VYNE Therapeutics Inc. (VYNE) P/E Ratio History
Historical price-to-earnings valuation from 2026 to 2026
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VYNE Valuation Context
How does the current P/E compare to historical and market benchmarks?
P/E Ratio Analysis
As of May 8, 2026, VYNE Therapeutics Inc. (VYNE) trades at a price-to-earnings ratio of -1.1x, with a stock price of $0.67 and trailing twelve-month earnings per share of $-0.62.
Compared to the Healthcare sector median P/E of 22.3x, VYNE trades at a 105% discount to its sector peers. The sector includes 241 companies with P/E ratios ranging from 0.0x to 177.5x.
Relative to the broader market, VYNE trades at a notable discount to the S&P 500 median P/E of 25.1x. Investors should consider the company's growth prospects, competitive position, and earnings quality when evaluating whether the current valuation is justified.
For a comprehensive intrinsic value estimate using discounted cash flow analysis, see our VYNE DCF Valuation Calculator →
Note: P/E ratio is just one valuation metric. It does not account for balance sheet strength, cash flow quality, or growth sustainability. Always conduct comprehensive due diligence before making investment decisions.
VYNE P/E vs Peers
P/E ratio compared to closely matched public peers
| Company | Market Cap | P/E Ratio | PEG Ratio | EPS Growth (1Y) |
|---|---|---|---|---|
| $323M | 16.7 | - | +1600%Best | |
| $973M | 33.3 | - | +104% | |
| $930M | 147.8 | - | +107% | |
| $2B | 6.9Lowest | 0.67Best | +817% | |
| $4B | 62.4 | - | +158% | |
| $92B | 29.2 | 0.75 | +15% |
Peers sorted by market capitalization. P/E below peers may indicate undervaluation or lower growth expectations. Consider PEG ratio for growth-adjusted comparison.
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Start ComparisonVYNE — Frequently Asked Questions
Quick answers to the most common questions about buying VYNE stock.
Is VYNE stock overvalued or undervalued?
VYNE current P/E: -1.1x. 5-year average P/E: N/A. Percentile: N/A.
How does VYNE's valuation compare to peers?
VYNE Therapeutics Inc. P/E of -1.1x compares to sector median of 22.3x. The discount suggests lower growth expectations or higher risk.
What is VYNE's PEG ratio?
VYNE PEG ratio is N/A. Above 2.0 indicates premium valuation relative to growth rate. Historical P/E data spans 2026-2026.