Last 32 quarters of trend data · Healthcare · Biotechnology
Quarterly valuation ratios — annualised for comparability. YoY Δ shows same-quarter-prior-year change.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P/E Ratio → | -0.07 | — | — | — | — | — | — | 2.57 | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| P/S Ratio | 0.37 | 0.96 | — | 3.47 | 0.90 | 0.68 | 1.92 | 0.49 | 20.95 | 20.68 | 17.47 | 36.68 | 31.30 |
| — | +41.1% | — | +602.2% | -95.7% | -96.7% | -89.0% | -98.7% | -33.0% | -15.0% | +38.8% | -67.1% | -94.1% | |
| P/B Ratio | 0.00 | — | 8.16 | 7.82 | 1.60 | 1.32 | 2.96 | 1.03 | 10.30 | 7.39 | — | 55.18 | 16.19 |
| — | — | +175.6% | +661.8% | -84.4% | -82.2% | — | -98.1% | -36.4% | — | — | — | — | |
| P/FCF | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBITDA | — | — | — | — | — | — | — | 1.12 | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBIT | — | — | — | — | — | — | — | 1.12 | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Quarterly margins and returns. Watch for margin compression across consecutive quarters.
Ensysce Biosciences, Inc.'s operating margin was -370.7% in Q1 2026, down 221.6 pp YoY. The trailing four-quarter average of -419.0% lags the current quarter, suggesting the recent improvement is above-trend.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | — | 99.3% | — | -499.2% | -40.2% | 100.0% | -191.7% | 50.5% | -421.0% | -154.7% | -333.5% | -339.8% | -235.1% |
| — | -0.7% | — | -1087.7% | +90.4% | +164.6% | +42.5% | +114.9% | -79.1% | -21.4% | +4.5% | +78.8% | +90.4% | |
| Operating Margin | -202.1% | -370.7% | — | -758.7% | -127.6% | -149.1% | -274.3% | 18.9% | -1075.6% | -602.8% | -612.7% | -621.8% | -467.7% |
| — | -148.6% | — | -4123.0% | +88.1% | +75.3% | +55.2% | +103.0% | -130.0% | -85.9% | -41.6% | +71.8% | +86.2% | |
| Net Margin | -200.8% | -370.1% | — | -756.3% | -126.4% | -147.4% | -273.4% | 19.4% | -1082.4% | -1019.2% | -680.2% | -617.8% | -455.1% |
| — | -151.0% | — | -4007.0% | +88.3% | +85.5% | +59.8% | +103.1% | -137.8% | -267.9% | -77.6% | +82.5% | +88.2% |
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | -0.0% | -321.0% | -147.2% | -189.5% | -60.0% | -63.8% | -71.6% | 16.4% | -80.3% | -225.0% | -1383.6% | -108.7% | -122.6% |
| — | -403.2% | -105.7% | -1254.1% | +25.3% | +71.6% | +94.8% | +115.1% | +34.5% | — | — | — | +97.6% | |
| ROA | -0.0% | -73.9% | -52.1% | -85.2% | -34.0% | -38.1% | -47.6% | 10.9% | -50.0% | -80.1% | -118.2% | -56.2% | -43.5% |
| — | -93.9% | -9.4% | -884.1% | +31.9% | +52.4% | +59.8% | +119.3% | -15.1% | -79.3% | -52.6% | +53.6% | +44.8% | |
| ROIC | -0.0% | — | — | -668.9% | -219.0% | -2813.3% | -179.3% | 26.1% | -254.4% | — | — | -869.7% | — |
| — | — | — | -2661.8% | +13.9% | — | — | +103.0% | — | — | — | — | — |
Quarterly solvency trend — watch for debt spikes or covenant pressure.
The current ratio has weakened 71.7% YoY to 0.71x, tightening the short-term liquidity position.
| Metric | TTM | Q1 '26 | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | 0.00 | — | 106320.48 | 0.42 | 0.14 | 0.09 | 0.09 | 0.06 | 0.31 | 0.07 | — | 0.31 | 0.12 |
| — | — | +119126486.4% | +607.3% | -54.8% | +31.6% | — | -80.7% | +155.1% | — | — | — | — | |
| Debt / EBITDA | — | — | — | — | — | — | — | 0.58 | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | |
| Current Ratio | 1.59 | 0.71 | 1.59 | 1.27 | 2.10 | 2.50 | 2.42 | 3.24 | 1.88 | 2.87 | 0.69 | 1.36 | 2.33 |
| — | -71.7% | -34.5% | -60.8% | +11.6% | -12.9% | +252.6% | +138.9% | -19.1% | +238.6% | +22.6% | +111.1% | +166.7% | |
| Quick Ratio | 1.59 | 0.71 | 1.59 | 1.27 | 2.10 | 2.50 | 2.42 | 3.24 | 1.88 | 2.87 | 0.69 | 1.36 | 2.33 |
| — | -71.7% | -34.5% | -60.8% | +11.6% | -12.9% | +252.6% | +138.9% | -19.1% | +238.6% | +22.6% | +111.1% | +166.7% | |
| Interest Coverage | -541.24 | -908.04 | -513.30 | -584.51 | -553.96 | -503.63 | -332.60 | 163.92 | -70.94 | -1.50 | -9.15 | -353.94 | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — |
Includes 30+ ratios · 32 years · Updated daily
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Quick answers to the most common questions about buying ENSC stock.
Ensysce Biosciences, Inc.'s current P/E is -0.1x. Quarterly P/E ratios can vary due to seasonal revenue patterns and one-time charges.
Ensysce Biosciences, Inc.'s current operating margin is -202.1%. Margins have been compressing over recent quarters. Quarterly margins are particularly useful for identifying trend inflections that annual data smooths over.
Quarterly financial ratios reveal short-term trend shifts — margin compression, debt spikes, or valuation re-ratings — that annual figures smooth over. They're essential for active investors tracking Ensysce Biosciences, Inc.'s business trajectory between earnings reports.