Ranked by reported Q2 2026 13F market value
Share of total reported institutional value in DFTX held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | BlackRock, Inc. | 11.2M | $528.4M | +32.5% | 8.360% | 0.01% |
| 2 | Avoro Capital Advisors LLC | 7.2M | $338.2M | +43.8% | 5.350% | 3.04% |
| 3 | DRIEHAUS CAPITAL MANAGEMENT LLC | 6.8M | $322.0M | +15.8% | 5.094% | 1.87% |
| 4 | Jupiter Topco LLC | 5.6M | $264.0M | β | 4.179% | 0.11% |
| 5 | Capital World Investors | 5.4M | $252.5M | β | 3.995% | 0.03% |
| 6 | FMR LLC | 4.8M | $223.6M | +162.7% | 3.537% | 0.01% |
| 7 | GEODE CAPITAL MANAGEMENT, LLC | 3.6M | $171.5M | +46.1% | 2.713% | 0.01% |
| 8 | STATE STREET CORP | 3.1M | $144.2M | +24.0% | 2.281% | 0.00% |
| 9 | Capital International Investors | 3.0M | $139.4M | β | 2.205% | 0.03% |
| 10 | Octagon Capital Advisors LP | 3.0M | $138.8M | +20.9% | 2.195% | 12.47% |
| 11 | WELLINGTON MANAGEMENT GROUP LLP | 2.9M | $138.8M | +126.1% | 2.195% | 0.02% |
| 12 | Deep Track Capital, LP | 2.8M | $129.4M | -8.3% | 2.047% | 1.88% |
| 13 | CITADEL ADVISORS LLC | 2.3M | $106.4M | +51.8% | 1.683% | 0.01% |
| 14 | Commodore Capital LP | 2.0M | $94.1M | 0.0% | 1.488% | 5.60% |
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1.9M | $89.3M | +66.9% | 1.413% | 0.01% |
| 16 | GOLDMAN SACHS GROUP INC | 1.8M | $84.7M | +7.5% | 1.340% | 0.01% |
| 17 | VANGUARD PORTFOLIO MANAGEMENT LLC | 1.6M | $77.5M | +88.9% | 1.227% | 0.00% |
| 18 | RA CAPITAL MANAGEMENT, L.P. | 1.5M | $70.6M | β | 1.116% | 0.61% |
| 19 | VANGUARD CAPITAL MANAGEMENT LLC | 1.5M | $69.9M | +35.5% | 1.106% | 0.00% |
| 20 | Siren, L.L.C. | 1.4M | $66.8M | +54.4% | 1.056% | 1.35% |
| 21 | MARSHALL WACE, LLP | 1.3M | $61.1M | +8.2% | 0.967% | 0.05% |
| 22 | NORTHERN TRUST CORP | 1.2M | $55.0M | +46.3% | 0.870% | 0.01% |
| 23 | AMERIPRISE FINANCIAL INC | 1.1M | $54.0M | +18.8% | 0.855% | 0.01% |
| 24 | Nuveen, LLC | 1.1M | $52.0M | +58.3% | 0.823% | 0.01% |
| 25 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1.1M | $51.0M | +34.0% | 0.806% | 0.01% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). β% of Fundβ shows how much of that investorβs total 13F portfolio is invested in DFTX β a direct measure of their conviction.
Filings activity in DFTX during Q2 2026, grouped by how each filer changed its position.
8 quarters of 13F filings Β· Ξ columns show change vs prior quarter
| Quarter | Inst. Holders | Ξ Holders | Ownership % | Ξ Ownership | Total 13F Value | Ξ Value |
|---|---|---|---|---|---|---|
| Q2 2026 | 369 | +48% | β | β | $5.34B | +254% |
| Q1 2026 | 249 | +3457% | β | β | $1.51B | +904% |
| Q4 2025 | 7 | 96% | β | β | $150M | 69% |
| Q3 2025 | 189 | +7.4% | 75.02% | +7.16 pp | $490M | +81% |
| Q2 2025 | 176 | 3.8% | 67.86% | 7.10 pp | $270M | +12% |
| Q1 2025 | 183 | +8.9% | 74.96% | 1.59 pp | $240M | 20% |
| Q4 2024 | 168 | +11% | 76.55% | 6.87 pp | $299M | +6.8% |
| Q3 2024 | 151 | β | 83.42% | β | $280M | β |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Ξ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying DFTX stock.
Based on Q2 2026 13F filings, institutional ownership of Definium Therapeutics, Inc. stands at not currently reported, held across 369 reporting institutions.
BlackRock, Inc. is the largest reported institutional holder of DFTX, with approximately 11,232,834 shares worth $0.53B as of Q2 2026.
Yes β 2 widely-followed marquee investors appear among the top 25 institutional holders of DFTX, including CITADEL ADVISORS LLC, SUSQUEHANNA INTERNATIONAL GROUP, LLP.
Our composite Smart Money Score for DFTX is 73 out of 100 (Bullish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
146 institutions opened new positions in DFTX during Q2 2026, while 28 fully exited. 206 added to existing positions and 7 trimmed.
Quarter-over-quarter ownership change for DFTX is not yet available β at least two quarters of 13F data are required.
The top 10 institutions account for 47.3% of all reported 13F value in DFTX, and the top 25 account for 69.8%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Definium Therapeutics, Inc. (DFTX) Institutional Ownership