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PBYI logoPuma Biotechnology, Inc.(PBYI)Earnings, Financials & Key Ratios

PBYI•NASDAQ
$7.45
$379M mkt cap·12.2× P/E·Price updated May 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryOncology Therapeutics Developers
AboutPuma Biotechnology, Inc., a biopharmaceutical company, focuses on the development and commercialization of products to enhance cancer care in the United States and internationally. The company's drug candidates include PB272 neratinib (oral) for the patients with early stage HER2-overexpressed/amplified breast cancer; PB272 (neratinib, oral) for the use of neratinib in combination with capecitabine for the treatment of adult patients with advanced or metastatic HER2-positive breast cancer; PB272 (neratinib, oral) for HER2 mutation-positive solid tumors. It has a license agreement with Pfizer, Inc.; and sub-license agreement with Specialised Therapeutics Asia Pte Ltd., CANbridge BIOMED Limited, Pint Pharma International SA, Knight Therapeutics, Inc., Pierre Fabre Medicament SAS, and Bixink Therapeutics Co., Ltd. The company was founded in 2010 and is headquartered in Los Angeles, California.Show more
  • Revenue$228M-0.9%
  • EBITDA$48M+13.5%
  • Net Income$31M+2.8%
  • EPS (Diluted)0.61-1.6%
  • Gross Margin74.53%+3.4%
  • EBITDA Margin21.12%+14.6%
  • Operating Margin16.33%+21.6%
  • Net Margin13.62%+3.7%
  • ROE27.97%-32.8%
  • ROIC24.73%-5.6%
  • Debt/Equity0.22-72.8%
  • Interest Coverage6.40+118.1%
Technical→

PBYI Key Insights

Puma Biotechnology, Inc. (PBYI) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Excellent 3Y average ROE of 42.4%
  • ✓Strong Piotroski F-Score: 7/9
  • ✓FCF machine: 18.3% free cash flow margin
  • ✓Momentum leader: RS Rating 85 (top 15%)
  • ✓High quality earnings: Operating CF exceeds net income
  • ✓Efficient asset utilization: 1.1x turnover

✗Weaknesses

No significant weaknesses identified

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

PBYI Price & Volume

Puma Biotechnology, Inc. (PBYI) stock price & volume — 10-year historical chart

Loading chart...

PBYI Growth Metrics

Puma Biotechnology, Inc. (PBYI) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years0.29%
3 Years0.05%
TTM-0.89%

Profit CAGR

10 Years-
5 Years-
3 Years2396.29%
TTM2.63%

EPS CAGR

10 Years-
5 Years-
3 Years210.89%
TTM0.54%

Return on Capital

10 Years-34.53%
5 Years19.47%
3 Years26.06%
Last Year29.57%

PBYI Recent Earnings

Puma Biotechnology, Inc. (PBYI) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 11/12 qtrs (92%)●Beat Revenue 7/12 qtrs (58%)
Q1 2026Latest
Feb 26, 2026
EPS
$0.29
Est $0.24
+20.8%
Revenue
$60M
Est $69M
-12.7%
Q4 2025
Nov 6, 2025
EPS
$0.21
Est $0.09
+133.3%
Revenue
$54M
Est $69M
-20.6%
Q3 2025
Aug 7, 2025
EPS
$0.15
Est $0.11
+36.4%
Revenue
$52M
Est $51M
+2.8%
Q2 2025
May 8, 2025
EPS
$0.10
Est $0.02
+400.0%
Revenue
$46M
Est $53M
-12.8%
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q1 2026LatestFeb 26, 2026
$0.29vs $0.24+20.8%
$60Mvs $69M-12.7%
Q4 2025Nov 6, 2025
$0.21vs $0.09+133.3%
$54Mvs $69M-20.6%
Q3 2025Aug 7, 2025
$0.15vs $0.11+36.4%
$52Mvs $51M+2.8%
Q2 2025May 8, 2025
$0.10vs $0.02+400.0%
$46Mvs $53M-12.8%
Based on last 12 quarters of dataView full earnings history →

PBYI Peer Comparison

Puma Biotechnology, Inc. (PBYI) competitors in Oncology Therapeutics Developers — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
RCUS logoRCUSArcus Biosciences, Inc.Direct Competitor2.62B26.00-7.90-4.26%-156.36%-68.97%0.16
TGTX logoTGTXTG Therapeutics, Inc.Direct Competitor6.7B41.9715.1587.32%65.95%87.36%0.40
PTCT logoPTCTPTC Therapeutics, Inc.Direct Competitor5.52B66.618.56114.51%39.44%
ACAD logoACADACADIA Pharmaceuticals Inc.Direct Competitor3.68B21.489.3811.87%36.49%41.9%0.04
EXEL logoEXELExelixis, Inc.Product Competitor12.37B48.7017.526.98%35.08%40.21%0.08
NKTR logoNKTRNektar TherapeuticsProduct Competitor1.67B85.09-8.75-43.89%-192.87%-356.81%0.95
PFE logoPFEPfizer Inc.Supply Chain150.77B26.5119.49-1.65%11.83%8.34%0.78
AZN logoAZNAstraZeneca PLCSupply Chain286.68B184.9228.288.63%17.19%22.24%0.61

Compare PBYI vs Peers

Puma Biotechnology, Inc. (PBYI) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs RCUS

Most directly comparable listed peer for PBYI.

Scale Benchmark

vs AZN

Larger-name benchmark to compare PBYI against a more recognizable public peer.

Peer Set

Compare Top 5

vs RCUS, TGTX, PTCT, ACAD

PBYI Income Statement

Puma Biotechnology, Inc. (PBYI) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Sales/Revenue27.7M251M272.26M225.11M253.16M228.03M235.64M230.47M228.37M
Revenue Growth %-806.14%8.47%-17.32%12.46%-9.92%3.34%-2.19%-0.91%
Cost of Goods Sold5.6M34.6M36.81M39.37M63.7M55.09M62.68M64.4M58.16M
COGS % of Revenue20.22%13.78%13.52%17.49%25.16%24.16%26.6%27.94%25.47%
Gross Profit
22.1M▲ 0%
216.4M▲ 879.2%
235.44M▲ 8.8%
185.74M▼ 21.1%
189.45M▲ 2.0%
172.94M▼ 8.7%
172.96M▲ 0.0%
166.06M▼ 4.0%
170.21M▲ 2.5%
Gross Margin %79.78%86.22%86.48%82.51%74.84%75.84%73.4%72.06%74.53%
Gross Profit Growth %2023.41%879.19%8.8%-21.11%2%-8.72%0.01%-3.98%2.5%
Operating Expenses314.5M311.1M311.04M216.14M188.16M149.22M140.31M135.1M132.91M
OpEx % of Revenue1135.38%123.94%114.24%96.01%74.33%65.44%59.55%58.62%58.2%
Selling, General & Admin106.7M146.2M141.64M118.49M116.29M89.98M89.31M80.16M70.85M
SG&A % of Revenue385.2%58.25%52.02%52.64%45.94%39.46%37.9%34.78%31.02%
Research & Development207.8M164.9M132.85M97.65M71.87M52.24M50.38M54.94M62.07M
R&D % of Revenue750.18%65.7%48.8%43.38%28.39%22.91%21.38%23.84%27.18%
Other Operating Expenses-100K036.55M007M625K00
Operating Income
-292.4M▲ 0%
-94.7M▲ 67.6%
-75.59M▲ 20.2%
-30.4M▲ 59.8%
1.29M▲ 104.2%
23.72M▲ 1738.8%
32.64M▲ 37.6%
30.97M▼ 5.1%
37.3M▲ 20.5%
Operating Margin %-1055.6%-37.73%-27.77%-13.51%0.51%10.4%13.85%13.44%16.33%
Operating Income Growth %-5.71%67.61%20.17%59.78%104.24%1738.76%37.61%-5.13%20.45%
EBITDA-289.59M-87.32M-67.52M-20.37M12.6M33.56M44.16M42.49M48.24M
EBITDA Margin %-1045.45%-34.79%-24.8%-9.05%4.98%14.72%18.74%18.44%21.12%
EBITDA Growth %-5.13%69.85%22.67%69.83%161.83%166.45%31.58%-3.78%13.53%
D&A (Non-Cash Add-back)2.81M7.38M8.08M10.03M11.3M9.84M11.52M11.52M10.94M
EBIT-291.24M-102.59M-60.52M-45.74M-15.99M12.05M36M36.55M42.4M
Net Interest Income536K-9.19M-12.17M-13.56M-12.65M-10.78M-10.72M-7.73M-2.54M
Interest Income1.26M1.8M2.8M489K160K813K2.6M4.72M4.08M
Interest Expense720K11M15M14.05M12.81M11.59M13.33M12.45M6.62M
Other Income/Expense435K-18.92M53K-29.39M-30.09M-23.26M-9.97M-6.87M-1.52M
Pretax Income
-292M▲ 0%
-113.6M▲ 61.1%
-75.54M▲ 33.5%
-59.79M▲ 20.9%
-28.8M▲ 51.8%
457K▲ 101.6%
22.67M▲ 4861.5%
24.1M▲ 6.3%
35.78M▲ 48.5%
Pretax Margin %-1054.15%-45.26%-27.75%-26.56%-11.38%0.2%9.62%10.46%15.67%
Income Tax-2.21M-7.92M53K207K324K455K1.08M-6.18M4.67M
Effective Tax Rate %0.76%6.97%-0.07%-0.35%-1.12%99.56%4.78%-25.63%13.05%
Net Income
-292M▲ 0%
-113.6M▲ 61.1%
-75.59M▲ 33.5%
-59.99M▲ 20.6%
-29.13M▲ 51.5%
2K▲ 100.0%
21.59M▲ 1079450.0%
30.28M▲ 40.2%
31.11M▲ 2.8%
Net Margin %-1054.15%-45.26%-27.77%-26.65%-11.51%0%9.16%13.14%13.62%
Net Income Growth %-5.8%61.1%33.46%20.64%51.45%100.01%1079450%40.23%2.75%
Net Income (Continuing)-291.95M-113.58M-75.59M-59.99M-29.13M2K21.59M30.28M31.11M
Discontinued Operations000000000
Minority Interest000000000
EPS (Diluted)
-7.86▲ 0%
-2.99▲ 62.0%
-2.13▲ 28.8%
-1.52▲ 28.6%
-0.72▲ 52.6%
0.02▲ 102.8%
0.45▲ 2116.7%
0.62▲ 37.8%
0.61▼ 1.6%
EPS Growth %5.19%61.96%28.76%28.64%52.63%102.82%2116.75%37.78%-1.61%
EPS (Basic)-7.86-2.99-2.13-1.52-0.720.020.460.620.62
Diluted Shares Outstanding37.17M37.94M38.77M39.58M40.64M44.93M47.55M49.1M50.65M
Basic Shares Outstanding37.17M37.94M38.77M39.58M40.64M44.67M47.13M48.65M50.01M
Dividend Payout Ratio---------

PBYI Balance Sheet

Puma Biotechnology, Inc. (PBYI) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Total Current Assets106.39M203M166.3M146.14M140.02M134.28M156.19M147.66M162.69M
Cash & Short-Term Investments81.7M108.4M111.64M93.39M82.11M81.07M95.94M100.97M97.53M
Cash Only81.7M108.4M60.04M85.29M63.13M76.2M84.58M69.22M29.64M
Short-Term Investments0051.61M8.1M18.98M4.87M11.35M31.75M67.89M
Accounts Receivable9.67M21.95M28.9M25.54M32.53M42.27M48.49M32.01M53.65M
Days Sales Outstanding127.4231.9238.7441.4246.967.6675.1150.785.75
Inventory2.03M2.63M3.17M3.45M7.11M4.53M7.08M8.72M5.51M
Days Inventory Outstanding132.2527.6931.4332.0240.7329.9941.2349.4434.61
Other Current Assets11.69M3.85M11.74M11.75M11.43M1.95M260K3.7M5.99M
Total Non-Current Assets59.13M56.12M68.61M98.08M86.56M87.78M74.34M65.67M53.62M
Property, Plant & Equipment4.47M3.96M21.83M18.89M15.77M12.51M8.65M5.09M5.56M
Fixed Asset Turnover6.20x63.34x12.47x11.92x16.05x18.23x27.25x45.24x41.07x
Goodwill000000000
Intangible Assets48.35M44.41M40.46M74.14M66.13M70.61M60.87M51.13M41.39M
Long-Term Investments4.32M2K00002.09M00
Other Non-Current Assets6.31M6.01M6.32M5.06M4.67M4.66M2.73M2.38M2.83M
Total Assets
165.53M▲ 0%
259.12M▲ 56.5%
234.91M▼ 9.3%
244.22M▲ 4.0%
226.59M▼ 7.2%
222.06M▼ 2.0%
230.53M▲ 3.8%
213.33M▼ 7.5%
216.3M▲ 1.4%
Asset Turnover0.17x0.97x1.16x0.92x1.12x1.03x1.02x1.08x1.06x
Asset Growth %-34.52%56.55%-9.35%3.97%-7.22%-2%3.81%-7.46%1.39%
Total Current Liabilities58.34M67.11M90.84M114.25M109.59M77.48M99.38M96.11M81.25M
Accounts Payable27.69M20.68M19.18M12.08M11.17M6.44M6.89M5.51M5.06M
Days Payables Outstanding1.8K218.2190.19111.9564.0342.6740.1131.2231.73
Short-Term Debt00014.29M0034M45.33M23.84M
Deferred Revenue (Current)000000000
Other Current Liabilities27.85M40.29M5.76M15.09M11.22M13.34M43.42M39.73M52.36M
Current Ratio1.82x3.02x1.83x1.28x1.28x1.73x1.57x1.54x2.00x
Quick Ratio1.79x2.99x1.80x1.25x1.21x1.67x1.50x1.45x1.93x
Cash Conversion Cycle-1.55K-158.59-120.02-38.5123.654.9876.2268.9288.63
Total Non-Current Liabilities53.88M157.7M126.61M135.92M119.44M122.97M77.7M25.1M4.71M
Long-Term Debt48.48M151.89M94.96M84.03M97.09M98.31M65.66M21.72M4.71M
Capital Lease Obligations0022.64M19.55M15.97M11.83M7.03M1.49M0
Deferred Tax Liabilities000000000
Other Non-Current Liabilities5.41M5.82M9M32.34M6.38M12.83M5.01M1.88M0
Total Liabilities112.22M224.82M217.44M250.17M229.03M200.45M177.09M121.21M85.96M
Total Debt48.48M151.89M120.23M120.95M116.64M114.28M111.49M74.08M28.55M
Net Debt-33.22M43.49M60.19M35.66M53.51M38.08M26.91M4.86M-1.09M
Debt / Equity0.91x4.43x6.88x--5.29x2.09x0.80x0.22x
Debt / EBITDA----9.26x3.41x2.52x1.74x0.59x
Net Debt / EBITDA----4.25x1.13x0.61x0.11x-0.02x
Interest Coverage-404.49x-9.33x-4.03x-3.26x-1.25x1.04x2.70x2.94x6.40x
Total Equity
53.3M▲ 0%
34.31M▼ 35.6%
17.46M▼ 49.1%
-5.95M▼ 134.1%
-2.45M▲ 58.9%
21.61M▲ 983.4%
53.44M▲ 147.3%
92.13M▲ 72.4%
130.34M▲ 41.5%
Equity Growth %-74.59%-35.64%-49.1%-134.08%58.9%983.4%147.33%72.38%41.48%
Book Value per Share1.430.900.45-0.15-0.060.481.121.882.57
Total Shareholders' Equity53.3M34.31M17.46M-5.95M-2.45M21.61M53.44M92.13M130.34M
Common Stock4K4K4K4K4K5K5K5K5K
Retained Earnings-1.09B-1.2B-1.28B-1.34B-1.37B-1.37B-1.35B-1.31B-1.28B
Treasury Stock000000000
Accumulated OCI-449K-12K62K0-2K0-4K6K36K
Minority Interest000000000

PBYI Cash Flow Statement

Puma Biotechnology, Inc. (PBYI) cash flow — operating, investing & free cash flow history

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Cash from Operations-172.5M-24.1M22.38M800K20.65M-15.83M27.01M38.92M41.8M
Operating CF Margin %-622.74%-9.6%8.22%0.36%8.16%-6.94%11.46%16.89%18.3%
Operating CF Growth %-21.74%86.03%192.85%-96.42%2481.25%-176.64%270.65%44.09%7.41%
Net Income-291.95M-113.58M-75.59M-59.99M-29.13M2K21.59M30.28M31.11M
Depreciation & Amortization2.81M7.38M8.08M10.03M11.3M9.84M11.52M11.52M10.94M
Stock-Based Compensation108.73M86.94M57.33M36.58M32.63M11.83M10.25M8.24M6.94M
Deferred Taxes05K00000-7.08M3.25M
Other Non-Cash Items-30K289K9.28M1.03M7.15M7M1.51M-519K-358K
Working Capital Changes7.94M-5.14M23.28M13.16M-1.31M-44.5M-17.85M-3.54M-10.08M
Change in Receivables-9.67M-11.1M-8.12M2.35M-5.98M-7.82M-8.37M16.34M-21.28M
Change in Inventory-2.03M-596K-545K-284K-3.65M2.58M-2.55M-1.64M3.21M
Change in Payables7.66M-7.01M-1.53M-7.11M-902K-4.73M449K-1.38M-453K
Cash from Investing-15.4M-57.6M5.16M23.3M-10.88M7.1M-19.13M-20.44M-36.19M
Capital Expenditures-50.43M-609K-306K-20.05M0-7M-140K-56K-71K
CapEx % of Revenue182.06%0.24%0.11%8.91%-3.07%0.06%0.02%0.03%
Acquisitions36K193K020M00000
Investments---------
Other Investing-15.01M-170K0-20.1M00-12.5M00
Cash from Financing75.1M108.4M-67.07M100K-31.93M12.22M0-33.85M-45.2M
Debt Issued (Net)50M105M-55M0-1.5M00-33.33M-44.44M
Equity Issued (Net)00068K012.5M0150K130K
Dividends Paid000000000
Share Repurchases000000000
Other Financing25.11M3.45M-12.07M32K-30.43M-277K0-666K-888K
Net Change in Cash
-112.8M▲ 0%
26.72M▲ 123.7%
-39.53M▼ 247.9%
24.24M▲ 161.3%
-22.16M▼ 191.4%
3.5M▲ 115.8%
7.88M▲ 125.3%
-15.37M▼ 294.9%
-39.58M▼ 157.6%
Free Cash Flow
-222.93M▲ 0%
-24.71M▲ 88.9%
22.07M▲ 189.3%
-19.25M▼ 187.2%
20.65M▲ 207.3%
-22.83M▼ 210.5%
14.37M▲ 162.9%
38.86M▲ 170.5%
41.73M▲ 7.4%
FCF Margin %-804.81%-9.84%8.11%-8.55%8.16%-10.01%6.1%16.86%18.27%
FCF Growth %-49.63%88.92%189.32%-187.2%207.3%-210.54%162.95%170.46%7.38%
FCF per Share-6.00-0.650.57-0.490.51-0.510.300.790.82
FCF Conversion (FCF/Net Income)0.59x0.21x-0.30x-0.01x-0.71x-7913.50x1.25x1.29x1.34x
Interest Paid08.05M11.74M9.7M10.34M10.32M11.63M10.77M0
Taxes Paid017K53K207K324K384K737K1.22M0

PBYI Key Ratios

Puma Biotechnology, Inc. (PBYI) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric2016201720182019202020212022202320242025
Return on Equity (ROE)-132.76%-221.97%-259.34%-292.05%-1042.3%-0.02%57.54%41.6%27.97%
Return on Invested Capital (ROIC)-218.71%-1239.79%-145.14%-72.95%-42.47%2.4%32.13%34.96%26.19%24.73%
Gross Margin-79.78%86.22%86.48%82.51%74.84%75.84%73.4%72.06%74.53%
Net Margin--1054.15%-45.26%-27.77%-26.65%-11.51%0%9.16%13.14%13.62%
Debt / Equity-0.91x4.43x6.88x--5.29x2.09x0.80x0.22x
Interest Coverage-288.72x-404.49x-9.33x-4.03x-3.26x-1.25x1.04x2.70x2.94x6.40x
FCF Conversion0.51x0.59x0.21x-0.30x-0.01x-0.71x-7913.50x1.25x1.29x1.34x
Revenue Growth--806.14%8.47%-17.32%12.46%-9.92%3.34%-2.19%-0.91%

PBYI SEC Filings & Documents

Puma Biotechnology, Inc. (PBYI) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Feb 26, 2026·SEC

Material company update

Nov 6, 2025·SEC

Material company update

Aug 7, 2025·SEC

10-K Annual Reports

4
FY 2026

Feb 26, 2026·SEC

FY 2025

Feb 27, 2025·SEC

FY 2024

Feb 29, 2024·SEC

10-Q Quarterly Reports

6
FY 2025

Nov 6, 2025·SEC

FY 2025

Aug 7, 2025·SEC

FY 2025

May 8, 2025·SEC

PBYI Frequently Asked Questions

Puma Biotechnology, Inc. (PBYI) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Puma Biotechnology, Inc. (PBYI) reported $228.4M in revenue for fiscal year 2025.

Puma Biotechnology, Inc. (PBYI) saw revenue decline by 0.9% over the past year.

Yes, Puma Biotechnology, Inc. (PBYI) is profitable, generating $31.1M in net income for fiscal year 2025 (13.6% net margin).

Dividend & Returns

Puma Biotechnology, Inc. (PBYI) has a return on equity (ROE) of 28.0%. This is excellent, indicating efficient use of shareholder capital.

Puma Biotechnology, Inc. (PBYI) generated $41.7M in free cash flow for fiscal year 2025. Positive FCF indicates the company can fund dividends, buybacks, or reinvestment.

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Puma Biotechnology, Inc. (PBYI) financial analysis — history, returns, DCA and operating performance tools

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