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PHVS vs KALV vs BCAB vs PRAX vs ARDX

Revenue, margins, valuation, and 5-year total return — side by side.

Live fundamentals10-year financials5-year price chart
PHVS
Pharvaris N.V.

Biotechnology

HealthcareNASDAQ • NL
Market Cap$1.93B
5Y Perf.-21.9%
KALV
KalVista Pharmaceuticals, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$1.37B
5Y Perf.-18.7%
BCAB
BioAtla, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$5M
5Y Perf.-99.8%
PRAX
Praxis Precision Medicines, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$9.63B
5Y Perf.-48.9%
ARDX
Ardelyx, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$1.71B
5Y Perf.+333.5%

PHVS vs KALV vs BCAB vs PRAX vs ARDX — Key Financials

Market cap, revenue, margins, and valuation side-by-side.

Company Snapshot
PHVS logoPHVS
KALV logoKALV
BCAB logoBCAB
PRAX logoPRAX
ARDX logoARDX
IndustryBiotechnologyBiotechnologyBiotechnologyBiotechnologyBiotechnology
Market Cap$1.93B$1.37B$5M$9.63B$1.71B
Revenue (TTM)$0.00$15M$2M$-92K$428M
Net Income (TTM)$-166M$-210M$-60M$-327M$-58M
Gross Margin-17.2%100.0%91.9%
Operating Margin-13.4%-29.7%-8.7%
Total Debt$861K$6M$6M$110K$212M
Cash & Equiv.$281M$99M$7M$357M$68M

PHVS vs KALV vs BCAB vs PRAX vs ARDXLong-Term Stock Performance

Price return indexed to 100 at period start. Dividends excluded.

PHVS
KALV
BCAB
PRAX
ARDX
StockFeb 21May 26Return
Pharvaris N.V. (PHVS)10078.1-21.9%
KalVista Pharmaceut… (KALV)10081.3-18.7%
BioAtla, Inc. (BCAB)1000.2-99.8%
Praxis Precision Me… (PRAX)10051.1-48.9%
Ardelyx, Inc. (ARDX)100433.5+333.5%

Price return only. Dividends and distributions are not included.

Quick Verdict: PHVS vs KALV vs BCAB vs PRAX vs ARDX

Each card shows where this stock fits in a portfolio — not just who wins on paper.

Bottom line: PRAX and ARDX are tied at the top with 2 categories each (5-stock set) — the right choice depends on your priorities. Ardelyx, Inc. is the stronger pick specifically for growth and revenue expansion and operational efficiency and capital deployment. BCAB also leads in specific categories worth noting. As sector peers, any of these can serve as alternatives in the same allocation.
PHVS
Pharvaris N.V.
The Healthcare Pick

PHVS lags the leaders in this set but could rank higher in a more targeted comparison.

Best for: healthcare exposure
KALV
KalVista Pharmaceuticals, Inc.
The Defensive Pick

KALV is the clearest fit if your priority is sleep-well-at-night and defensive.

  • Lower volatility, beta 0.82, Low D/E 6.6%, current ratio 5.35x
  • Beta 0.82, current ratio 5.35x
Best for: sleep-well-at-night and defensive
BCAB
BioAtla, Inc.
The Income Pick

BCAB ranks third and is worth considering specifically for income & stability and growth exposure.

  • beta 0.51
  • Rev growth -81.8%, EPS growth 29.9%
  • Beta 0.51 vs PRAX's 1.55
Best for: income & stability and growth exposure
PRAX
Praxis Precision Medicines, Inc.
The Quality Compounder

PRAX carries the broadest edge in this set and is the clearest fit for quality and momentum.

  • 2.4% margin vs BCAB's -29.8%
  • +7.7% vs BCAB's -80.6%
Best for: quality and momentum
ARDX
Ardelyx, Inc.
The Long-Run Compounder

ARDX is the #2 pick in this set and the best alternative if long-term compounding is your priority.

  • 263.5% 10Y total return vs KALV's 154.5%
  • 22.1% revenue growth vs PRAX's -100.0%
  • -11.8% ROA vs BCAB's -250.6%
Best for: long-term compounding
See the full category breakdown
CategoryWinnerWhy
GrowthARDX logoARDX22.1% revenue growth vs PRAX's -100.0%
Quality / MarginsPRAX logoPRAX2.4% margin vs BCAB's -29.8%
Stability / SafetyBCAB logoBCABBeta 0.51 vs PRAX's 1.55
DividendsTieNone of these 5 stocks pay a meaningful dividend
Momentum (1Y)PRAX logoPRAX+7.7% vs BCAB's -80.6%
Efficiency (ROA)ARDX logoARDX-11.8% ROA vs BCAB's -250.6%

PHVS vs KALV vs BCAB vs PRAX vs ARDX — Revenue Breakdown by Segment

How each company's revenue is distributed across its business units

PHVSPharvaris N.V.

Segment breakdown not available.

KALVKalVista Pharmaceuticals, Inc.

Segment breakdown not available.

BCABBioAtla, Inc.

Segment breakdown not available.

PRAXPraxis Precision Medicines, Inc.
FY 2024
License
76.8%$9M
Upfront Payment
23.2%$3M
ARDXArdelyx, Inc.
FY 2025
Product
57.5%$378M
Product, IBSRELA
41.7%$274M
License
0.8%$5M

PHVS vs KALV vs BCAB vs PRAX vs ARDX — Financial Metrics

Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.

BEST OVERALLARDXLAGGINGBCAB

Income & Cash Flow (Last 12 Months)

ARDX leads this category, winning 3 of 5 comparable metrics.

ARDX and PRAX operate at a comparable scale, with $428M and -$92,000 in trailing revenue. ARDX is the more profitable business, keeping -13.6% of every revenue dollar as net income compared to BCAB's -29.8%.

MetricPHVS logoPHVSPharvaris N.V.KALV logoKALVKalVista Pharmace…BCAB logoBCABBioAtla, Inc.PRAX logoPRAXPraxis Precision …ARDX logoARDXArdelyx, Inc.
RevenueTrailing 12 months$0$15M$2M-$92,000$428M
EBITDAEarnings before interest/tax-$86M-$202M-$59M-$357M-$35M
Net IncomeAfter-tax profit-$166M-$210M-$60M-$327M-$58M
Free Cash FlowCash after capex-$134M-$160M-$34M-$283M-$37M
Gross MarginGross profit ÷ Revenue-17.2%+100.0%+91.9%
Operating MarginEBIT ÷ Revenue-13.4%-29.7%-8.7%
Net MarginNet income ÷ Revenue-13.9%-29.8%-13.6%
FCF MarginFCF ÷ Revenue-10.6%-17.0%-8.8%
Rev. Growth (YoY)Latest quarter vs prior year+27.5%
EPS Growth (YoY)Latest quarter vs prior year+22.1%-1.1%+46.7%+2.7%+11.8%
ARDX leads this category, winning 3 of 5 comparable metrics.

Valuation Metrics

Evenly matched — PHVS and BCAB and ARDX each lead in 1 of 3 comparable metrics.
MetricPHVS logoPHVSPharvaris N.V.KALV logoKALVKalVista Pharmace…BCAB logoBCABBioAtla, Inc.PRAX logoPRAXPraxis Precision …ARDX logoARDXArdelyx, Inc.
Market CapShares × price$1.9B$1.4B$5M$9.6B$1.7B
Enterprise ValueMkt cap + debt − cash$1.6B$1.3B$4M$9.3B$1.9B
Trailing P/EPrice ÷ TTM EPS-10.18x-7.24x-0.09x-24.72x-26.85x
Forward P/EPrice ÷ next-FY EPS est.
PEG RatioP/E ÷ EPS growth rate
EV / EBITDAEnterprise value multiple
Price / SalesMarket cap ÷ Revenue2.56x4.20x
Price / BookPrice ÷ Book value/share5.10x13.91x8.54x10.08x
Price / FCFMarket cap ÷ FCF
Evenly matched — PHVS and BCAB and ARDX each lead in 1 of 3 comparable metrics.

Profitability & Efficiency

ARDX leads this category, winning 6 of 9 comparable metrics.

ARDX delivers a -38.1% return on equity — every $100 of shareholder capital generates $-38 in annual profit, vs $-3 for KALV. PRAX carries lower financial leverage with a 0.00x debt-to-equity ratio, signaling a more conservative balance sheet compared to ARDX's 1.27x. On the Piotroski fundamental quality scale (0–9), PRAX scores 3/9 vs PHVS's 1/9, reflecting mixed financial health.

MetricPHVS logoPHVSPharvaris N.V.KALV logoKALVKalVista Pharmace…BCAB logoBCABBioAtla, Inc.PRAX logoPRAXPraxis Precision …ARDX logoARDXArdelyx, Inc.
ROE (TTM)Return on equity-53.2%-2.8%-43.0%-38.1%
ROA (TTM)Return on assets-49.0%-77.7%-2.5%-40.2%-11.8%
ROICReturn on invested capital-152.3%-65.0%-10.7%
ROCEReturn on capital employed-44.7%-89.9%-4.0%-49.3%-10.6%
Piotroski ScoreFundamental quality 0–912233
Debt / EquityFinancial leverage0.00x0.07x0.00x1.27x
Net DebtTotal debt minus cash-$280M-$92M-$918,000-$357M$144M
Cash & Equiv.Liquid assets$281M$99M$7M$357M$68M
Total DebtShort + long-term debt$861,470$6M$6M$110,000$212M
Interest CoverageEBIT ÷ Interest expense-13.75x-0.28x
ARDX leads this category, winning 6 of 9 comparable metrics.

Total Returns (Dividends Reinvested)

PRAX leads this category, winning 3 of 6 comparable metrics.

A $10,000 investment in ARDX five years ago would be worth $41,302 today (with dividends reinvested), compared to $19 for BCAB. Over the past 12 months, PRAX leads with a +775.0% total return vs BCAB's -80.6%. The 3-year compound annual growth rate (CAGR) favors PRAX at 174.9% vs BCAB's -70.1% — a key indicator of consistent wealth creation.

MetricPHVS logoPHVSPharvaris N.V.KALV logoKALVKalVista Pharmace…BCAB logoBCABBioAtla, Inc.PRAX logoPRAXPraxis Precision …ARDX logoARDXArdelyx, Inc.
YTD ReturnYear-to-date+12.1%+72.8%-83.7%+16.4%+13.5%
1-Year ReturnPast 12 months+73.6%+118.1%-80.6%+775.0%+88.6%
3-Year ReturnCumulative with dividends+220.5%+180.1%-97.3%+1976.5%+66.6%
5-Year ReturnCumulative with dividends+31.2%+5.9%-99.8%-20.8%+313.0%
10-Year ReturnCumulative with dividends+2.3%+154.5%-99.7%-20.1%+263.5%
CAGR (3Y)Annualised 3-year return+47.4%+41.0%-70.1%+174.9%+18.5%
PRAX leads this category, winning 3 of 6 comparable metrics.

Risk & Volatility

Evenly matched — KALV and BCAB each lead in 1 of 2 comparable metrics.

BCAB is the less volatile stock with a 0.51 beta — it tends to amplify market swings less than PRAX's 1.55 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. KALV currently trades 99.5% from its 52-week high vs BCAB's 6.1% drawdown — a narrower gap to the peak suggests stronger recent price momentum.

MetricPHVS logoPHVSPharvaris N.V.KALV logoKALVKalVista Pharmace…BCAB logoBCABBioAtla, Inc.PRAX logoPRAXPraxis Precision …ARDX logoARDXArdelyx, Inc.
Beta (5Y)Sensitivity to S&P 5001.02x0.82x0.51x1.55x0.87x
52-Week HighHighest price in past year$31.12$26.84$71.50$356.00$8.40
52-Week LowLowest price in past year$14.59$9.83$0.33$35.18$3.21
% of 52W HighCurrent price vs 52-week peak+95.4%+99.5%+6.1%+93.6%+83.1%
RSI (14)Momentum oscillator 0–10057.275.440.555.668.6
Avg Volume (50D)Average daily shares traded227K3.0M40K378K3.5M
Evenly matched — KALV and BCAB each lead in 1 of 2 comparable metrics.

Analyst Outlook

Insufficient data to determine a leader in this category.

Analyst consensus: PHVS as "Buy", KALV as "Buy", BCAB as "Buy", PRAX as "Buy", ARDX as "Buy". Consensus price targets imply 5647.1% upside for BCAB (target: $250) vs 6.7% for KALV (target: $29).

MetricPHVS logoPHVSPharvaris N.V.KALV logoKALVKalVista Pharmace…BCAB logoBCABBioAtla, Inc.PRAX logoPRAXPraxis Precision …ARDX logoARDXArdelyx, Inc.
Analyst RatingConsensus buy/hold/sellBuyBuyBuyBuyBuy
Price TargetConsensus 12-month target$43.67$28.50$250.00$544.40$17.00
# AnalystsCovering analysts111391616
Dividend YieldAnnual dividend ÷ price
Dividend StreakConsecutive years of raises
Dividend / ShareAnnual DPS
Buyback YieldShare repurchases ÷ mkt cap0.0%0.0%0.0%0.0%0.0%
Insufficient data to determine a leader in this category.
Key Takeaway

ARDX leads in 2 of 6 categories (Income & Cash Flow, Profitability & Efficiency). PRAX leads in 1 (Total Returns). 2 tied.

Best OverallArdelyx, Inc. (ARDX)Leads 2 of 6 categories
Loading custom metrics...

PHVS vs KALV vs BCAB vs PRAX vs ARDX: Key Questions Answered

8 questions · data-driven answers · updated daily

01

Is PHVS or KALV or BCAB or PRAX or ARDX a better buy right now?

For growth investors, Ardelyx, Inc.

(ARDX) is the stronger pick with 22. 1% revenue growth year-over-year, versus -100. 0% for Praxis Precision Medicines, Inc. (PRAX). Analysts rate Pharvaris N. V. (PHVS) a "Buy" — based on 11 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

02

Which is the better long-term investment — PHVS or KALV or BCAB or PRAX or ARDX?

Over the past 5 years, Ardelyx, Inc.

(ARDX) delivered a total return of +313. 0%, compared to -99. 8% for BioAtla, Inc. (BCAB). Over 10 years, the gap is even starker: ARDX returned +263. 5% versus BCAB's -99. 7%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

03

Which is safer — PHVS or KALV or BCAB or PRAX or ARDX?

By beta (market sensitivity over 5 years), BioAtla, Inc.

(BCAB) is the lower-risk stock at 0. 51β versus Praxis Precision Medicines, Inc. 's 1. 55β — meaning PRAX is approximately 203% more volatile than BCAB relative to the S&P 500. On balance sheet safety, Praxis Precision Medicines, Inc. (PRAX) carries a lower debt/equity ratio of 0% versus 127% for Ardelyx, Inc. — giving it more financial flexibility in a downturn.

04

Which is growing faster — PHVS or KALV or BCAB or PRAX or ARDX?

By revenue growth (latest reported year), Ardelyx, Inc.

(ARDX) is pulling ahead at 22. 1% versus -100. 0% for Praxis Precision Medicines, Inc. (PRAX). On earnings-per-share growth, the picture is similar: BioAtla, Inc. grew EPS 29. 9% year-over-year, compared to -52. 9% for Ardelyx, Inc.. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

05

Which has better profit margins — PHVS or KALV or BCAB or PRAX or ARDX?

Pharvaris N.

V. (PHVS) is the more profitable company, earning 0. 0% net margin versus -29. 8% for BioAtla, Inc. — meaning it keeps 0. 0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: PHVS leads at 0. 0% versus -29. 7% for BCAB. At the gross margin level — before operating expenses — BCAB leads at 100. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

06

Which pays a better dividend — PHVS or KALV or BCAB or PRAX or ARDX?

None of the stocks in this comparison currently pay a material dividend.

All are effectively zero-yield and should be held for capital appreciation rather than income.

07

Is PHVS or KALV or BCAB or PRAX or ARDX better for a retirement portfolio?

For long-horizon retirement investors, BioAtla, Inc.

(BCAB) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0. 51)). Praxis Precision Medicines, Inc. (PRAX) carries a higher beta of 1. 55 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (BCAB: -99. 7%, PRAX: -20. 1%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

08

What are the main differences between PHVS and KALV and BCAB and PRAX and ARDX?

Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.

In terms of investment character: PHVS is a small-cap quality compounder stock; KALV is a small-cap quality compounder stock; BCAB is a small-cap quality compounder stock; PRAX is a small-cap quality compounder stock; ARDX is a small-cap high-growth stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.

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