Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in ANNX held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | Redmile Group, LLC | 14.5M | $80.6M | +44.8% | 7.492% | 5.34% |
| 2 | BlackRock, Inc. | 10.9M | $60.6M | +22.1% | 5.633% | 0.00% |
| 3 | FMR LLC | 10.6M | $58.9M | +4.0% | 5.477% | 0.00% |
| 4 | BVF INC/IL | 8.7M | $48.2M | -4.7% | 4.479% | 1.54% |
| 5 | STATE STREET CORP | 6.9M | $38.3M | +48.7% | 3.563% | 0.00% |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | 6.0M | $33.0M | β | 3.067% | 0.00% |
| 7 | Bain Capital Life Sciences Investors, LLC | 5.2M | $28.9M | -0.7% | 2.684% | 2.60% |
| 8 | Bellevue Group AG | 5.2M | $28.6M | 0.0% | 2.656% | 0.68% |
| 9 | MAK CAPITAL ONE LLC | 4.7M | $26.2M | +59.7% | 2.433% | 3.86% |
| 10 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 4.3M | $23.8M | -21.8% | 2.214% | 0.04% |
| 11 | BANK OF AMERICA CORP /DE/ | 4.3M | $23.6M | +165.3% | 2.194% | 0.00% |
| 12 | Nuveen, LLC | 4.2M | $23.5M | +45.7% | 2.187% | 0.01% |
| 13 | Siren, L.L.C. | 4.0M | $21.9M | β | 2.038% | 0.61% |
| 14 | BALYASNY ASSET MANAGEMENT LLC | 3.9M | $21.5M | +17.8% | 2.002% | 0.07% |
| 15 | AMERIPRISE FINANCIAL INC | 3.4M | $19.1M | -20.7% | 1.776% | 0.00% |
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 3.4M | $18.7M | +16.4% | 1.739% | 0.00% |
| 17 | Qube Research & Technologies Ltd | 3.1M | $17.3M | +30.8% | 1.604% | 0.02% |
| 18 | Palo Alto Investors LP | 2.9M | $16.3M | +23.6% | 1.518% | 2.50% |
| 19 | MORGAN STANLEY | 2.7M | $15.2M | -4.2% | 1.409% | 0.00% |
| 20 | GREAT POINT PARTNERS LLC | 2.5M | $13.8M | β | 1.287% | 3.39% |
| 21 | Woodline Partners LP | 2.3M | $12.9M | -41.6% | 1.204% | 0.05% |
| 22 | Opaleye Management Inc. | 2.3M | $12.9M | -10.3% | 1.201% | 1.70% |
| 23 | GOLDMAN SACHS GROUP INC | 2.2M | $11.9M | +21.7% | 1.109% | 0.00% |
| 24 | Point72 Asset Management, L.P. | 1.9M | $10.4M | +404.3% | 0.964% | 0.01% |
| 25 | VANGUARD PORTFOLIO MANAGEMENT LLC | 1.5M | $8.2M | β | 0.764% | 0.00% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). β% of Fundβ shows how much of that investorβs total 13F portfolio is invested in ANNX β a direct measure of their conviction.
Filings activity in ANNX during Q1 2026, grouped by how each filer changed its position.
Institutions that opened a new ANNX position in Q1 2026
Institutions that fully closed their ANNX position in Q1 2026
8 quarters of 13F filings Β· Ξ columns show change vs prior quarter
| Quarter | Inst. Holders | Ξ Holders | Ownership % | Ξ Ownership | Total 13F Value | Ξ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 211 | +31% | 93.34% | +19.21 pp | $854M | +26% |
| Q4 2025 | 161 | +14% | 74.13% | +40.94 pp | $678M | +123% |
| Q3 2025 | 141 | +10% | 33.19% | +7.60 pp | $304M | +30% |
| Q2 2025 | 128 | 13% | 25.59% | +4.97 pp | $234M | +24% |
| Q1 2025 | 147 | 3.3% | 20.62% | 41.05 pp | $189M | 67% |
| Q4 2024 | 152 | +7.8% | 61.67% | 8.01 pp | $564M | 11% |
| Q3 2024 | 141 | +2.2% | 69.68% | +12.14 pp | $637M | +21% |
| Q2 2024 | 138 | β | 57.54% | β | $526M | β |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Ξ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying ANNX stock.
Based on Q1 2026 13F filings, institutional ownership of Annexon, Inc. stands at 93.3%, held across 211 reporting institutions.
Redmile Group, LLC is the largest reported institutional holder of ANNX, with approximately 14,549,768 shares worth $0.08B as of Q1 2026.
Yes β 1 widely-followed marquee investor appear among the top 25 institutional holders of ANNX, including Point72 Asset Management, L.P..
Our composite Smart Money Score for ANNX is 72 out of 100 (Bullish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
67 institutions opened new positions in ANNX during Q1 2026, while 17 fully exited. 106 added to existing positions and 38 trimmed.
ANNX institutional ownership rose by 19.21 percentage points quarter-over-quarter, with a net change of +50 holders.
The top 10 institutions account for 50.0% of all reported 13F value in ANNX, and the top 25 account for 79.0%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Annexon, Inc. (ANNX) Institutional Ownership