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CUE logoCue Biopharma, Inc.(CUE)Earnings, Financials & Key Ratios

CUE•NASDAQ
$35.73
$94M mkt cap·Price updated May 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryOncology Therapeutics Developers
AboutCue Biopharma, Inc., a clinical-stage biopharmaceutical company, develops biologic drugs for the selective modulation of the human immune system to treat a range of cancers, chronic infectious diseases, and autoimmune disorders. Its lead drug candidate is CUE-101, a fusion protein biologic that is in Phase 1b clinical trial designed to target and activate antigen-specific T cells for human papilloma virus-driven cancers. The company offers CUE-102, a fusion protein biologic to target and activate antigen-specific T cells to fight cancers; CUE-103 a CUE-100 series Immuno-STAT targeting the KRAS G12V mutation, including colorectal carcinoma, lung cancer, and pancreatic cancer; CUE-200 that focuses on cell surface receptors, including CD80 and/or 4-1BBL to address T cell exhaustion associated with chronic infections; and CUE-300 and CUE-400 framework to target various autoimmune diseases. Cue Biopharma, Inc. has collaboration agreements with Merck Sharp & Dohme Corp. for the research and development of its proprietary biologics that target various autoimmune disease indications; LG Chem Life Sciences for the development of Immuno-STATs focused on the field of oncology; and Albert Einstein College of Medicine. The company was formerly known as Imagen Biopharma, Inc. and changed its name to Cue Biopharma, Inc. in October 2016. Cue Biopharma, Inc. was incorporated in 2014 and is headquartered in Cambridge, Massachusetts.Show more
  • Revenue$27M+195.7%
  • EBITDA-$23M+41.1%
  • Net Income-$27M+34.6%
  • EPS (Diluted)-8.40+61.1%
  • Gross Margin87.33%-12.7%
  • EBITDA Margin-84%+80.1%
  • Operating Margin-96.67%+78.4%
  • Net Margin-96.85%+77.9%
  • ROE-121.11%+18.7%
  • ROIC-537.56%+38.0%
  • Debt/Equity0.16-68.7%
  • Interest Coverage-74.29-48.3%
Technical→

CUE Key Insights

Cue Biopharma, Inc. (CUE) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Momentum leader: RS Rating 98 (top 2%)
  • ✓Strong 5Y sales CAGR of 54.2%

✗Weaknesses

  • ✗Negative free cash flow
  • ✗Shares diluted 68.2% in last year

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

CUE Price & Volume

Cue Biopharma, Inc. (CUE) stock price & volume — 10-year historical chart

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CUE Growth Metrics

Cue Biopharma, Inc. (CUE) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years54.16%
3 Years180.46%
TTM195.75%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM34.6%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM57.56%

Return on Capital

10 Years-79.94%
5 Years-91.19%
3 Years-109.43%
Last Year-112.46%

CUE Peer Comparison

Cue Biopharma, Inc. (CUE) competitors in Oncology Therapeutics Developers — business model, growth, and fundamentals comparison

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Stock Universe
Valuation
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Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
IMVT logoIMVTImmunovant, Inc.Direct Competitor5.53B27.22-9.97-47.07%0.00
AGIO logoAGIOAgios Pharmaceuticals, Inc.Direct Competitor1.64B27.53-3.8748.03%-6.4%-34.11%0.05
KYMR logoKYMRKymera Therapeutics, Inc.Direct Competitor6.91B84.63-22.94-16.72%-6.12%-25.02%0.05
RCUS logoRCUSArcus Biosciences, Inc.Direct Competitor2.5B24.80-7.54-4.26%-156.36%-68.97%0.16
TGTX logoTGTXTG Therapeutics, Inc.Direct Competitor6.87B43.0315.5387.32%65.95%87.36%0.40
NKTR logoNKTRNektar TherapeuticsDirect Competitor1.69B83.37-8.57-43.89%-297.07%-399.1%1.66
AGEN logoAGENAgenus Inc.Product Competitor132.45M3.75-1102.9410.37%0.1%
FATE logoFATEFate Therapeutics, Inc.Product Competitor280.32M2.43-2.11-51.24%-20.51%-65.79%0.38

Compare CUE vs Peers

Cue Biopharma, Inc. (CUE) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs IMVT

Most directly comparable listed peer for CUE.

Scale Benchmark

vs MRK

Larger-name benchmark to compare CUE against a more recognizable public peer.

Peer Set

Compare Top 5

vs IMVT, AGIO, KYMR, RCUS

CUE Income Statement

Cue Biopharma, Inc. (CUE) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Sales/Revenue01.14M3.46M3.15M14.94M1.25M5.49M9.29M27.47M
Revenue Growth %--202.67%-8.79%373.68%-91.67%340.96%69.16%195.75%
Cost of Goods Sold419.57K28.54M27.49M33.55M-1.78M038.1M03.48M
COGS % of Revenue-2498.16%794.82%1063.48%-11.9%-693.93%-12.67%
Gross Profit
-419.57K▲ 0%
-27.4M▼ 6430.9%
-24.03M▲ 12.3%
-30.39M▼ 26.5%
16.72M▲ 155.0%
1.25M▼ 92.6%
-32.61M▼ 2719.0%
9.29M▲ 128.5%
23.99M▲ 158.3%
Gross Margin %--2398.16%-694.82%-963.48%111.9%100%-593.93%100%87.33%
Gross Profit Growth %-107.62%-6430.87%12.31%-26.48%155.01%-92.55%-2719.04%128.48%158.28%
Operating Expenses23.23M39.84M12.74M14.65M60.43M54.47M19.54M50.79M50.51M
OpEx % of Revenue-3486.71%368.39%464.48%404.46%4375.1%355.96%546.86%183.89%
Selling, General & Admin4.33M11.3M12.74M14.65M17.31M16.17M16.68M14.59M16.24M
SG&A % of Revenue-988.55%368.39%464.48%115.83%1298.71%303.83%157.05%59.14%
Research & Development18.9M28.54M27.49M33.55M41.35M38.58M40.8M36.3M37.74M
R&D % of Revenue-2498.16%794.82%1063.48%276.73%3098.63%743.21%390.82%137.42%
Other Operating Expenses0165.34K-27.49M-33.55M1.78M-277K-37.94M-93K-3.48M
Operating Income
-23.23M▲ 0%
-38.7M▼ 66.6%
-36.77M▲ 5.0%
-45.04M▼ 22.5%
-43.71M▲ 3.0%
-53.23M▼ 21.8%
-52.15M▲ 2.0%
-41.5M▲ 20.4%
-26.55M▲ 36.0%
Operating Margin %--3386.71%-1063.21%-1427.96%-292.56%-4275.1%-949.89%-446.86%-96.67%
Operating Income Growth %-203.38%-66.55%4.98%-22.5%2.95%-21.76%2.02%20.42%36.02%
EBITDA-22.81M-37.94M-35.96M-43.99M-45.49M-51.42M-48.71M-39.15M-23.07M
EBITDA Margin %--3320.19%-1039.76%-1394.44%-304.46%-4130.04%-887.3%-421.56%-84%
EBITDA Growth %-205.98%-66.28%5.21%-22.32%-3.42%-13.03%5.26%19.63%41.07%
D&A (Non-Cash Add-back)419.57K760.01K810.78K1.06M-1.78M1.81M3.44M2.35M3.48M
EBIT-23.23M-38.7M-36.77M-45.04M-43.67M-52.3M-49.49M-39.88M-26.52M
Net Interest Income0376.01K482.79K463.91K45.9K215K1.42M826K450K
Interest Income35376.01K419K463.91K45.9K928.24K2.66M1.62M807K
Interest Expense00000713.82K1.25M796K357K
Other Income/Expense35541.35K482.79K463.91K45.9K215K1.42M826K419K
Pretax Income
-23.23M▲ 0%
-38.16M▼ 64.2%
-36.29M▲ 4.9%
-44.58M▼ 22.9%
-43.67M▲ 2.0%
-53.01M▼ 21.4%
-50.73M▲ 4.3%
-40.67M▲ 19.8%
-26.1M▲ 35.8%
Pretax Margin %--3339.33%-1049.25%-1413.26%-292.25%-4257.83%-924.1%-437.97%-95.03%
Income Tax0825K412.5K206.25K495K000500K
Effective Tax Rate %0%-2.16%-1.14%-0.46%-1.13%0%0%0%-1.92%
Net Income
-23.23M▲ 0%
-38.98M▼ 67.8%
-36.7M▲ 5.9%
-44.78M▼ 22.0%
-44.16M▲ 1.4%
-53.01M▼ 20.0%
-50.73M▲ 4.3%
-40.67M▲ 19.8%
-26.6M▲ 34.6%
Net Margin %--3411.53%-1061.18%-1419.79%-295.56%-4257.83%-924.1%-437.97%-96.85%
Net Income Growth %-203.38%-67.77%5.85%-22.03%1.39%-20.04%4.3%19.83%34.6%
Net Income (Continuing)-23.23M-38.98M-36.7M-44.78M-44.16M-53.01M-50.73M-40.67M-26.6M
Discontinued Operations000000000
Minority Interest000000000
EPS (Diluted)
-33.90▲ 0%
-58.20▼ 71.7%
-49.80▲ 14.4%
-46.80▲ 6.0%
-42.30▲ 9.6%
-44.70▼ 5.7%
-33.30▲ 25.5%
-21.60▲ 35.1%
-8.40▲ 61.1%
EPS Growth %-205.41%-71.68%14.43%6.02%9.62%-5.67%25.5%35.14%61.11%
EPS (Basic)-33.90-58.20-49.80-46.80-42.30-44.70-33.30-21.60-8.40
Diluted Shares Outstanding688.02K671.13K734.73K956.29K1.04M1.19M1.53M1.88M3.16M
Basic Shares Outstanding688.02K671.13K734.73K956.29K1.04M1.19M1.53M1.88M3.16M
Dividend Payout Ratio---------

CUE Balance Sheet

Cue Biopharma, Inc. (CUE) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Total Current Assets65.07M40.61M61.02M87.53M68.47M77.19M51.45M25.14M36.98M
Cash & Short-Term Investments63.58M39.21M59.41M84.87M64.37M76.29M48.51M23.39M27.14M
Cash Only63.53M20.8M44.29M74.87M64.37M51.61M48.51M22.46M27.14M
Short-Term Investments50.07K18.41M15.12M10M024.68M0929K0
Accounts Receivable00754.9K1.42M3.14M57K1.7M945K7.45M
Days Sales Outstanding--79.67164.0276.7716.71112.8937.1498.94
Inventory225.5K00000000
Days Inventory Outstanding196.17--------
Other Current Assets453.49K104.07K000841K1.24M02.4M
Total Non-Current Assets1.89M4.75M10.58M12.01M14.93M14.1M10.08M7.05M5.23M
Property, Plant & Equipment1.69M2.78M7.18M8.88M11.92M10.7M7.12M4.84M4.32M
Fixed Asset Turnover-0.41x0.48x0.36x1.25x0.12x0.77x1.92x6.37x
Goodwill000000000
Intangible Assets175K011.67K000000
Long-Term Investments0150K00150K0151K0154K
Other Non-Current Assets23.28K1.82M3.38M3.12M2.86M3.39M2.81M2.21M760K
Total Assets
66.95M▲ 0%
45.36M▼ 32.2%
71.61M▲ 57.8%
99.53M▲ 39.0%
83.4M▼ 16.2%
91.28M▲ 9.5%
61.53M▼ 32.6%
32.19M▼ 47.7%
42.21M▲ 31.1%
Asset Turnover-0.03x0.05x0.03x0.18x0.01x0.09x0.29x0.65x
Asset Growth %311.3%-32.25%57.85%39%-16.21%9.45%-32.59%-47.68%31.13%
Total Current Liabilities5.35M6.22M11.66M16.32M12.79M11.55M17.08M13.69M13.49M
Accounts Payable1.33M2.04M882.67K2.07M2.59M2.73M3.5M2.82M3.95M
Days Payables Outstanding1.16K26.0311.7222.53-531.84-33.54-414.09
Short-Term Debt00001.97M1.96M3.96M4.33M0
Deferred Revenue (Current)623.85K2.01M06.68M645.35K02.11M00
Other Current Liabilities2.54M1.58M4.1M1.96M38.31K2.27M1.92M85K7.63M
Current Ratio12.17x6.53x5.24x5.36x5.35x6.68x3.01x1.84x2.74x
Quick Ratio12.13x6.53x5.24x5.36x5.35x6.68x3.01x1.84x2.74x
Cash Conversion Cycle---------
Total Non-Current Liabilities05.17M5.37M4.31M5.12M14.05M7.36M1M2.29M
Long-Term Debt000008.04M4.2M00
Capital Lease Obligations001.35M2.37M5.12M6.02M3.16M1M2.29M
Deferred Tax Liabilities000000000
Other Non-Current Liabilities004.02M000010
Total Liabilities5.35M11.39M17.02M20.62M17.91M25.6M24.45M14.69M15.78M
Total Debt2.5M05.8M7.15M12.02M19.32M14.7M8.88M4.2M
Net Debt-61.03M-20.8M-38.49M-67.72M-52.35M-32.3M-33.82M-13.58M-22.94M
Debt / Equity0.04x-0.11x0.09x0.18x0.29x0.40x0.51x0.16x
Debt / EBITDA---------
Net Debt / EBITDA---------
Interest Coverage------73.26x-39.75x-50.10x-74.29x
Total Equity
61.61M▲ 0%
33.97M▼ 44.9%
54.58M▲ 60.7%
78.91M▲ 44.6%
65.49M▼ 17.0%
65.68M▲ 0.3%
37.09M▼ 43.5%
17.5M▼ 52.8%
26.43M▲ 51.0%
Equity Growth %305.99%-44.86%60.68%44.57%-17.01%0.29%-43.54%-52.81%51.05%
Book Value per Share89.5450.6274.2982.5262.8055.2724.329.328.37
Total Shareholders' Equity61.61M33.97M54.58M78.91M65.49M65.68M37.09M17.5M26.43M
Common Stock20.13K20.7K26.56K30.35K32.2K43K47K62K97K
Retained Earnings-32.82M-71.8M-108.5M-153.29M-197.45M-250.46M-301.19M-341.86M-368.47M
Treasury Stock000000000
Accumulated OCI-661.15K-10.96K-10.32K7.13K0-96K000
Minority Interest000000000

CUE Cash Flow Statement

Cue Biopharma, Inc. (CUE) cash flow — operating, investing & free cash flow history

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Cash from Operations-12.19M-26.41M-30.8M-32.49M-38.84M-41.81M-39.96M-36.33M-21.69M
Operating CF Margin %--2311.47%-890.51%-1030.14%-259.93%-3357.91%-727.89%-391.18%-78.96%
Operating CF Growth %-104.27%-116.63%-16.61%-5.51%-19.52%-7.64%4.41%9.09%40.3%
Net Income-23.23M-38.98M-36.7M-44.78M-44.16M-53.01M-50.73M-40.67M-26.6M
Depreciation & Amortization419.57K760.01K5.17M-3.15M-1.78M1.81M3.44M2.35M958K
Stock-Based Compensation2.78M7.17M6.52M10.48M11.52M9.5M8.18M6.85M4.74M
Deferred Taxes10.68K79.86K-18.19K000000
Other Non-Cash Items4.93M345.1K-4.28M-479.54K-26.13K-454K90K74K2.51M
Working Capital Changes2.91M4.21M-1.49M5.43M-4.39M356K-934K-4.92M-3.29M
Change in Receivables00-754.9K-662.58K-1.73M3.08M-1.64M753K-6.5M
Change in Inventory00-509.8K000000
Change in Payables561.59K376.15K-1.15M741.26K520.4K83K770K-678K1.13M
Cash from Investing-1.2M-20.35M3.45M4.46M9.11M-24.61M25M32K75K
Capital Expenditures-1.2M-1.85M-46.35K-595.26K-913.04K-171K0-66K-177K
CapEx % of Revenue-162.28%1.34%18.87%6.11%13.73%-0.71%0.64%
Acquisitions00127.5K0000040K
Investments---------
Other Investing-35-18.5M0021.55K6K2K98K212K
Cash from Financing62M4.18M50.79M58.61M19.23M53.66M11.86M10.24M26.29M
Debt Issued (Net)0000010M-2M-4M-4.5M
Equity Issued (Net)62M4.17M49M56.68M17.38M39.3M13.39M14.22M30.79M
Dividends Paid000000000
Share Repurchases-4.16M0-91.03K000000
Other Financing9.01K12.5K1.79M1.93M1.85M4.36M473K18K0
Net Change in Cash
48.61M▲ 0%
-42.58M▼ 187.6%
23.44M▲ 155.0%
30.58M▲ 30.4%
-10.5M▼ 134.3%
-12.76M▼ 21.5%
-3.1M▲ 75.7%
-26.05M▼ 740.7%
4.68M▲ 118.0%
Free Cash Flow
-13.4M▲ 0%
-28.27M▼ 111.0%
-30.84M▼ 9.1%
-33.09M▼ 7.3%
-39.75M▼ 20.1%
-41.98M▼ 5.6%
-39.96M▲ 4.8%
-36.4M▲ 8.9%
-21.86M▲ 39.9%
FCF Margin %--2473.75%-891.85%-1049.01%-266.04%-3371.65%-727.89%-391.89%-79.6%
FCF Growth %-106.6%-110.99%-9.12%-7.28%-20.13%-5.6%4.8%8.92%39.93%
FCF per Share-19.47-42.12-41.98-34.60-38.12-35.33-26.20-19.38-6.92
FCF Conversion (FCF/Net Income)0.52x0.68x0.84x0.73x0.88x0.79x0.79x0.89x0.82x
Interest Paid00000570K1M669K0
Taxes Paid0825K412.5K000000

CUE Key Ratios

Cue Biopharma, Inc. (CUE) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric2016201720182019202020212022202320242025
Return on Equity (ROE)-69.27%-60.52%-81.57%-82.88%-67.1%-61.16%-80.82%-98.73%-149.03%-121.11%
Return on Invested Capital (ROIC)-1469.1%-4237.96%-422.31%-188.49%-247.66%-269.45%-171.6%-213.43%-866.75%-537.56%
Gross Margin---2398.16%-694.82%-963.48%111.9%100%-593.93%100%87.33%
Net Margin---3411.53%-1061.18%-1419.79%-295.56%-4257.83%-924.1%-437.97%-96.85%
Debt / Equity-0.04x-0.11x0.09x0.18x0.29x0.40x0.51x0.16x
Interest Coverage-------73.26x-39.75x-50.10x-74.29x
FCF Conversion0.78x0.52x0.68x0.84x0.73x0.88x0.79x0.79x0.89x0.82x
Revenue Growth---202.67%-8.79%373.68%-91.67%340.96%69.16%195.75%

CUE Frequently Asked Questions

Cue Biopharma, Inc. (CUE) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Cue Biopharma, Inc. (CUE) reported $27.5M in revenue for fiscal year 2025.

Cue Biopharma, Inc. (CUE) grew revenue by 195.7% over the past year. This is strong growth.

Cue Biopharma, Inc. (CUE) reported a net loss of $26.6M for fiscal year 2025.

Dividend & Returns

Cue Biopharma, Inc. (CUE) has a return on equity (ROE) of -121.1%. Negative ROE indicates the company is unprofitable.

Cue Biopharma, Inc. (CUE) had negative free cash flow of $21.9M in fiscal year 2025, likely due to heavy capital investments.

Explore More CUE

Cue Biopharma, Inc. (CUE) financial analysis — history, returns, DCA and operating performance tools

Total Return Calculator

Historical returns with dividends reinvested

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DCA Calculator

Dollar cost averaging vs lump sum

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Dividend History

Yield, growth, payout safety & DRIP

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Earnings History

EPS trends, net income & profitability

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Price History

Long-term charts & historical price data

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Revenue History

Sales growth patterns & revenue breakdown

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Financial Ratios

30 years of market, efficiency and balance-sheet ratios

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Valuation

DCF intrinsic value, peer multiples & estimates

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