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Clearside Biomedical, Inc. (CLSD) Total Return Calculator with Dividends Reinvested

Clearside Biomedical, Inc.

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The total return for Clearside Biomedical, Inc. (CLSD) stock is -96.77% over the past 12 months. So far it's down 45.33% this year. The 5-year total return is -99.00%, meaning $10,000 invested in CLSD stock 5 years ago would be worth $100 today. Total return includes price appreciation plus reinvesting any dividends paid out.

If you invested $10,000 in CLSD 1 year ago, it would be worth $322 today — you'd have lost $9,678.

With Dividends Reinvested$322-96.78%

Price Only (No DRIP)$322-96.78%

Period2025-05-08 → 2026-03-12

Price

Total Return (DRIP)

S&P 500

If You Invested $10,000 in CLSD

1Y$323-$9,677 (-96.8%)-96.8% CAGR

3Y$246-$9,754 (-97.5%)-70.9% CAGR

5Y$100-$9,900 (-99.0%)-60.2% CAGR

10Y$38-$9,962 (-99.6%)-42.8% CAGR

15Y$38-$9,962 (-99.6%)-31.1% CAGR

20Y$38-$9,962 (-99.6%)-24.3% CAGR

30Y$38-$9,962 (-99.6%)-17.0% CAGR

Clearside Biomedical, Inc. did not pay dividends during this period. Total return = price return.

Loading CLSD total return...

As of 2026-05-07

Returns at a Glance

Period	Total Return	CAGR	Price Only	Div. Contrib.	$10K →
YTD	-45.33%	—	-45.33%	—	$5,467
1Y	-96.77%	-96.77%	-96.77%	—	$323
3Y	-97.54%	-70.91%	-97.54%	—	$246
5Y	-99.00%	-60.15%	-99.00%	—	$100
10Y	-99.62%	-42.77%	-99.62%	—	$38
15Y	-99.62%	-31.07%	-99.62%	—	$38
20Y	-99.62%	-24.35%	-99.62%	—	$38
30Y	-99.62%	-16.97%	-99.62%	—	$38

Risk & Highlights

Best Year+152.17%2019

Worst Year-95.08%2025

Max Drawdown-96.96%2025-05-13 → 2025-11-28

Annual Returns

Year	Total Return	Price Return	Div.	S&P 500	vs S&P
2026YTD	+0.00%	+0.00%	—	+0.41%	-0.4pp
2025	-95.08%	-95.08%	—	+16.64%	-111.7pp
2024	-26.36%	-26.36%	—	+24.00%	-50.4pp
2023	-4.10%	-4.10%	—	+24.81%	-28.9pp
2022	-61.11%	-61.11%	—	-19.95%	-41.2pp

CLSD underperformed the S&P 500 by 127.15pp over the past year (-96.77% vs +30.37%).

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CLSD Peers' Total Return

Accurate peer set · 10 comparable names

Name	Mkt Cap	30D Rtn	YTD Total Rtn	1Y Total Rtn	Div Contrib	3Y Total Rtn	5Y Total Rtn	10Y Total Rtn
CLSDClearside Biomedical, Inc.	$2M	—	-45.3%	-96.8%	—	-97.5%	-99.0%	-99.6%
OCULOcular Therapeutix, Inc.	$2.1B	+16.1%	-18.1%	+37.3%	—	+51.2%	-40.4%	-10.6%
ADVMAdverum Biotechnologies, Inc.	$96M	—	—	+45.3%	—	-46.5%	-88.5%	-89.2%
RCKTRocket Pharmaceuticals, Inc.	$398M	+5.5%	+6.1%	-45.2%	—	-82.8%	-91.6%	-91.3%
REPLReplimune Group, Inc.	$266M	-57.2%	-62.5%	-53.4%	—	-81.5%	-90.7%	-78.0%
NVCRNovoCure Limited	$1.9B	+62.6%	+28.3%	+1.1%	—	-75.7%	-91.3%	+30.3%
AGIOAgios Pharmaceuticals, Inc.	$1.6B	-21.6%	+1.3%	-2.4%	—	+8.3%	-50.7%	-42.2%
PRAXPraxis Precision Medicines, Inc.	$9.6B	+8.7%	+16.4%	+775.0%	—	+1976.5%	-20.8%	-20.1%
ALDXAldeyra Therapeutics, Inc.	$104M	+13.8%	-63.0%	-13.9%	—	-83.8%	-86.1%	-72.1%
HALOHalozyme Therapeutics, Inc.	$7.7B	+2.5%	-7.3%	-7.1%	—	+115.3%	+37.0%	+570.7%
EWEdwards Lifesciences Corporation	$47.7B	+2.4%	-3.0%	+10.3%	—	-7.0%	-10.2%	+133.4%

Compare:CLSD vs OCUL CLSD vs ADVM CLSD vs RCKT CLSD vs OCUL vs ADVM

About CLSD Dividend Returns

Clearside Biomedical, Inc. (CLSD) does not currently pay dividends. Many growth-focused companies reinvest profits back into the business rather than distributing them as dividends.

How We Calculate Total Return

Our total return calculator simulates dividend reinvestment (DRIP) by assuming each dividend payment is used to purchase additional shares at the closing price on the ex-dividend date. This methodology provides an accurate representation of how a dividend reinvestment plan would perform.

Frequently Asked Questions

Q1What is the total return of CLSD over the past year?

Clearside Biomedical, Inc. (CLSD) delivered a return of -96.77% over the past year. Since CLSD does not currently pay dividends, the total return equals the price-only return.

Q2How much would $10,000 invested in CLSD be worth today?

A $10,000 investment in Clearside Biomedical, Inc. one year ago would be worth $323 today, representing a loss of $9,677.

Q3Does CLSD pay dividends?

Clearside Biomedical, Inc. (CLSD) does not currently pay dividends. Many growth-focused companies reinvest profits back into the business rather than distributing them as dividends. For CLSD, the total return equals the price-only return.

Q4Did CLSD beat the S&P 500?

No, Clearside Biomedical, Inc. (CLSD) underperformed the S&P 500 by 127.15 percentage points over the past year. CLSD delivered a total return of -96.77%, compared to the S&P 500's 30.37%. This means a passive S&P 500 index fund outperformed CLSD by 127.15pp during this period.

Q5What is CLSD's worst drawdown?

Clearside Biomedical, Inc. (CLSD) experienced a maximum drawdown of -96.96% over the past year, declining from its peak on 2025-05-13 to its trough on 2025-11-28. The stock has not yet fully recovered to its prior peak. Maximum drawdown measures the worst peak-to-trough decline and is an important risk metric for investors.

Q6What is CLSD's long-term total return over 10, 20, or 30 years?

Here are Clearside Biomedical, Inc. (CLSD)'s long-term returns with dividends reinvested. Over 10 years, the total return is -99.6% (-42.8% CAGR) — $10,000 would have grown to $38. Over 20 years: -99.6% total return (-24.3% CAGR) — $10,000 → $38. Over 30 years: -99.6% total return (-17.0% CAGR) — $10,000 → $38. Long-term investors benefit from compounding: dividends buy additional shares, which generate their own dividends, creating an exponential growth effect.

Q7What was CLSD's best and worst year?

Clearside Biomedical, Inc.'s best calendar year was 2019 with a total return of 152.2%. Its worst year was 2025 with a total return of -95.1%. This range shows the volatility investors should expect — the difference between the best and worst year is 247.3 percentage points.