FOLD is no longer listed. Its last trade on record was Apr 27, 2026. The price and figures on this page are from its last trading day and final filings, and are no longer updated.
Last 45 quarters of trend data · Healthcare · Rare Disease Biotech
Quarterly valuation ratios — annualised for comparability. YoY Δ shows same-quarter-prior-year change.
| Metric | TTM | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 | Q4 '22 | Q3 '22 | Q2 '22 | Q1 '22 | Q4 '21 | Q3 '21 | Q2 '21 | Q1 '21 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P/E Ratio → | — | 659.26 | 35.30 | — | — | 47.77 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | +1280.1% | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |
| P/S Ratio | — | 6.04 | 3.62 | 2.85 | 5.01 | 4.70 | 5.75 | 5.95 | 8.08 | 9.05 | 8.69 | 9.73 | 9.36 | 9.74 | 9.24 | 9.71 | 8.68 | 9.80 | 8.03 | 8.29 | 9.83 |
| — | +28.4% | -37.1% | -52.0% | -38.0% | -48.0% | -33.8% | -38.9% | -13.7% | -7.1% | -6.0% | +0.2% | +7.9% | -0.6% | +15.1% | +17.1% | -11.8% | -54.3% | -40.8% | -46.8% | +0.3% | |
| P/B Ratio | — | 16.32 | 10.62 | 8.65 | 12.97 | 14.52 | 18.20 | 22.74 | 27.30 | 26.01 | 26.99 | 32.96 | 31.50 | 27.89 | 22.78 | 18.08 | 11.45 | 10.48 | 6.78 | 12.01 | 10.41 |
| — | +12.4% | -41.7% | -62.0% | -52.5% | -44.2% | -32.6% | -31.0% | -13.3% | -6.8% | +18.5% | +82.3% | +175.1% | +166.2% | +235.9% | +50.6% | +10.0% | -50.4% | -40.6% | +11.4% | +76.5% | |
| P/FCF | — | 70.15 | 17.34 | — | 83.18 | — | — | 34.89 | — | 603.08 | — | — | — | — | — | — | — | — | — | — | — |
| — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBITDA | — | 66.49 | 18.67 | — | — | 42.29 | 36.35 | 47.35 | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | +57.2% | -48.7% | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |
| EV / EBIT | — | 81.42 | 14.67 | — | — | 38.29 | 44.48 | 64.35 | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | +112.6% | -67.0% | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
Quarterly margins and returns. Watch for margin compression across consecutive quarters.
| Metric | TTM | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 | Q4 '22 | Q3 '22 | Q2 '22 | Q1 '22 | Q4 '21 | Q3 '21 | Q2 '21 | Q1 '21 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gross Margin | — | 84.6% | 87.4% | 90.2% | 90.7% | 90.1% | 90.6% | 91.1% | 87.7% | 90.2% | 90.4% | 90.4% | 92.0% | 89.3% | 83.6% | 89.8% | 90.4% | 90.4% | 85.3% | 89.2% | 90.2% |
| — | -6.0% | -3.6% | -1.0% | +3.4% | -0.1% | +0.3% | +0.8% | -4.6% | +0.9% | +8.2% | +0.6% | +1.8% | -1.2% | -2.0% | +0.8% | +0.2% | +4.4% | -2.6% | -0.1% | +1.1% | |
| Operating Margin | — | 8.6% | 20.3% | -6.1% | -6.3% | 10.7% | 15.3% | 11.8% | -25.1% | -3.2% | -16.4% | -20.0% | -43.6% | -48.0% | -41.4% | -75.1% | -95.7% | -87.8% | -53.3% | -50.2% | -79.9% |
| — | -19.3% | +32.4% | -151.8% | +74.7% | +432.5% | +193.1% | +159.2% | +42.4% | +93.3% | +60.3% | +73.4% | +54.4% | +45.3% | +22.3% | -49.7% | -19.8% | +4.4% | +31.9% | +39.1% | +38.0% | |
| Net Margin | — | 0.9% | 10.2% | -15.8% | -17.3% | 9.8% | -4.8% | -12.4% | -43.9% | -29.4% | -20.8% | -45.7% | -61.4% | -63.4% | -40.7% | -77.0% | -108.3% | -101.4% | -63.2% | -66.2% | -98.9% |
| — | -90.7% | +315.3% | -27.4% | +60.5% | +133.5% | +77.2% | +72.9% | +28.5% | +53.6% | +48.8% | +40.6% | +43.4% | +37.4% | +35.6% | -16.4% | -9.5% | -0.2% | +33.4% | +21.4% | +32.7% |
| Metric | TTM | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 | Q4 '22 | Q3 '22 | Q2 '22 | Q1 '22 | Q4 '21 | Q3 '21 | Q2 '21 | Q1 '21 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROE | — | 0.7% | 8.0% | -12.3% | -11.2% | 7.9% | -4.3% | -11.9% | -33.3% | -23.1% | -17.6% | -40.4% | -46.9% | -43.7% | -21.8% | -30.2% | -31.2% | -24.4% | -17.0% | -22.0% | -24.4% |
| — | -91.5% | +284.2% | -2.9% | +66.4% | +134.3% | +75.5% | +70.5% | +29.0% | +47.2% | +19.0% | -33.8% | -50.2% | -79.5% | -27.7% | -36.9% | -27.8% | -3.4% | +9.4% | -60.3% | -20.8% | |
| ROA | — | 0.2% | 2.1% | -3.0% | -2.8% | 1.9% | -0.9% | -2.1% | -6.5% | -4.4% | -2.9% | -6.0% | -7.4% | -7.5% | -4.3% | -7.6% | -9.8% | -8.9% | -5.8% | -6.4% | -7.7% |
| — | -90.1% | +334.6% | -42.6% | +57.4% | +142.7% | +69.7% | +64.7% | +13.1% | +41.7% | +32.3% | +20.9% | +24.5% | +15.8% | +26.0% | -19.1% | -27.2% | -11.9% | +27.8% | +12.0% | +30.9% | |
| ROIC | — | 2.3% | 5.3% | -1.5% | -1.4% | 2.9% | 4.3% | 3.1% | -5.7% | -0.8% | -3.8% | -3.8% | -6.9% | -8.7% | -7.3% | -10.8% | -11.8% | -11.6% | -7.0% | -5.9% | -7.4% |
| — | -20.8% | +23.3% | -149.1% | +76.4% | +462.8% | +213.7% | +180.8% | +16.5% | +90.6% | +48.4% | +64.9% | +41.8% | +25.3% | -4.5% | -82.8% | -59.3% | -33.1% | +16.1% | +31.9% | +34.5% |
Quarterly solvency trend — watch for debt spikes or covenant pressure.
| Metric | TTM | Q4 '25 | Q3 '25 | Q2 '25 | Q1 '25 | Q4 '24 | Q3 '24 | Q2 '24 | Q1 '24 | Q4 '23 | Q3 '23 | Q2 '23 | Q1 '23 | Q4 '22 | Q3 '22 | Q2 '22 | Q1 '22 | Q4 '21 | Q3 '21 | Q2 '21 | Q1 '21 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Debt / Equity | — | 1.76 | 1.92 | 2.17 | 2.29 | 2.29 | 2.49 | 3.35 | 3.40 | 2.78 | 3.41 | 4.05 | 4.41 | 3.67 | 3.40 | 2.60 | 1.88 | 1.43 | 1.17 | 2.07 | 1.76 |
| — | -22.9% | -22.7% | -35.2% | -32.6% | -17.7% | -27.1% | -17.3% | -22.8% | -24.4% | +0.3% | +55.8% | +134.9% | +156.6% | +191.5% | +25.9% | +6.7% | -7.2% | -15.2% | +268.6% | +237.3% | |
| Debt / EBITDA | — | 27.09 | 12.25 | — | — | 24.63 | 18.66 | 25.89 | — | — | — | — | — | — | — | — | — | — | — | — | — |
| — | +10.0% | -34.3% | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |
| Current Ratio | — | 2.84 | 2.99 | 3.21 | 3.34 | 3.39 | 3.15 | 2.75 | 3.03 | 2.88 | 2.73 | 2.72 | 2.89 | 3.05 | 2.78 | 3.02 | 4.00 | 4.09 | 5.37 | 4.29 | 5.05 |
| — | -16.2% | -5.3% | +16.8% | +10.1% | +17.8% | +15.3% | +1.1% | +5.1% | -5.5% | -1.8% | -10.1% | -27.8% | -25.4% | -48.2% | -29.5% | -20.7% | -8.5% | +2.5% | +21.0% | +13.5% | |
| Quick Ratio | — | 1.88 | 2.09 | 2.29 | 2.47 | 2.60 | 2.42 | 2.26 | 2.61 | 2.52 | 2.40 | 2.40 | 2.69 | 2.88 | 2.70 | 2.90 | 3.81 | 3.90 | 5.19 | 4.08 | 4.86 |
| — | -27.5% | -13.7% | +1.0% | -5.1% | +2.8% | +1.0% | -5.5% | -3.2% | -12.3% | -11.3% | -17.3% | -29.4% | -26.3% | -47.9% | -28.9% | -21.5% | -9.6% | +1.8% | +19.0% | +12.8% | |
| Interest Coverage | — | 1.28 | 3.93 | -0.66 | -0.58 | 1.66 | 1.53 | 1.01 | -2.50 | -1.47 | -0.90 | -2.24 | -3.49 | -5.32 | -2.04 | -6.42 | -9.00 | -8.84 | -5.18 | -4.73 | -7.02 |
| — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
Includes 30+ ratios · 45 years · Updated daily
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Quarterly financial ratios reveal short-term trend shifts — margin compression, debt spikes, or valuation re-ratings — that annual figures smooth over. They're essential for active investors tracking Amicus Therapeutics, Inc.'s business trajectory between earnings reports.