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PBYIPuma Biotechnology, Inc.
$9.51$484M
Overview & Tools
OverviewChart Terminal ↗Visualize
Valuation & Forecasts
Valuation ModelsEstimatesDCF Model
Price & Analyst Data
Analyst TargetsPrice History
Financial Statements
Income StatementBalance SheetCash FlowRatios & Margins
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P/E HistoryRevenue HistoryEarnings HistoryDividend HistoryTotal Return
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PBYI logo

Puma Biotechnology, Inc.

PBYI
NASDAQ · Biotechnology
$9.51
At close - Oct 2, 4:00 PM EDT - USD
Market Cap$484M
P/E15.6x
52W High$10.10
Volume454.38K
OverviewTerminalAnalysisFinancialsValuationEarningsBreakoutsOwnership
VCP Research Verdict2026Q2

Erratic Revenue Path Obscures Deleveraging and Margin Resilience

Puma Biotechnology's investment case is defined by a stark contrast between its structurally high gross margins, averaging ~75%, and its volatile revenue trajectory, which has swung from a 32.4% decline to a 27.7% surge in recent quarters. The company has succ...

GrowthMixed
ProfitabilityModerate
ValuationAttractive
TechnicalsHealthy
Explore valuation models
MARKET ACTION

PBYI price & volume

Price trend, volume and key moving averages

Launch Terminal
Loading chart...
Decision Checklist4 Core Signals

What matters now

The signals most likely to change the investment case.

01

Earnings momentum

11/12 Beats

EPS beat 11 of last 12 quarters

02

Valuation risk

-22% Peers

P/E is 22% below peer median

03

Market leadership

RS 89 · Leader

High momentum (Outperforming 89% of market)

04

Healthy Uptrend

Uptrend

Price > 50DMA > 200DMA

Next CatalystEstimated earnings · Nov 6

Market performance

Price History →

Trailing total returns as of 10/3/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC).

YTD Return
PBYI+64.82%
S&P 500 (^GSPC)+12.66%
1-Year Return
PBYI+82.18%
S&P 500 (^GSPC)+15.01%
3-Year Return
PBYI+271.48%
S&P 500 (^GSPC)+72.36%
5-Year Return
PBYI+51.67%
S&P 500 (^GSPC)+79.08%
02

Test the fundamentals

Check whether operating performance supports the current valuation.

VALUATION & INTRINSIC VALUE

Valuation Scenarios

Valuation Analysis
Trailing P/E5Y High
15.6x
Forward P/E
25.0x
EV/EBITDA80th %ile
10.0x
FCF YieldCash Flow
8.6%

Valuation vs 5-Year History

Multiple Range
Metric
Current
5Y Median
Historical Range
Percentile
P/E
15.6x
9.8x
75th· Fair
EV/EBITDA
10.0x
6.2x
80th· High
Price/FCF
11.6x
7.2x
75th· Fair
Current Multiple
5Y Median (50th %ile)

Intrinsic Value Scenarios

DCF Projection
No DCF Model AvailableIntrinsic value modeling is not supported for this equity.

Growth & profitability

Annual revenue & EPS trend
Revenue
$228M-0.9% YoY
Net income
$31M+2.8% YoY
Free cash flow
$42M+7.4% YoY
Operating margin
16.3%+2.9 pts YoY
ROIC (TTM)24.7%
Avg ROIC 5Y-
ROE (TTM)28%
Piotroski Score7 / 9
Financial Statements →
03

Monitor what changed

Recent results and news deserve attention only when they alter the forward view.

OPERATING RESULTS

Recent Earnings

Earnings History
EPS Beat Rate11/12 (92%)
Revenue Beat Rate6/12 (50%)
QuarterEPS (Act vs Est)Revenue (Act vs Est)
Q3 2026Latest
Aug 6, 2026
$0.19+375.0%
vs $0.04
$57M+6.6%
vs $53M
Q2 2026
May 7, 2026
-$0.04+69.2%
vs -$0.13
$45M+6.7%
vs $42M
Q1 2026
Feb 26, 2026
$0.29+20.8%
vs $0.24
$60M-12.7%
vs $69M
Q4 2025
Nov 6, 2025
$0.21+133.3%
vs $0.09
$52M+1.8%
vs $51M
Historical baseline: 12 quarters analyzedGAAP / Adjusted
MARKET COVERAGE

Latest News

5 Stories
Defense World·6d ago
Comparing TG Therapeutics (NASDAQ:TGTX) and Puma Biotechnology (NASDAQ:PBYI)

Puma Biotechnology (NASDAQ: PBYI - Get Free Report) and TG Therapeutics (NASDAQ: TGTX - Get Free Report) are both healthcare companies, but which is the superior investment? We will compare the two businesses based on the strength of their dividends, analyst recommendations, earnings, institutional ownership, valuation, profitability and risk. Institutional and Insider Ownership 61.3% of Puma Biotechnology

Zacks Investment Research·Sep 18, 2026
PBYI's Alisertib Combo Phase II Study in Small Cell Lung Cancer Begins

Puma Biotechnology starts the ALISCA-Lung2 phase II study evaluating alisertib in combination with paclitaxel in patients with advanced small cell lung cancer.

Business Wire·Sep 17, 2026
Puma Biotechnology Initiates ALISCA®-Lung2, a Phase II Trial of Alisertib in Combination with Paclitaxel for the Treatment of Patients with Advanced Small Cell Lung Cancer

LOS ANGELES--(BUSINESS WIRE)--Puma Biotechnology has initiated ALISCA®-Lung2, a Phase II trial of alisertib in combination with paclitaxel to treat advanced small cell lung cancer.

Business Wire·Sep 9, 2026
Puma Biotechnology to Present at H.C. Wainwright's 28th Annual Global Investment Conference

LOS ANGELES--(BUSINESS WIRE)--On Sept. 14, 2026, Puma Biotechnology CEO Alan Auerbach will present a corporate overview at H.C. Wainwright's 28th Annual Global Investment Conf.

Filtered for Puma Biotechnology, Inc.More Headlines
04

Compare before deciding

Benchmark PBYI against direct peers instead of judging its metrics in isolation.

Peers Comparison

Key metrics vs top competitors for Puma Biotechnology, Inc. (PBYI)

Full Screener →
CompanyPriceMarket CapP/E RatioRev Growth (1Y)Net MarginROEDiv Yield
PBYI logoPBYIPuma Biotechnology, Inc.Current
$9.51$484.05M15.59-0.91%13.62%27.97%—
RCUS logoRCUSArcus Biosciences, Inc.
$24.44$3.07B-7.43-4.26%-386.32%-87.98%—
TGTX logoTGTXTG Therapeutics, Inc.
$54.29$8.31B19.6087.32%55.22%72.3%—
PTCT logoPTCTPTC Therapeutics, Inc.
$63.46$5.26B8.16114.51%-3.8%——
ACAD logoACADACADIA Pharmaceuticals Inc.
$19.95$3.42B8.7111.87%33.42%32.39%—
EXEL logoEXELExelixis, Inc.
$58.39$14.68B21.006.98%35.33%42.49%—

Compare PBYI vs Peers

Puma Biotechnology, Inc. (PBYI) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs RCUS

Most directly comparable listed peer for PBYI.

Scale Benchmark

vs PFE

Larger-name benchmark to compare PBYI against a more recognizable public peer.

Peer Set

Compare Top 5

vs RCUS, TGTX, PTCT, ACAD

05

Keep researching

Verify the primary filings, follow material updates, and answer the remaining questions.

PBYI SEC Filings & Documents

Puma Biotechnology, Inc. (PBYI) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Aug 6, 2026·SEC

Material company update

Jun 16, 2026·SEC

Material company update

May 7, 2026·SEC

10-K Annual Reports

4
FY 2026

Feb 26, 2026·SEC

FY 2025

Feb 27, 2025·SEC

FY 2024

Feb 29, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

Aug 6, 2026·SEC

FY 2026

May 7, 2026·SEC

FY 2025

Nov 6, 2025·SEC

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PBYI Frequently Asked Questions

Puma Biotechnology, Inc. (PBYI) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials
What is Puma Biotechnology, Inc.'s revenue?

Puma Biotechnology, Inc. (PBYI) reported $231.2M in revenue for fiscal year 2025.

How fast is Puma Biotechnology, Inc. growing?

Puma Biotechnology, Inc. (PBYI) saw revenue decline by 0.9% over the past year.

Is PBYI profitable?

Yes, Puma Biotechnology, Inc. (PBYI) is profitable, generating $26.7M in net income for fiscal year 2025 (13.6% net margin).

Dividend & Returns
What is PBYI's return on equity?

Puma Biotechnology, Inc. (PBYI) has a return on equity (ROE) of 28.0%. This is excellent, indicating efficient use of shareholder capital.

What is Puma Biotechnology, Inc.'s free cash flow?

Puma Biotechnology, Inc. (PBYI) generated $41.2M in free cash flow for fiscal year 2025. Positive FCF indicates the company can fund dividends, buybacks, or reinvestment.

What if you invested $1,000 in PBYI back in 2007?

Total return calculator · dividends reinvested · 19+ years of data

See returns →