Last 45 quarters of trend data · Healthcare · Biotechnology
Quarterly valuation ratios — annualised for comparability. YoY Δ shows same-quarter-prior-year change.
| Metric | TTM | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 | Q4 '22 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P/E Ratio → | -0.06 | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| P/S Ratio | 1.29 | 25.84 | 31.64 | 7.58 | 58.87 | 22.86 | 269.86 | 116.17 | 2.88 | 15.69 | 16.96 | 3976.02 | 51.26 |
| — | +13.0% | -88.3% | -93.5% | +1946.4% | +45.7% | +1491.4% | -97.1% | -94.4% | -75.4% | -70.5% | +3912.2% | +3030.3% | |
| P/B Ratio | — | — | — | — | — | — | — | — | — | — | — | 23.56 | 6.38 |
| — | — | — | — | — | — | — | — | — | — | — | +443.1% | +44.0% | |
| P/FCF | — | — | — | — | — | — | — | — | 48.68 | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBITDA | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBIT | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Quarterly margins and returns. Watch for margin compression across consecutive quarters.
Clearside Biomedical, Inc.'s operating margin was -3502.5% in Q3 2025, down 2777.3 pp QoQ and down 2930.8 pp YoY. This marks the 3rd consecutive quarter of margin compression, signaling a persistent pressure on profitability that investors should monitor. The trailing four-quarter average of -1696.8% exceeds the current quarter, suggesting the latest result may reflect seasonal weakness or a one-off headwind.
| Metric | TTM | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 | Q4 '22 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | 91.0% | 100.0% | 82.9% | 89.4% | 51.3% | 100.0% | 100.0% | 87.8% | 99.7% | 83.5% | 79.1% | 100.0% | 31.5% |
| — | 0.0% | -17.1% | +1.7% | -48.5% | +19.8% | +26.5% | -12.2% | +216.3% | -16.5% | -12.2% | 0.0% | -68.4% | |
| Operating Margin | -1735.7% | -3502.5% | -725.2% | -223.4% | -2336.3% | -571.7% | -8433.3% | -3569.1% | -45.9% | -821.2% | -714.1% | -190125.0% | -2445.5% |
| — | -512.7% | +91.4% | +93.7% | -4985.3% | +30.4% | -1080.9% | +98.1% | +98.1% | +67.5% | +65.0% | -8528.5% | -3457.9% | |
| Net Margin | -2064.4% | -2971.1% | -913.6% | -352.9% | -2387.6% | -740.7% | -8437.8% | -5114.3% | -76.2% | -1078.8% | -894.5% | -232000.0% | -2928.2% |
| — | -301.2% | +89.2% | +93.1% | -3035.2% | +31.3% | -843.3% | +97.8% | +97.4% | +63.3% | +56.0% | -10434.4% | -4120.3% |
| Metric | TTM | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 | Q4 '22 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | — | — | — | — | — | — | — | — | — | — | — | -139.5% | -66.3% |
| — | — | — | — | — | — | — | — | — | — | — | -535.9% | -198.9% | |
| ROA | -116.2% | -44.3% | -25.7% | -36.7% | -26.9% | -24.4% | -20.5% | -31.7% | -14.1% | -25.2% | -21.7% | -19.3% | -18.1% |
| — | -81.7% | -25.3% | -15.7% | -90.6% | +3.2% | +5.6% | -64.1% | +21.8% | -39.0% | +7.2% | +0.1% | -133.9% | |
| ROIC | — | — | — | — | — | -376.0% | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Quarterly solvency trend — watch for debt spikes or covenant pressure.
The current ratio has weakened 33.6% YoY to 2.98x, tightening the short-term liquidity position.
| Metric | TTM | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 | Q4 '22 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | — | — | — | — | — | — | — | — | — | — | — | 0.45 | 3.32 |
| — | — | — | — | — | — | — | — | — | — | — | +2329.8% | +18602.7% | |
| Debt / EBITDA | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| Current Ratio | 4.44 | 2.98 | 3.87 | 3.19 | 4.44 | 4.49 | 5.07 | 6.07 | 4.42 | 5.28 | 6.85 | 8.54 | 8.54 |
| — | -33.6% | -23.7% | -47.5% | +0.4% | -15.0% | -26.0% | -28.9% | -48.2% | -49.9% | +23.1% | +0.6% | -5.9% | |
| Quick Ratio | 4.44 | 2.98 | 3.87 | 3.19 | 4.44 | 4.49 | 5.07 | 6.07 | 4.42 | 5.28 | 6.85 | 8.54 | 8.54 |
| — | -33.6% | -23.7% | -47.5% | +0.4% | -15.0% | -26.0% | -28.9% | -48.2% | -49.9% | +23.1% | +0.6% | -3.8% | |
| Interest Coverage | -2.95 | -2.74 | -1.29 | -1.95 | -2.77 | -2.42 | -3.24 | -3.42 | -1.28 | -2.69 | -3.17 | -3.51 | -3.95 |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Includes 30+ ratios · 45 years · Updated daily
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Clearside Biomedical, Inc.'s current P/E is -0.1x. Quarterly P/E ratios can vary due to seasonal revenue patterns and one-time charges.
Clearside Biomedical, Inc.'s current operating margin is -1735.7%. Margins have been compressing over recent quarters. Quarterly margins are particularly useful for identifying trend inflections that annual data smooths over.
Quarterly financial ratios reveal short-term trend shifts — margin compression, debt spikes, or valuation re-ratings — that annual figures smooth over. They're essential for active investors tracking Clearside Biomedical, Inc.'s business trajectory between earnings reports.