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CYCN logoCyclerion Therapeutics, Inc.(CYCN)Earnings, Financials & Key Ratios

CYCN•NASDAQ
$3.24
$14M mkt cap·Price updated May 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryNeuroscience and Psychiatry Therapies
AboutCyclerion Therapeutics, Inc., a clinical-stage biopharmaceutical company, engages in the discovering, development, and commercialization of medicines for serious central nervous system (CNS) diseases. Its lead product candidate is CY6463, a CNS-penetrant, soluble guanylate cyclase (sGC) stimulator that is in Phase IIa trials for the treatment of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes, as well as Alzheimer's disease with vascular pathology; and Phase 1 trials diagnosed with schizophrenia in adults. It is also developing Praliciguat, an orally administered systemic sGC stimulator, which is in Phase II studies to treat resistant hypertension and diabetic nephropathy; Olinciguat, an orally administered vascular sGC stimulator that is in Phase II studies for the sickle cell disease; and CY3018 for the treatment of disorders of the CNS. It has license agreement with Akebia Therapeutics, Inc. for the development, manufacture, medical affairs, and commercialization of pharmaceutical products, including pharmaceutical compound, and other related products and forms. The company was incorporated in 2018 and is headquartered in Cambridge, Massachusetts.Show more
  • Revenue$2M+3.7%
  • EBITDA-$5M-37.1%
  • Net Income-$4M-15.4%
  • EPS (Diluted)-1.09+9.9%
  • Gross Margin100%
  • EBITDA Margin-239.78%-32.2%
  • Operating Margin-239.78%-32.2%
  • Net Margin-170.11%-11.3%
  • ROE-39.34%-29.6%
  • ROIC-65.07%-11.6%
Technical→

CYCN Key Insights

Cyclerion Therapeutics, Inc. (CYCN) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Strong 5Y profit CAGR of 46.1%
  • ✓Momentum leader: RS Rating 96 (top 4%)
  • ✓Trading at only 1.2x book value

✗Weaknesses

  • ✗Weak Piotroski F-Score: 1/9
  • ✗Negative free cash flow
  • ✗Shares diluted 28.1% in last year
  • ✗Trading more than 30% below 52-week high
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

CYCN Price & Volume

Cyclerion Therapeutics, Inc. (CYCN) stock price & volume — 10-year historical chart

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CYCN Growth Metrics

Cyclerion Therapeutics, Inc. (CYCN) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-2.01%
3 Years91.14%
TTM3.7%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-15.41%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM0.81%

Return on Capital

10 Years-81.22%
5 Years-69.81%
3 Years-70.21%
Last Year-55.46%

CYCN Peer Comparison

Cyclerion Therapeutics, Inc. (CYCN) competitors in Neuroscience and Psychiatry Therapies — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
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Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
ADMA logoADMAADMA Biologics, Inc.Direct Competitor2.46B10.0816.8019.63%28.8%34.98%0.17
IMVT logoIMVTImmunovant, Inc.Direct Competitor5.83B28.67-10.50-47.07%0.00
KALA logoKALAKALA BIO, Inc.Direct Competitor855.53K0.12-0.02-141.11%-388.29%2.62
PRTA logoPRTAProthena Corporation plcDirect Competitor601.85M11.18-2.47-92.84%-25.21%-73%0.05
MNKD logoMNKDMannKind CorporationProduct Competitor1.1B3.5617822.23%-6.63%
AGIO logoAGIOAgios Pharmaceuticals, Inc.Product Competitor1.6B26.98-3.7948.03%-6.4%-34.11%0.05
RARE logoRAREUltragenyx Pharmaceutical Inc.Product Competitor2.55B25.93-4.4520.13%-91.03%-6.08%
FOLD logoFOLDAmicus Therapeutics, Inc.Product Competitor4.47B14.49-80.5032.29%-2.35%-6.1%2.29

Compare CYCN vs Peers

Cyclerion Therapeutics, Inc. (CYCN) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs ADMA

Most directly comparable listed peer for CYCN.

Scale Benchmark

vs ABBV

Larger-name benchmark to compare CYCN against a more recognizable public peer.

Peer Set

Compare Top 5

vs ADMA, IMVT, KALA, PRTA

CYCN Income Statement

Cyclerion Therapeutics, Inc. (CYCN) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Sales/Revenue004.51M2.3M3.32M297K02M2.07M
Revenue Growth %----49.06%44.6%-91.05%-100%-3.7%
Cost of Goods Sold1.75M1.53M95.14M56.41M05.58M000
COGS % of Revenue--2110.94%2457.06%-1878.45%---
Gross Profit
-1.75M▲ 0%
-1.53M▲ 12.4%
-90.63M▼ 5831.5%
-54.12M▲ 40.3%
3.32M▲ 106.1%
-5.28M▼ 259.1%
0▲ 100.0%
2M▲ 0%
2.07M▲ 3.7%
Gross Margin %---2010.94%-2357.06%100%-1778.45%-100%100%
Gross Profit Growth %-12.44%-5831.48%40.29%106.13%-259.1%100%-3.7%
Operating Expenses93.92M115.25M34.4M27.15M58.52M13.26M12.95M5.63M7.05M
OpEx % of Revenue--763.35%1182.36%1762.5%4463.97%-281.4%339.78%
Selling, General & Admin15.12M27.54M34.4M28.82M20.62M13.26M8.33M5.34M6.09M
SG&A % of Revenue--763.35%1255.05%621.08%4463.97%-267.1%293.54%
Research & Development78.8M87.72M95.14M56.41M37.64M5.98M1.51M286K959K
R&D % of Revenue--2110.94%2457.06%1133.61%2013.13%-14.3%46.24%
Other Operating Expenses00-95.14M-58.08M259K-5.98M3.1M00
Operating Income
-93.92M▲ 0%
-115.25M▼ 22.7%
-125.04M▼ 8.5%
-81.27M▲ 35.0%
-55.2M▲ 32.1%
-18.54M▲ 66.4%
-12.95M▲ 30.1%
-3.63M▲ 72.0%
-4.97M▼ 37.1%
Operating Margin %---2774.28%-3539.42%-1662.5%-6242.42%--181.4%-239.78%
Operating Income Growth %--22.71%-8.49%35.01%32.08%66.41%30.15%71.99%-37.07%
EBITDA-92.18M-113.72M-122.34M-78.97M-54.72M-18.48M-12.89M-3.63M-4.97M
EBITDA Margin %---2714.38%-3439.37%-1648.28%-6220.54%--181.4%-239.78%
EBITDA Growth %--23.38%-7.57%35.45%30.7%66.24%30.25%71.85%-37.07%
D&A (Non-Cash Add-back)1.75M1.53M2.7M2.3M472K65K65K00
EBIT-93.92M-115.25M-125.04M-82.93M-54.31M-18.54M-9.65M-3.63M-4.97M
Net Interest Income002.03M588K-16K294K358K208K128K
Interest Income002.03M588K0294K358K208K128K
Interest Expense000016K0000
Other Income/Expense002.03M3.46M3.55M294K358K571K1.45M
Pretax Income
-93.92M▲ 0%
-115.25M▼ 22.7%
-123.01M▼ 6.7%
-77.8M▲ 36.8%
-51.65M▲ 33.6%
-18.25M▲ 64.7%
-12.59M▲ 31.0%
-3.06M▲ 75.7%
-3.53M▼ 15.4%
Pretax Margin %---2729.27%-3388.59%-1555.63%-6143.43%--152.85%-170.11%
Income Tax000000000
Effective Tax Rate %0%0%0%0%0%0%0%0%0%
Net Income
-93.92M▲ 0%
-115.25M▼ 22.7%
-123.01M▼ 6.7%
-77.8M▲ 36.8%
-51.65M▲ 33.6%
-44.08M▲ 14.7%
-5.26M▲ 88.1%
-3.06M▲ 41.9%
-3.53M▼ 15.4%
Net Margin %---2729.27%-3388.59%-1555.63%-14841.08%--152.85%-170.11%
Net Income Growth %--22.71%-6.73%36.75%33.62%14.66%88.06%41.92%-15.41%
Net Income (Continuing)-93.92M-115.25M-123.01M-77.8M-51.65M-18.25M-12.59M-3.06M-3.53M
Discontinued Operations00000-25.83M7.33M00
Minority Interest000000000
EPS (Diluted)
-68.80▲ 0%
-84.42▼ 22.7%
-88.37▼ 4.7%
-47.80▲ 45.9%
-26.40▲ 44.8%
-20.15▲ 23.7%
-8.99▲ 55.4%
-1.21▲ 86.5%
-1.09▲ 9.9%
EPS Growth %--22.7%-4.68%45.91%44.77%23.67%55.38%86.54%9.92%
EPS (Basic)-68.80-84.42-88.37-47.80-26.40-20.15-8.99-1.21-1.09
Diluted Shares Outstanding1.37M1.37M1.37M1.52M1.96M2.17M2.34M2.52M3.23M
Basic Shares Outstanding1.37M1.37M1.37M1.52M1.96M2.17M2.34M2.52M3.23M
Dividend Payout Ratio---------

CYCN Balance Sheet

Cyclerion Therapeutics, Inc. (CYCN) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Total Current Assets1.26M879K101.2M58.5M55.46M14.82M8.02M4.22M4.63M
Cash & Short-Term Investments0097.59M54.4M53.96M13.38M7.57M3.23M3.24M
Cash Only0097.59M54.4M53.96M13.38M7.57M3.23M3.24M
Short-Term Investments000000000
Accounts Receivable001.47M127K100K96K0556K1M
Days Sales Outstanding--119.3720.1910.99117.98-101.47175.99
Inventory0000928K0000
Days Inventory Outstanding---------
Other Current Assets8K12K162K1.56M468K537K11K16K11K
Total Non-Current Assets4.21M6.52M85.28M56.88M3.87M3.26M5.35M5.35M5.35M
Property, Plant & Equipment4.13M6.5M79.75M50.27M1.47M1.22M000
Fixed Asset Turnover--0.06x0.05x2.26x0.24x---
Goodwill000000000
Intangible Assets000000000
Long-Term Investments004.99M0005.35M5.35M5.35M
Other Non-Current Assets80K25K540K6.61M2.41M2.04M000
Total Assets
5.47M▲ 0%
7.4M▲ 35.3%
186.48M▲ 2419.6%
115.38M▼ 38.1%
59.33M▼ 48.6%
18.08M▼ 69.5%
13.37M▼ 26.0%
9.57M▼ 28.4%
9.98M▲ 4.3%
Asset Turnover--0.02x0.02x0.06x0.02x-0.21x0.21x
Asset Growth %-35.3%2419.63%-38.13%-48.58%-69.53%-26.02%-28.41%4.28%
Total Current Liabilities14.04M17.85M18.25M16.95M11.09M7.63M2.09M725K900K
Accounts Payable1.8M2.78M3.31M1.15M1.83M2.97M1.2M390K508K
Days Payables Outstanding376.92664.3112.77.43-194.31---
Short-Term Debt003.42M3.51M00000
Deferred Revenue (Current)000000000
Other Current Liabilities5.62M7.27M5.05M176K7.28M68K102K63K51K
Current Ratio0.09x0.05x5.55x3.45x5.00x1.94x3.85x5.83x5.15x
Quick Ratio0.09x0.05x5.55x3.45x4.92x1.94x3.85x5.83x5.15x
Cash Conversion Cycle---------
Total Non-Current Liabilities0070.5M38.93M00000
Long-Term Debt000000000
Capital Lease Obligations0070.5M38.93M00000
Deferred Tax Liabilities000000000
Other Non-Current Liabilities000000000
Total Liabilities14.04M17.85M88.75M55.88M11.09M7.63M2.09M725K900K
Total Debt0073.92M45.73M00000
Net Debt00-23.68M-8.66M-53.96M-13.38M-7.57M-3.23M-3.24M
Debt / Equity--0.76x0.77x-----
Debt / EBITDA---------
Net Debt / EBITDA---------
Interest Coverage-----3394.63x----
Total Equity
-8.57M▲ 0%
-10.45M▼ 21.9%
97.73M▲ 1035.7%
59.49M▼ 39.1%
48.25M▼ 18.9%
10.45M▼ 78.3%
11.29M▲ 8.0%
8.85M▼ 21.6%
9.09M▲ 2.7%
Equity Growth %--21.92%1035.65%-39.12%-18.9%-78.34%8%-21.6%2.66%
Book Value per Share-6.28-7.6571.3939.1424.654.814.833.512.82
Total Shareholders' Equity-8.57M-10.45M97.73M59.49M48.25M10.45M11.29M8.85M9.09M
Common Stock000000000
Retained Earnings00-85.63M-163.43M-215.08M-259.15M-264.42M-267.49M-271.02M
Treasury Stock000000000
Accumulated OCI-15.87M-15.49M-20K-27K-23K-20K-12K00
Minority Interest000000000

CYCN Cash Flow Statement

Cyclerion Therapeutics, Inc. (CYCN) cash flow — operating, investing & free cash flow history

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Cash from Operations-81.22M-97.5M-102.22M-72.49M-36.52M-40.61M-21.25M-4.33M-3.31M
Operating CF Margin %---2267.92%-3157.23%-1099.91%-13673.74%--216.65%-159.79%
Operating CF Growth %--20.05%-4.83%29.08%49.62%-11.21%47.69%79.6%23.52%
Net Income-93.92M-115.25M-123.01M-77.8M-51.65M-18.25M-12.59M-3.06M-3.53M
Depreciation & Amortization1.75M1.53M2.7M2.3M472K65K000
Stock-Based Compensation9.49M12.43M19.63M14.99M9.61M00625K441K
Deferred Taxes000000000
Other Non-Cash Items12.59M14.51M751K-4.38M3.64M-19.58M-4.05M-363K0
Working Capital Changes1.47M3.79M-2.29M-7.59M1.41M-2.85M-4.6M-1.54M-227K
Change in Receivables00-1.47M1.35M27K4K96K-556K-444K
Change in Inventory00-3.18M000000
Change in Payables392K979K-250K-1.1M393K1.14M-1.77M-445K118K
Cash from Investing-1.4M-3.44M-6.71M18K1.46M010.4M00
Capital Expenditures-1.4M-3.44M-6.89M-1.52M-7K0000
CapEx % of Revenue--152.83%66.38%0.21%----
Acquisitions00173K00010.4M00
Investments---------
Other Investing00173K1.54M1.46M0000
Cash from Financing82.62M100.94M211.57M28.09M30.79M29K5.02M03.32M
Debt Issued (Net)0003.51M00000
Equity Issued (Net)00175M24.25M30.5M29K5.02M01.25M
Dividends Paid000000000
Share Repurchases00000000-130K
Other Financing82.62M100.94M36.57M331K282K0002.08M
Net Change in Cash
0▲ 0%
0▲ 0%
102.62M▲ 0%
-44.39M▼ 143.3%
-4.27M▲ 90.4%
-40.58M▼ 850.1%
-5.81M▲ 85.7%
-4.34M▲ 25.3%
8K▲ 100.2%
Free Cash Flow
-82.62M▲ 0%
-100.94M▼ 22.2%
-109.1M▼ 8.1%
-74.01M▲ 32.2%
-36.52M▲ 50.7%
-40.61M▼ 11.2%
-21.25M▲ 47.7%
-4.33M▲ 79.6%
-3.31M▲ 23.5%
FCF Margin %---2420.75%-3223.61%-1100.12%-13673.74%--216.65%-159.79%
FCF Growth %--22.17%-8.09%32.16%50.65%-11.19%47.69%79.6%23.52%
FCF per Share-60.52-73.94-79.70-48.69-18.66-18.69-9.09-1.72-1.03
FCF Conversion (FCF/Net Income)0.86x0.85x0.83x0.93x0.71x0.92x4.04x1.42x0.94x
Interest Paid000000000
Taxes Paid000000000

CYCN Key Ratios

Cyclerion Therapeutics, Inc. (CYCN) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025
Return on Equity (ROE)---281.86%-98.97%-95.87%-150.19%-48.42%-30.36%-39.34%
Return on Invested Capital (ROIC)---294.86%-97.61%-183.5%--2468.42%-58.3%-65.07%
Gross Margin---2010.94%-2357.06%100%-1778.45%-100%100%
Net Margin---2729.27%-3388.59%-1555.63%-14841.08%--152.85%-170.11%
Debt / Equity--0.76x0.77x-----
Interest Coverage-----3394.63x----
FCF Conversion0.86x0.85x0.83x0.93x0.71x0.92x4.04x1.42x0.94x
Revenue Growth----49.06%44.6%-91.05%-100%-3.7%

CYCN SEC Filings & Documents

Cyclerion Therapeutics, Inc. (CYCN) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Apr 1, 2026·SEC

Material company update

Feb 17, 2026·SEC

Material company update

Jan 6, 2026·SEC

10-K Annual Reports

3
FY 2025

Mar 4, 2025·SEC

FY 2024

Mar 5, 2024·SEC

FY 2023

Mar 22, 2023·SEC

10-Q Quarterly Reports

6
FY 2025

Nov 12, 2025·SEC

FY 2025

Aug 5, 2025·SEC

FY 2025

May 6, 2025·SEC

CYCN Frequently Asked Questions

Cyclerion Therapeutics, Inc. (CYCN) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Cyclerion Therapeutics, Inc. (CYCN) reported $2.1M in revenue for fiscal year 2025.

Cyclerion Therapeutics, Inc. (CYCN) grew revenue by 3.7% over the past year. Growth has been modest.

Cyclerion Therapeutics, Inc. (CYCN) reported a net loss of $3.5M for fiscal year 2025.

Dividend & Returns

Cyclerion Therapeutics, Inc. (CYCN) has a return on equity (ROE) of -39.3%. Negative ROE indicates the company is unprofitable.

Cyclerion Therapeutics, Inc. (CYCN) had negative free cash flow of $3.3M in fiscal year 2025, likely due to heavy capital investments.

Explore More CYCN

Cyclerion Therapeutics, Inc. (CYCN) financial analysis — history, returns, DCA and operating performance tools

Total Return Calculator

Historical returns with dividends reinvested

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DCA Calculator

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Dividend History

Yield, growth, payout safety & DRIP

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Earnings History

EPS trends, net income & profitability

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Price History

Long-term charts & historical price data

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Revenue History

Sales growth patterns & revenue breakdown

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Financial Ratios

30 years of market, efficiency and balance-sheet ratios

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Valuation

DCF intrinsic value, peer multiples & estimates

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