SEPN
Septerna, Inc.
Biotechnology
Market Cap$1.07B
5Y Perf.+4.8%
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Stock Comparison
SEPN vs DBVT
Revenue, margins, valuation, and 5-year total return — side by side.
DBVT
DBV Technologies S.A.
Biotechnology
Market Cap$1712.35T
5Y Perf.+309.6%
SEPN vs DBVT — Key Financials
Market cap, revenue, margins, and valuation side-by-side.
| Company Snapshot | SEPN | DBVT |
|---|---|---|
| Industry | Biotechnology | Biotechnology |
| Market Cap | $1.07B | $1712.35T |
| Revenue (TTM) | $46M | $0.00 |
| Net Income (TTM) | $-49M | $-168M |
| Operating Margin | -148.6% | — |
| Total Debt | $24M | $22M |
| Cash & Equiv. | $121M | $194M |
SEPN vs DBVT — Long-Term Stock Performance
Price return indexed to 100 at period start. Dividends excluded.
SEPN
DBVT
| Stock | Oct 24 | May 26 | Return |
|---|---|---|---|
| Septerna, Inc. (SEPN) | 100 | 104.8 | +4.8% |
| DBV Technologies S.… (DBVT) | 100 | 409.6 | +309.6% |
Price return only. Dividends and distributions are not included.
Quick Verdict: SEPN vs DBVT
Each card shows where this stock fits in a portfolio — not just who wins on paper.
Bottom line: SEPN leads in 3 of 6 categories, making it the strongest pick for growth and revenue expansion and recent price momentum and sentiment. DBV Technologies S.A. is the stronger pick specifically for profitability and margin quality and capital preservation and lower volatility. As sector peers, any of these can serve as alternatives in the same allocation.
SEPN
Septerna, Inc.
The Growth Play
SEPN carries the broadest edge in this set and is the clearest fit for growth exposure and long-term compounding.
- Rev growth 41.7%, EPS growth 84.8%
- 12.1% 10Y total return vs DBVT's -87.0%
- Lower volatility, beta 1.37, Low D/E 6.2%, current ratio 4.73x
Best for: growth exposure and long-term compounding
DBVT
DBV Technologies S.A.
The Income Pick
DBVT is the clearest fit if your priority is income & stability and defensive.
- Dividend streak 0 yrs, beta 1.26
- Beta 1.26, current ratio 3.67x
- 0.3% margin vs SEPN's -106.4%
Best for: income & stability and defensive
See the full category breakdown
| Category | Winner | Why |
|---|---|---|
| Growth | SEPN | 41.7% revenue growth vs DBVT's -100.0% |
| Quality / Margins | DBVT | 0.3% margin vs SEPN's -106.4% |
| Stability / Safety | DBVT | Beta 1.26 vs SEPN's 1.37 |
| Dividends | Tie | Neither stock pays a meaningful dividend |
| Momentum (1Y) | SEPN | +240.1% vs DBVT's +110.4% |
| Efficiency (ROA) | SEPN | -9.5% ROA vs DBVT's -89.0% |
SEPN vs DBVT — Financial Metrics
Side-by-side numbers across 2 stocks — who leads on profitability, valuation, growth, and risk.
BEST OVERALLDBVTLAGGINGSEPN
SEPNSepterna, Inc.
1leads
DBVTDBV Technologies S.A.
2leads
6 Total Categories
CATEGORYLEADERvs SEPNMETRICS WON
Income & Cash FlowRevenue, margins, and cash flow strength
DBVT1/1
Valuation MetricsMultiples, price ratios, and targets
Tied
—
Profitability & EfficiencyROE, ROIC, leverage, and quality scores
SEPN5/7
Total Returns1Y, 3Y, 5Y total returns with dividends
Tied
—
Risk & VolatilityBeta, volatility, and downside exposure
DBVT2/2
Analyst OutlookRatings, price targets, and dividends
—
—
Income & Cash Flow (Last 12 Months)
DBVT leads this category, winning 1 of 1 comparable metric.
Income & Cash Flow (Last 12 Months)
SEPN and DBVT operate at a comparable scale, with $46M and $0 in trailing revenue.
| Metric | SEPNSepterna, Inc. | DBVTDBV Technologies … |
|---|---|---|
| RevenueTrailing 12 months | $46M | $0 |
| EBITDAEarnings before interest/tax | -$68M | -$112M |
| Net IncomeAfter-tax profit | -$49M | -$168M |
| Free Cash FlowCash after capex | $110M | -$151M |
| Gross MarginGross profit ÷ Revenue | — | — |
| Operating MarginEBIT ÷ Revenue | -148.6% | — |
| Net MarginNet income ÷ Revenue | -106.4% | — |
| FCF MarginFCF ÷ Revenue | +2.4% | — |
| Rev. Growth (YoY)Latest quarter vs prior year | +112.8% | — |
| EPS Growth (YoY)Latest quarter vs prior year | +64.1% | +91.5% |
DBVT leads this category, winning 1 of 1 comparable metric.
Valuation Metrics
Evenly matched — SEPN and DBVT each lead in 1 of 2 comparable metrics.
Valuation Metrics
| Metric | SEPNSepterna, Inc. | DBVTDBV Technologies … |
|---|---|---|
| Market CapShares × price | $1.1B | $1712.35T |
| Enterprise ValueMkt cap + debt − cash | $977M | $1712.35T |
| Trailing P/EPrice ÷ TTM EPS | -21.80x | -0.76x |
| Forward P/EPrice ÷ next-FY EPS est. | — | — |
| PEG RatioP/E ÷ EPS growth rate | — | — |
| EV / EBITDAEnterprise value multiple | — | — |
| Price / SalesMarket cap ÷ Revenue | 23.38x | — |
| Price / BookPrice ÷ Book value/share | 2.78x | 0.66x |
| Price / FCFMarket cap ÷ FCF | 9.80x | — |
Evenly matched — SEPN and DBVT each lead in 1 of 2 comparable metrics.
Profitability & Efficiency
SEPN leads this category, winning 5 of 7 comparable metrics.
Profitability & Efficiency
SEPN delivers a -12.6% return on equity — every $100 of shareholder capital generates $-13 in annual profit, vs $-130 for DBVT. SEPN carries lower financial leverage with a 0.06x debt-to-equity ratio, signaling a more conservative balance sheet compared to DBVT's 0.13x. On the Piotroski fundamental quality scale (0–9), SEPN scores 5/9 vs DBVT's 4/9, reflecting solid financial health.
| Metric | SEPNSepterna, Inc. | DBVTDBV Technologies … |
|---|---|---|
| ROE (TTM)Return on equity | -12.6% | -130.2% |
| ROA (TTM)Return on assets | -9.5% | -89.0% |
| ROICReturn on invested capital | -20.8% | — |
| ROCEReturn on capital employed | -14.3% | -145.7% |
| Piotroski ScoreFundamental quality 0–9 | 5 | 4 |
| Debt / EquityFinancial leverage | 0.06x | 0.13x |
| Net DebtTotal debt minus cash | -$97M | -$172M |
| Cash & Equiv.Liquid assets | $121M | $194M |
| Total DebtShort + long-term debt | $24M | $22M |
| Interest CoverageEBIT ÷ Interest expense | — | -189.82x |
SEPN leads this category, winning 5 of 7 comparable metrics.
Total Returns (Dividends Reinvested)
Evenly matched — SEPN and DBVT each lead in 3 of 6 comparable metrics.
Total Returns (Dividends Reinvested)
A $10,000 investment in SEPN five years ago would be worth $11,206 today (with dividends reinvested), compared to $3,090 for DBVT. Over the past 12 months, SEPN leads with a +240.1% total return vs DBVT's +110.4%. The 3-year compound annual growth rate (CAGR) favors DBVT at 6.2% vs SEPN's 3.9% — a key indicator of consistent wealth creation.
| Metric | SEPNSepterna, Inc. | DBVTDBV Technologies … |
|---|---|---|
| YTD ReturnYear-to-date | -14.3% | +4.9% |
| 1-Year ReturnPast 12 months | +240.1% | +110.4% |
| 3-Year ReturnCumulative with dividends | +12.1% | +19.7% |
| 5-Year ReturnCumulative with dividends | +12.1% | -69.1% |
| 10-Year ReturnCumulative with dividends | +12.1% | -87.0% |
| CAGR (3Y)Annualised 3-year return | +3.9% | +6.2% |
Evenly matched — SEPN and DBVT each lead in 3 of 6 comparable metrics.
Risk & Volatility
DBVT leads this category, winning 2 of 2 comparable metrics.
Risk & Volatility
DBVT is the less volatile stock with a 1.26 beta — it tends to amplify market swings less than SEPN's 1.37 beta. A beta below 1.0 means the stock typically moves less than the S&P 500.
| Metric | SEPNSepterna, Inc. | DBVTDBV Technologies … |
|---|---|---|
| Beta (5Y)Sensitivity to S&P 500 | 1.37x | 1.26x |
| 52-Week HighHighest price in past year | $32.63 | $26.18 |
| 52-Week LowLowest price in past year | $6.44 | $7.53 |
| % of 52W HighCurrent price vs 52-week peak | +73.5% | +76.3% |
| RSI (14)Momentum oscillator 0–100 | 50.1 | 48.1 |
| Avg Volume (50D)Average daily shares traded | 303K | 252K |
DBVT leads this category, winning 2 of 2 comparable metrics.
Analyst Outlook
Insufficient data to determine a leader in this category.
Analyst Outlook
Wall Street rates SEPN as "Buy" and DBVT as "Buy". Consensus price targets imply 131.8% upside for DBVT (target: $46) vs 62.6% for SEPN (target: $39).
| Metric | SEPNSepterna, Inc. | DBVTDBV Technologies … |
|---|---|---|
| Analyst RatingConsensus buy/hold/sell | Buy | Buy |
| Price TargetConsensus 12-month target | $39.00 | $46.33 |
| # AnalystsCovering analysts | 6 | 15 |
| Dividend YieldAnnual dividend ÷ price | — | — |
| Dividend StreakConsecutive years of raises | — | 0 |
| Dividend / ShareAnnual DPS | — | — |
| Buyback YieldShare repurchases ÷ mkt cap | +0.0% | 0.0% |
Insufficient data to determine a leader in this category.
Key Takeaway
DBVT leads in 2 of 6 categories (Income & Cash Flow, Risk & Volatility). SEPN leads in 1 (Profitability & Efficiency). 2 tied.
Best OverallDBV Technologies S.A. (DBVT)Leads 2 of 6 categories
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SEPN vs DBVT: Frequently Asked Questions
8 questions · data-driven answers · updated daily
01Is SEPN or DBVT a better buy right now?
Analysts rate Septerna, Inc.
(SEPN) a "Buy" — based on 6 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.
02Which is the better long-term investment — SEPN or DBVT?
Over the past 5 years, Septerna, Inc.
(SEPN) delivered a total return of +12. 1%, compared to -69. 1% for DBV Technologies S. A. (DBVT). Over 10 years, the gap is even starker: SEPN returned +12. 1% versus DBVT's -87. 0%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.
03Which is safer — SEPN or DBVT?
By beta (market sensitivity over 5 years), DBV Technologies S.
A. (DBVT) is the lower-risk stock at 1. 26β versus Septerna, Inc. 's 1. 37β — meaning SEPN is approximately 9% more volatile than DBVT relative to the S&P 500. On balance sheet safety, Septerna, Inc. (SEPN) carries a lower debt/equity ratio of 6% versus 13% for DBV Technologies S. A. — giving it more financial flexibility in a downturn.
04Which is growing faster — SEPN or DBVT?
On earnings-per-share growth, the picture is similar: Septerna, Inc.
grew EPS 84. 8% year-over-year, compared to -347. 5% for DBV Technologies S. A.. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.
05Which has better profit margins — SEPN or DBVT?
DBV Technologies S.
A. (DBVT) is the more profitable company, earning 0. 0% net margin versus -106. 4% for Septerna, Inc. — meaning it keeps 0. 0% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: DBVT leads at 0. 0% versus -148. 6% for SEPN. At the gross margin level — before operating expenses — SEPN leads at 0. 0%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.
06Which pays a better dividend — SEPN or DBVT?
None of the stocks in this comparison currently pay a material dividend.
All are effectively zero-yield and should be held for capital appreciation rather than income.
07Is SEPN or DBVT better for a retirement portfolio?
For long-horizon retirement investors, DBV Technologies S.
A. (DBVT) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 1. 26)). Both have compounded well over 10 years (DBVT: -87. 0%, SEPN: +12. 1%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.
08What are the main differences between SEPN and DBVT?
Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.
In terms of investment character: SEPN is a small-cap high-growth stock; DBVT is a mega-cap quality compounder stock. These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.
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