Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in DTIL held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | Octagon Capital Advisors LP | 2.2M | $12.3M | +16.6% | 17.436% | 1.36% |
| 2 | abrdn plc | 2.2M | $12.3M | +4.3% | 17.385% | 0.02% |
| 3 | Empery Asset Management, LP | 2.0M | $10.8M | -10.3% | 15.348% | 13.04% |
| 4 | Bleichroeder LP | 1.7M | $9.1M | 0.0% | 12.960% | 1.58% |
| 5 | BOOTHBAY FUND MANAGEMENT, LLC | 1.1M | $5.9M | 0.0% | 8.310% | 0.15% |
| 6 | DRIEHAUS CAPITAL MANAGEMENT LLC | 995K | $5.5M | +26.4% | 7.759% | 0.04% |
| 7 | Lynx1 Capital Management LP | 985K | $5.4M | -0.9% | 7.679% | 0.86% |
| 8 | VANGUARD CAPITAL MANAGEMENT LLC | 911K | $5.0M | — | 7.099% | 0.00% |
| 9 | Affinity Asset Advisors, LLC | 598K | $3.3M | — | 4.661% | 0.19% |
| 10 | MARSHALL WACE, LLP | 416K | $2.3M | +486.2% | 3.240% | 0.00% |
| 11 | TWO SIGMA INVESTMENTS, LP | 308K | $1.7M | +120.6% | 2.399% | 0.00% |
| 12 | GEODE CAPITAL MANAGEMENT, LLC | 287K | $1.6M | +27.2% | 2.238% | 0.00% |
| 13 | RENAISSANCE TECHNOLOGIES LLC | 223K | $1.2M | -31.6% | 1.740% | 0.00% |
| 14 | BlackRock, Inc. | 200K | $1.1M | +18.7% | 1.557% | 0.00% |
| 15 | ArrowMark Colorado Holdings LLC | 179K | $985K | — | 1.397% | 0.03% |
| 16 | VANGUARD FIDUCIARY TRUST CO | 156K | $856K | — | 1.213% | 0.00% |
| 17 | Alyeska Investment Group, L.P. | 139K | $764K | -82.6% | 1.082% | 0.00% |
| 18 | MORGAN STANLEY | 122K | $673K | +22.5% | 0.953% | 0.00% |
| 19 | CITADEL ADVISORS LLC | 116K | $638K | +636.3% | 0.904% | 0.00% |
| 20 | COMMONWEALTH EQUITY SERVICES, LLC | 113K | $620K | +20.8% | 0.878% | 0.00% |
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 85K | $467K | +27.5% | 0.661% | 0.00% |
| 22 | UBS Group AG | 81K | $446K | +32.3% | 0.632% | 0.00% |
| 23 | NORTHERN TRUST CORP | 76K | $418K | -12.0% | 0.593% | 0.00% |
| 24 | STATE STREET CORP | 73K | $401K | +23.5% | 0.569% | 0.00% |
| 25 | Quarry LP | 68K | $376K | 0.0% | 0.532% | 0.07% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in DTIL — a direct measure of their conviction.
Filings activity in DTIL during Q1 2026, grouped by how each filer changed its position.
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 77 | +12% | 112.43% | +32.69 pp | $88M | +41% |
| Q4 2025 | 69 | +25% | 79.74% | +48.45 pp | $62M | +155% |
| Q3 2025 | 55 | +3.8% | 31.29% | +8.97 pp | $24M | +40% |
| Q2 2025 | 53 | +8.2% | 22.32% | +1.25 pp | $17M | +5.9% |
| Q1 2025 | 49 | 11% | 21.07% | +3.98 pp | $16M | +23% |
| Q4 2024 | 55 | +7.8% | 17.09% | 18.89 pp | $13M | 53% |
| Q3 2024 | 51 | +8.5% | 35.98% | 2.76 pp | $28M | 7.1% |
| Q2 2024 | 47 | — | 38.74% | — | $30M | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying DTIL stock.
Based on Q1 2026 13F filings, institutional ownership of Precision BioSciences, Inc. stands at 112.4%, held across 77 reporting institutions.
Octagon Capital Advisors LP is the largest reported institutional holder of DTIL, with approximately 2,236,732 shares worth $0.01B as of Q1 2026.
Yes — 4 widely-followed marquee investors appear among the top 25 institutional holders of DTIL, including TWO SIGMA INVESTMENTS, LP, RENAISSANCE TECHNOLOGIES LLC, CITADEL ADVISORS LLC, SUSQUEHANNA INTERNATIONAL GROUP, LLP.
Our composite Smart Money Score for DTIL is 75 out of 100 (Bullish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
21 institutions opened new positions in DTIL during Q1 2026, while 13 fully exited. 48 added to existing positions and 7 trimmed.
DTIL institutional ownership rose by 32.69 percentage points quarter-over-quarter, with a net change of +8 holders.
The top 10 institutions account for 81.7% of all reported 13F value in DTIL, and the top 25 account for 95.6%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Precision BioSciences, Inc. (DTIL) Institutional Ownership