SHPH vs AGEN

Analysts rate Agenus Inc.

(AGEN) a "Buy" — based on 11 analyst ratings — the highest consensus in this comparison. The "better buy" depends entirely on your goals: growth investors should weight revenue trajectory, value investors should weight P/E and PEG, and income investors should weight dividend yield and streak.

Over the past 5 years, Agenus Inc.

(AGEN) delivered a total return of -93. 9%, compared to -100. 0% for Shuttle Pharmaceuticals Holdings, Inc. (SHPH). Over 10 years, the gap is even starker: AGEN returned -94. 3% versus SHPH's -100. 0%. Past returns do not guarantee future results, and the stock with the higher historical return may already have its best growth priced in.

By beta (market sensitivity over 5 years), Shuttle Pharmaceuticals Holdings, Inc.

(SHPH) is the lower-risk stock at 1. 24β versus Agenus Inc. 's 2. 72β — meaning AGEN is approximately 120% more volatile than SHPH relative to the S&P 500.

On earnings-per-share growth, the picture is similar: Agenus Inc.

grew EPS 100. 0% year-over-year, compared to -2159. 3% for Shuttle Pharmaceuticals Holdings, Inc.. Higher growth typically commands a higher valuation multiple — check whether the premium P/E or P/S is justified by the growth rate using the PEG ratio.

Agenus Inc.

(AGEN) is the more profitable company, earning 0. 1% net margin versus 0. 0% for Shuttle Pharmaceuticals Holdings, Inc. — meaning it keeps 0. 1% of every revenue dollar as bottom-line profit. Operating margin tells a similar story: SHPH leads at 0. 0% versus -18. 0% for AGEN. At the gross margin level — before operating expenses — AGEN leads at 90. 3%, reflecting greater pricing power or product mix advantage. Stronger margins indicate durable pricing power, lower cost of revenue, or higher mix of software/services. They are one of the clearest signs of business quality.

None of the stocks in this comparison currently pay a material dividend.

All are effectively zero-yield and should be held for capital appreciation rather than income.

For long-horizon retirement investors, Shuttle Pharmaceuticals Holdings, Inc.

(SHPH) is the stronger choice — it scores higher on the combination of lower volatility, dividend reliability, and long-term compounding (low volatility (β 1. 24)). Agenus Inc. (AGEN) carries a higher beta of 2. 72 — meaning larger drawdowns in market downturns, which matters significantly when you cannot wait years for a recovery. Both have compounded well over 10 years (SHPH: -100. 0%, AGEN: -94. 3%), confirming both are viable long-term holds — but the lower-volatility option typically results in less emotional selling during corrections. Retirement portfolios generally favour predictability over maximum returns. Consult a financial advisor before making allocation decisions.

Both stocks operate in the Healthcare sector, making this a peer-level intra-sector comparison — the same macro tailwinds and headwinds will affect both.

These fundamental differences mean investors should not choose between them on a single metric — the "better stock" depends entirely on which of these characteristics aligns with your investment strategy.