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PALI logoPalisade Bio, Inc.(PALI)Earnings, Financials & Key Ratios

PALI•NASDAQ
$2.00
$111M mkt cap·Price updated May 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryImmunology and Inflammation Therapies
AboutPalisade Bio, Inc., a clinical-stage biopharmaceutical company, focuses on discovering, developing, and commercializing oral therapies that target serious diseases associated with the breakdown of the mucosal barrier protecting the gastrointestinal tract. Its lead therapeutic candidate is LB1148, an oral liquid formulation of the digestive enzyme inhibitor that is intended to inhibit digestive enzyme activity and preserve gut integrity during intestinal stress resulting from reduced blood flow to the intestine, infections, or due to surgery. The company was founded in 2005 and is headquartered in Carlsbad, California.Show more
  • Revenue$0
  • EBITDA-$18M-21.5%
  • Net Income-$17M-16.2%
  • EPS (Diluted)-0.30+97.1%
  • ROE-24.52%+84.0%
  • Debt/Equity0.00-97.6%
  • Interest Coverage-1805.60-45.8%
Technical→

PALI Key Insights

Palisade Bio, Inc. (PALI) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Company is almost debt free
  • ✓Momentum leader: RS Rating 87 (top 13%)
  • ✓Trading at only 0.9x book value

✗Weaknesses

  • ✗Shares diluted 100.0% in last year
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

PALI Price & Volume

Palisade Bio, Inc. (PALI) stock price & volume — 10-year historical chart

Loading chart...

PALI Growth Metrics

Palisade Bio, Inc. (PALI) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years-
TTM-

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-16.23%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM86.1%

Return on Capital

10 Years-889.29%
5 Years-423.58%
3 Years-96.58%
Last Year-26.29%

PALI Recent Earnings

Palisade Bio, Inc. (PALI) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 5/12 qtrs (42%)
Q2 2026Latest
Mar 23, 2026
EPS
$0.04
Est $0.02
-100.0%
Revenue
—
Q4 2025
Nov 10, 2025
EPS
$0.38
Est $0.32
-18.8%
Revenue
—
Q3 2025
Aug 11, 2025
EPS
$0.58
Est $0.48
-20.8%
Revenue
—
Q2 2025
May 12, 2025
EPS
$0.47
Est $0.84
+44.0%
Revenue
—
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMar 23, 2026
$0.04vs $0.02-100.0%
—
Q4 2025Nov 10, 2025
$0.38vs $0.32-18.8%
—
Q3 2025Aug 11, 2025
$0.58vs $0.48-20.8%
—
Q2 2025May 12, 2025
$0.47vs $0.84+44.0%
—
Based on last 12 quarters of dataView full earnings history →

PALI Peer Comparison

Palisade Bio, Inc. (PALI) competitors in Immunology and Inflammation Therapies — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
NKTR logoNKTRNektar TherapeuticsDirect Competitor1.67B85.09-8.75-43.89%-192.87%-356.81%0.95
HALO logoHALOHalozyme Therapeutics, Inc.Direct Competitor7.81B66.3525.9237.55%22.69%6.49%
CHRS logoCHRSCoherus Oncology, Inc.Product Competitor212.02M1.751.22-84.2%398.43%7.89%0.02
PRTA logoPRTAProthena Corporation plcProduct Competitor601.85M11.18-2.47-92.84%-25.21%-73%0.05
VNDA logoVNDAVanda Pharmaceuticals Inc.Product Competitor439.76M7.44-1.998.72%-102.02%-49.24%0.04
ACAD logoACADACADIA Pharmaceuticals Inc.Product Competitor3.68B21.489.3811.87%36.49%41.9%0.04
PTGX logoPTGXProtagonist Therapeutics, Inc.Product Competitor6.63B103.97-50.72-89.41%-6.48%-17.76%0.02
INVA logoINVAInnoviva, Inc.Product Competitor1.91B22.526.8218.52%118.91%46.47%0.23

Compare PALI vs Peers

Palisade Bio, Inc. (PALI) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs NKTR

Most directly comparable listed peer for PALI.

Scale Benchmark

vs IQV

Larger-name benchmark to compare PALI against a more recognizable public peer.

Peer Set

Compare Top 5

vs NKTR, HALO, CHRS, PRTA

PALI Income Statement

Palisade Bio, Inc. (PALI) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Sales/Revenue260K260K15.39K000250K00
Revenue Growth %1500.39%0%-94.08%-100%----100%-
Cost of Goods Sold0-990K0146K00003K
COGS % of Revenue--380.77%-------
Gross Profit
260K▲ 0%
1.25M▲ 380.8%
15.39K▼ 98.8%
-146K▼ 1048.4%
0▲ 100.0%
0▲ 0%
250K▲ 0%
0▼ 100.0%
-3K▲ 0%
Gross Margin %100%480.77%100%---100%--
Gross Profit Growth %1500.39%380.77%-98.77%-1048.42%100%---100%-
Operating Expenses13.57M8.52M8.65M9.15M41.85M15.72M13.32M14.86M18.06M
OpEx % of Revenue5218.08%3276.54%56171.24%---5328%--
Selling, General & Admin5.18M4.37M4.44M6.05M9.31M8.76M6.2M5.8M7.86M
SG&A % of Revenue1993.08%1681.92%28855.4%---2480.8%--
Research & Development8M3.96M4.06M3.1M2.43M6.55M6.89M9.06M10.19M
R&D % of Revenue3078.46%1523.08%26380.41%---2757.2%--
Other Operating Expenses000030.12M410K225K00
Operating Income
-13.21M▲ 0%
-8.26M▲ 37.5%
-8.63M▼ 4.5%
-9.3M▼ 7.7%
-41.85M▼ 350.2%
-15.72M▲ 62.4%
-13.07M▲ 16.9%
-14.86M▼ 13.7%
-18.06M▼ 21.5%
Operating Margin %-5082.69%-3176.54%-56073.79%----5228%--
Operating Income Growth %34.47%37.5%-4.52%-7.7%-350.19%62.44%16.86%-13.69%-21.52%
EBITDA-12.93M-8.07M-8.49M-9.15M-41.85M-15.72M-13.07M-14.86M-18.05M
EBITDA Margin %-4971.46%-3105.08%-55139.28%----5226.4%--
EBITDA Growth %34.82%37.54%-5.14%-7.81%-357.35%62.44%16.87%-13.7%-21.52%
D&A (Non-Cash Add-back)289.21K185.8K143.86K146K2K3K4K3K3K
EBIT-15.51M-4.92M-8.34M-10.09M-24.22M-14.25M-12.29M-14.43M-18.06M
Net Interest Income-88.8K71.08K58.81K-235K-2.4M0-15K-12K-10K
Interest Income70.27K78.78K67.73K0013K000
Interest Expense159.07K7.7K8.92K235K2.4M13K15K12K10K
Other Income/Expense-2.45M3.33M280.04K-1.02M15.24M1.46M770K421K1.27M
Pretax Income
-15.67M▲ 0%
-4.92M▲ 68.6%
-8.35M▼ 69.6%
-10.32M▼ 23.6%
-26.62M▼ 157.9%
-14.26M▲ 46.4%
-12.3M▲ 13.7%
-14.44M▼ 17.4%
-16.78M▼ 16.2%
Pretax Margin %-6025.38%-1894.23%-54254.9%----4920%--
Income Tax000000000
Effective Tax Rate %0%0%0%0%0%0%0%0%0%
Net Income
-15.67M▲ 0%
-4.92M▲ 68.6%
-8.35M▼ 69.6%
-10.32M▼ 23.6%
-26.62M▼ 157.9%
-14.26M▲ 46.4%
-12.3M▲ 13.7%
-14.44M▼ 17.4%
-16.78M▼ 16.2%
Net Margin %-6025.38%-1894.23%-54254.9%----4920%--
Net Income Growth %25.67%68.56%-69.58%-23.59%-157.86%46.42%13.74%-17.38%-16.23%
Net Income (Continuing)-15.67M-4.92M-8.35M-10.32M-26.62M-14.26M-12.3M-14.44M-16.78M
Discontinued Operations000000000
Minority Interest000000000
EPS (Diluted)
-71.34▲ 0%
-18.02▲ 74.7%
-35.18▼ 95.2%
-186.00▼ 428.7%
-2546.10▼ 1268.9%
-16.53▲ 99.4%
-27.01▼ 63.4%
-10.19▲ 62.3%
-0.30▲ 97.1%
EPS Growth %43.43%74.74%-95.23%-428.71%-1268.87%99.35%-63.4%62.27%97.06%
EPS (Basic)-71.59-18.02-14.78-186.00-2144.25-16.53-27.01-10.19-0.30
Diluted Shares Outstanding219.6K273.24K237.39K237.39K12.46K880.3K456.01K1.42M55.67M
Basic Shares Outstanding218.84K273.24K122.41K832.3K12.41K880.1K456.01K1.42M55.67M
Dividend Payout Ratio---------

PALI Balance Sheet

Palisade Bio, Inc. (PALI) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Total Current Assets12.45M6.51M5.65M896K11.51M14.73M13.33M10.49M134.22M
Cash & Short-Term Investments11.67M5.79M5.11M729K10.49M12.38M12.43M9.82M133.38M
Cash Only6.67M5.79M5.11M713K10.49M12.38M12.43M9.82M133.38M
Short-Term Investments5M0016K00000
Accounts Receivable371.59K358K21.06K0150K1.44M148K24K264K
Days Sales Outstanding521.65502.57499.44---216.08--
Inventory000000000
Days Inventory Outstanding---------
Other Current Assets000100K0114K112K87K572K
Total Non-Current Assets1.44M1.18M937.01K2.12M1.01M1.03M724K386K123K
Property, Plant & Equipment172.89K90.31K242.74K280K112K310K208K87K0
Fixed Asset Turnover1.50x2.88x0.06x---1.20x--
Goodwill000000000
Intangible Assets883.46K763.54K668.94K000000
Long-Term Investments365.46K298.24K00026K026K55K
Other Non-Current Assets13.85K23.96K25.34K1.84M894K694K516K273K68K
Total Assets
13.88M▲ 0%
7.68M▼ 44.7%
6.58M▼ 14.3%
3.02M▼ 54.1%
12.51M▲ 314.4%
15.76M▲ 26.0%
14.05M▼ 10.9%
10.88M▼ 22.6%
134.34M▲ 1134.8%
Asset Turnover0.02x0.03x0.00x---0.02x--
Asset Growth %-38.58%-44.65%-14.32%-54.15%314.44%25.98%-10.85%-22.57%1134.78%
Total Current Liabilities1.51M1.05M1.22M8.08M2.5M3.01M2.59M3.24M4.64M
Accounts Payable875.07K832.56K824.41K2.54M1.52M1.76M698K1.1M767K
Days Payables Outstanding--306.96-6.34K----93.32K
Short-Term Debt0001.05M87K88K158K79K71K
Deferred Revenue (Current)0-4.5M0000000
Other Current Liabilities220.88K-756.4K124.67K0511K574K831K03.8M
Current Ratio8.22x6.19x4.61x0.11x4.61x4.89x5.15x3.24x28.95x
Quick Ratio8.22x6.19x4.61x0.11x4.61x4.89x5.15x3.24x28.95x
Cash Conversion Cycle---------
Total Non-Current Liabilities3.85M583.73K233.14K2.04M2.65M272K153K152K328K
Long-Term Debt0535K094K00000
Capital Lease Obligations00148.54K112K0211K90K00
Deferred Tax Liabilities000000000
Other Non-Current Liabilities3.85M48.73K84.59K1.83M2.65M61K63K152K328K
Total Liabilities5.37M1.63M1.46M10.12M5.15M3.28M2.74M3.39M4.96M
Total Debt05.04M288.54K1.42M199K404K369K169K71K
Net Debt-6.67M-749.11K-4.83M708K-10.3M-11.98M-12.06M-9.65M-133.31M
Debt / Equity-0.83x0.06x-0.03x0.03x0.03x0.02x0.00x
Debt / EBITDA---------
Net Debt / EBITDA---------
Interest Coverage-83.08x-1072.88x-967.71x-39.56x-17.45x-1209.31x-871.33x-1238.25x-1805.60x
Total Equity
8.52M▲ 0%
6.05M▼ 29.0%
5.13M▼ 15.3%
-7.1M▼ 238.5%
7.37M▲ 203.7%
12.48M▲ 69.4%
11.31M▼ 9.3%
7.49M▼ 33.8%
129.38M▲ 1626.9%
Equity Growth %-24.85%-28.96%-15.27%-238.49%203.75%69.44%-9.34%-33.78%1626.91%
Book Value per Share38.7822.1421.59-29.90590.9514.1824.815.292.32
Total Shareholders' Equity8.52M6.05M5.13M-7.1M7.37M12.48M11.31M7.49M129.38M
Common Stock151.6K182.05K38.66K28K3K30K93K27K1.59M
Retained Earnings-208.7M-213.62M-221.98M-68.03M-94.64M-109.19M-121.51M-135.94M-152.72M
Treasury Stock000000000
Accumulated OCI2.63K-413-6.19K000000
Minority Interest000000000

PALI Cash Flow Statement

Palisade Bio, Inc. (PALI) cash flow — operating, investing & free cash flow history

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Cash from Operations-13.42M-7.69M-7.26M-4.77M-14.77M-13.36M-11.13M-12.19M-10.85M
Operating CF Margin %-5160.06%-2958.62%-47133.17%----4453.2%--
Operating CF Growth %14.09%42.66%5.68%34.29%-209.84%9.56%16.67%-9.52%11.04%
Net Income-15.67M-4.92M-8.35M-10.32M-26.62M-14.26M-12.3M-14.44M-16.78M
Depreciation & Amortization289.21K185.8K143.86K3K2K3K4K3K3K
Stock-Based Compensation1.77M1.09M02.01M1.89M1.03M624K652K3.96M
Deferred Taxes000-38K00000
Other Non-Cash Items6.47M-2.29M743.83K1.19M14.71M-1.39M139K199K337K
Working Capital Changes-2.15M-336.88K208.28K2.39M-4.76M1.25M400K1.39M1.64M
Change in Receivables-249.23K80.81K272.99K-59K84K0000
Change in Inventory-11.75M36.99K0-947K00000
Change in Payables-1.52M-36.99K-15.74K1.01M0399K-492K818K624K
Cash from Investing-94.05K5M0-6K-54K-10K-4K00
Capital Expenditures-94.05K-1.71K0-6K0-10K-4K00
CapEx % of Revenue36.17%0.66%----1.6%--
Acquisitions82.64K000-54K0000
Investments---------
Other Investing-82.64K00000000
Cash from Financing4.99M1.81M6.59M1.89M24.61M15.26M11.19M9.58M134.44M
Debt Issued (Net)-3.75M-13.77K36.43K802K-183K-790K-391K-426K-320K
Equity Issued (Net)8.74M1.83M6.55M1.18M25.11M14.4M9.42M8.44M135.25M
Dividends Paid000000000
Share Repurchases000000000
Other Financing000-87K-317K1.65M2.16M1.57M-495K
Net Change in Cash
-8.52M▲ 0%
-887.83K▲ 89.6%
-672.19K▲ 24.3%
-2.88M▼ 329.0%
9.78M▲ 439.2%
1.89M▼ 80.7%
49K▼ 97.4%
-2.61M▼ 5428.6%
123.59M▲ 4833.6%
Free Cash Flow
-13.51M▲ 0%
-7.69M▲ 43.0%
-7.26M▲ 5.7%
-4.77M▲ 34.2%
-14.77M▼ 209.4%
-13.37M▲ 9.5%
-11.14M▲ 16.7%
-12.19M▼ 9.5%
-10.85M▲ 11.0%
FCF Margin %-5196.23%-2959.28%-47133.17%----4454.8%--
FCF Growth %14.37%43.05%5.7%34.2%-209.45%9.5%16.7%-9.48%11.04%
FCF per Share-61.52-28.16-30.56-20.11-1185.35-15.19-24.42-8.61-0.19
FCF Conversion (FCF/Net Income)0.86x1.56x0.87x0.46x0.56x0.94x0.91x0.84x0.65x
Interest Paid000064K0014K0
Taxes Paid000000000

PALI Key Ratios

Palisade Bio, Inc. (PALI) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric2016201720182019202020212022202320242025
Return on Equity (ROE)-258.62%-157.88%-67.63%-149.47%--20012.03%-143.72%-103.4%-153.55%-24.52%
Return on Invested Capital (ROIC)-377.18%-1178.64%-173.49%-231.21%------
Gross Margin100%100%480.77%100%---100%--
Net Margin-129724.24%-6025.38%-1894.23%-54254.9%----4920%--
Debt / Equity0.33x-0.83x0.06x-0.03x0.03x0.03x0.02x0.00x
Interest Coverage-17.67x-83.08x-1072.88x-967.71x-39.56x-17.45x-1209.31x-871.33x-1238.25x-1805.60x
FCF Conversion0.74x0.86x1.56x0.87x0.46x0.56x0.94x0.91x0.84x0.65x
Revenue Growth55.96%1500.39%0%-94.08%-100%----100%-

PALI SEC Filings & Documents

Palisade Bio, Inc. (PALI) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Apr 2, 2026·SEC

Material company update

Dec 4, 2025·SEC

Material company update

Oct 22, 2025·SEC

10-K Annual Reports

3
FY 2026

Mar 20, 2026·SEC

FY 2025

Mar 24, 2025·SEC

FY 2024

Mar 26, 2024·SEC

10-Q Quarterly Reports

6
FY 2025

Nov 10, 2025·SEC

FY 2025

Aug 11, 2025·SEC

FY 2025

May 12, 2025·SEC

PALI Frequently Asked Questions

Palisade Bio, Inc. (PALI) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Palisade Bio, Inc. (PALI) grew revenue by 0.0% over the past year. Growth has been modest.

Palisade Bio, Inc. (PALI) reported a net loss of $16.8M for fiscal year 2025.

Dividend & Returns

Palisade Bio, Inc. (PALI) has a return on equity (ROE) of -24.5%. Negative ROE indicates the company is unprofitable.

Palisade Bio, Inc. (PALI) had negative free cash flow of $10.8M in fiscal year 2025, likely due to heavy capital investments.

Explore More PALI

Palisade Bio, Inc. (PALI) financial analysis — history, returns, DCA and operating performance tools

Total Return Calculator

Historical returns with dividends reinvested

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DCA Calculator

Dollar cost averaging vs lump sum

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Dividend History

Yield, growth, payout safety & DRIP

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Earnings History

EPS trends, net income & profitability

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Price History

Long-term charts & historical price data

→

Revenue History

Sales growth patterns & revenue breakdown

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Financial Ratios

30 years of market, efficiency and balance-sheet ratios

→

Valuation

DCF intrinsic value, peer multiples & estimates

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