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ENSCEnsysce Biosciences, Inc.
$0.27$2M
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ENSC logoEnsysce Biosciences, Inc.(ENSC)Earnings, Financials & Key Ratios

ENSC•NASDAQ
Price updated Jun 19, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryDrug Delivery Technology Platforms
AboutEnsysce Biosciences, Inc., a clinical-stage pharmaceutical company, engages in developing various prescription drugs for severe pain relief in opioid addiction, misuse, abuse, and overdose in the United States. It develops products using Trypsin Activated Abuse Protection platform, an abuse-resistant opioid prodrug technology; and Multi-Pill Abuse Resistance platform, an over-dose protection opioid prodrug technology. The company is developing PF614, a TAAP prodrug candidate of oxycodone, which is in Phase II clinical trial for the treatment of acute or chronic pain; and PF614-MPAR, a combination product of PF614 and nafamostat that is in Phase I clinical trial for overdose protection against excessive oral ingestion, as well as an oral and inhalation drug product of nafamostat for use against coronaviral infections and other pulmonary diseases, such as cystic fibrosis. It is also developing PF329, an extended-release prodrug of hydromorphone that is similar to PF614; PF8001 and PF8026 are extended and immediate-release prodrugs of amphetamine for ADHD medication abuse; and PF26810, an extended-release prodrug of methadone for opioid use disorder. The company is based in La Jolla, California.Show more
  • Revenue$5M-2.8%
  • EBITDA-$10M-52.1%
  • Net Income-$10M-27.4%
  • EPS (Diluted)-3.98+12.9%
  • EBITDA Margin-202%-56.4%
  • Operating Margin-202.12%-56.5%
  • Net Margin-200.84%-31.0%
  • ROE-0%+100.0%

ENSC Key Insights

Ensysce Biosciences, Inc. (ENSC) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓Company is almost debt free
  • ✓High quality earnings: Operating CF exceeds net income

✗Weaknesses

  • ✗Weak Piotroski F-Score: 2/9
  • ✗Negative free cash flow
  • ✗Weak momentum: RS Rating 4 (bottom 4%)
  • ✗Shares diluted 100.0% in last year
  • ✗Trading more than 30% below 52-week high
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

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ENSC Price & Volume

Ensysce Biosciences, Inc. (ENSC) stock price & volume — 10-year historical chart

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ENSC Growth Metrics

Ensysce Biosciences, Inc. (ENSC) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-
5 Years5.21%
3 Years26.16%
TTM-54.6%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM-72.91%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM36.79%

Return on Capital

10 Years-99.2%
5 Years-243.39%
3 Years-243.39%
Last Year-0%

ENSC Recent Earnings

Ensysce Biosciences, Inc. (ENSC) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 9/12 qtrs (75%)●Beat Revenue 5/12 qtrs (45%)
Q2 2026Latest
May 15, 2026
Metric
Actual
Est
EPS
$0.52+28.8%
$0.73
Rev
$960,999-49.4%
$2M
Q2 2026
Mar 30, 2026
Metric
Actual
Est
EPS
$0.75+40.5%
$1.26
Rev
$2M+277.8%
$502,966
Q4 2025
Nov 14, 2025
Metric
Actual
Est
EPS
$1.29-51.8%
$0.85
Rev
$493,104-29.6%
$700,000
Q3 2025
Aug 13, 2025
Metric
Actual
Est
EPS
$0.79+22.5%
$1.02
Rev
$1M-2.0%
$1M
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMay 15, 2026
$0.52vs $0.73+28.8%
$960,999vs $2M-49.4%
Q2 2026Mar 30, 2026
$0.75vs $1.26+40.5%
$2Mvs $502,966+277.8%
Q4 2025Nov 14, 2025
$1.29vs $0.85-51.8%
$493,104vs $700,000-29.6%
Q3 2025Aug 13, 2025
$0.79vs $1.02+22.5%
$1Mvs $1M-2.0%
Based on last 12 quarters of dataView full earnings history →

ENSC Peer Comparison

Ensysce Biosciences, Inc. (ENSC) competitors in Drug Delivery Technology Platforms — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
Institutional Holdings
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
COLL logoCOLLCollegium Pharmaceutical, Inc.Direct Competitor1.09B33.5419.3923.62%9.41%26.74%3.12
PCRX logoPCRXPacira BioSciences, Inc.Direct Competitor878.35M22.33139.563.63%1.27%1.31%0.66
AVDL logoAVDLAvadel Pharmaceuticals plcProduct Competitor2.1B21.64-42.435.05%-0.11%-0.33%0.02
NKTR logoNKTRNektar TherapeuticsProduct Competitor1.19B60.98-6.27-43.89%-284.18%-87%1.66
PRGO logoPRGOPerrigo Company plcSupply Chain1.42B10.25-1.00-2.75%-43.5%-50.65%1.35
PAHC logoPAHCPhibro Animal Health CorporationSupply Chain1.29B31.8526.7627.37%6.29%30.81%2.67
ATAI logoATAIAtai Beckley N.VOften Compared1.49B4.06-1.4012.28%-190.19%-366.21%0.01
MNMD logoMNMDMind Medicine (MindMed) Inc.Often Compared2.04B20.69-10.04-102.48%

Compare ENSC vs Peers

Ensysce Biosciences, Inc. (ENSC) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs COLL

Most directly comparable listed peer for ENSC.

Scale Benchmark

vs AVDL

Larger-name benchmark to compare ENSC against a more recognizable public peer.

Peer Set

Compare Top 5

vs COLL, PCRX, AVDL, NKTR

ENSC Income Statement

Ensysce Biosciences, Inc. (ENSC) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Sales/Revenue
001.76M3.93M3.53M2.52M2.23M5.21M5.07M2.83M
Revenue Growth %
---122.86%-10.18%-28.54%-11.59%133.53%-2.75%-54.6%
Cost of Goods Sold
01.56M3.4M20115119.84M7.59M7.22M04.88M
COGS % of Revenue
--192.88%0.01%0%786.08%340.07%138.56%--
Gross Profit
0▲ 0%
-1.56M▲ 0%
-1.64M▼ 5.1%
3.93M▲ 339.9%
3.53M▼ 10.2%
-17.31M▼ 590.3%
-5.36M▲ 69.1%
-2.01M▲ 62.5%
0▲ 100.0%
-2.06M▲ 0%
Gross Margin %
---92.88%99.99%100%-686.08%-240.12%-38.57%--72.88%
Gross Profit Growth %
---5.09%339.94%-10.17%-590.29%69.06%62.49%100%-
Operating Expenses
146.69K-600K6.93M5.54M23.4M6.91M5.36M4.72M10.24M9.78M
OpEx % of Revenue
--392.86%141.03%662.71%273.82%240.3%90.61%202.12%-
Selling, General & Admin
146.69K06.93M1.15M18.71M6.91M5.36M4.72M4.93M4.71M
SG&A % of Revenue
--392.86%29.37%529.89%273.82%240.3%90.61%97.32%-
Research & Development
003.4M4.39M4.69M19.84M7.59M7.22M10.38M11.84M
R&D % of Revenue
--192.88%111.66%132.82%786.08%340.07%138.56%204.81%-
Other Operating Expenses
00-3.4M00-19.84M-7.59M-7.22M-5.07M-3M
Operating Income
-147K▲ 0%
-959K▼ 552.4%
-8.57M▼ 793.5%
-1.61M▲ 81.2%
-19.87M▼ 1131.7%
-24.22M▼ 21.9%
-10.72M▲ 55.8%
-6.73M▲ 37.2%
-10.24M▼ 52.2%
-11.84M▲ 0%
Operating Margin %
---485.74%-41.04%-562.71%-959.91%-480.41%-129.17%-202.12%-418.88%
Operating Income Growth %
--552.38%-793.46%81.17%-1131.67%-21.9%55.75%37.21%-52.17%-
EBITDA
-27.55K2.68M-8.57M-1.61M-19.87M-24.22M-10.72M-6.73M-10.23M-6.32M
EBITDA Margin %
---485.73%-41.03%-562.71%-959.9%-480.41%-129.17%-202%-223.84%
EBITDA Growth %
-9811.49%-420.18%81.17%-1131.82%-21.9%55.75%37.21%-52.07%-395.61%
D&A (Non-Cash Add-back)
00201201151151-346.53K5.49M
EBIT
-27.55K2.68M-8.57M834.62K-25.93M-24.22M-10.72M-6.73M-10.16M-11.8M
Net Interest Income
004.25M-276K1.92M1.14M-354K-1.29M-18.77K-18.83K
Interest Income
03.63M4.25M719.65K3.21M1.25M0000
Interest Expense
000995.5K1.29M109.53K353.94K1.29M18.77K18.83K
Other Income/Expense
119.14K3.63M-1.53M1.45M-9.28M14.41K91.91K-1.26M64.76K48.64K
Pretax Income
-27.56K▲ 0%
2.68M▲ 9810.4%
-10.1M▼ 477.5%
-160.88K▲ 98.4%
-29.15M▼ 18017.1%
-24.21M▲ 16.9%
-10.63M▲ 56.1%
-7.99M▲ 24.8%
-10.18M▼ 27.4%
-11.79M▲ 0%
Pretax Margin %
---572.7%-4.09%-825.38%-959.33%-476.29%-153.3%-200.85%-417.16%
Income Tax
3.63K553.92K00000000
Effective Tax Rate %
-13.19%20.7%0%0%0%0%0%0%0%0%
Net Income
-31.19K▲ 0%
-1.34M▼ 4205.5%
-10.1M▼ 652.2%
56.77K▲ 100.6%
-29.08M▼ 51330.8%
-24.17M▲ 16.9%
-10.61M▲ 56.1%
-7.99M▲ 24.7%
-10.18M▼ 27.4%
-11.79M▲ 0%
Net Margin %
---572.7%1.44%-823.62%-957.93%-475.71%-153.3%-200.84%-417.14%
Net Income Growth %
--4205.45%-652.22%100.56%-51330.78%16.89%56.09%24.74%-27.4%-72.91%
Net Income (Continuing)
-31.19K2.12M-10.1M-160.88K-29.15M-24.21M-10.63M-7.99M-10.18M-11.79M
Discontinued Operations
0000000000
Minority Interest
000-217.63K-279.81K-315.21K-328.41K-328.48K-328.97B-328.97K
EPS (Diluted)
-0.01▲ 0%
-0.22▼ 4130.8%
0.24▲ 209.1%
0.56▲ 133.3%
-355.68▼ 63614.3%
-139.44▲ 60.8%
-4.69▲ 96.6%
-4.57▲ 2.6%
-3.98▲ 12.9%
-1.72▲ 0%
EPS Growth %
--209.09%133.33%-63614.29%60.8%96.64%2.56%12.91%36.79%
EPS (Basic)
-0.01-0.220.240.56-355.68-139.44-4.69-4.57-3.98-
Diluted Shares Outstanding
5.98M6.01M6.09M6.37M84.02K179.93K2.26M1.75M25.57M6.84M
Basic Shares Outstanding
5.98M6.01M6.09M4.46M84.02K179.93K2.26M1.75M2.56M6.84M
Dividend Payout Ratio
----------

ENSC Balance Sheet

Ensysce Biosciences, Inc. (ENSC) balance sheet — assets, liabilities & shareholders' equity

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Total Current Assets
2.31M1.92M618.59K347.88K15.66M5.3M2.29M5.34M7.24T2.01M
Cash & Short-Term Investments
2.09M1.66M341.54K194.21K12.26M3.15M1.12M3.5M3.5M745.48K
Cash Only
2.09M1.66M341.54K194.21K12.26M3.15M1.12M3.5M3.5M745.48K
Short-Term Investments
0000000000
Accounts Receivable
0170.53K173.55K0441.72K276.82K97.56K124.11K420.35K0
Days Sales Outstanding
--35.91-45.6640.0415.968.730.2852.63
Inventory
0000-441.72K00000
Days Inventory Outstanding
----------
Other Current Assets
0068.81K23.54K2.59M1.33M18K18K2.93T1.26M
Total Non-Current Assets
200.12M202.92M5.35K3.93K754.76K585.88K419.22K252.55K210.01B159.26K
Property, Plant & Equipment
0035115124.72B000124.13B117.6K
Fixed Asset Turnover
--5025.53x26034.50x0.00x---0.00x25.05x
Goodwill
0000000000
Intangible Assets
0000000000
Long-Term Investments
200.12M202.92M00000000
Other Non-Current Assets
005K3.78K-24.72B585.88K419.22K252.55K85.88B41.67K
Total Assets
202.43M▲ 0%
204.83M▲ 1.2%
623.94K▼ 99.7%
351.81K▼ 43.6%
16.42M▲ 4566.6%
5.89M▼ 64.2%
2.71M▼ 54.0%
5.6M▲ 106.7%
7.45T▲ 133145694.2%
2.17M▲ 0%
Asset Turnover
--2.83x11.17x0.22x0.43x0.82x0.93x0.00x0.62x
Asset Growth %
-1.19%-99.7%-43.62%4566.58%-64.15%-53.98%106.69%99999900%13.43%
Total Current Liabilities
156.24K437.89K7.3M7.01M16.48M9.46M3.33M2.21M4.57T2.84M
Accounts Payable
00540.78K1.72M301.1K2.94M1.94M1.36M3.27M1.61M
Days Payables Outstanding
--58.011000K727.83K54.1793.1468.62-119.26
Short-Term Debt
002.62M4.25M12.75M4.27M854.7K301.66K306.71B245.85K
Deferred Revenue (Current)
000159.05K000000
Other Current Liabilities
152.6K437.89K2.93M670.26K00004.26T980.78K
Current Ratio
14.77x4.38x0.08x0.05x0.95x0.56x0.69x2.42x1.59x0.71x
Quick Ratio
14.77x4.38x0.08x0.05x0.98x0.56x0.69x2.42x1.59x0.71x
Cash Conversion Cycle
----------66.63
Total Non-Current Liabilities
7M7M06.75M8.09M450.49K26.39K10.1K00
Long-Term Debt
00004.44M140.15K0000
Capital Lease Obligations
0000000000
Deferred Tax Liabilities
01.76K00000000
Other Non-Current Liabilities
00003.65M310.35K26.39K10.1K00
Total Liabilities
7.16M7.44M7.3M7.01M24.58M9.91M3.36M2.22M4.57T2.84M
Total Debt
002.62M4.27M17.21M4.43M854.7K301.66K301.66K245.85K
Net Debt
-2.09M-1.66M2.28M4.08M4.95M1.29M-268.91K-3.2M-3.2M-499.63K
Debt / Equity
-------0.09x0.00x-0.37x
Debt / EBITDA
----------0.04x
Net Debt / EBITDA
--0.62x-------0.08x
Interest Coverage
---0.84x-20.02x-221.16x-30.28x-5.22x-541.24x-626.43x
Total Equity
195.27M▲ 0%
197.39M▲ 1.1%
-6.68M▼ 103.4%
-6.66M▲ 0.3%
-8.16M▼ 22.5%
-4.03M▲ 50.6%
-651.27K▲ 83.8%
3.38M▲ 619.0%
2.88T▲ 85349073.5%
-669.01K▲ 0%
Equity Growth %
-1.09%-103.38%0.27%-22.52%50.61%83.84%618.98%85349073.46%-119.08%
Book Value per Share
32.6332.87-1.10-1.05-97.10-22.40-0.291.93112800.11-0.10
Total Shareholders' Equity
195.27M197.39M-6.68M-6.44M-7.88M-3.71M-322.86K3.71M3.21T-340.04K
Common Stock
6736045.99K1.58K12453315136459M929
Retained Earnings
-31.19K2.09M-56.02M-55.96M-85.85M-110.93M-121.56M-129.54M-139.72T-143.28M
Treasury Stock
0000000000
Accumulated OCI
-673-60400000000
Minority Interest
000-217.63K-279.81K-315.21K-328.41K-328.48K-328.97B-328.97K

ENSC Cash Flow Statement

Ensysce Biosciences, Inc. (ENSC) cash flow — operating, investing & free cash flow history

MetricDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25TTM
Cash from Operations
-251.83K-1.24M10.99M-1.25M-8.24M-17.89M-10.78M-7.5T-7.81T-9.6M
Operating CF Margin %
--623.31%-31.73%-233.41%-708.87%-483.19%-99999900%-99999900%-
Operating CF Growth %
--391.7%987.93%-111.34%-560.78%-117.02%39.73%-69598346.45%-4.05%-304.82%
Net Income
-31.19K-1.34M365.95K-160.88K-29.15M-24.21M-10.63M-7.99M-10.18T-11.79M
Depreciation & Amortization
0002011510006.53B6.53K
Stock-Based Compensation
000178.68K121.76K1.07M879.16K110.72B668.68B511.35K
Deferred Taxes
01.76K-1.76K-2.45M000000
Other Non-Cash Items
-231.1K-317.21K8.17M997.46K22.09M-233.42K-85.79K-7.61T1.69T2.58M
Working Capital Changes
-101.5K273.13K2.46M185.1K-1.3M5.48M-947.08K-851.25K1.52M1.95M
Change in Receivables
0-170.53K0173.55K-441.72K164.9K179.26K-26.55K-296.23K22K
Change in Inventory
000-173.55K000000
Change in Payables
111.96K317.28K01.18M-1.42M2.64M-1.23M-578.93K1.82M1.47M
Cash from Investing
-200M838.59K-566.29K183.4M04.5K00-123.64B-123.64K
Capital Expenditures
00000000-123.64K-123.64K
CapEx % of Revenue
--0%-----2.44%4.38%
Acquisitions
0000000000
Investments
----------
Other Investing
0838.59K0183.4M04.5K00-123.64B0
Cash from Financing
202.34M-32K-11.03M1.1M20.31M8.77M8.76M9.88T8.74T7.42M
Debt Issued (Net)
00566.27K1.1M13.91M6.13M605.43K-485.19K0-64.05K
Equity Issued (Net)
202.34M-32K-11.59M06.63M3.78M9.05M1.67M9.85M6.9M
Dividends Paid
0000000-290M00
Share Repurchases
00-11.58M0000000
Other Financing
0000-225.68K-1.14M-899.55K9.88T8.74T578.25K
Net Change in Cash
2.09M▲ 0%
-431.68K▼ 120.7%
-597.25K▼ 38.4%
-147.32K▲ 75.3%
12.07M▲ 8293.3%
-9.12M▼ 175.5%
-2.02M▲ 77.8%
2.38T▲ 117507898.5%
808.28B▼ 66.0%
-2.31M▲ 0%
Free Cash Flow
-251.83K▲ 0%
-1.24M▼ 391.7%
10.99M▲ 987.9%
-1.25M▼ 111.3%
-8.24M▼ 560.8%
-17.89M▼ 117.0%
-10.78M▲ 39.7%
-7.5T▼ 69598346.5%
-7.81T▼ 4.0%
-9.72M▲ 0%
FCF Margin %
--623.31%-31.73%-233.41%-708.87%-483.19%-99999900%-99999900%-344.13%
FCF Growth %
--391.7%987.93%-111.34%-560.78%-117.02%39.73%-69598346.45%-4.05%-67.6%
FCF per Share
-0.04-0.211.81-0.20-98.10-99.41-4.76-999999.00-305243.29-1.42
FCF Conversion (FCF/Net Income)
8.07x0.92x-1.09x-21.97x0.28x0.74x1.02x939363.97x767150.37x0.82x
Interest Paid
0000000000
Taxes Paid
0001.6K1.6K1.6K3.2K3.2K2.5K0

ENSC Key Ratios

Ensysce Biosciences, Inc. (ENSC) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric20182019202020212022202320242025TTM
Return on Equity (ROE)
-0.68%-10.59%-----585.41%-0%-766.5%
Return on Invested Capital (ROIC)
-0.37%-6.72%------0%0%
Gross Margin
--92.88%99.99%100%-686.08%-240.12%-38.57%--72.88%
Net Margin
--572.7%1.44%-823.62%-957.93%-475.71%-153.3%-200.84%-417.14%
Debt / Equity
------0.09x0.00x-0.37x
Interest Coverage
--0.84x-20.02x-221.16x-30.28x-5.22x-541.24x-626.43x
FCF Conversion
0.92x-1.09x-21.97x0.28x0.74x1.02x939363.97x767150.37x0.82x
Revenue Growth
--122.86%-10.18%-28.54%-11.59%133.53%-2.75%-54.6%
Related:ENSC Dividend History·ENSC Revenue History·ENSC Price History·ENSC P/E History·ENSC Financial Ratios·ENSC Institutional Holders

ENSC SEC Filings & Documents

Ensysce Biosciences, Inc. (ENSC) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

May 22, 2026·SEC

Material company update

May 15, 2026·SEC

Material company update

Apr 8, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 30, 2026·SEC

FY 2025

Mar 10, 2025·SEC

FY 2024

Mar 15, 2024·SEC

10-Q Quarterly Reports

6
FY 2026

May 15, 2026·SEC

FY 2025

Nov 14, 2025·SEC

FY 2025

Aug 13, 2025·SEC

ENSC Frequently Asked Questions

Ensysce Biosciences, Inc. (ENSC) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Ensysce Biosciences, Inc. (ENSC) reported $2.8M in revenue for fiscal year 2025.

Ensysce Biosciences, Inc. (ENSC) saw revenue decline by 2.8% over the past year.

Ensysce Biosciences, Inc. (ENSC) reported a net loss of $11.8M for fiscal year 2025.

Dividend & Returns

Ensysce Biosciences, Inc. (ENSC) has a return on equity (ROE) of -0.0%. Negative ROE indicates the company is unprofitable.

Ensysce Biosciences, Inc. (ENSC) had negative free cash flow of $9.7M in fiscal year 2025, likely due to heavy capital investments.

What if you invested $1,000 in ENSC back in 2017?

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How much would $100/month in ENSC be worth today?

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