Puma Biotechnology, Inc. (PBYI) Revenue History
Annual and quarterly revenue from 2007 to present
PBYI Revenue Over Time (2007–2025)
PBYI Revenue Growth History
5 of 9 years with positive growth- FY2007 revenue growth
- N/A
- FY2008 revenue growth
- N/A
- FY2009 revenue growth
- N/A
- FY2010 revenue growth
- N/A
- FY2011 revenue growth
- N/A
- FY2012 revenue growth
- +100.0%
- FY2013 revenue growth
- N/A
- FY2014 revenue growth
- N/A
- FY2015 revenue growth
- N/A
- FY2016 revenue growth
- N/A
- FY2017 revenue growth
- N/A
- FY2018 revenue growth
- +806.1%
- FY2019 revenue growth
- +8.5%
- FY2020 revenue growth
- -17.3%
- FY2021 revenue growth
- +12.5%
- FY2022 revenue growth
- -9.9%
- FY2023 revenue growth
- +3.3%
- FY2024 revenue growth
- -2.2%
- FY2025 revenue growth
- -0.9%
| Quarter | Revenue | YoY |
|---|---|---|
| Q1 2026 | $44.8M | -2.6% |
| Q4 2025 | $75.5M | +27.7% |
| Q3 2025 | $54.5M | -32.4% |
| Q2 2025 | $52.4M | +11.4% |
| Q1 2025 | $46.0M | +5.1% |
| Q4 2024 | $59.1M | -18.2% |
| Q3 2024 | $80.5M | +43.5% |
| Q2 2024 | $47.1M | -13.7% |
Multi-year avg. share of annual revenue by fiscal quarter
Revenue Breakdown (FY 2025)
PBYI's revenue distribution by segment and geography for fiscal year 2025
By Product/Segment
PBYI Revenue Analysis (2007–2025)
Current Revenue & Growth
As of June 22, 2026, Puma Biotechnology, Inc. (PBYI) generated trailing twelve-month (TTM) revenue of $227.2 million, reflecting slight decline in growth of -2.6% year-over-year. The most recent quarter (Q1 2026) recorded $44.8 million in revenue, down 40.6% sequentially.
Historical Growth Trajectory
PBYI's 5-year compound annual growth rate (CAGR) stands at +0.3%, indicating moderate growth over time. The 3-year CAGR of +0.0% is in line with the 5-year average, suggesting consistent growth. Puma Biotechnology, Inc.'s highest annual revenue of $272.3 million was recorded in 2019.
Revenue by Segment
PBYI's revenue is primarily driven by Product (89%), and Royalty (11%). With over half of revenue concentrated in Product, the company has a focused business model while developing other growth vectors.
Peer Comparison
Compared to Healthcare sector peers — including RCUS (+67.4% YoY), TGTX (+81.3% YoY), and PTCT (-53.3% YoY) — PBYI has underperformed the peer group in revenue growth. Compare PBYI vs RCUS →
PBYI Revenue vs Peers
Revenue metrics vs comparable public companies
| Company | TTM Revenue | YoY Growth | 5Y CAGR | Op. Margin | Compare |
|---|---|---|---|---|---|
| PBYICurrent | $227M | -2.6% | +0.3% | 16.3% | |
 RCUS | $247M | +67.4% | +25.9% | -156.3% | |
 TGTX | $616M | +81.3% | +426.7% | 20.0% | |
 PTCT | $1.7B | -53.3% | +35.4% | 49.5% | |
 ACAD | $1.1B | +9.9% | +19.4% | 9.8% | |
 EXEL | $2.3B | +3.3% | +18.6% | 37.6% |
PBYI Historical Revenue Data (2007–2025)
| Year | Revenue | YoY % | Gross Profit | Gross Margin | Op. Income | Op. Margin |
|---|---|---|---|---|---|---|
| 2025 | $228.4M | -0.9% | $170.2M | 74.5% | $37.3M | 16.3% |
| 2024 | $230.5M | -2.2% | $166.1M | 72.1% | $31.0M | 13.4% |
| 2023 | $235.6M | +3.3% | $173.0M | 73.4% | $32.6M | 13.9% |
| 2022 | $228.0M | -9.9% | $172.9M | 75.8% | $23.7M | 10.4% |
| 2021 | $253.2M | +12.5% | $189.5M | 74.8% | $1.3M | 0.5% |
| 2020 | $225.1M | -17.3% | $185.7M | 82.5% | $-30,402,000 | -13.5% |
| 2019 | $272.3M | +8.5% | $235.4M | 86.5% | $-75,595,000 | -27.8% |
| 2018 | $251.0M | +806.1% | $216.4M | 86.2% | $-94,700,000 | -37.7% |
| 2017 | $27.7M | - | $22.1M | 79.8% | $-292,400,000 | -1055.6% |
| 2016 | $0 | - | $-1,149,000 | - | $-276,600,000 | - |
| 2015 | $0 | - | $-776,000 | - | $-240,300,000 | - |
| 2014 | $0 | - | $0 | - | $-142,300,000 | - |
| 2013 | $0 | - | $0 | - | $-54,833,000 | - |
| 2012 | $0 | +100.0% | $0 | - | $-74,400,000 | - |
| 2011 | $-281,096 | - | $-281,096 | 100.0% | $-10,156,661 | 3613.2% |
Intrinsic Valuation
DCF models, multiple analysis, and analyst estimates.
Historical Returns
19+ years return with dividends reinvested.
DCA Calculator
See how regular investing compounds over time.
Peer Comparison
Compare growth, multiples, and margins vs sector.
PBYI — Frequently Asked Questions
Quick answers to the most common questions about buying PBYI stock.
Is PBYI's revenue growth accelerating or slowing?
PBYI revenue growth is slowing. TTM revenue is $227M, up -2.6% year-over-year — below the 5-year CAGR of +0.3%. The deceleration suggests maturing end-markets or increased competition.
What is PBYI's revenue history from 2007 to 2026?
Puma Biotechnology, Inc. (PBYI) revenue history spans 2007 to 2026. TTM revenue as of 2026 is $227M, growing at -2.6% YoY. The 5-year CAGR is +0.3%. Complete annual and quarterly revenue figures are available on this page, including gross profit, operating income, and margin trends.
What is PBYI's long-term revenue growth rate (CAGR)?
Puma Biotechnology, Inc.'s 5-year revenue CAGR of +0.3% reflects the variable nature of its business expansion. As of 2026, the current YoY growth rate of -2.6% is below this long-term average. CAGR is the most reliable measure of sustained revenue momentum for PBYI.
Why does PBYI's quarterly revenue fluctuate?
PBYI quarterly revenue can fluctuate significantly between periods. A quarter-over-quarter (QoQ) change does not always indicate a trend; comparing the same quarter year-over-year (YoY) is a more reliable signal for underlying growth. Puma Biotechnology, Inc.'s revenue data from 2007 to 2026 shows full historical quarterly detail on this page.
How is PBYI's revenue distributed by segment?
PBYI reports revenue broken down by product line and geographic region. The segment breakdown on this page shows which business units contribute the most to total revenue as of the latest fiscal year. Concentration in a single segment above 50% indicates category dependence, while a diversified mix signals more resilient revenue streams.
How does PBYI's revenue compare to industry peers?
Puma Biotechnology, Inc. (PBYI) with TTM revenue of $227M and -2.6% YoY growth can be benchmarked against sector peers using the comparison table on this page. Revenue growth relative to peers indicates market share gains or losses. The peer section shows TTM revenue, YoY growth, and operating margin for direct comparisons.