Annexon, Inc. (ANNX) P/E Ratio History
Historical price-to-earnings valuation from 2026 to 2026
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ANNX Valuation Context
How does the current P/E compare to historical and market benchmarks?
P/E Ratio Analysis
As of May 7, 2026, Annexon, Inc. (ANNX) trades at a price-to-earnings ratio of -5.6x, with a stock price of $5.71 and trailing twelve-month earnings per share of $-1.39.
Compared to the Healthcare sector median P/E of 22.1x, ANNX trades at a 126% discount to its sector peers. The sector includes 242 companies with P/E ratios ranging from 0.0x to 178.0x.
Relative to the broader market, ANNX trades at a notable discount to the S&P 500 median P/E of 25.2x. Investors should consider the company's growth prospects, competitive position, and earnings quality when evaluating whether the current valuation is justified.
For a comprehensive intrinsic value estimate using discounted cash flow analysis, see our ANNX DCF Valuation Calculator →
Note: P/E ratio is just one valuation metric. It does not account for balance sheet strength, cash flow quality, or growth sustainability. Always conduct comprehensive due diligence before making investment decisions.
ANNX P/E vs Peers
P/E ratio compared to closely matched public peers
| Company | Market Cap | P/E Ratio | PEG Ratio | EPS Growth (1Y) |
|---|---|---|---|---|
| $5B | 228.4 | -Best | +111% | |
| $28B | 21.6 | -Best | -21% | |
| $6B | 8.6Lowest | -Best | +264%Best | |
| $4B | 9.4 | -Best | +68% |
Peers sorted by market capitalization. P/E below peers may indicate undervaluation or lower growth expectations. Consider PEG ratio for growth-adjusted comparison.
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Start ComparisonANNX — Frequently Asked Questions
Quick answers to the most common questions about buying ANNX stock.
Is ANNX stock overvalued or undervalued?
ANNX current P/E: -5.6x. 5-year average P/E: N/A. Percentile: N/A.
How does ANNX's valuation compare to peers?
Annexon, Inc. P/E of -5.6x compares to sector median of 22.1x. The discount suggests lower growth expectations or higher risk.
What is ANNX's PEG ratio?
ANNX PEG ratio is N/A. Above 2.0 indicates premium valuation relative to growth rate. Historical P/E data spans 2026-2026.