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VYNEVYNE Therapeutics Inc.
$0.64$27M
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VYNE logoVYNE Therapeutics Inc.(VYNE)Earnings, Financials & Key Ratios

VYNE•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryImmunology and Inflammation Therapies
AboutVYNE Therapeutics Inc., a pharmaceutical company, focuses on developing various therapeutics for the treatment of immuno-inflammatory conditions. The company develops FCD105, a topical combination foam that has completed Phase III clinical trials for the treatment of moderate-to-severe acne vulgaris; and FMX114, a combination of tofacitinib, which is in Phase IIa preclinical trial for the treatment of mild-to-moderate atopic dermatitis. It is also developing VYN201, a bromodomain and extra-terminal (BET) inhibitor for various immuno-inflammatory diseases, including skin diseases; and VYN202, BET inhibitor compounds that are selective for bromodomain 2. The company was formerly known as Menlo Therapeutics Inc. and changed its name to VYNE Therapeutics Inc. in September 2020. VYNE Therapeutics Inc. was founded in 2003 and is based in Bridgewater, New Jersey.Show more
  • Revenue$570K+13.8%
  • EBITDA-$27M+38.7%
  • Net Income-$26M+33.5%
  • EPS (Diluted)-0.62+34.0%
  • Gross Margin95.96%-4.0%
  • EBITDA Margin-4689.82%+46.2%
  • Operating Margin-5219.12%+40.1%
  • Net Margin-4646.14%+41.6%
  • ROE-66.33%-17.2%

VYNE Key Insights

VYNE Therapeutics Inc. (VYNE) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Strong 5Y profit CAGR of 36.5%
  • ✓Momentum leader: RS Rating 82 (top 18%)
  • ✓High quality earnings: Operating CF exceeds net income
  • ✓Trading at only 1.0x book value

✗Weaknesses

  • ✗Weak Piotroski F-Score: 2/9
  • ✗Negative free cash flow
  • ✗Sales declining 51.4% over 5 years
  • ✗Trading more than 30% below 52-week high
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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VYNE Price & Volume

VYNE Therapeutics Inc. (VYNE) stock price & volume — 10-year historical chart

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VYNE Growth Metrics

VYNE Therapeutics Inc. (VYNE) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years-51.39%
3 Years6.12%
TTM-24.96%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM49.15%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM51.13%

Return on Capital

10 Years-20.51%
5 Years-66.84%
3 Years-61.34%
Last Year-74.51%

VYNE Recent Earnings

VYNE Therapeutics Inc. (VYNE) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 7/12 qtrs (58%)●Beat Revenue 4/12 qtrs (33%)
Q2 2026Latest
May 15, 2026
Metric
Actual
Est
EPS
$0.08+55.6%
$0.18
Rev
$86,000-57.0%
$200,000
Q2 2026
Mar 12, 2026
Metric
Actual
Est
EPS
$0.28-40.0%
$0.20
Rev
$130,000-25.7%
$175,000
Q4 2025
Nov 6, 2025
Metric
Actual
Est
EPS
$0.17+10.5%
$0.19
Rev
$169,000+35.2%
$125,000
Q3 2025
Aug 14, 2025
Metric
Actual
Est
EPS
$0.13+43.5%
$0.23
Rev
$69,000-65.5%
$200,000
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 15, 2026
$0.08vs $0.18+55.6%
$86,000vs $200,000-57.0%
Q2 2026Mar 12, 2026
$0.28vs $0.20-40.0%
$130,000vs $175,000-25.7%
Q4 2025Nov 6, 2025
$0.17vs $0.19+10.5%
$169,000vs $125,000+35.2%
Q3 2025Aug 14, 2025
$0.13vs $0.23+43.5%
$69,000vs $200,000-65.5%
Based on last 12 quarters of dataView full earnings history →

VYNE Peer Comparison

VYNE Therapeutics Inc. (VYNE) competitors in Immunology and Inflammation Therapies — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
DERM logoDERMJourney Medical CorporationDirect Competitor171.19M6.22-13.2310.2%-14.82%-35.57%0.00
PRGO logoPRGOPerrigo Company plcDirect Competitor1.42B10.25-1.00-2.75%-43.5%-50.65%1.35
SKIN logoSKINThe Beauty Health CompanyDirect Competitor85.9M0.66-4.14-10.02%-2.03%-9.41%6.20
ORGO logoORGOOrganogenesis Holdings Inc.Direct Competitor313.97M2.4416.2716.8%-0.06%-0.07%0.31
GDRX logoGDRXGoodRx Holdings, Inc.Product Competitor922.03M2.6631.180.57%3.74%4.75%0.10
NKTR logoNKTRNektar TherapeuticsProduct Competitor1.19B60.98-6.27-43.89%-284.18%-87%1.66
PCRX logoPCRXPacira BioSciences, Inc.Product Competitor878.35M22.33139.563.63%1.27%1.31%0.66
INVA logoINVAInnoviva, Inc.Product Competitor1.66B22.496.8218.52%118.91%47.59%0.23

Compare VYNE vs Peers

VYNE Therapeutics Inc. (VYNE) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs DERM

Most directly comparable listed peer for VYNE.

Scale Benchmark

vs MCK

Larger-name benchmark to compare VYNE against a more recognizable public peer.

Peer Set

Compare Top 5

vs DERM, PRGO, SKIN, ORGO

VYNE Income Statement

VYNE Therapeutics Inc. (VYNE) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
4.58M10.64M443K20.99M931K477K424K501K570K454K
Revenue Growth %
579.82%132.21%-95.84%4638.83%-95.57%-48.76%-11.11%18.16%13.77%-24.96%
Cost of Goods Sold
00350K1.39M000023K6K
COGS % of Revenue
--79.01%6.63%----4.04%-
Gross Profit
4.58M▲ 0%
10.64M▲ 132.2%
93K▼ 99.1%
19.6M▲ 20976.3%
931K▼ 95.3%
477K▼ 48.8%
424K▼ 11.1%
501K▲ 18.2%
547K▲ 9.2%
448K▲ 0%
Gross Margin %
100%100%20.99%93.37%100%100%100%100%95.96%98.68%
Gross Profit Growth %
579.82%132.21%-99.13%20976.34%-95.25%-48.76%-11.11%18.16%9.18%-
Operating Expenses
34.17M65.17M76.24M-232.94M39.84M34.77M29.68M44.14M30.3M24.82M
OpEx % of Revenue
745.85%612.55%17210.38%-1109.63%4279.48%7289.73%7000.47%8809.98%5315.09%-
Selling, General & Admin
5.17M12.19M22.48M89.54M20.3M16.39M13.38M13.19M11.08M10.89M
SG&A % of Revenue
112.79%114.53%5074.72%426.54%2180.34%3435.43%3154.48%2633.13%1944.21%-
Research & Development
29.01M52.99M53.76M43.53M19.54M18.39M16.31M30.95M19.24M13.93M
R&D % of Revenue
633.06%498.02%12135.67%207.37%2099.14%3854.3%3845.99%6176.85%3374.91%-
Other Operating Expenses
000-366.02M0000-23K0
Operating Income
-29.59M▲ 0%
-54.53M▼ 84.3%
-76.24M▼ 39.8%
252.55M▲ 431.2%
-38.91M▼ 115.4%
-34.3M▲ 11.9%
-29.26M▲ 14.7%
-43.64M▼ 49.1%
-29.75M▲ 31.8%
-24.37M▲ 0%
Operating Margin %
-645.85%-512.55%-17210.38%1203%-4179.48%-7189.73%-6900.47%-8709.98%-5219.12%-5367.62%
Operating Income Growth %
-106.48%-84.28%-39.8%431.24%-115.41%11.86%14.69%-49.15%31.83%-
EBITDA
-29.59M-54.51M-75.89M252.89M-38.8M-34.22M-29.26M-43.63M-26.73M-24.35M
EBITDA Margin %
-645.68%-512.34%-17131.38%1204.63%-4167.78%-7174.63%-6900.47%-8709.18%-4689.82%-5362.56%
EBITDA Growth %
-106.48%-84.26%-39.22%433.22%-115.34%11.8%14.51%-49.13%38.73%45.22%
D&A (Non-Cash Add-back)
8K22K350K341K109K72K04K023K
EBIT
-29.59M-54.53M-94.43M-251.44M-38.91M-34.3M-29.26M-43.64M-26.73M-24.37M
Net Interest Income
517K3.09M-921K-4.39M-5.61M00000
Interest Income
517K3.09M00000000
Interest Expense
00921K4.39M5.61M00000
Other Income/Expense
517K3.09M-19.11M-508.37M-4.85M363K1.39M3.83M3.02M2.65M
Pretax Income
-29.08M▲ 0%
-51.45M▼ 76.9%
-73.7M▼ 43.3%
-255.83M▼ 247.1%
-43.76M▲ 82.9%
-33.93M▲ 22.5%
-27.87M▲ 17.9%
-39.8M▼ 42.8%
-26.73M▲ 32.8%
-21.71M▲ 0%
Pretax Margin %
-634.57%-483.51%-16637.25%-1218.63%-4700.32%-7113.63%-6573.58%-7944.71%-4689.82%-4782.82%
Income Tax
-8K0-3.24M-258K448K13K04K4K4K
Effective Tax Rate %
0.03%0%4.39%0.1%-1.02%-0.04%0%-0.01%-0.01%-0.02%
Net Income
-29.08M▲ 0%
-51.45M▼ 76.9%
-70.46M▼ 37.0%
-255.57M▼ 262.7%
-73.33M▲ 71.3%
-23.21M▲ 68.3%
-28.45M▼ 22.6%
-39.83M▼ 40.0%
-26.48M▲ 33.5%
-21.46M▲ 0%
Net Margin %
-634.57%-483.51%-15906.09%-1217.4%-7876.37%-4865.83%-6710.38%-7950.9%-4646.14%-4726.21%
Net Income Growth %
-106.68%-76.93%-36.97%-262.69%71.31%68.35%-22.59%-40%33.52%49.15%
Net Income (Continuing)
-29.08M-51.45M-95.18M-255.57M-44.21M-33.95M-27.87M-39.81M-26.74M-21.72M
Discontinued Operations
0000-29.12M10.73M-580K-27K253K261K
Minority Interest
0000000000
EPS (Diluted)
-101.65▲ 0%
-170.94▼ 68.2%
-149.48▲ 12.6%
-141.90▲ 5.1%
-25.65▲ 81.9%
-10.65▲ 58.5%
-2.77▲ 74.0%
-0.94▲ 66.1%
-0.62▲ 34.0%
-0.50▲ 0%
EPS Growth %
-118.65%-68.17%12.55%5.07%81.92%58.48%73.99%66.06%34.04%51.13%
EPS (Basic)
-101.65-170.94-149.48-141.90-25.65-10.65-2.77-0.94-0.62-
Diluted Shares Outstanding
286.04K300.95K471.39K1.8M2.86M3.19M10.27M42.59M42.77M42.77M
Basic Shares Outstanding
286.04K300.95K471.39K1.8M2.86M3.19M10.27M42.59M42.77M42.77M
Dividend Payout Ratio
----------

VYNE Balance Sheet

VYNE Therapeutics Inc. (VYNE) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
63.86M139.5M78.33M87.26M63.19M38.27M95.96M64.44M30.01M25.79M
Cash & Short-Term Investments
62.48M136.25M76.94M58.59M42.25M30.91M93.25M61.52M29.01M24.93M
Cash Only
10.21M49.51M30.78M57.56M42.25M30.91M30.62M19.93M24.03M24.63M
Short-Term Investments
49.3M86.74M46.17M1.03M0062.63M41.59M4.98M297K
Accounts Receivable
786K0015.82M7.58M5M0000
Days Sales Outstanding
62.61--275.042.97K3.83K----
Inventory
-2.98M007.4M7.29M00000
Days Inventory Outstanding
---1.94K------
Other Current Assets
03.25M0855K1.5M240K2.71M2.92M1M861K
Total Non-Current Assets
3.01M428K842K6.48M3.86M2.48M1.72M2.47M150K84K
Property, Plant & Equipment
28K146K769K2.14M354K0207K206K90K84K
Fixed Asset Turnover
163.64x72.88x0.58x9.82x2.63x-2.05x2.43x6.33x4.50x
Goodwill
0000000000
Intangible Assets
0000000000
Long-Term Investments
2.98M000000000
Other Non-Current Assets
0282K73K4.34M3.51M2.48M1.51M2.26M60K0
Total Assets
66.87M▲ 0%
139.93M▲ 109.3%
79.17M▼ 43.4%
93.74M▲ 18.4%
67.05M▼ 28.5%
40.76M▼ 39.2%
97.69M▲ 139.7%
66.91M▼ 31.5%
30.16M▼ 54.9%
25.87M▲ 0%
Asset Turnover
0.07x0.08x0.01x0.22x0.01x0.01x0.00x0.01x0.02x0.01x
Asset Growth %
59.01%109.26%-43.42%18.41%-28.48%-39.21%139.67%-31.51%-54.92%-210.04%
Total Current Liabilities
7.82M9.54M10.66M21.77M18.41M9.35M7.54M14.82M2.4M1.24M
Accounts Payable
2.46M3.29M3.77M4.78M6.51M2.39M1.66M2.71M1.04M261K
Days Payables Outstanding
--3.93K1.25K----16.52K59.51K
Short-Term Debt
0000000000
Deferred Revenue (Current)
1.8M000000000
Other Current Liabilities
2.45M3.6M485K4.78M2.96M2.58M4.12M2.74M1.35M975K
Current Ratio
8.17x14.62x7.35x4.01x3.43x4.10x12.73x4.35x12.53x20.86x
Quick Ratio
8.55x14.62x7.35x3.67x3.04x4.10x12.73x4.35x12.53x20.86x
Cash Conversion Cycle
---963.09------
Total Non-Current Liabilities
116.08M7K034.48M0211K1.41M000
Long-Term Debt
00033.17M000000
Capital Lease Obligations
000853K0099K000
Deferred Tax Liabilities
0000000000
Other Non-Current Liabilities
109.35M7K0457K0211K1.31M000
Total Liabilities
123.9M9.55M10.66M56.25M18.41M9.56M8.95M14.82M2.4M1.24M
Total Debt
00700K34.78M349K0214K99K00
Net Debt
-10.21M-49.51M-30.08M-22.78M-41.9M-30.91M-30.41M-19.83M-24.03M-24.63M
Debt / Equity
--0.01x0.93x0.01x-0.00x0.00x-0.00x
Debt / EBITDA
---0.14x------0.00x
Net Debt / EBITDA
----0.09x-----1.01x
Interest Coverage
---102.53x-57.27x-6.94x-----
Total Equity
-57.03M▲ 0%
130.38M▲ 328.6%
68.51M▼ 47.5%
37.49M▼ 45.3%
48.64M▲ 29.7%
31.2M▼ 35.8%
88.73M▲ 184.4%
52.09M▼ 41.3%
27.77M▼ 46.7%
24.64M▲ 0%
Equity Growth %
-93.72%328.6%-47.45%-45.27%29.72%-35.85%184.39%-41.3%-46.69%-188.43%
Book Value per Share
-199.39433.21145.3320.8217.019.798.641.220.650.58
Total Shareholders' Equity
-57.03M130.38M68.51M37.49M48.64M31.2M88.73M52.09M27.77M24.64M
Common Stock
1K3K3K4K5K01K1K3K3K
Retained Earnings
-59.19M-110.64M-184.34M-566.2M-639.52M-662.74M-691.34M-731.17M-757.65M-761.24M
Treasury Stock
0000000000
Accumulated OCI
-51K-96K24K00026K20K2K0
Minority Interest
0000000000

VYNE Cash Flow Statement

VYNE Therapeutics Inc. (VYNE) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-28.25M-52.73M-65.1M-137.08M-56.37M-29.2M-25.34M-33.97M-33.12M-25.74M
Operating CF Margin %
-616.48%-495.61%-14695.49%-652.99%-6054.46%-6121.59%-5976.65%-6780.84%-5811.23%-
Operating CF Growth %
-1132.95%-86.69%-23.45%-110.57%58.88%48.2%13.22%-34.06%2.5%111.82%
Net Income
-29.08M-51.45M-73.7M-255.57M-73.33M-23.21M-28.45M-39.83M-26.48M-21.46M
Depreciation & Amortization
8K22K700K341K109K72K04K-755K5K
Stock-Based Compensation
1.45M3.64M6.7M18.1M8.08M4.3M3.31M3.3M2.31M2.02M
Deferred Taxes
60K0056.3M1.52M00000
Other Non-Cash Items
31K-774K-691K84.07M2.47M-12.64M-254K-2.44M0-454K
Working Capital Changes
-722K-4.17M1.89M-40.33M4.78M2.28M60K5M-8.19M-5.86M
Change in Receivables
-786K786K1.36M-17.14M7.71M11.21M405K-899K4.21M5.18M
Change in Inventory
1.19M2.76M-1.36M-6.05M113K97K0000
Change in Payables
620K825K481K-12.97M-2.67M-8.68M-559K6.01M-12.31M-10.98M
Cash from Investing
-15.06M-33.88M41.37M89.11M1.03M15.67M-57.35M23.36M37.37M22.24M
Capital Expenditures
-27K-140K-11K-113K000-117K00
CapEx % of Revenue
0.59%1.32%2.48%0.54%---23.35%-0%
Acquisitions
-25K040K38.64M015.67M5M000
Investments
----------
Other Investing
25K0-40K38.64M000000
Cash from Financing
49.49M125.91M4.99M61.81M39.78M1.65M82.39M-141K-143K-71K
Debt Issued (Net)
0000-36.43M00000
Equity Issued (Net)
50.32M125.42M4.53M61.64M75.98M1.68M82.46M-141K0-49K
Dividends Paid
0000000000
Share Repurchases
0000000-141K0-34K
Other Financing
-833K496K465K169K228K-28K-67K0-143K-22K
Net Change in Cash
6.18M▲ 0%
39.3M▲ 536.1%
-18.73M▼ 147.7%
13.83M▲ 173.8%
-15.56M▼ 212.5%
-11.88M▲ 23.7%
-301K▲ 97.5%
-10.75M▼ 3470.8%
4.1M▲ 138.2%
-3.58M▲ 0%
Free Cash Flow
-28.27M▲ 0%
-52.87M▼ 87.0%
-65.11M▼ 23.1%
-137.19M▼ 110.7%
-56.37M▲ 58.9%
-29.2M▲ 48.2%
-25.34M▲ 13.2%
-34.09M▼ 34.5%
-33.12M▲ 2.8%
-25.74M▲ 0%
FCF Margin %
-617.07%-496.93%-14697.97%-653.53%-6054.46%-6121.59%-5976.65%-6804.19%-5811.23%-5670.48%
FCF Growth %
-1117.66%-87%-23.15%-110.71%58.91%48.2%13.22%-34.52%2.83%31.48%
FCF per Share
-98.85-175.68-138.13-76.18-19.72-9.17-2.47-0.80-0.77-0.60
FCF Conversion (FCF/Net Income)
0.97x1.03x0.92x0.54x0.77x1.26x0.89x0.85x1.25x1.20x
Interest Paid
0000000000
Taxes Paid
0000000000

VYNE Key Ratios

VYNE Therapeutics Inc. (VYNE) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric201720182019202020212022202320242025TTM
Return on Equity (ROE)
--140.29%-70.86%-482.2%-170.28%-58.14%-47.44%-56.57%-66.33%-69.57%
Return on Invested Capital (ROIC)
--600.3%-95.86%712.8%-272.12%-731.86%-74.86%-72.26%-123.96%-219.24%
Gross Margin
100%100%20.99%93.37%100%100%100%100%95.96%98.68%
Net Margin
-634.57%-483.51%-15906.09%-1217.4%-7876.37%-4865.83%-6710.38%-7950.9%-4646.14%-4726.21%
Debt / Equity
--0.01x0.93x0.01x-0.00x0.00x-0.00x
Interest Coverage
---102.53x-57.27x-6.94x-----
FCF Conversion
0.97x1.03x0.92x0.54x0.77x1.26x0.89x0.85x1.25x1.20x
Revenue Growth
579.82%132.21%-95.84%4638.83%-95.57%-48.76%-11.11%18.16%13.77%-24.96%
Related:VYNE Dividend History·VYNE Revenue History·VYNE Price History·VYNE P/E History·VYNE Financial Ratios·VYNE Institutional Holders

VYNE SEC Filings & Documents

VYNE Therapeutics Inc. (VYNE) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 21, 2026·SEC

Material company update

Mar 11, 2026·SEC

Material company update

Jan 30, 2026·SEC

10-K Annual Reports

4
FY 2026

Feb 27, 2026·SEC

FY 2025

Mar 6, 2025·SEC

FY 2024

Mar 1, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 15, 2026·SEC

FY 2025

Nov 6, 2025·SEC

FY 2025

Aug 14, 2025·SEC

VYNE Frequently Asked Questions

VYNE Therapeutics Inc. (VYNE) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

VYNE Therapeutics Inc. (VYNE) reported $0.5M in revenue for fiscal year 2025.

VYNE Therapeutics Inc. (VYNE) grew revenue by 13.8% over the past year. This is steady growth.

VYNE Therapeutics Inc. (VYNE) reported a net loss of $21.5M for fiscal year 2025.

Dividend & Returns

VYNE Therapeutics Inc. (VYNE) has a return on equity (ROE) of -66.3%. Negative ROE indicates the company is unprofitable.

VYNE Therapeutics Inc. (VYNE) had negative free cash flow of $25.7M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in VYNE back in 2015?

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