Liquidity is under severe pressure, with cash and equivalents falling from a peak of $159.1 million in 2024Q3 to $35.0 million in 2026Q1, highlighting a persistent inability to achieve self-sustaining free cash flow.
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 | Dec'08 | Dec'07 |
|---|
| Cash from Operations | -37.91M | -40.14M | 22.1M | -24.75M | -87.44M | -104.56M | -80.26M | -69.14M | -68.14M | -52.33M | -31.09M | 3.54M | 50.74M | -25.63M | -26.11M | -13.19M | -21.1M | -7.05M | 1.78M | -5.62M |
| Operating CF Margin % | - | -55.02% | 53.25% | -3277.62% | -456.13% | -344.57% | -157.2% | -455.18% | -535.21% | -207.75% | -73% | 6.43% | 192.93% | -112.33% | -93.87% | -63.64% | -100.58% | -40.7% | 12.05% | -137.08% |
| Operating CF Growth % | -22221.24% | -281.59% | 189.32% | 71.7% | 16.37% | -30.28% | -16.08% | -1.47% | -30.21% | -68.32% | -978.69% | -93.03% | 297.97% | 1.84% | -97.93% | 37.48% | -199.35% | -496.22% | 131.64% | - |
| Net Income | -67.29M | -67.8M | -36.7M | -116.83M | -98.69M | -96.75M | -53.58M | -115.21M | -88.33M | -103.68M | -63.92M | -22.27M | 2.25M | -85.77M | -29.45M | -30.9M | -10.72M | -5.52M | 185.15K | -4.36M |
| Depreciation & Amortization | 19.68M | 20.12M | 19.84M | 18.52M | 18.43M | 14.16M | 7.83M | 6.88M | 2.38M | 3.37M | 2.1M | 1.91M | 1.67M | 45.93M | 2.42M | 0 | 1.58M | 368.21K | 400.92K | 852.93K |
| Stock-Based Compensation | 1.28M | 0 | 0 | 5.23M | 6.04M | 11.49M | 10.03M | 26.88M | 37.22M | 50.42M | 55.71M | 32.91M | 666.37K | 634.86K | 254.47K | 0 | 578.53K | 0 | 281.2K | 351.38K |
| Deferred Taxes | 0 | 0 | 0 | 371K | 87K | 0 | 0 | 0 | 6.46M | 4.32M | 1.32M | 0 | -567.88K | 4.68M | 0 | 0 | -4.04M | 0 | -1.23M | -2.32M |
| Other Non-Cash Items | 19.72M | 49.26M | -14.61M | 71.95M | -7.6M | -21.16M | -27.22M | 661K | -16.76M | 11.04M | -1.4M | -7.49M | -8.99M | 1.1M | 10.01M | 12.54M | 191.51K | 0 | -8.35K | -481.14K |
| Working Capital Changes | -11.31M | -41.72M | 53.57M | -3.99M | -5.72M | -12.3M | -17.32M | 11.65M | -9.1M | -17.79M | -24.9M | -1.52M | 55.72M | 8.57M | -6.67M | 5.16M | -8.69M | -1.9M | 2.15M | 333.88K |
| Change in Receivables | 2.24M | -4.44M | -6.72M | 2.25M | -8.99M | -12.44M | -3.23M | 4.68M | -3.7M | -549K | -947.58K | 1.25M | -8.48M | 4.08M | -3.53M | 0 | 0 | 0 | 0 | 0 |
| Change in Inventory | 0 | 0 | 0 | 0 | 0 | 215K | 100K | -2.63M | -37K | -109K | 47.33K | -25.15K | 117.95K | 462.59K | -80.43K | 0 | 0 | 0 | 0 | 0 |
| Change in Payables | -1.34M | -3.27M | 2.05M | -6.3M | 3.25M | 177K | 5.69M | 9.63M | 9.37M | -335K | -4.17M | 2.92M | -819.59K | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cash from Investing | -39.77M | -29.58M | -102.63M | -15.51M | -2.76M | 7.28M | -54.34M | -35.87M | 35.62M | 1.78M | -50.5M | -7.61M | -1.65M | -2.08M | -6.1M | -29.41M | -5.69M | 316.64K | -1.12M | 316.39K |
| Capital Expenditures | -2.24M | -3.54M | -3.84M | -1.07M | -2.43M | -18.54M | -44.08M | -12.91M | -4.89M | -2.66M | -13.34M | -4.25M | -430.47K | -1.91M | -5.49M | -4.25M | -6.66M | -713.51K | -790.71K | -147.26K |
| CapEx % of Revenue | 3.29% | 4.86% | 9.24% | 142.12% | 12.68% | 61.11% | 86.33% | 85.01% | 38.38% | 10.54% | 31.32% | 7.73% | 1.64% | 8.39% | 19.72% | 20.49% | 31.73% | 4.12% | 5.35% | 3.59% |
| Acquisitions | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.26M | 7.16M | -298.68K | -3.12M | 614.09K | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Investments | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Other Investing | -2.26M | 0 | 0 | -14.44M | -456K | 10.96M | -13.15M | 369K | 1.26M | 7.16M | 321.82K | 14.21K | -1.83M | -169.85K | -611K | -25.17M | 969.54K | 1.03M | 0 | 463.64K |
| Cash from Financing | -17.39M | -16.2M | 89.8M | 82.86M | 1.15M | 47.52M | 27.32M | -3.86M | 236.49M | 41.27M | 460.64K | 217.35M | 70.41M | 7.5M | 4.93M | 66.39M | -1.18M | 30.91M | 4.05M | 34.79M |
| Debt Issued (Net) | -10.97M | -5.4M | 18.17M | 24.56M | -6.6M | -10.64M | 19.43M | -3.39M | -127K | -41K | -91K | -625K | -1.37M | -509.81K | 372.95K | 66.9M | -1.31M | -1.5M | -218.56K | 0 |
| Equity Issued (Net) | 74.25K | 44.14K | 82.68M | 67.94M | -569K | 44.64M | 9.21M | 0 | 228.85M | 41.31M | 576K | 221.22M | 71.67M | 7.7M | 3.44M | 2.21M | 127.68K | 31.94M | 4.26M | 0 |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | 0 | 0 | 0 | 0 | -569K | 0 | 0 | -469K | 0 | 0 | -137K | 0 | 0 | -318.63K | -32.11K | -20.86K | 0 | 0 | 0 | 0 |
| Other Financing | -6.49M | -10.85M | -11.04M | -9.63M | 8.32M | 13.53M | -1.32M | -469K | 7.77M | 0 | 0 | -1K | -209.05K | -20.45K | 970.61K | -2.72M | 965.35K | -45.64K | 0 | 34.79M |
| Net Change in Cash | -94.68M | -79.67M | 6.54M | 43.49M | -92.42M | -55.51M | -99.37M | -110.98M | 195.12M | 1.81M | -76.5M | 220.73M | 127.42M | -19.68M | -27.21M | 23.77M | -27.97M | 24.17M | 4.7M | 29.49M |
| Free Cash Flow | -40.14M | -42.5M | 19.52M | -25.82M | -89.89M | -123.12M | -124.68M | -82.1M | -73.02M | -54.98M | -44.42M | -715.02K | 50.31M | -27.54M | -31.6M | -17.44M | -27.76M | -7.76M | 988.39K | -5.77M |
| FCF Margin % | -58.95% | -58.27% | 47.04% | -3419.74% | -468.86% | -405.71% | -244.21% | -540.49% | -573.58% | -218.29% | -104.32% | -1.3% | 191.29% | -120.72% | -113.59% | -84.13% | -132.3% | -44.82% | 6.69% | -140.67% |
| FCF Growth % | -259.54% | -317.7% | 175.62% | 71.28% | 26.99% | 1.26% | -51.87% | -12.43% | -32.81% | -23.77% | -6113.1% | -101.42% | 282.65% | 12.83% | -81.18% | 37.17% | -257.58% | -885.38% | 117.13% | - |
| FCF per Share | -0.40 | -0.42 | 0.22 | -0.45 | -1.97 | -2.75 | -2.93 | -1.93 | -1.79 | -1.54 | -1.24 | -0.02 | 1.92 | -1.33 | -1.58 | -1.23 | -1.96 | -0.55 | 0.07 | -0.41 |
| FCF Conversion (FCF/Net Income) | 0.60x | 0.59x | -0.60x | 0.24x | 0.82x | 0.92x | 0.99x | 0.68x | 0.87x | 0.53x | 0.49x | -0.16x | 2086.27x | 0.30x | 0.89x | 0.43x | 1.97x | 1.28x | 9.61x | 1.29x |
| Interest Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Taxes Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical Milestone Funding Dependency
As reported in recent financial filings, the relationship between net income and operating cash flow is highly erratic, with OCF/NI ratios fluctuating wildly from -4.13 in 2024Q1 to 0.87 in 2026Q1, reflecting the company's reliance on non-recurring milestone payments rather than sustainable operational cash generation.
The extreme volatility in the conversion of net income to cash suggests that reported earnings are heavily influenced by accounting recognition of partnership milestones rather than core business performance. Investors should interpret these figures with caution, as the lack of a consistent positive correlation between income and cash flow indicates that the company's earnings quality remains fundamentally strained.
Based on the provided cash flow data, Cellectis exhibits a persistent free cash flow deficit, with the company recording negative FCF in nine of the last ten quarters, highlighting a structural inability to self-fund operations through its current therapeutic development pipeline and partnership-driven revenue model.
The sporadic positive FCF quarters appear to be outliers driven by large, one-time working capital inflows rather than organic operational improvements. This trajectory suggests that the company remains in a capital-intensive phase where cash burn is the primary operational reality, necessitating ongoing external financing to maintain its clinical programs.
According to historical cash flow statements, working capital changes are the primary driver of short-term liquidity, with massive swings such as the $61.0 million inflow in 2024Q2, which suggests that the company's cash position is highly sensitive to the timing of partner payments and milestone settlements.
These large, lumpy working capital movements indicate that the company lacks a predictable cash conversion cycle. The reliance on these inflows to offset operating losses implies that any delay in milestone achievement could lead to immediate liquidity pressure, warranting close monitoring of accounts receivable and deferred revenue balances.
As indicated by the provided data, Cellectis maintains a relatively low capital intensity, with CapEx/Revenue ratios generally remaining in the low single digits, suggesting that the company's primary cash drain is operational R&D rather than heavy investment in physical manufacturing infrastructure or equipment.
While the company has invested in its own manufacturing facilities, the relatively modest CapEx figures suggest that the bulk of its capital is consumed by clinical trial costs and personnel rather than asset-heavy expansion. This implies that the company's financial risk is tied more to the success of its clinical programs than to the maintenance of its physical asset base.
Quick answers to the most common questions about buying CLLS stock.
Cellectis S.A. (CLLS) generated $-40.1M in net cash from operating activities in 2025. This reflects the cash generated directly from core business operations.
Cellectis S.A. (CLLS) reported negative free cash flow of $42.5M in 2025, indicating capital requirements exceeded cash from operations.
Cellectis S.A. (CLLS) spent $3.5M on capital expenditures in 2025. CapEx represents the cash invested in physical assets like property, plant, and equipment to maintain or grow the business.