Agios Pharmaceuticals, Inc. (AGIO) P/E Ratio History
Historical price-to-earnings valuation from 2021 to 2025
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Valuation Context
How does the current P/E compare to historical and market benchmarks?
P/E Ratio Analysis
As of March 1, 2026, Agios Pharmaceuticals, Inc. (AGIO) trades at a price-to-earnings ratio of -4.2x, with a stock price of $30.23 and trailing twelve-month earnings per share of $-6.90.
The current P/E is 265% below its 5-year average of 2.6x. Over the past five years, AGIO's P/E has ranged from a low of 1.5x to a high of 3.9x, placing the current valuation at the 0th percentile of its historical range.
Compared to the Healthcare sector median P/E of 23.7x, AGIO trades at a 118% discount to its sector peers. The sector includes 224 companies with P/E ratios ranging from 0.0x to 184.4x.
Relative to the broader market, AGIO trades at a notable discount to the S&P 500 median P/E of 26.2x. Investors should consider the company's growth prospects, competitive position, and earnings quality when evaluating whether the current valuation is justified.
For a comprehensive intrinsic value estimate using discounted cash flow analysis, see our AGIO DCF Valuation Calculator →
Note: P/E ratio is just one valuation metric. It does not account for balance sheet strength, cash flow quality, or growth sustainability. Always conduct comprehensive due diligence before making investment decisions.
Peer Comparison
P/E metrics vs. Commercial Rare Disease Biopharma peers
| Company | Market Cap | P/E Ratio | PEG Ratio | EPS Growth (1Y) |
|---|---|---|---|---|
VRTXVertex Pharmaceuticals Incorporated | $126B | 32.4 | 3.91 | +837% |
BMRNBioMarin Pharmaceutical Inc. | $12B | 34.3 | - | +1186%Best |
PTCTPTC Therapeutics, Inc. | $5B | 8.8 | - | +264% |
CORTCorcept Therapeutics Incorporated | $4B | 43.5 | - | -33% |
CPRXCatalyst Pharmaceuticals, Inc. | $3B | 13.7 | 0.73Best | +28% |
BCRXBioCryst Pharmaceuticals, Inc. | $2B | 7.2Lowest | - | +381% |
HRMYHarmony Biosciences Holdings, Inc. | $2B | 10.5 | - | +8% |
PLXProtalix BioTherapeutics, Inc. | $218M | 78.7 | - | -63% |
SLNOSoleno Therapeutics, Inc. | $145,692 | 100.2 | - | +109% |
Peers sorted by market capitalization. P/E below peers may indicate undervaluation or lower growth expectations. Consider PEG ratio for growth-adjusted comparison.
Historical P/E Data
Quarterly P/E ratios calculated from closing price and TTM EPS
| Quarter | Date | Price | TTM EPS | P/E Ratio | vs Avg |
|---|---|---|---|---|---|
| FY2025 Q2 | Mon Jun 30 2025 00:00:00 GM | $33.26 | $11.05 | 3.0x | +17% |
| FY2025 Q1 | Mon Mar 31 2025 00:00:00 GM | $29.30 | $11.29 | 2.6x | +1% |
| FY2024 Q4 | $32.86 | $11.39 | 2.9x | +12% | |
| FY2024 Q3 | Mon Sep 30 2024 00:00:00 GM | $44.43 | $11.36 | 3.9x | +52% |
| FY2021 Q4 | Fri Dec 31 2021 00:00:00 GM | $32.87 | $22.24 | 1.5x | -43% |
| FY2021 Q3 | $46.15 | $22.57 | 2.0x | -21% | |
| FY2021 Q2 | Wed Jun 30 2021 00:00:00 GM | $55.11 | $22.70 | 2.4x | -6% |
| FY2021 Q1 | Wed Mar 31 2021 00:00:00 GM | $51.64 | $22.80 | 2.3x | -12% |
Average P/E for displayed period: 2.6x
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Start ComparisonFrequently Asked Questions
Is AGIO stock overvalued or undervalued?
AGIO trades at -4.2x P/E, below its 5-year average of 2.6x. At the N/A percentile of historical range, the stock is priced at a discount to its own history.
How does AGIO's valuation compare to peers?
Agios Pharmaceuticals, Inc. P/E of -4.2x compares to sector median of 23.7x. The discount suggests lower growth expectations or higher risk.
What is AGIO's PEG ratio?
AGIO PEG ratio is N/A. Above 2.0 indicates premium valuation relative to growth rate. Historical P/E data spans 2021-2025.