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TSHA logoTaysha Gene Therapies, Inc.(TSHA)Earnings, Financials & Key Ratios

TSHA•NASDAQ
$6.67
$1.92B mkt cap·Price updated May 7, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryCell and Gene Therapy Developers
AboutTaysha Gene Therapies, Inc., a gene therapy company, focuses on developing and commercializing adeno-associated virus-based gene therapies for the treatment of monogenic diseases of the central nervous system. It primarily develops TSHA-120 for the treatment of giant axonal neuropathy; TSHA-102 for the treatment of Rett syndrome; TSHA-121 for the treatment of CLN1 disease; TSHA-118 for the treatment of CLN1 disease; TSHA-105 foe the treatment of for SLC13A5 Deficiency; and TSHA-101 for the treatment of GM2 gangliosidosis. Taysha Gene Therapies, Inc. has a strategic partnership with The University of Texas Southwestern Medical Center to develop and commercialize transformative gene therapy treatments. The company was incorporated in 2019 and is based in Dallas, Texas.Show more
  • Revenue$10M+17.3%
  • EBITDA-$109M-21.2%
  • Net Income-$109M-22.1%
  • EPS (Diluted)-0.34+5.6%
  • Gross Margin88.28%-11.7%
  • EBITDA Margin-1118.93%-3.4%
  • Operating Margin-1130.65%-3.0%
  • Net Margin-1115.27%-4.1%
  • ROE-68.45%+43.9%
  • Debt/Equity0.07-91.7%
  • Interest Coverage-1753.94-100.6%
Technical→

TSHA Key Insights

Taysha Gene Therapies, Inc. (TSHA) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Company is almost debt free
  • ✓Momentum leader: RS Rating 89 (top 11%)

✗Weaknesses

  • ✗Profits declining 20.4% over 5 years
  • ✗Negative free cash flow
  • ✗Shares diluted 27.8% in last year
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

TSHA Price & Volume

Taysha Gene Therapies, Inc. (TSHA) stock price & volume — 10-year historical chart

Loading chart...

TSHA Growth Metrics

Taysha Gene Therapies, Inc. (TSHA) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-
3 Years57.49%
TTM3.42%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-49.69%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM-7.29%

Return on Capital

10 Years-69.82%
5 Years-76.95%
3 Years-63.12%
Last Year-49.01%

TSHA Recent Earnings

Taysha Gene Therapies, Inc. (TSHA) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 5/12 qtrs (42%)●Beat Revenue 7/12 qtrs (70%)
Q2 2026Latest
May 6, 2026
EPS
$0.12
Est $0.10
-20.0%
Revenue
—
Est $755,556
Q2 2026
Mar 19, 2026
EPS
$0.08
Est $0.11
+27.3%
Revenue
$5M
Est $2M
+144.5%
Q4 2025
Nov 4, 2025
EPS
$0.09
Est $0.09
+0.0%
Revenue
—
Est $2M
Q3 2025
Aug 12, 2025
EPS
$0.09
Est $0.07
-28.6%
Revenue
$2M
Est $2M
+14.9%
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 6, 2026
$0.12vs $0.10-20.0%
—vs $755,556
Q2 2026Mar 19, 2026
$0.08vs $0.11+27.3%
$5Mvs $2M+144.5%
Q4 2025Nov 4, 2025
$0.09vs $0.09+0.0%
—vs $2M
Q3 2025Aug 12, 2025
$0.09vs $0.07-28.6%
$2Mvs $2M+14.9%
Based on last 12 quarters of dataView full earnings history →

TSHA Peer Comparison

Taysha Gene Therapies, Inc. (TSHA) competitors in Cell and Gene Therapy Developers — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
SRPT logoSRPTSarepta Therapeutics, Inc.Direct Competitor2.18B20.80-2.9215.58%2.98%4.89%0.91
RARE logoRAREUltragenyx Pharmaceutical Inc.Direct Competitor2.57B26.13-4.4820.13%-91.03%-6.08%
FOLD logoFOLDAmicus Therapeutics, Inc.Direct Competitor4.55B14.49-164.8520.05%-4.27%-12.02%1.76
ARWR logoARWRArrowhead Pharmaceuticals, Inc.Direct Competitor10.92B77.95-6389.34232.58%-48.38%-55.47%0.73
RCKT logoRCKTRocket Pharmaceuticals, Inc.Direct Competitor397.53M3.67-1.83-80.49%0.09
SGMO logoSGMOSangamo Therapeutics, Inc.Product Competitor21.54M0.10-0.21-67.2%-331.28%-8.14%1.34
CRSP logoCRSPCRISPR Therapeutics AGProduct Competitor5.06B52.42-8.10-89.97%-138.57%-30.88%0.21
EDIT logoEDITEditas Medicine, Inc.Product Competitor296.54M3.03-1.68-100%-5.23%0.66

Compare TSHA vs Peers

Taysha Gene Therapies, Inc. (TSHA) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs SRPT

Most directly comparable listed peer for TSHA.

Scale Benchmark

vs VRTX

Larger-name benchmark to compare TSHA against a more recognizable public peer.

Peer Set

Compare Top 5

vs SRPT, RARE, FOLD, ARWR

TSHA Income Statement

Taysha Gene Therapies, Inc. (TSHA) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue0002.5M15.45M8.33M9.77M7.47M
Revenue Growth %----517.55%-46.07%17.28%3.42%
Cost of Goods Sold09K02.49M001.15M585K
COGS % of Revenue---99.4%--11.72%-
Gross Profit
0▲ 0%
-9K▲ 0%
0▲ 100.0%
15K▲ 0%
15.45M▲ 102913.5%
8.33M▼ 46.1%
8.63M▲ 3.5%
6.89M▲ 0%
Gross Margin %---0.6%100%100%88.28%92.17%
Gross Profit Growth %--100%-102913.53%-46.07%3.54%-
Operating Expenses1.11M42.99M173.27M126.04M87.89M99.79M119.13M139.45M
OpEx % of Revenue---5037.65%568.83%1197.55%1218.93%-
Selling, General & Admin128K11.1M41.32M34.87M30.05M28.95M32.72M35.39M
SG&A % of Revenue---1393.81%194.47%347.45%334.83%-
Research & Development987K31.89M131.94M91.17M56.78M66M86.4M104.06M
R&D % of Revenue---3643.84%367.47%792.04%884.1%-
Other Operating Expenses00001.06M4.84M00
Operating Income
-1.11M▲ 0%
-43M▼ 3756.7%
-173.27M▼ 302.9%
-126.03M▲ 27.3%
-72.44M▲ 42.5%
-91.46M▼ 26.3%
-110.5M▼ 20.8%
-132.56M▲ 0%
Operating Margin %----5037.05%-468.83%-1097.55%-1130.65%-1774.37%
Operating Income Growth %--3756.68%-302.93%27.26%42.52%-26.26%-20.82%-
EBITDA3.35M-42.99M-172.78M-123.54M-71.07M-90.21M-109.35M-131.7M
EBITDA Margin %----4937.65%-459.96%-1082.61%-1118.93%-1762.83%
EBITDA Growth %--1385.29%-301.87%28.5%42.47%-26.94%-21.22%-50.78%
D&A (Non-Cash Add-back)4.46M9K492K2.49M1.37M1.25M1.15M862K
EBIT-4.46M-59.98M-173.09M-162.22M-106.57M-89.2M-110.5M-87.88M
Net Interest Income021K-1.26M-3.55M-1.43M6.84M9.16M7.85M
Interest Income049K172K249K3.57M6.94M9.22M10.48M
Interest Expense028K1.43M3.8M5M102K63K35K
Other Income/Expense0-17.01M-1.26M-39.99M-39.13M2.16M1.5M2.69M
Pretax Income
-1.11M▲ 0%
-60.01M▼ 5282.2%
-174.52M▼ 190.8%
-166.01M▲ 4.9%
-111.57M▲ 32.8%
-89.3M▲ 20.0%
-109M▼ 22.1%
-129.88M▲ 0%
Pretax Margin %----6635.25%-722.06%-1071.62%-1115.27%-1738.4%
Income Tax00000000
Effective Tax Rate %0%0%0%0%0%0%0%0%
Net Income
-1.11M▲ 0%
-43M▼ 3756.5%
-174.52M▼ 305.9%
-166.01M▲ 4.9%
-111.57M▲ 32.8%
-89.3M▲ 20.0%
-109M▼ 22.1%
-129.88M▲ 0%
Net Margin %----6635.25%-722.06%-1071.62%-1115.27%-1738.4%
Net Income Growth %--3756.5%-305.87%4.88%32.8%19.96%-22.06%-49.69%
Net Income (Continuing)-1.11M-60.01M-174.52M-166.01M-111.57M-89.3M-109M-129.88M
Discontinued Operations00000000
Minority Interest00000000
EPS (Diluted)
-0.03▲ 0%
-3.40▼ 11195.7%
-4.64▼ 36.5%
-3.78▲ 18.5%
-0.96▲ 74.6%
-0.36▲ 62.5%
-0.34▲ 5.6%
-0.35▲ 0%
EPS Growth %--11195.68%-36.47%18.53%74.6%62.5%5.56%-7.29%
EPS (Basic)-0.03-3.40-4.64-3.78-0.96-0.36-0.34-
Diluted Shares Outstanding36.99M17.67M37.65M43.95M116.12M250.13M319.71M366.63M
Basic Shares Outstanding36.99M17.67M37.65M43.95M116.12M250.13M319.71M366.63M
Dividend Payout Ratio--------

TSHA Balance Sheet

Taysha Gene Therapies, Inc. (TSHA) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets15K257.88M159.6M96.42M149.87M142.13M324.65M282.25M
Cash & Short-Term Investments0251.25M149.1M87.88M143.94M139.04M319.77M276.58M
Cash Only0251.25M149.1M87.88M143.94M139.04M319.77M276.58M
Short-Term Investments00000000
Accounts Receivable00000000
Days Sales Outstanding--------
Inventory00000000
Days Inventory Outstanding--------
Other Current Assets15K331K6.63M1.19M3.42M892K4.88M5.67M
Total Non-Current Assets15K1M54.35M29.86M22.86M18.23M18.67M18.1M
Property, Plant & Equipment0287K50.61M25.91M20.41M15.87M16.18M15.61M
Fixed Asset Turnover---0.10x0.76x0.53x0.60x0.49x
Goodwill00000000
Intangible Assets00000000
Long-Term Investments002.64M0002.31M2.31M
Other Non-Current Assets15K715K1.11M3.95M2.46M2.37M183K7.35M
Total Assets
15K▲ 0%
258.88M▲ 1725773.3%
213.96M▼ 17.4%
126.28M▼ 41.0%
172.73M▲ 36.8%
160.36M▼ 7.2%
343.32M▲ 114.1%
300.35M▲ 0%
Asset Turnover---0.02x0.09x0.05x0.03x0.02x
Asset Growth %-1725773.33%-17.35%-40.98%36.79%-7.16%114.09%373.15%
Total Current Liabilities150K7.13M51.75M62.79M36.76M26.23M26.55M20.1M
Accounts Payable01.99M21.76M10.95M6.37M3.59M6.28M4.56M
Days Payables Outstanding-80.87K-1.61K--2K3.74K
Short-Term Debt00000000
Deferred Revenue (Current)00033.56M18.11M9.77M05.49M
Other Current Liabilities21K1.86M4.13M4.63M4.99M6.43M10.85M15.53M
Current Ratio0.10x36.17x3.08x1.54x4.08x5.42x12.23x12.23x
Quick Ratio0.10x36.17x3.08x1.54x4.08x5.42x12.23x12.23x
Cash Conversion Cycle--------
Total Non-Current Liabilities0450K66.83M62.54M61.04M62.61M69.83M68.31M
Long-Term Debt0037.19M37.97M40.51M43.94M18.17M17.77M
Capital Lease Obligations0025.9M20.44M18.95M17.36M033.37M
Deferred Tax Liabilities00000000
Other Non-Current Liabilities0450K3.73M4.13M1.58M1.31M51.66M105.12M
Total Liabilities150K7.58M118.57M125.33M97.79M88.84M96.38M88.41M
Total Debt0063.09M59.93M61.11M63.18M18.17M17.77M
Net Debt0-251.25M-86.01M-27.95M-82.83M-75.86M-301.6M-258.81M
Debt / Equity--0.66x63.15x0.82x0.88x0.07x0.07x
Debt / EBITDA--------0.13x
Net Debt / EBITDA-------1.97x
Interest Coverage--2142.25x-121.21x-42.71x-21.32x-874.47x-1753.94x-2510.94x
Total Equity
-135K▲ 0%
251.3M▲ 186249.6%
95.38M▼ 62.0%
949K▼ 99.0%
74.94M▲ 7796.4%
71.53M▼ 4.6%
246.94M▲ 245.2%
211.94M▲ 0%
Equity Growth %-186249.63%-62.04%-99.01%7796.42%-4.55%245.25%805.27%
Book Value per Share-0.0014.232.530.020.650.290.770.58
Total Shareholders' Equity-135K251.3M95.38M949K74.94M71.53M246.94M211.94M
Common Stock0001K2K2K3K3K
Retained Earnings-1.11M-61.13M-235.65M-401.44M-513.01M-602.3M-711.3M-753.71M
Treasury Stock00000000
Accumulated OCI00000-4.03M-192K985K
Minority Interest00000000

TSHA Cash Flow Statement

Taysha Gene Therapies, Inc. (TSHA) cash flow — operating, investing & free cash flow history

Line itemDec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations135K-30.73M-117.04M-88.39M-73.02M-81.22M-93.09M-93.09M
Operating CF Margin %----3532.77%-472.58%-974.74%-952.52%-
Operating CF Growth %--22862.22%-280.88%24.48%17.39%-11.24%-14.61%-137.25%
Net Income-1.11M-60.01M-174.52M-166.01M-111.57M-89.3M-109M-129.88M
Depreciation & Amortization09K492K1.17M1.37M1.25M1.15M1.3M
Stock-Based Compensation03.35M18.18M18.04M7.91M13.1M13.3M15.55M
Deferred Taxes00000000
Other Non-Cash Items710K26.03M10.14M39.89M47.28M6.19M6.83M-60K
Working Capital Changes540K-111K28.67M18.52M-18.01M-12.47M-5.37M1.13M
Change in Receivables00000000
Change in Inventory00000000
Change in Payables01.96M14.49M-7.8M-2.29M-2.92M-153K2.16M
Cash from Investing0-9.08M-21.55M-24.93M-7.35M-363K-604K-3.26M
Capital Expenditures0-82K-21.55M-24.87M-3.87M-374K-738K-384K
CapEx % of Revenue---993.96%25.04%4.49%7.55%-
Acquisitions00000000
Investments--------
Other Investing0-9M0-61K-3.48M11K134K-2.87M
Cash from Financing0291.06M39.08M52.1M136.39M76.68M274.59M275.35M
Debt Issued (Net)0039.96M0-3.45M09.24M0
Equity Issued (Net)0291.06M-360K53.24M140.79M76.78M265.69M265.61M
Dividends Paid00000000
Share Repurchases0000000-173K
Other Financing00-514K-1.15M-947K-96K-337K9.74M
Net Change in Cash
135K▲ 0%
251.25M▲ 186013.3%
-99.51M▼ 139.6%
-61.22M▲ 38.5%
56.02M▲ 191.5%
-4.9M▼ 108.8%
180.9M▲ 3788.7%
160.15M▲ 0%
Free Cash Flow
135K▲ 0%
-39.81M▼ 29589.6%
-138.6M▼ 248.1%
-113.26M▲ 18.3%
-80.39M▲ 29.0%
-81.6M▼ 1.5%
-93.83M▼ 15.0%
-112.33M▲ 0%
FCF Margin %----4526.74%-520.27%-979.23%-960.07%-1503.57%
FCF Growth %--29589.63%-248.13%18.28%29.02%-1.51%-14.99%-33.63%
FCF per Share0.00-2.25-3.68-2.58-0.69-0.33-0.29-0.29
FCF Conversion (FCF/Net Income)-0.12x0.71x0.67x0.53x0.65x0.91x0.85x0.86x
Interest Paid028K641K2.77M4.95M5.28M01.36M
Taxes Paid00000000

TSHA Key Ratios

Taysha Gene Therapies, Inc. (TSHA) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric202020212022202320242025TTM
Return on Equity (ROE)-34.24%-100.68%-344.67%-294.04%-121.94%-68.45%-56.07%
Return on Invested Capital (ROIC)--2758.74%----345.12%
Gross Margin--0.6%100%100%88.28%92.17%
Net Margin---6635.25%-722.06%-1071.62%-1115.27%-1738.4%
Debt / Equity-0.66x63.15x0.82x0.88x0.07x0.07x
Interest Coverage-2142.25x-121.21x-42.71x-21.32x-874.47x-1753.94x-2510.94x
FCF Conversion0.71x0.67x0.53x0.65x0.91x0.85x0.86x
Revenue Growth---517.55%-46.07%17.28%3.42%

TSHA SEC Filings & Documents

Taysha Gene Therapies, Inc. (TSHA) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 6, 2026·SEC

Material company update

Mar 19, 2026·SEC

Material company update

Nov 4, 2025·SEC

10-K Annual Reports

3
FY 2026

Mar 19, 2026·SEC

FY 2025

Feb 26, 2025·SEC

FY 2024

Mar 19, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 6, 2026·SEC

FY 2025

Nov 4, 2025·SEC

FY 2025

Aug 12, 2025·SEC

TSHA Frequently Asked Questions

Taysha Gene Therapies, Inc. (TSHA) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Taysha Gene Therapies, Inc. (TSHA) reported $7.5M in revenue for fiscal year 2025.

Taysha Gene Therapies, Inc. (TSHA) grew revenue by 17.3% over the past year. This is strong growth.

Taysha Gene Therapies, Inc. (TSHA) reported a net loss of $129.9M for fiscal year 2025.

Dividend & Returns

Taysha Gene Therapies, Inc. (TSHA) has a return on equity (ROE) of -68.5%. Negative ROE indicates the company is unprofitable.

Taysha Gene Therapies, Inc. (TSHA) had negative free cash flow of $112.3M in fiscal year 2025, likely due to heavy capital investments.

Explore More TSHA

Taysha Gene Therapies, Inc. (TSHA) financial analysis — history, returns, DCA and operating performance tools

Total Return Calculator

Historical returns with dividends reinvested

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DCA Calculator

Dollar cost averaging vs lump sum

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Dividend History

Yield, growth, payout safety & DRIP

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Earnings History

EPS trends, net income & profitability

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Price History

Long-term charts & historical price data

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Revenue History

Sales growth patterns & revenue breakdown

→

Financial Ratios

30 years of market, efficiency and balance-sheet ratios

→

Valuation

DCF intrinsic value, peer multiples & estimates

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