Cash flow generation remains inconsistent, highlighted by a volatile operating cash flow to net income ratio that reached 9.34 in 2026Q1 following a negative 2025Q4 performance.
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 | Dec'08 | Dec'07 | Dec'06 | Dec'05 | Dec'04 | Dec'03 | Dec'02 | Dec'00 |
|---|
| Cash from Operations | 123.49M | 109.84M | 157.72M | 16.7M | -114.03M | -125.66M | -136.17M | -151.13M | -167.47M | -217.86M | -210.41M | -121.8M | -66.43M | -31.77M | -21.63M | -19.9M | -10.7M | -13.73M | -64.87M | -54.93M | -41.42M | -20.26M | -20.69M | -9.82M | -9.24M | 0 |
| Operating CF Margin % | - | 10.25% | 16.47% | 2.3% | -22.05% | -25.96% | -30.82% | -44.57% | -74.83% | -174.42% | -1214.06% | -199663.93% | -55361.67% | -2774.59% | -440.86% | -962.6% | -25.4% | -214.52% | -4079.81% | -727.02% | -509.26% | -184.94% | -449.44% | -133.04% | -147.29% | - |
| Operating CF Growth % | 19.68% | -30.36% | 844.31% | 114.65% | 9.25% | 7.72% | 9.9% | 9.76% | 23.13% | -3.54% | -72.76% | -83.33% | -109.12% | -46.85% | -8.72% | -85.9% | 22.03% | 78.84% | -18.1% | -32.61% | -104.41% | 2.08% | -110.8% | -6.2% | - | - |
| Net Income | 375.65M | 391M | 226.45M | -61.29M | -215.97M | -167.87M | -281.58M | -235.26M | -245.19M | -289.4M | -271.39M | -164.44M | -92.47M | -37.95M | -20.85M | -22.77M | 15.14M | -45.15M | -64.24M | -56.39M | -45.05M | -34.14M | -25.92M | -14.09M | -12.87M | -10.19M |
| Depreciation & Amortization | 7.71M | 11.76M | 15.88M | 5.55M | 2.03M | 3.34M | 2.93M | 2.77M | 3M | 2.71M | 1.83M | 647K | 206K | 79K | 109K | 285K | 607K | 1.11M | 1.04M | 768K | -146K | 1.03M | 1.31M | 1.34M | 1.4M | 0 |
| Stock-Based Compensation | 27.52M | 0 | 67.05M | 66.42M | 68.2M | 63.62M | 84.42M | 82.27M | 81.56M | 75.53M | 55.27M | 40.19M | 16.04M | 5.71M | 1.93M | 1.6M | 1.58M | 2.13M | 2.99M | 3.38M | 3.38M | 1.31B | 2.36B | 0 | 0 | 0 |
| Deferred Taxes | -249.97M | -249.88M | 0 | 0 | 0 | 0 | 2.75M | 0 | 0 | 0 | -596K | -247K | 0 | 0 | 0 | 105K | 0 | 0 | 911K | -3.53M | -3.55M | -1.31B | -2.36B | 0 | 0 | 0 |
| Other Non-Cash Items | 28.27M | 46.71M | -155.82M | -12.12M | -6.28M | 75K | 44.28M | -4.61M | 1.35M | -287K | 94K | -2.06M | 484K | 1.52M | -385K | 806K | -211K | 583K | 5K | 4.29M | 3.38M | 1.46M | 2.36M | 1.39M | 1.16M | -15.14M |
| Working Capital Changes | -65.68M | -89.76M | 4.16M | 18.13M | 37.99M | -24.82M | 11.04M | 3.71M | -8.2M | -6.41M | 4.39M | 4.11M | 9.31M | -1.13M | -2.44M | 74K | -27.82M | 27.59M | -5.57M | -3.44M | 574K | 11.39M | 1.55M | 1.54M | 1.06M | 25.33M |
| Change in Receivables | -34.67M | -43.54M | -2.35M | -39.27M | 2.26M | -16.12M | -12.47M | -9.69M | -8.75M | -11.44M | -5.9M | -674K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Inventory | -7.67M | -18.2M | -49.55M | -28.81M | 2.42M | -4.21M | -3.32M | -1.74M | 1.93M | -1.01M | -3.31M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Payables | -5.85M | -5.29M | -1.35M | 4.8M | 5.87M | -1.62M | 1.27M | 4.05M | -5.62M | 4.87M | 2.24M | -344K | 1.64M | -1M | -585K | -29K | -990K | 656K | -276K | 1.31M | 1.31M | -79.5M | 577.6M | 0 | 0 | 0 |
| Cash from Investing | -112.23M | -302.56M | -30.54M | 32M | 73.24M | -71.1M | 192.51M | -165.84M | -71.49M | 92.47M | -261.92M | 147.57M | -87.27M | -126.1M | -25.53M | 5.98M | -1.06M | 9.44M | 69.71M | -41.9M | -22.94M | -6.65M | -7.38M | -14.69M | 3.85M | 0 |
| Capital Expenditures | 88.94M | -103.53M | -523K | -40.05M | 0 | -1.12M | -7.59M | -1.13M | -2.15M | -812K | -9.51M | -2.14M | -180K | -618K | -3K | -3K | 0 | -41K | -226K | -416K | -2.03M | -1.02M | -585.3K | -1.78M | -380.6K | 0 |
| CapEx % of Revenue | 8.12% | 9.66% | 0.05% | 5.51% | - | 0.23% | 1.72% | 0.33% | 0.96% | 0.65% | 54.85% | 3509.84% | 150% | 53.97% | 0.06% | 0.15% | - | 0.64% | 14.21% | 5.51% | 24.91% | 9.33% | 12.71% | 24.09% | 6.06% | - |
| Acquisitions | 0 | 0 | 0 | -32.05M | 0 | 69.98M | -200.1M | 164.71M | 44K | 0 | 8M | -2.06M | 0 | 0 | 3K | 3K | 0 | 0 | 0 | -12.52M | 0 | 0 | 0 | 0 | 0 | 0 |
| Investments | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Other Investing | -98.84M | 0 | 146.51M | 32.05M | 0 | -69.98M | 200.1M | -164.71M | 44K | 93.28M | -8M | 2.06M | -87.09M | 12K | 252K | -3K | 128K | 0 | 0 | 12.52M | 12.52M | 0 | 0 | 0 | 0 | 0 |
| Cash from Financing | 52.28M | 49.88M | 6.84M | 25.13M | 8.2M | 18.16M | 81M | 371.85M | 306.65M | 31.19M | 533.81M | 14.5M | 203.85M | 111.68M | 98.17M | 13.94M | 470K | 1.16M | -374K | 98.22M | 70M | 28.37M | 30.11M | 26.4M | 4.39M | 0 |
| Debt Issued (Net) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -32K | -78K | -353K | -762K | -909K | -379K | 593K | -779.7K | -1.39M | -1.62M | 4.37M | 0 |
| Equity Issued (Net) | 52.28M | 49.88M | 6.84M | 25.13M | 8.2M | 18.16M | 81M | 371.85M | 306.65M | 31.19M | 518.9M | 14.55M | 203.85M | 111.68M | 98.2M | 14.02M | 823K | 1.92M | 535K | 98.6M | 69.4M | 41.67M | 31.5M | 28.02M | 15K | 0 |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other Financing | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 14.92M | -45K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -12.52M | 0 | 0 | 0 | 0 |
| Net Change in Cash | 65.22M | -141.89M | 133.93M | 73.81M | -32.59M | -178.59M | 137.33M | 54.88M | 67.69M | -94.2M | 61.48M | 40.28M | 50.15M | -46.19M | 51.01M | 40K | -11.27M | -3.05M | 4.18M | 1.51M | 5.68M | 1.49M | 1.99M | 1.85M | -1.06M | 0 |
| Free Cash Flow | 212.43M | 105.15M | 157.2M | -23.35M | -114.03M | -126.78M | -143.75M | -152.26M | -169.62M | -218.67M | -219.91M | -123.94M | -66.61M | -32.39M | -21.64M | -19.9M | -10.7M | -13.77M | -65.09M | -55.34M | -43.44M | -21.28M | -21.28M | -11.59M | -9.62M | 0 |
| FCF Margin % | 19.4% | 9.81% | 16.41% | -3.21% | -22.05% | -26.19% | -32.54% | -44.9% | -75.79% | -175.07% | -1268.91% | -203173.77% | -55511.67% | -2828.56% | -440.92% | -962.75% | -25.4% | -215.16% | -4094.03% | -732.52% | -534.17% | -194.27% | -462.15% | -157.13% | -153.35% | - |
| FCF Growth % | 328.27% | -33.11% | 773.27% | 79.53% | 10.05% | 11.81% | 5.59% | 10.23% | 22.43% | 0.57% | -77.44% | -86.05% | -105.68% | -49.69% | -8.72% | -85.93% | 22.26% | 78.85% | -17.62% | -27.39% | -104.11% | -0.03% | -83.54% | -20.47% | - | - |
| FCF per Share | 1.23 | 0.61 | 0.94 | -0.14 | -0.71 | -0.79 | -0.91 | -1.03 | -1.34 | -1.78 | -1.90 | -1.23 | -0.68 | -0.38 | -0.39 | -0.38 | -0.28 | -0.37 | -1.75 | -1.57 | -1.56 | -0.97 | -2.06 | -1.02 | -6.63 | - |
| FCF Conversion (FCF/Net Income) | 0.57x | 0.28x | 0.70x | -0.27x | 0.53x | 0.75x | 0.48x | 0.64x | 0.68x | 0.75x | 0.78x | 0.74x | 0.72x | 0.84x | 1.04x | 0.87x | -0.71x | 0.30x | 1.01x | 0.97x | 0.92x | 0.59x | 0.80x | 0.70x | 0.72x | - |
| Interest Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Taxes Paid | 0 | 0 | 19.52M | 5.85M | 2.19M | 1.04M | 1.11M | 1.6M | 1.26M | 1.37M | 365K | -415K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pipeline concentration and regulatory exposure
As reported in financial statements, ACAD's operating cash flow to net income ratio has exhibited extreme volatility, ranging from a low of -0.18 in 2025Q4 to a high of 9.34 in 2026Q1, indicating that reported earnings are frequently decoupled from actual cash generation capabilities.
The significant variance between net income and operating cash flow suggests that non-cash items and working capital swings are heavily influencing the bottom line. Investors should interpret this as a signal that earnings quality is inconsistent, necessitating a focus on cash flow rather than GAAP net income for valuation purposes.
Based on ACAD's reported figures, free cash flow margins have fluctuated wildly between -32.1% and 61.4% over the last ten quarters, reflecting a lack of predictable cash conversion as the company navigates the transition from a single-product entity to a more diversified commercial-stage biopharmaceutical business.
The erratic FCF trajectory appears to be driven by the timing of commercial investments and the lumpy nature of working capital requirements. This instability suggests that the company has not yet achieved a steady-state cash generation profile, which may complicate long-term capital allocation planning.
According to recent SEC filings, ACAD experienced a substantial $87.9 million working capital outflow in 2025Q4, which directly contributed to a negative operating cash flow despite the company reporting positive net income during the same period, highlighting the sensitivity of cash flow to inventory and receivables management.
These large swings in working capital suggest that the company's cash position is highly susceptible to shifts in specialty pharmacy inventory levels and the timing of government rebates. Analysts should monitor whether these fluctuations are temporary timing differences or indicative of structural challenges in the revenue collection cycle.
As indicated by the data, ACAD's capital expenditure as a percentage of revenue has remained generally low, with the exception of anomalous spikes in 2025, suggesting that the company's business model is not inherently capital-intensive regarding physical infrastructure or manufacturing capacity maintenance.
The minimal maintenance capex requirements reflect the outsourced or low-asset nature of the company's drug manufacturing processes. This low capital intensity is a positive attribute, as it allows the company to direct the majority of its cash flow toward R&D and commercialization efforts rather than asset replacement.
Quick answers to the most common questions about buying ACAD stock.
ACADIA Pharmaceuticals Inc. (ACAD) generated $109.8M in net cash from operating activities in 2025. This reflects the cash generated directly from core business operations.
ACADIA Pharmaceuticals Inc. (ACAD) generated $105.1M in free cash flow in 2025. Free cash flow is the cash left over after capital expenditures, which can be used to pay dividends, repurchase shares, or pay down debt.
ACADIA Pharmaceuticals Inc. (ACAD) spent $103.5M on capital expenditures in 2025. CapEx represents the cash invested in physical assets like property, plant, and equipment to maintain or grow the business.