No significant weaknesses identified
| Name | Market Cap | Current Price | P/E Ratio | Revenue Growth 1Y | Net Margin | ROE | FCF Yield | Debt/Equity |
|---|---|---|---|---|---|---|---|---|
| CORTCorcept Therapeutics Incorporated | 3.78B | 35.70 | 43.54 | 12.79% | 13.01% | 15.3% | 3.75% | 0.01 |
| BMRNBioMarin Pharmaceutical Inc. | 11.86B | 61.73 | 34.29 | 10.83% | 5.73% | 6.11% | 0.10 | |
| VRTXVertex Pharmaceuticals Incorporated | 126.19B | 496.83 | 32.43 | 8.9% | 31.35% | 21.22% | 2.53% | 0.20 |
| CPRXCatalyst Pharmaceuticals, Inc. | 2.83B | 23.08 | 13.74 | 19.78% | 36.39% | 22.46% | 7.38% | 0.00 |
| HRMYHarmony Biosciences Holdings, Inc. | 1.65B | 28.54 | 10.53 | 21.51% | 18.27% | 18.24% | 21.12% | 0.02 |
| PTCTPTC Therapeutics, Inc. | 5.45B | 68.19 | 8.76 | 114.51% | 42.25% | |||
| BCRXBioCryst Pharmaceuticals, Inc. | 1.86B | 8.75 | 7.23 | 94.1% | 30.16% | 18.63% | ||
| RAREUltragenyx Pharmaceutical Inc. | 2.26B | 23.39 | -3.72 | 29.01% | -91.95% | -35.88% | 0.15 |
Analyze head-to-head performance against top industry competitors across valuation, growth, and profitability metrics.
| Dec 2016 | Dec 2017 | Dec 2018 | Dec 2019 | Dec 2020 | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 | |
|---|---|---|---|---|---|---|---|---|---|---|
| Sales/Revenue | 4.61M | 1.53M | 10.58M | 13.38M | 6.95M | 7.78M | 51.17M | 266.72M | 363.64M | 691.71M |
| Revenue Growth % | -43.26% | -66.78% | 591.57% | 26.41% | -48.02% | 11.87% | 557.93% | 421.2% | 36.34% | 90.22% |
| Cost of Goods Sold | 0 | 0 | 0 | 0 | 0 | 3.52M | 12.14M | 44.4M | 44.26M | 103.18M |
| COGS % of Revenue | - | - | - | - | - | 45.29% | 23.72% | 16.64% | 12.17% | 14.92% |
| Gross Profit | 4.61M | 1.53M | 10.58M | 13.38M | 6.95M | 4.25M | 39.04M | 222.32M | 319.38M | 588.53M |
| Gross Margin % | 100% | 100% | 100% | 100% | 100% | 54.71% | 76.28% | 83.36% | 87.83% | 85.08% |
| Gross Profit Growth % | -43.26% | -66.78% | 591.57% | 26.41% | -48.02% | -38.8% | 817.44% | 469.52% | 43.66% | 84.27% |
| Operating Expenses | 77.53M | 113.07M | 165.34M | 240.09M | 337.57M | 456.05M | 600.85M | 677.86M | 598.15M | 719.42M |
| OpEx % of Revenue | 1683.15% | 7390.26% | 1562.59% | 1795.1% | 4855.07% | 5863.29% | 1174.13% | 254.15% | 164.49% | 104.01% |
| Selling, General & Admin | 11.5M | 13.48M | 25.06M | 48.47M | 76.67M | 160.18M | 215.85M | 258.79M | 284.55M | 435.92M |
| SG&A % of Revenue | 249.76% | 881.18% | 236.81% | 362.42% | 1102.68% | 2059.4% | 421.8% | 97.03% | 78.25% | 63.02% |
| Research & Development | 66.02M | 99.59M | 140.28M | 191.62M | 260.9M | 295.87M | 379.62M | 413.45M | 307M | 283.5M |
| R&D % of Revenue | 1433.39% | 6509.09% | 1325.78% | 1432.68% | 3752.39% | 3803.9% | 741.83% | 155.02% | 84.42% | 40.99% |
| Other Operating Expenses | 0 | 0 | 0 | 0 | 0 | 0 | 5.38M | 5.62M | 6.6M | 0 |
| Operating Income | -72.92M | -111.54M | -154.76M | -226.72M | -330.62M | -451.79M | -561.81M | -455.54M | -278.76M | -130.89M |
| Operating Margin % | -1583.15% | -7290.26% | -1462.59% | -1695.1% | -4755.07% | -5808.59% | -1097.85% | -170.8% | -76.66% | -18.92% |
| Operating Income Growth % | -74.35% | -52.96% | -38.74% | -46.5% | -45.83% | -36.65% | -24.35% | 18.92% | 38.81% | 53.05% |
| EBITDA | -72.21M | -110.85M | -153.85M | -220.05M | -321.17M | -436.4M | -544.3M | -436.63M | -261.05M | -113.9M |
| EBITDA Margin % | -1567.74% | -7245.2% | -1454.01% | -1645.24% | -4619.19% | -5610.71% | -1063.63% | -163.7% | -71.79% | -16.47% |
| EBITDA Growth % | -74.98% | -53.51% | -38.79% | -43.03% | -45.95% | -35.88% | -24.72% | 19.78% | 40.21% | 56.37% |
| D&A (Non-Cash Add-back) | 710.02K | 689.46K | 908.17K | 6.67M | 9.45M | 15.39M | 17.51M | 18.91M | 17.71M | 17M |
| EBIT | -68.73M | -124.28M | -130.36M | -217.03M | -417.26M | -380.03M | -547.13M | -430.08M | -307.74M | -130.89M |
| Net Interest Income | 118K | 826K | 3.89M | 8.84M | -106K | -3.22M | -23.26M | -27.21M | -51.14M | -62.77M |
| Interest Income | 123K | 923K | 4.02M | 10.06M | 1.81M | 692K | 7.43M | 16.86M | 14.36M | 14.7M |
| Interest Expense | 5K | 97K | 127K | 1.22M | 1.92M | 3.91M | 30.68M | 44.06M | 65.5M | 77.46M |
| Other Income/Expense | 4.19M | -12.83M | 24.27M | 8.47M | -88.55M | 67.85M | -16M | -18.6M | -94.48M | -73.37M |
| Pretax Income | -68.73M | -124.37M | -130.49M | -218.25M | -419.17M | -383.94M | -577.82M | -474.14M | -373.24M | -204.26M |
| Pretax Margin % | -1492.23% | -8129.02% | -1233.26% | -1631.78% | -6028.68% | -4936.28% | -1129.12% | -177.77% | -102.64% | -29.53% |
| Income Tax | -227K | -477K | -394K | -234K | -219K | -367K | 5.38M | 7.3M | 4.84M | 14.78M |
| Effective Tax Rate % | 99.67% | 99.62% | 99.7% | 99.89% | 99.95% | 99.9% | 100.93% | 101.54% | 101.3% | 107.23% |
| Net Income | -68.5M | -123.9M | -130.1M | -218.02M | -418.95M | -383.58M | -583.19M | -481.45M | -378.08M | -219.03M |
| Net Margin % | -1487.3% | -8097.84% | -1229.53% | -1630.03% | -6025.53% | -4931.56% | -1139.63% | -180.51% | -103.97% | -31.67% |
| Net Income Growth % | -108.08% | -80.86% | -5% | -67.58% | -92.17% | 8.44% | -52.04% | 17.45% | 21.47% | 42.07% |
| Net Income (Continuing) | -68.5M | -123.9M | -130.1M | -218.02M | -418.95M | -383.58M | -583.19M | -481.45M | -378.08M | -219.03M |
| Discontinued Operations | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| EPS (Diluted) | -2.58 | -3.68 | -3.17 | -4.69 | -8.28 | -7.00 | -10.40 | -8.55 | -6.53 | -3.62 |
| EPS Growth % | -85.61% | -42.64% | 13.86% | -47.95% | -76.55% | 15.46% | -48.57% | 17.79% | 23.63% | 44.56% |
| EPS (Basic) | -2.58 | -3.68 | -3.17 | -4.69 | -8.28 | -7.00 | -10.40 | -8.55 | -6.53 | -3.62 |
| Diluted Shares Outstanding | 26.56M | 33.63M | 41.09M | 46.51M | 50.62M | 54.77M | 56.07M | 56.29M | 57.89M | 60.61M |
| Basic Shares Outstanding | 26.56M | 33.63M | 41.09M | 46.51M | 50.62M | 54.77M | 56.07M | 56.29M | 57.89M | 60.61M |
| Dividend Payout Ratio | - | - | - | - | - | - | - | - | - | - |
| Dec 2016 | Dec 2017 | Dec 2018 | Dec 2019 | Dec 2020 | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 | |
|---|---|---|---|---|---|---|---|---|---|---|
| Total Current Assets | 183.96M | 204.63M | 292.91M | 611.17M | 740.13M | 805.89M | 923.47M | 702.72M | 1.06B | 1.11B |
| Cash & Short-Term Investments | 180.33M | 195.35M | 277.86M | 598.11M | 718.79M | 682.06M | 735.46M | 399.44M | 559.54M | 615.78M |
| Cash Only | 180.33M | 195.35M | 277.86M | 598.11M | 584.52M | 446.27M | 444.77M | 392.16M | 559.54M | 615.78M |
| Short-Term Investments | 0 | 0 | 0 | 0 | 134.28M | 235.8M | 290.69M | 7.28M | 0 | 0 |
| Accounts Receivable | 287K | 188K | 6K | 804K | 387K | 2.2M | 11.91M | 35.87M | 166.28M | 157.63M |
| Days Sales Outstanding | 22.74 | 44.85 | 0.21 | 21.94 | 20.32 | 103.24 | 84.95 | 49.09 | 166.9 | 83.18 |
| Inventory | 0 | 0 | 0 | 0 | 0 | 75.41M | 130.67M | 208.93M | 295.61M | 301.4M |
| Days Inventory Outstanding | - | - | - | - | - | 7.81K | 3.93K | 1.72K | 2.44K | 1.07K |
| Other Current Assets | 1.38M | 2.19M | 2.62M | 4.61M | 6.96M | 20.99M | 13.72M | 19.9M | 11.16M | 0 |
| Total Non-Current Assets | 6.11M | 6.34M | 26.06M | 65.56M | 239.66M | 279.04M | 166.27M | 122.87M | 118.63M | 193.5M |
| Property, Plant & Equipment | 2.35M | 2.56M | 4.33M | 45.07M | 108.11M | 126.05M | 129.09M | 110.63M | 98.71M | 146.42M |
| Fixed Asset Turnover | 1.96x | 0.60x | 2.45x | 0.30x | 0.06x | 0.06x | 0.40x | 2.41x | 3.68x | 4.72x |
| Goodwill | 3.5M | 3.5M | 3.5M | 3.5M | 3.5M | 3.5M | 3.5M | 3.5M | 3.5M | 3.49M |
| Intangible Assets | 0 | 0 | 0 | 0 | 2.22M | 1.78M | 1.33M | 924K | 533K | 214.91K |
| Long-Term Investments | 0 | 0 | 17.08M | 15.54M | 124.46M | 145.91M | 30.42M | 5.69M | 13.57M | 43.38M |
| Other Non-Current Assets | 268K | 293K | 1.16M | 1.46M | 1.38M | 1.81M | 1.92M | 2.13M | 2.32M | 0 |
| Total Assets | 190.07M | 210.98M | 318.97M | 676.73M | 979.79M | 1.08B | 1.09B | 825.59M | 1.18B | 1.3B |
| Asset Turnover | 0.02x | 0.01x | 0.03x | 0.02x | 0.01x | 0.01x | 0.05x | 0.32x | 0.31x | 0.53x |
| Asset Growth % | 44.24% | 11% | 51.18% | 112.16% | 44.78% | 10.73% | 0.44% | -24.24% | 42.87% | 10.39% |
| Total Current Liabilities | 13.46M | 23.77M | 38.92M | 47.99M | 52.8M | 100.36M | 716.78M | 736.51M | 907.86M | 1.07B |
| Accounts Payable | 13.08M | 17.43M | 19.74M | 27.77M | 21.9M | 59.42M | 101.03M | 94.57M | 96.39M | 90.62M |
| Days Payables Outstanding | - | - | - | - | - | 6.16K | 3.04K | 777.49 | 794.97 | 320.56 |
| Short-Term Debt | 0 | 0 | 0 | 0 | 0 | 7M | 412.98M | 421.27M | 491.54M | 486.32M |
| Deferred Revenue (Current) | 94K | 0 | 6.9M | 858K | 363K | 2.6M | 0 | 1.18M | 936K | 4.94M |
| Other Current Liabilities | 0 | 0 | 0 | 13.35M | 23.38M | 24.15M | 183.49M | 203.02M | 317.77M | 480.63M |
| Current Ratio | 13.67x | 8.61x | 7.53x | 12.74x | 14.02x | 8.03x | 1.29x | 0.95x | 1.17x | 1.04x |
| Quick Ratio | 13.67x | 8.61x | 7.53x | 12.74x | 14.02x | 7.28x | 1.11x | 0.67x | 0.84x | 0.76x |
| Cash Conversion Cycle | - | - | - | - | - | 1.76K | 976.35 | 989.36 | 1.81K | 828.84 |
| Total Non-Current Liabilities | 0 | 0 | 0 | 31.63M | 88.28M | 100.93M | 109.61M | 234.78M | 377.34M | 395.83M |
| Long-Term Debt | 0 | 0 | 0 | 0 | 0 | 97.97M | 95.4M | 223M | 365.08M | 385.09M |
| Capital Lease Obligations | 0 | 0 | 0 | 30.72M | 85.12M | 97.97M | 95.4M | 84.62M | 0 | 0 |
| Deferred Tax Liabilities | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.83M | 7.26M | 9.62M |
| Other Non-Current Liabilities | 0 | 0 | 0 | 908K | 3.16M | -97.97M | -95.4M | -84.62M | 0 | 0 |
| Total Liabilities | 13.46M | 23.77M | 38.92M | 79.62M | 141.08M | 201.29M | 826.39M | 971.28M | 1.29B | 1.46B |
| Total Debt | 0 | 0 | 0 | 36.62M | 91.97M | 209.92M | 617.57M | 743.06M | 856.62M | 871.41M |
| Net Debt | -180.33M | -195.35M | -277.86M | -561.49M | -492.54M | -236.34M | 172.8M | 350.89M | 297.07M | 255.64M |
| Debt / Equity | - | - | - | 0.06x | 0.11x | 0.24x | 2.35x | - | - | - |
| Debt / EBITDA | - | - | - | - | - | - | - | - | - | - |
| Net Debt / EBITDA | - | - | - | - | - | - | - | - | - | - |
| Interest Coverage | -14584.00x | -1149.91x | -1218.56x | -185.68x | -172.38x | -115.52x | -18.31x | -10.34x | -4.26x | -1.69x |
| Total Equity | 176.61M | 187.21M | 280.05M | 597.11M | 838.71M | 883.63M | 263.35M | -145.7M | -105.71M | -162.75M |
| Equity Growth % | 46.78% | 6% | 49.59% | 113.22% | 40.46% | 5.36% | -70.2% | -155.32% | 27.45% | -53.97% |
| Book Value per Share | 6.65 | 5.57 | 6.82 | 12.84 | 16.57 | 16.13 | 4.70 | -2.59 | -1.83 | -2.69 |
| Total Shareholders' Equity | 176.61M | 187.21M | 280.05M | 597.11M | 838.71M | 883.63M | 263.35M | -145.7M | -105.71M | -162.75M |
| Common Stock | 4.35M | 4.97M | 5.66M | 6.44M | 7.22M | 7.65M | 7.67M | 7.75M | 8.15M | 8.32M |
| Retained Earnings | -139.31M | -263.21M | -393.31M | -611.32M | -1.03B | -1.24B | -1.86B | -2.28B | -2.56B | -2.7B |
| Treasury Stock | 0 | 0 | 0 | 0 | 0 | -21K | -149K | -146K | -113K | -79.97K |
| Accumulated OCI | 13M | 22.78M | 42.45M | 79.9M | 133.02M | 3.78M | 3.45M | 721K | 1.78M | -1.75M |
| Minority Interest | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Dec 2016 | Dec 2017 | Dec 2018 | Dec 2019 | Dec 2020 | Dec 2021 | Dec 2022 | Dec 2023 | Dec 2024 | Dec 2025 | |
|---|---|---|---|---|---|---|---|---|---|---|
| Cash from Operations | -60.18M | -95.1M | -138.8M | -175.94M | -271.55M | -417.65M | -495.7M | -467.36M | -306.2M | 51.77M |
| Operating CF Margin % | -1306.54% | -6215.62% | -1311.8% | -1315.41% | -3905.48% | -5369.62% | -968.65% | -175.23% | -84.2% | 7.48% |
| Operating CF Growth % | -38.45% | -58.03% | -45.96% | -26.75% | -54.34% | -53.8% | -18.69% | 5.72% | 34.48% | 116.91% |
| Net Income | -68.5M | -123.9M | -130.1M | -218.02M | -418.95M | -383.58M | -583.19M | -481.45M | -378.08M | -219.03M |
| Depreciation & Amortization | 677K | 734K | 880K | 6.69M | 9.45M | 15.39M | 17.96M | 18.91M | 17.71M | 17M |
| Stock-Based Compensation | 7.32M | 9.71M | 19.65M | 37.49M | 53.17M | 66.83M | 64.18M | 66.66M | 95.51M | 0 |
| Deferred Taxes | -227K | -477K | -394K | -234K | -219K | -367K | 5.38M | 0 | 4.84M | 3.21M |
| Other Non-Cash Items | -3.51M | 13.81M | -30.55M | -5.93M | 85.97M | -68.2M | 12.45M | 24.77M | 60.98M | 182.44M |
| Working Capital Changes | 4.07M | 5.02M | 1.71M | 4.07M | -964K | -47.72M | -12.47M | -96.26M | -107.16M | 68.16M |
| Change in Receivables | 777K | 99K | 182K | -1.87M | -2M | -6.66M | -11.53M | -32.77M | -118.61M | 14.97M |
| Change in Inventory | 1.55M | -5.71M | 0 | -5.64M | 0 | -75.41M | -55.27M | -78.26M | -86.68M | -5.69M |
| Change in Payables | 4.71M | 10.76M | 8.26M | 7.51M | 0 | 0 | 0 | 0 | 0 | -9.96M |
| Cash from Investing | -672K | -941K | -2.65M | -5.16M | -291.2M | -110.58M | 61.73M | 286.47M | 6.88M | -8.15M |
| Capital Expenditures | -672K | -941K | -2.65M | -5.16M | -19.86M | -23.7M | -14.49M | -2.44M | -1.43M | -8.15M |
| CapEx % of Revenue | 14.59% | 61.5% | 25.03% | 38.57% | 285.63% | 304.76% | 28.31% | 0.92% | 0.39% | 1.18% |
| Acquisitions | 0 | 0 | 0 | 0 | 0 | -10.19M | 0 | 0 | 0 | 0 |
| Investments | - | - | - | - | - | - | - | - | - | - |
| Other Investing | 0 | 0 | 0 | 0 | 3.36M | -530K | 9.54M | 288.92M | 950K | 0 |
| Cash from Financing | 117.46M | 124.72M | 203.27M | 493.59M | 602.65M | 351.39M | 396.77M | 134.29M | 443.93M | 34.89M |
| Debt Issued (Net) | 0 | 0 | 0 | -4.04M | -4.77M | -6.43M | 496.93M | 125.82M | 122.79M | -21.09M |
| Equity Issued (Net) | 1000K | 1000K | 1000K | 1000K | 1000K | 1000K | -1000K | -1000K | 1000K | 1000K |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | 0 | 0 | 0 | 0 | 0 | -21.61M | -105.31M | -1.81M | 0 | -16.71M |
| Other Financing | -8.5M | -8.39M | -13.12M | 17.38M | 26.88M | 11.54M | 5.15M | 10.29M | 11.22M | -10.95M |
| Net Change in Cash | 60.68M | 15.02M | 82.51M | 320.24M | -13.59M | -138.25M | -1.5M | -52.6M | 167.38M | 122.65M |
| Free Cash Flow | -60.85M | -96.04M | -141.45M | -181.09M | -293.1M | -441.88M | -510.19M | -469.8M | -307.62M | 43.62M |
| FCF Margin % | -1321.12% | -6277.12% | -1336.83% | -1353.98% | -4215.45% | -5681.19% | -996.97% | -176.14% | -84.6% | 6.31% |
| FCF Growth % | -36.73% | -57.83% | -47.28% | -28.03% | -61.85% | -50.76% | -15.46% | 7.92% | 34.52% | 114.18% |
| FCF per Share | -2.29 | -2.86 | -3.44 | -3.89 | -5.79 | -8.07 | -9.10 | -8.35 | -5.31 | 0.72 |
| FCF Conversion (FCF/Net Income) | 0.88x | 0.77x | 1.07x | 0.81x | 0.65x | 1.09x | 0.85x | 0.97x | 0.81x | -0.24x |
| Interest Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 15.67M | 0 | 0 |
| Taxes Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Metric | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|---|---|---|---|---|
| Return on Equity (ROE) | -46.14% | -68.11% | -55.68% | -49.71% | -58.36% | -44.54% | -101.69% | -818.43% | - | - |
| Return on Invested Capital (ROIC) | - | - | -5304.74% | -899.32% | -129.89% | -68.22% | -77.78% | -106.54% | -105.44% | -69.07% |
| Gross Margin | 100% | 100% | 100% | 100% | 100% | 54.71% | 76.28% | 83.36% | 87.83% | 85.08% |
| Net Margin | -1487.3% | -8097.84% | -1229.53% | -1630.03% | -6025.53% | -4931.56% | -1139.63% | -180.51% | -103.97% | -31.67% |
| Debt / Equity | - | - | - | 0.06x | 0.11x | 0.24x | 2.35x | - | - | - |
| Interest Coverage | -14584.00x | -1149.91x | -1218.56x | -185.68x | -172.38x | -115.52x | -18.31x | -10.34x | -4.26x | -1.69x |
| FCF Conversion | 0.88x | 0.77x | 1.07x | 0.81x | 0.65x | 1.09x | 0.85x | 0.97x | 0.81x | -0.24x |
| Revenue Growth | -43.26% | -66.78% | 591.57% | 26.41% | -48.02% | 11.87% | 557.93% | 421.2% | 36.34% | 90.22% |
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