Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in ENSC held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 150K | $81K | 0.0% | 2.189% | 0.00% |
| 2 | PERCEPTIVE ADVISORS LLC | 87K | $47K | 0.0% | 1.267% | 0.00% |
| 3 | GEODE CAPITAL MANAGEMENT, LLC | 74K | $40K | +234.4% | 1.080% | 0.00% |
| 4 | CITADEL ADVISORS LLC | 57K | $31K | — | 0.839% | 0.00% |
| 5 | XTX Topco Ltd | 24K | $13K | — | 0.356% | 0.00% |
| 6 | VANGUARD FIDUCIARY TRUST CO | 24K | $13K | — | 0.349% | 0.00% |
| 7 | JANE STREET GROUP, LLC | 14K | $7K | — | 0.198% | 0.00% |
| 8 | TRU INDEPENDENCE ASSET MANAGEMENT 2, LLC | 13K | $7K | +8.3% | 0.190% | 0.00% |
| 9 | VANGUARD CAPITAL MANAGEMENT LLC | 13K | $7K | — | 0.188% | 0.00% |
| 10 | UBS Group AG | 9K | $5K | +8691.0% | 0.129% | 0.00% |
| 11 | Tower Research Capital LLC (TRC) | 6K | $3K | +14.6% | 0.089% | 0.00% |
| 12 | SBI Securities Co., Ltd. | 486 | $262 | +15.4% | 0.007% | 0.00% |
| 13 | BlackRock, Inc. | 65 | $35 | 0.0% | 0.001% | 0.00% |
| 14 | Virtu Financial LLC | 13K | $7 | — | 0.195% | 0.00% |
| 15 | FNY Investment Advisers, LLC | 3K | $1 | 0.0% | 0.044% | 0.00% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). “% of Fund” shows how much of that investor’s total 13F portfolio is invested in ENSC — a direct measure of their conviction.
Filings activity in ENSC during Q1 2026, grouped by how each filer changed its position.
Institutions that opened a new ENSC position in Q1 2026
Institutions that fully closed their ENSC position in Q1 2026
8 quarters of 13F filings · Δ columns show change vs prior quarter
| Quarter | Inst. Holders | Δ Holders | Ownership % | Δ Ownership | Total 13F Value | Δ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 15 | 6.3% | 14.75% | 5.42 pp | $0M | 27% |
| Q4 2025 | 16 | +6.7% | 20.17% | 16.43 pp | $0M | 45% |
| Q3 2025 | 15 | +25% | 36.60% | +13.74 pp | $1M | +60% |
| Q2 2025 | 12 | +20% | 22.86% | 29.32 pp | $0M | 56% |
| Q1 2025 | 10 | +11% | 52.18% | 13.12 pp | $1M | 20% |
| Q4 2024 | 9 | 36% | 65.30% | +31.80 pp | $1M | +95% |
| Q3 2024 | 14 | +17% | 33.50% | +19.12 pp | $1M | +133% |
| Q2 2024 | 12 | — | 14.38% | — | $0M | — |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Δ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying ENSC stock.
Based on Q1 2026 13F filings, institutional ownership of Ensysce Biosciences, Inc. stands at 14.8%, held across 15 reporting institutions.
ADAGE CAPITAL PARTNERS GP, L.L.C. is the largest reported institutional holder of ENSC, with approximately 149,711 shares worth $0.00B as of Q1 2026.
Yes — 2 widely-followed marquee investors appear among the top 25 institutional holders of ENSC, including CITADEL ADVISORS LLC, JANE STREET GROUP, LLC.
Our composite Smart Money Score for ENSC is 40 out of 100 (Neutral). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
6 institutions opened new positions in ENSC during Q1 2026, while 7 fully exited. 2 added to existing positions and 7 trimmed.
ENSC institutional ownership fell by 5.42 percentage points quarter-over-quarter, with a net change of -1 holders.
The top 10 institutions account for 98.6% of all reported 13F value in ENSC, and the top 25 account for 100.0%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Ensysce Biosciences, Inc. (ENSC) Institutional Ownership