Agios Pharmaceuticals, Inc. (AGIO) Earnings History
Net Loss15 years of earnings data (2011–2025) · Currently unprofitable on a TTM basis
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Agios Pharmaceuticals, Inc. (AGIO) Earnings Overview
As of June 22, 2026, Agios Pharmaceuticals, Inc. (AGIO) reported trailing twelve-month net income of -$423M, reflecting -161.2% year-over-year growth. The company earned $-7.19 per diluted share over the past four quarters, with a net profit margin of -764.0%.
Looking at the long-term picture, AGIO's historical earnings data spans multiple years. The company achieved its highest annual net income of $1.60B in fiscal 2021.
Agios Pharmaceuticals, Inc. is currently reporting a net loss, though operating performance should be evaluated in the context of growth investments and industry dynamics View revenue history →
Compared to peers including IONS (-$327M net income, -40.4% margin), PTCT (-$187M net income, 39.4% margin), RARE (-$609M net income, -85.4% margin), AGIO has room to improve margins relative to the peer group. Compare AGIO vs IONS →
AGIO Earnings vs Peers
Earnings metrics vs comparable public companies
AGIO Historical Earnings Data (2011–2025)
15 years| Fiscal Year | Net Income | YoY % | Operating Income | EPS (Diluted) | Net Margin | Op. Margin |
|---|---|---|---|---|---|---|
| 2025 | -$413M | -161.3% | -$472M | $-7.12 | -764.0% | -873.9% |
| 2024 | $674M | +291.4% | -$426M | $11.64 | 1845.9% | -1166.5% |
| 2023 | -$352M | -51.9% | -$391M | $-6.33 | -1312.6% | -1459.5% |
| 2022 | -$232M | -114.4% | -$389M | $-4.23 | -1627.8% | -2732.1% |
| 2021 | $1.60B | +590.2% | -$378M | $-6.36 | - | - |
| 2020 | -$327M | +20.4% | -$336M | $-4.74 | - | - |
| 2019 | -$411M | -18.9% | -$426M | $-6.61 | -349.0% | -361.6% |
| 2018 | -$346M | -10.0% | -$362M | $-6.03 | -366.6% | -384.0% |
| 2017 | -$315M | -58.5% | -$321M | $-6.75 | -731.6% | -745.8% |
| 2016 | -$198M | -68.6% | -$201M | $-5.07 | -284.0% | -287.6% |
| 2015 | -$118M | -120.0% | -$119M | $-3.15 | -199.1% | -200.8% |
| 2014 | -$54M | -35.8% | -$54M | $-1.59 | -81.9% | -82.8% |
| 2013 | -$39M | -96.0% | -$39M | $-2.56 | -154.2% | -152.2% |
| 2012 | -$20M | +15.2% | -$23M | $-0.86 | -80.1% | -91.6% |
| 2011 | -$24M | - | -$17M | $-1.01 | -108.6% | -76.2% |
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AGIO — Frequently Asked Questions
Quick answers to the most common questions about buying AGIO stock.
What is AGIO earnings per share (EPS)?
AGIO trailing twelve-month (TTM) diluted EPS is $-7.19, reflecting -161.2% year-over-year growth. The 5-year EPS CAGR is N/A. Complete EPS history from 2011 to 2025 is available in the table on this page.
What is Agios Pharmaceuticals, Inc.'s net income?
Agios Pharmaceuticals, Inc. (AGIO) trailing twelve-month net income is $-423M as of 2025. Earnings declined -161.2% year-over-year.
Is AGIO profitable?
AGIO is not currently profitable on a TTM basis, reporting a net loss of $-423M. Net margin is -764.0%. Investors should monitor for a return to profitability.
What is AGIO's earnings growth rate?
AGIO compound annual EPS growth rates (CAGR): 1-Year: N/A, 3-Year: N/A, 5-Year: N/A, 10-Year: N/A. These figures measure the annualised rate of diluted EPS growth over each period, based on data from 2011 to 2025.
What are AGIO's profit margins?
Agios Pharmaceuticals, Inc. net profit margin is -764.0%, operating margin is -873.9%, and gross margin is +78.7%. Below-average margins reflect competitive or cost pressures. Return on Equity is -30.2%.
Is AGIO growing earnings?
AGIO earnings are declining — EPS fell -161.2% year-over-year. TTM net income dropped to $-423M. This contrasts with the 5-year CAGR of N/A.
What was AGIO's best earnings year?
Agios Pharmaceuticals, Inc.'s highest annual net income on record is $1.6B, achieved in fiscal year 2021. Earnings history on this page spans 2011 to 2025 and includes all annual and quarterly figures.
What were AGIO's earnings last quarter?
AGIO's most recent reported quarter was Q1 2026. Net income was $-99M with diluted EPS of $-1.69. For a full breakdown of all quarters, see the quarterly earnings table on this page.