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REVB vs ADMA vs HALO vs GRFS vs ALNY

Revenue, margins, valuation, and 5-year total return — side by side.

Live fundamentals10-year financials5-year price chart
REVB
Revelation Biosciences, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$3M
5Y Perf.-100.0%
ADMA
ADMA Biologics, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$1.89B
5Y Perf.+300.5%
HALO
Halozyme Therapeutics, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$7.55B
5Y Perf.+64.0%
GRFS
Grifols, S.A.

Drug Manufacturers - General

HealthcareNASDAQ • ES
Market Cap$6.85B
5Y Perf.-56.3%
ALNY
Alnylam Pharmaceuticals, Inc.

Biotechnology

HealthcareNASDAQ • US
Market Cap$39.37B
5Y Perf.+127.1%

REVB vs ADMA vs HALO vs GRFS vs ALNY — Key Financials

Market cap, revenue, margins, and valuation side-by-side.

Company Snapshot
REVB logoREVB
ADMA logoADMA
HALO logoHALO
GRFS logoGRFS
ALNY logoALNY
IndustryBiotechnologyBiotechnologyBiotechnologyDrug Manufacturers - GeneralBiotechnology
Market Cap$3M$1.89B$7.55B$6.85B$39.37B
Revenue (TTM)$0.00$510M$1.40B$7.51B$4.29B
Net Income (TTM)$-16M$165M$317M$401M$577M
Gross Margin61.3%81.9%38.4%80.9%
Operating Margin42.1%58.4%17.0%17.5%
Forward P/E9.7x8.0x9.4x39.9x
Total Debt$747K$80M$0.00$8.74B$1.28B
Cash & Equiv.$11M$88M$134M$825M$1.66B

REVB vs ADMA vs HALO vs GRFS vs ALNYLong-Term Stock Performance

Price return indexed to 100 at period start. Dividends excluded.

REVB
ADMA
HALO
GRFS
ALNY
StockNov 20May 26Return
Revelation Bioscien… (REVB)1000.0-100.0%
ADMA Biologics, Inc. (ADMA)100400.5+300.5%
Halozyme Therapeuti… (HALO)100164.0+64.0%
Grifols, S.A. (GRFS)10043.7-56.3%
Alnylam Pharmaceuti… (ALNY)100227.1+127.1%

Price return only. Dividends and distributions are not included.

Quick Verdict: REVB vs ADMA vs HALO vs GRFS vs ALNY

Each card shows where this stock fits in a portfolio — not just who wins on paper.

Bottom line: ADMA and HALO are tied at the top with 2 categories each (5-stock set) — the right choice depends on your priorities. Halozyme Therapeutics, Inc. is the stronger pick specifically for valuation and capital efficiency and capital preservation and lower volatility. ALNY and GRFS also each lead in at least one category. As sector peers, any of these can serve as alternatives in the same allocation.
REVB
Revelation Biosciences, Inc.
The Healthcare Pick

Among these 5 stocks, REVB doesn't own a clear edge in any measured category.

Best for: healthcare exposure
ADMA
ADMA Biologics, Inc.
The Quality Compounder

ADMA has the current edge in this matchup, primarily because of its strength in quality and efficiency.

  • 32.4% margin vs GRFS's 5.3%
  • 27.4% ROA vs REVB's -138.6%
Best for: quality and efficiency
HALO
Halozyme Therapeutics, Inc.
The Long-Run Compounder

HALO is the #2 pick in this set and the best alternative if long-term compounding and sleep-well-at-night is your priority.

  • 5.6% 10Y total return vs ALNY's 410.4%
  • Lower volatility, beta 0.51, current ratio 4.66x
  • Beta 0.51, current ratio 4.66x
  • Lower P/E (8.0x vs 39.9x)
Best for: long-term compounding and sleep-well-at-night
GRFS
Grifols, S.A.
The Income Pick

GRFS is the clearest fit if your priority is income & stability.

  • Dividend streak 2 yrs, beta 1.10, yield 2.6%
  • 2.6% yield; 2-year raise streak; the other 4 pay no meaningful dividend
Best for: income & stability
ALNY
Alnylam Pharmaceuticals, Inc.
The Growth Play

ALNY ranks third and is worth considering specifically for growth exposure.

  • Rev growth 65.2%, EPS growth 206.9%, 3Y rev CAGR 53.0%
  • 65.2% revenue growth vs REVB's -100.0%
  • +14.2% vs REVB's -97.4%
Best for: growth exposure
See the full category breakdown
CategoryWinnerWhy
GrowthALNY logoALNY65.2% revenue growth vs REVB's -100.0%
ValueHALO logoHALOLower P/E (8.0x vs 39.9x)
Quality / MarginsADMA logoADMA32.4% margin vs GRFS's 5.3%
Stability / SafetyHALO logoHALOBeta 0.51 vs REVB's 1.34
DividendsGRFS logoGRFS2.6% yield; 2-year raise streak; the other 4 pay no meaningful dividend
Momentum (1Y)ALNY logoALNY+14.2% vs REVB's -97.4%
Efficiency (ROA)ADMA logoADMA27.4% ROA vs REVB's -138.6%

REVB vs ADMA vs HALO vs GRFS vs ALNY — Revenue Breakdown by Segment

How each company's revenue is distributed across its business units

REVBRevelation Biosciences, Inc.

Segment breakdown not available.

ADMAADMA Biologics, Inc.
FY 2024
ADMA BioManufacturing Segment
97.4%$416M
Plasma Collection Centers Segment
2.6%$11M
HALOHalozyme Therapeutics, Inc.
FY 2025
Royalty
53.6%$868M
Product
23.3%$376M
Collaborative Agreements
9.4%$152M
Bulk rHuPH20
8.2%$133M
Sales-based milestone
4.3%$70M
Upfront Fees
1.1%$18M
GRFSGrifols, S.A.
FY 2025
Haemoderivatives
86.2%$6.5B
Transfusional medicine
8.3%$623M
Other Product
3.2%$243M
Bio supplies
2.0%$154M
Other diagnostic
0.2%$17M
ALNYAlnylam Pharmaceuticals, Inc.
FY 2025
GIVLAARI
64.1%$308M
ONPATTRO
35.9%$173M

REVB vs ADMA vs HALO vs GRFS vs ALNY — Financial Metrics

Side-by-side numbers across 5 stocks — who leads on profitability, valuation, growth, and risk.

BEST OVERALLHALOLAGGINGALNY

Income & Cash Flow (Last 12 Months)

HALO leads this category, winning 3 of 6 comparable metrics.

GRFS and REVB operate at a comparable scale, with $7.5B and $0 in trailing revenue. ADMA is the more profitable business, keeping 32.4% of every revenue dollar as net income compared to GRFS's 5.3%. On growth, ALNY holds the edge at +96.4% YoY revenue growth, suggesting stronger near-term business momentum.

MetricREVB logoREVBRevelation Biosci…ADMA logoADMAADMA Biologics, I…HALO logoHALOHalozyme Therapeu…GRFS logoGRFSGrifols, S.A.ALNY logoALNYAlnylam Pharmaceu…
RevenueTrailing 12 months$0$510M$1.4B$7.5B$4.3B
EBITDAEarnings before interest/tax-$10M$221M$945M$1.6B$677M
Net IncomeAfter-tax profit-$16M$165M$317M$401M$577M
Free Cash FlowCash after capex-$9M$108M$645M$772M$641M
Gross MarginGross profit ÷ Revenue+61.3%+81.9%+38.4%+80.9%
Operating MarginEBIT ÷ Revenue+42.1%+58.4%+17.0%+17.5%
Net MarginNet income ÷ Revenue+32.4%+22.7%+5.3%+13.5%
FCF MarginFCF ÷ Revenue+21.2%+46.2%+10.3%+15.0%
Rev. Growth (YoY)Latest quarter vs prior year-0.3%+51.6%-0.6%+96.4%
EPS Growth (YoY)Latest quarter vs prior year-28.4%+72.7%-2.1%+40.0%+4.4%
HALO leads this category, winning 3 of 6 comparable metrics.

Valuation Metrics

Evenly matched — REVB and HALO and GRFS each lead in 2 of 6 comparable metrics.

At 12.1x trailing earnings, GRFS trades at a 90% valuation discount to ALNY's 126.6x P/E. On an enterprise value basis, HALO's 8.2x EV/EBITDA is more attractive than ALNY's 70.0x.

MetricREVB logoREVBRevelation Biosci…ADMA logoADMAADMA Biologics, I…HALO logoHALOHalozyme Therapeu…GRFS logoGRFSGrifols, S.A.ALNY logoALNYAlnylam Pharmaceu…
Market CapShares × price$3M$1.9B$7.6B$6.9B$39.4B
Enterprise ValueMkt cap + debt − cash-$7M$1.9B$7.4B$16.1B$39.0B
Trailing P/EPrice ÷ TTM EPS-0.04x13.62x25.05x12.11x126.63x
Forward P/EPrice ÷ next-FY EPS est.9.69x7.96x9.35x39.92x
PEG RatioP/E ÷ EPS growth rate1.09x
EV / EBITDAEnterprise value multiple9.45x8.20x8.49x69.97x
Price / SalesMarket cap ÷ Revenue3.71x5.41x0.81x10.60x
Price / BookPrice ÷ Book value/share0.07x4.19x162.76x0.62x50.35x
Price / FCFMarket cap ÷ FCF68.06x11.72x7.77x84.59x
Evenly matched — REVB and HALO and GRFS each lead in 2 of 6 comparable metrics.

Profitability & Efficiency

Evenly matched — ADMA and HALO each lead in 3 of 9 comparable metrics.

HALO delivers a 6.5% return on equity — every $100 of shareholder capital generates $6 in annual profit, vs $-170 for REVB. REVB carries lower financial leverage with a 0.08x debt-to-equity ratio, signaling a more conservative balance sheet compared to ALNY's 1.62x. On the Piotroski fundamental quality scale (0–9), GRFS scores 6/9 vs REVB's 4/9, reflecting solid financial health.

MetricREVB logoREVBRevelation Biosci…ADMA logoADMAADMA Biologics, I…HALO logoHALOHalozyme Therapeu…GRFS logoGRFSGrifols, S.A.ALNY logoALNYAlnylam Pharmaceu…
ROE (TTM)Return on equity-169.6%+39.0%+6.5%+5.2%+98.3%
ROA (TTM)Return on assets-138.6%+27.4%+12.5%+2.0%+11.8%
ROICReturn on invested capital+36.0%+73.4%+5.4%+33.4%
ROCEReturn on capital employed-126.9%+38.8%+38.2%+6.4%+15.3%
Piotroski ScoreFundamental quality 0–945566
Debt / EquityFinancial leverage0.08x0.17x1.15x1.62x
Net DebtTotal debt minus cash-$10M-$8M-$134M$7.9B-$379M
Cash & Equiv.Liquid assets$11M$88M$134M$825M$1.7B
Total DebtShort + long-term debt$746,784$80M$0$8.7B$1.3B
Interest CoverageEBIT ÷ Interest expense50.85x46.08x2.05x2.02x
Evenly matched — ADMA and HALO each lead in 3 of 9 comparable metrics.

Total Returns (Dividends Reinvested)

ADMA leads this category, winning 3 of 6 comparable metrics.

A $10,000 investment in ADMA five years ago would be worth $48,922 today (with dividends reinvested), compared to $0 for REVB. Over the past 12 months, ALNY leads with a +14.2% total return vs REVB's -97.4%. The 3-year compound annual growth rate (CAGR) favors ADMA at 32.7% vs REVB's -94.8% — a key indicator of consistent wealth creation.

MetricREVB logoREVBRevelation Biosci…ADMA logoADMAADMA Biologics, I…HALO logoHALOHalozyme Therapeu…GRFS logoGRFSGrifols, S.A.ALNY logoALNYAlnylam Pharmaceu…
YTD ReturnYear-to-date-70.5%-54.3%-8.8%-12.3%-26.3%
1-Year ReturnPast 12 months-97.4%-61.5%-5.3%+13.4%+14.2%
3-Year ReturnCumulative with dividends-100.0%+133.4%+111.8%+9.5%+40.5%
5-Year ReturnCumulative with dividends-100.0%+389.2%+39.1%-53.6%+129.4%
10-Year ReturnCumulative with dividends-100.0%+34.8%+559.7%-35.2%+410.4%
CAGR (3Y)Annualised 3-year return-94.8%+32.7%+28.4%+3.1%+12.0%
ADMA leads this category, winning 3 of 6 comparable metrics.

Risk & Volatility

HALO leads this category, winning 2 of 2 comparable metrics.

HALO is the less volatile stock with a 0.51 beta — it tends to amplify market swings less than REVB's 1.34 beta. A beta below 1.0 means the stock typically moves less than the S&P 500. HALO currently trades 78.0% from its 52-week high vs REVB's 2.4% drawdown — a narrower gap to the peak suggests stronger recent price momentum.

MetricREVB logoREVBRevelation Biosci…ADMA logoADMAADMA Biologics, I…HALO logoHALOHalozyme Therapeu…GRFS logoGRFSGrifols, S.A.ALNY logoALNYAlnylam Pharmaceu…
Beta (5Y)Sensitivity to S&P 5001.34x1.25x0.51x1.10x0.74x
52-Week HighHighest price in past year$40.08$22.73$82.22$11.14$495.55
52-Week LowLowest price in past year$0.60$7.21$47.50$7.09$245.96
% of 52W HighCurrent price vs 52-week peak+2.4%+35.9%+78.0%+72.7%+59.5%
RSI (14)Momentum oscillator 0–10029.726.047.745.439.9
Avg Volume (50D)Average daily shares traded78K7.4M1.4M681K1.1M
HALO leads this category, winning 2 of 2 comparable metrics.

Analyst Outlook

GRFS leads this category, winning 1 of 1 comparable metric.

Analyst consensus: ADMA as "Buy", HALO as "Buy", GRFS as "Buy", ALNY as "Buy". Consensus price targets imply 157.0% upside for ADMA (target: $21) vs 17.9% for HALO (target: $76). GRFS is the only dividend payer here at 2.62% yield — a key consideration for income-focused portfolios.

MetricREVB logoREVBRevelation Biosci…ADMA logoADMAADMA Biologics, I…HALO logoHALOHalozyme Therapeu…GRFS logoGRFSGrifols, S.A.ALNY logoALNYAlnylam Pharmaceu…
Analyst RatingConsensus buy/hold/sellBuyBuyBuyBuy
Price TargetConsensus 12-month target$21.00$75.60$445.67
# AnalystsCovering analysts1027852
Dividend YieldAnnual dividend ÷ price+2.6%
Dividend StreakConsecutive years of raises12
Dividend / ShareAnnual DPS$0.18
Buyback YieldShare repurchases ÷ mkt cap0.0%+1.7%+4.5%+2.1%0.0%
GRFS leads this category, winning 1 of 1 comparable metric.
Key Takeaway

HALO leads in 2 of 6 categories (Income & Cash Flow, Risk & Volatility). ADMA leads in 1 (Total Returns). 2 tied.

Best OverallHalozyme Therapeutics, Inc. (HALO)Leads 2 of 6 categories
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REVB vs ADMA vs HALO vs GRFS vs ALNY: Key Questions Answered

10 questions · data-driven answers · updated daily

01

Is REVB or ADMA or HALO or GRFS or ALNY a better buy right now?

For growth investors, Alnylam Pharmaceuticals, Inc.

(ALNY) is the stronger pick with 65. 2% revenue growth year-over-year, versus 0. 2% for Grifols, S. A. (GRFS). Grifols, S. A. (GRFS) offers the better valuation at 12. 1x trailing P/E (9. 4x forward), making it the more compelling value choice. Analysts rate ADMA Biologics, Inc. (ADMA) a "Buy" — based on 10 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

02

Which has the better valuation — REVB or ADMA or HALO or GRFS or ALNY?

On trailing P/E, Grifols, S.

A. (GRFS) is the cheapest at 12. 1x versus Alnylam Pharmaceuticals, Inc. at 126. 6x. On forward P/E, Halozyme Therapeutics, Inc. is actually cheaper at 8. 0x — notably different from the trailing picture, reflecting expected earnings growth.

03

Which is the better long-term investment — REVB or ADMA or HALO or GRFS or ALNY?

Over the past 5 years, ADMA Biologics, Inc.

(ADMA) delivered a total return of +389. 2%, compared to -100. 0% for Revelation Biosciences, Inc. (REVB). Over 10 years, the gap is even starker: HALO returned +559. 7% versus REVB's -100. 0%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

04

Which is safer — REVB or ADMA or HALO or GRFS or ALNY?

By beta (market sensitivity over 5 years), Halozyme Therapeutics, Inc.

(HALO) is the lower-risk stock at 0. 51β versus Revelation Biosciences, Inc. 's 1. 34β — meaning REVB is approximately 162% more volatile than HALO relative to the S&P 500. On balance sheet safety, Revelation Biosciences, Inc. (REVB) carries a lower debt/equity ratio of 8% versus 162% for Alnylam Pharmaceuticals, Inc. — giving it more financial flexibility in a downturn.

05

Which is growing faster — REVB or ADMA or HALO or GRFS or ALNY?

By revenue growth (latest reported year), Alnylam Pharmaceuticals, Inc.

(ALNY) is pulling ahead at 65. 2% versus 0. 2% for Grifols, S. A. (GRFS). On earnings-per-share growth, the picture is similar: Alnylam Pharmaceuticals, Inc. grew EPS 206. 9% year-over-year, compared to -25. 9% for ADMA Biologics, Inc.. Over a 3-year CAGR, ALNY leads at 53. 0% annualised revenue growth. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

06

Which has better profit margins — REVB or ADMA or HALO or GRFS or ALNY?

ADMA Biologics, Inc.

(ADMA) is the more profitable company, earning 28. 8% net margin versus 0. 0% for Revelation Biosciences, Inc. — meaning it keeps 28. 8% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: HALO leads at 58. 4% versus 0. 0% for REVB. At the gross margin level — before operating expenses — ALNY leads at 81. 8%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

07

Is REVB or ADMA or HALO or GRFS or ALNY more undervalued right now?

On forward earnings alone, Halozyme Therapeutics, Inc.

(HALO) trades at 8. 0x forward P/E versus 39. 9x for Alnylam Pharmaceuticals, Inc. — 32. 0x cheaper on a one-year earnings basis. Analyst consensus price targets imply the most upside for ADMA: 157. 0% to $21. 00.

08

Which pays a better dividend — REVB or ADMA or HALO or GRFS or ALNY?

In this comparison, GRFS (2.

6% yield) pays a dividend. REVB, ADMA, HALO, ALNY do not pay a meaningful dividend and should not be held primarily for income.

09

Is REVB or ADMA or HALO or GRFS or ALNY better for a retirement portfolio?

For long-horizon retirement investors, Halozyme Therapeutics, Inc.

(HALO) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 0. 51), +559. 7% 10Y return). Both have compounded well over 10 years (HALO: +559. 7%, REVB: -100. 0%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

10

What are the main differences between REVB and ADMA and HALO and GRFS and ALNY?

Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.

In terms of investment character: REVB is a small-cap quality compounder stock; ADMA is a small-cap high-growth stock; HALO is a small-cap high-growth stock; GRFS is a small-cap deep-value stock; ALNY is a mid-cap high-growth stock. GRFS pays a dividend while REVB, ADMA, HALO, ALNY do not, making them suitable for different income and tax situations. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.

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  • Sector: Healthcare
  • Market Cap > $100B
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  • Net Margin > 19%
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  • Sector: Healthcare
  • Market Cap > $100B
  • Net Margin > 5%
  • Dividend Yield > 1.0%
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