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Palisade Bio, Inc. (PALI) Total Return Calculator with Dividends Reinvested

Palisade Bio, Inc.

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The total return for Palisade Bio, Inc. (PALI) stock is +161.84% over the past 12 months. So far it's down 20.40% this year. The 5-year total return is -99.96%, meaning $10,000 invested in PALI stock 5 years ago would be worth $4 today. Total return includes price appreciation plus reinvesting any dividends paid out.

If you invested $10,000 in PALI 1 year ago, it would be worth $26,016 today — you'd have gained $16,016.

With Dividends Reinvested$26,016+160.16%

Price Only (No DRIP)$26,016+160.16%

Period2025-05-08 → 2026-05-07

Price

Total Return (DRIP)

S&P 500

If You Invested $10,000 in PALI

1Y$26,184+$16,184 (+161.8%)161.8% CAGR

3Y$799-$9,201 (-92.0%)-56.9% CAGR

5Y$4-$9,996 (-100.0%)-78.6% CAGR

10Y$0-$10,000 (-100.0%)-70.5% CAGR

15Y$0-$10,000 (-100.0%)-58.3% CAGR

20Y$0-$10,000 (-100.0%)-48.1% CAGR

30Y$0-$10,000 (-100.0%)-35.4% CAGR

Palisade Bio, Inc. did not pay dividends during this period. Total return = price return.

Loading PALI total return...

As of 2026-05-08

Returns at a Glance

Period	Total Return	CAGR	Price Only	Div. Contrib.	$10K →
YTD	-20.40%	—	-20.40%	—	$7,960
1Y	+161.84%	161.84%	+161.84%	—	$26,184
3Y	-92.01%	-56.93%	-92.01%	—	$799
5Y	-99.96%	-78.65%	-99.96%	—	$4
10Y	-100.00%	-70.49%	-100.00%	—	$0
15Y	-100.00%	-58.31%	-100.00%	—	$0
20Y	-100.00%	-48.11%	-100.00%	—	$0
30Y	-100.00%	-35.43%	-100.00%	—	$0

Risk & Highlights

Best Year+26.34%2025

Worst Year-93.11%2022

Max Drawdown-56.53%2025-07-28 → 2025-09-10 · Recovered 2025-10-01

Annual Returns

Year	Total Return	Price Return	Div.	S&P 500	vs S&P
2026YTD	-29.20%	-29.20%	—	+0.41%	-29.6pp
2025	+26.34%	+26.34%	—	+16.64%	+9.7pp
2024	-80.99%	-80.99%	—	+24.00%	-105.0pp
2023	-84.56%	-84.56%	—	+24.81%	-109.4pp
2022	-93.11%	-93.11%	—	-19.95%	-73.2pp

PALI outperformed the S&P 500 by 131.47pp over the past year (+161.84% vs +30.37%).

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PALI Peers' Total Return

Accurate peer set · 10 comparable names

Name	Mkt Cap	30D Rtn	YTD Total Rtn	1Y Total Rtn	Div Contrib	3Y Total Rtn	5Y Total Rtn	10Y Total Rtn
PALIPalisade Bio, Inc.	$111M	+4.2%	-20.4%	+161.8%	—	-92.0%	-100.0%	-100.0%
NKTRNektar Therapeutics	$1.7B	+9.4%	+92.0%	+818.2%	—	+621.8%	-72.3%	-59.1%
HALOHalozyme Therapeutics, Inc.	$7.7B	+2.5%	-7.3%	-7.1%	—	+115.3%	+37.0%	+570.7%
CHRSCoherus Oncology, Inc.	$213M	+5.4%	+28.5%	+86.0%	—	-78.4%	-87.7%	-90.8%
PRTAProthena Corporation plc	$567M	+1.6%	+14.5%	+44.4%	—	-86.3%	-57.2%	-73.0%
VNDAVanda Pharmaceuticals Inc.	$378M	-14.2%	-22.5%	+45.9%	—	-7.8%	-64.2%	-26.8%
ACADACADIA Pharmaceuticals Inc.	$3.9B	+2.2%	-13.7%	+52.4%	—	+4.7%	+7.1%	-22.9%
PTGXProtagonist Therapeutics, Inc.	$6.4B	-4.7%	+13.4%	+129.4%	—	+296.5%	+238.8%	+744.9%
INVAInnoviva, Inc.	$1.9B	-2.1%	+14.7%	+21.7%	—	+95.2%	+94.4%	+94.9%
CRLCharles River Laboratories International, Inc.	$9.0B	+7.3%	-10.1%	+32.8%	—	-4.2%	-46.9%	+119.2%
IQVIQVIA Holdings Inc.	$30.3B	+4.7%	-20.7%	+16.5%	—	-5.9%	-23.8%	+166.5%

Compare:PALI vs NKTR PALI vs HALO PALI vs CHRS PALI vs NKTR vs HALO

About PALI Dividend Returns

Palisade Bio, Inc. (PALI) does not currently pay dividends. Many growth-focused companies reinvest profits back into the business rather than distributing them as dividends.

How We Calculate Total Return

Our total return calculator simulates dividend reinvestment (DRIP) by assuming each dividend payment is used to purchase additional shares at the closing price on the ex-dividend date. This methodology provides an accurate representation of how a dividend reinvestment plan would perform.

Frequently Asked Questions

Q1What is the total return of PALI over the past year?

Palisade Bio, Inc. (PALI) delivered a return of 161.84% over the past year. Since PALI does not currently pay dividends, the total return equals the price-only return.

Q2How much would $10,000 invested in PALI be worth today?

A $10,000 investment in Palisade Bio, Inc. one year ago would be worth $26,184 today, representing a gain of $16,184.

Q3Does PALI pay dividends?

Palisade Bio, Inc. (PALI) does not currently pay dividends. Many growth-focused companies reinvest profits back into the business rather than distributing them as dividends. For PALI, the total return equals the price-only return.

Q4Did PALI beat the S&P 500?

Yes, Palisade Bio, Inc. (PALI) outperformed the S&P 500 by 131.47 percentage points over the past year. PALI delivered a total return of 161.84%, compared to the S&P 500's 30.37%. This 131.47pp alpha means investors in PALI earned more than a passive S&P 500 index fund.

Q5What is PALI's worst drawdown?

Palisade Bio, Inc. (PALI) experienced a maximum drawdown of -56.53% over the past year, declining from its peak on 2025-07-28 to its trough on 2025-09-10. The stock recovered to its prior peak by 2025-10-01. Maximum drawdown measures the worst peak-to-trough decline and is an important risk metric for investors.

Q6What is PALI's long-term total return over 10, 20, or 30 years?

Here are Palisade Bio, Inc. (PALI)'s long-term returns with dividends reinvested. Over 10 years, the total return is -100.0% (-70.5% CAGR) — $10,000 would have grown to $0. Over 20 years: -100.0% total return (-48.1% CAGR) — $10,000 → $0. Over 30 years: -100.0% total return (-35.4% CAGR) — $10,000 → $0. Long-term investors benefit from compounding: dividends buy additional shares, which generate their own dividends, creating an exponential growth effect.

Q7What was PALI's best and worst year?

Palisade Bio, Inc.'s best calendar year was 2025 with a total return of 26.3%. Its worst year was 2022 with a total return of -93.1%. This range shows the volatility investors should expect — the difference between the best and worst year is 119.5 percentage points.