B$1.92B$1.37B$9.63B
Revenue (TTM)$1M$0.00$674M$15M$-92K
Net Income (TTM)$-3M$-166M$-173M$-210M$-327M
Gross Margin-37.0%75.2%-17.2%
Operating Margin-7.1%-27.2%-13.4%
Total Debt$570K$861K$290M$6M$110K
Cash & Equiv.$585K$281M$103M$99M$357M

ONMD vs PHVS vs NVCR vs KALV vs PRAXLong-Term Stock Performance

Price return indexed to 100 at period start. Dividends excluded.

ONMD
PHVS
NVCR
KALV
PRAX
StockJun 21May 26Return
OneMedNet Corporati… (ONMD)1009.9-90.1%
Pharvaris N.V. (PHVS)100159.3+59.3%
NovoCure Limited (NVCR)1007.6-92.4%
KalVista Pharmaceut… (KALV)100111.5+11.5%
Praxis Precision Me… (PRAX)100121.5+21.5%

Price return only. Dividends and distributions are not included.

Quick Verdict: ONMD vs PHVS vs NVCR vs KALV vs PRAX

Each card shows where this stock fits in a portfolio — not just who wins on paper.

Bottom line: ONMD and PRAX are tied at the top with 2 categories each (5-stock set) — the right choice depends on your priorities. Praxis Precision Medicines, Inc. is the stronger pick specifically for profitability and margin quality and recent price momentum and sentiment. NVCR also leads in specific categories worth noting. As sector peers, any of these can serve as alternatives in the same allocation.
ONMD
OneMedNet Corporation
The Income Pick

ONMD carries the broadest edge in this set and is the clearest fit for income & stability and growth exposure.

  • beta 0.37
  • Rev growth 111.4%, EPS growth 83.3%, 3Y rev CAGR 5.6%
  • 111.4% revenue growth vs PRAX's -100.0%
  • Beta 0.37 vs NVCR's 2.20
Best for: income & stability and growth exposure
PHVS
Pharvaris N.V.
The Defensive Pick

PHVS is the clearest fit if your priority is sleep-well-at-night and defensive.

  • Lower volatility, beta 1.02, Low D/E 0.3%, current ratio 12.60x
  • Beta 1.02, current ratio 12.60x
Best for: sleep-well-at-night and defensive
NVCR
NovoCure Limited
The Niche Pick

NVCR ranks third and is worth considering specifically for efficiency.

  • -16.5% ROA vs ONMD's -145.0%
Best for: efficiency
KALV
KalVista Pharmaceuticals, Inc.
The Long-Run Compounder

KALV is the clearest fit if your priority is long-term compounding.

  • 154.5% 10Y total return vs PHVS's 2.3%
Best for: long-term compounding
PRAX
Praxis Precision Medicines, Inc.
The Quality Compounder

PRAX is the #2 pick in this set and the best alternative if quality and momentum is your priority.

  • 2.4% margin vs KALV's -13.9%
  • +7.7% vs NVCR's +1.1%
Best for: quality and momentum
See the full category breakdown
CategoryWinnerWhy
GrowthONMD logoONMD111.4% revenue growth vs PRAX's -100.0%
Quality / MarginsPRAX logoPRAX2.4% margin vs KALV's -13.9%
Stability / SafetyONMD logoONMDBeta 0.37 vs NVCR's 2.20
DividendsTieNone of these 5 stocks pay a meaningful dividend
Momentum (1Y)PRAX logoPRAX+7.7% vs NVCR's +1.1%
Efficiency (ROA)NVCR logoNVCR-16.5% ROA vs ONMD's -145.0%

ONMD vs PHVS vs NVCR vs KALV vs PRAX — Revenue Breakdown by Segment

How each company's revenue is distributed across its business units

ONMDOneMedNet Corporation
FY 2025
Subscription Revenue
100.0%$105,000
PHVSPharvaris N.V.

Segment breakdown not available.

NVCRNovoCure Limited

Segment breakdown not available.

KALVKalVista Pharmaceuticals, Inc.

Segment breakdown not available.

PRAXPraxis Precision Medicines, Inc.
FY 2024
License
76.8%$9M
Upfront Payment
23.2%$3M

ONMD vs PHVS vs NVCR vs KALV vs PRAX — Financial Metrics

Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.

BEST OVERALLNVCRLAGGINGKALV

Income & Cash Flow (Last 12 Months)

NVCR leads this category, winning 4 of 6 comparable metrics.

NVCR and PRAX operate at a comparable scale, with $674M and -$92,000 in trailing revenue. Profitability is closely matched — net margins range from -25.7% (NVCR) to -13.9% (KALV). On growth, ONMD holds the edge at +33.2% YoY revenue growth, suggesting stronger near-term business momentum.

MetricONMD logoONMDOneMedNet Corpora…PHVS logoPHVSPharvaris N.V.NVCR logoNVCRNovoCure LimitedKALV logoKALVKalVista Pharmace…PRAX logoPRAXPraxis Precision …
RevenueTrailing 12 months$1M$0$674M$15M-$92,000
EBITDAEarnings before interest/tax-$10M-$86M-$165M-$202M-$357M
Net IncomeAfter-tax profit-$3M-$166M-$173M-$210M-$327M
Free Cash FlowCash after capex-$8M-$134M-$48M-$160M-$283M
Gross MarginGross profit ÷ Revenue-37.0%+75.2%-17.2%
Operating MarginEBIT ÷ Revenue-7.1%-27.2%-13.4%
Net MarginNet income ÷ Revenue-2.1%-25.7%-13.9%
FCF MarginFCF ÷ Revenue-5.5%-7.1%-10.6%
Rev. Growth (YoY)Latest quarter vs prior year+33.2%+12.3%
EPS Growth (YoY)Latest quarter vs prior year+26.3%+22.1%-100.0%-1.1%+2.7%
NVCR leads this category, winning 4 of 6 comparable metrics.

Valuation Metrics

Evenly matched — PHVS and NVCR and PRAX each lead in 1 of 3 comparable metrics.
MetricONMD logoONMDOneMedNet Corpora…PHVS logoPHVSPharvaris N.V.NVCR logoNVCRNovoCure LimitedKALV logoKALVKalVista Pharmace…PRAX logoPRAXPraxis Precision …
Market CapShares × price$32M$1.9B$1.9B$1.4B$9.6B
Enterprise ValueMkt cap + debt − cash$32M$1.6B$2.1B$1.3B$9.3B
Trailing P/EPrice ÷ TTM EPS-16.29x-10.18x-13.80x-7.24x-24.72x
Forward P/EPrice ÷ next-FY EPS est.
PEG RatioP/E ÷ EPS growth rate
EV / EBITDAEnterprise value multiple
Price / SalesMarket cap ÷ Revenue23.58x2.92x
Price / BookPrice ÷ Book value/share5.10x5.51x13.91x8.54x
Price / FCFMarket cap ÷ FCF
Evenly matched — PHVS and NVCR and PRAX each lead in 1 of 3 comparable metrics.

Profitability & Efficiency

Evenly matched — NVCR and PRAX each lead in 4 of 9 comparable metrics.

PRAX delivers a -43.0% return on equity — every $100 of shareholder capital generates $-43 in annual profit, vs $-3 for KALV. PRAX carries lower financial leverage with a 0.00x debt-to-equity ratio, signaling a more conservative balance sheet compared to NVCR's 0.85x. On the Piotroski fundamental quality scale (0–9), ONMD scores 5/9 vs PHVS's 1/9, reflecting solid financial health.

MetricONMD logoONMDOneMedNet Corpora…PHVS logoPHVSPharvaris N.V.NVCR logoNVCRNovoCure LimitedKALV logoKALVKalVista Pharmace…PRAX logoPRAXPraxis Precision …
ROE (TTM)Return on equity-53.2%-50.8%-2.8%-43.0%
ROA (TTM)Return on assets-145.0%-49.0%-16.5%-77.7%-40.2%
ROICReturn on invested capital-16.4%-152.3%-65.0%
ROCEReturn on capital employed-44.7%-28.9%-89.9%-49.3%
Piotroski ScoreFundamental quality 0–951523
Debt / EquityFinancial leverage0.00x0.85x0.07x0.00x
Net DebtTotal debt minus cash-$15,000-$280M$187M-$92M-$357M
Cash & Equiv.Liquid assets$585,000$281M$103M$99M$357M
Total DebtShort + long-term debt$570,000$861,470$290M$6M$110,000
Interest CoverageEBIT ÷ Interest expense-40.79x-96.80x-13.75x
Evenly matched — NVCR and PRAX each lead in 4 of 9 comparable metrics.

Total Returns (Dividends Reinvested)

PRAX leads this category, winning 3 of 6 comparable metrics.

A $10,000 investment in PHVS five years ago would be worth $13,115 today (with dividends reinvested), compared to $875 for NVCR. Over the past 12 months, PRAX leads with a +775.0% total return vs NVCR's +1.1%. The 3-year compound annual growth rate (CAGR) favors PRAX at 174.9% vs ONMD's -55.0% — a key indicator of consistent wealth creation.

MetricONMD logoONMDOneMedNet Corpora…PHVS logoPHVSPharvaris N.V.NVCR logoNVCRNovoCure LimitedKALV logoKALVKalVista Pharmace…PRAX logoPRAXPraxis Precision …
YTD ReturnYear-to-date-19.9%+12.1%+28.3%+72.8%+16.4%
1-Year ReturnPast 12 months+151.3%+73.6%+1.1%+118.1%+775.0%
3-Year ReturnCumulative with dividends-90.9%+220.5%-75.7%+180.1%+1976.5%
5-Year ReturnCumulative with dividends-90.1%+31.2%-91.3%+5.9%-20.8%
10-Year ReturnCumulative with dividends-90.1%+2.3%+30.3%+154.5%-20.1%
CAGR (3Y)Annualised 3-year return-55.0%+47.4%-37.6%+41.0%+174.9%
PRAX leads this category, winning 3 of 6 comparable metrics.

Risk & Volatility

Evenly matched — ONMD and KALV each lead in 1 of 2 comparable metrics.

ONMD is the less volatile stock with a 0.37 beta — it tends to amplify market swings less than NVCR's 2.20 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. KALV currently trades 99.5% from its 52-week high vs ONMD's 23.2% drawdown — a narrower gap to the peak suggests stronger recent price momentum.

MetricONMD logoONMDOneMedNet Corpora…PHVS logoPHVSPharvaris N.V.NVCR logoNVCRNovoCure LimitedKALV logoKALVKalVista Pharmace…PRAX logoPRAXPraxis Precision …
Beta (5Y)Sensitivity to S&P 5000.37x1.02x2.20x0.82x1.55x
52-Week HighHighest price in past year$4.22$31.12$20.06$26.84$356.00
52-Week LowLowest price in past year$0.31$14.59$9.82$9.83$35.18
% of 52W HighCurrent price vs 52-week peak+23.2%+95.4%+83.9%+99.5%+93.6%
RSI (14)Momentum oscillator 0–10050.657.269.875.455.6
Avg Volume (50D)Average daily shares traded5.2M227K1.5M3.0M378K
Evenly matched — ONMD and KALV each lead in 1 of 2 comparable metrics.

Analyst Outlook

Insufficient data to determine a leader in this category.

Analyst consensus: PHVS as "Buy", NVCR as "Buy", KALV as "Buy", PRAX as "Buy". Consensus price targets imply 99.0% upside for NVCR (target: $34) vs 6.7% for KALV (target: $29).

MetricONMD logoONMDOneMedNet Corpora…PHVS logoPHVSPharvaris N.V.NVCR logoNVCRNovoCure LimitedKALV logoKALVKalVista Pharmace…PRAX logoPRAXPraxis Precision …
Analyst RatingConsensus buy/hold/sellBuyBuyBuyBuy
Price TargetConsensus 12-month target$43.67$33.50$28.50$544.40
# AnalystsCovering analysts11151316
Dividend YieldAnnual dividend ÷ price
Dividend StreakConsecutive years of raises
Dividend / ShareAnnual DPS
Buyback YieldShare repurchases ÷ mkt cap0.0%0.0%0.0%0.0%0.0%
Insufficient data to determine a leader in this category.
Key Takeaway

NVCR leads in 1 of 6 categories (Income & Cash Flow). PRAX leads in 1 (Total Returns). 3 tied.

Best OverallNovoCure Limited (NVCR)Leads 1 of 6 categories
Loading custom metrics...

ONMD vs PHVS vs NVCR vs KALV vs PRAX: Key Questions Answered

8 questions · data-driven answers · updated daily

01

Is ONMD or PHVS or NVCR or KALV or PRAX a better buy right now?

For growth investors, OneMedNet Corporation (ONMD) is the stronger pick with 111.

4% revenue growth year-over-year, versus -100. 0% for Praxis Precision Medicines, Inc. (PRAX). Analysts rate Pharvaris N. V. (PHVS) a "Buy" — based on 11 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

02

Which is the better long-term investment — ONMD or PHVS or NVCR or KALV or PRAX?

Over the past 5 years, Pharvaris N.

V. (PHVS) delivered a total return of +31. 2%, compared to -91. 3% for NovoCure Limited (NVCR). Over 10 years, the gap is even starker: KALV returned +154. 5% versus ONMD's -90. 1%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

03

Which is safer — ONMD or PHVS or NVCR or KALV or PRAX?

By beta (market sensitivity over 5 years), OneMedNet Corporation (ONMD) is the lower-risk stock at 0.

37β versus NovoCure Limited's 2. 20β — meaning NVCR is approximately 491% more volatile than ONMD relative to the S&P 500. On balance sheet safety, Praxis Precision Medicines, Inc. (PRAX) carries a lower debt/equity ratio of 0% versus 85% for NovoCure Limited — giving it more financial flexibility in a downturn.

04

Which is growing faster — ONMD or PHVS or NVCR or KALV or PRAX?

By revenue growth (latest reported year), OneMedNet Corporation (ONMD) is pulling ahead at 111.

4% versus -100. 0% for Praxis Precision Medicines, Inc. (PRAX). On earnings-per-share growth, the picture is similar: OneMedNet Corporation grew EPS 83. 3% year-over-year, compared to -32. 0% for Praxis Precision Medicines, Inc.. Over a 3-year CAGR, NVCR leads at 6. 8% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

05

Which has better profit margins — ONMD or PHVS or NVCR or KALV or PRAX?

Pharvaris N.

V. (PHVS) is the more profitable company, earning 0. 0% net margin versus -1391. 1% for KalVista Pharmaceuticals, Inc. — meaning it keeps 0. 0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: PHVS leads at 0. 0% versus -1343. 0% for KALV. At the gross margin level — before operating expenses — NVCR leads at 74. 5%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

06

Which pays a better dividend — ONMD or PHVS or NVCR or KALV or PRAX?

None of the stocks in this comparison currently pay a material dividend.

All are effectively zero-yield and should be held for capital appreciation rather than income.

07

Is ONMD or PHVS or NVCR or KALV or PRAX better for a retirement portfolio?

For long-horizon retirement investors, OneMedNet Corporation (ONMD) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0.

37)). NovoCure Limited (NVCR) carries a higher beta of 2. 20 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (ONMD: -90. 1%, NVCR: +30. 3%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

08

What are the main differences between ONMD and PHVS and NVCR and KALV and PRAX?

Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.

In terms of investment character: ONMD is a small-cap high-growth stock; PHVS is a small-cap quality compounder stock; NVCR is a small-cap quality compounder stock; KALV is a small-cap quality compounder stock; PRAX is a small-cap quality compounder stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.

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