Ranked by reported Q1 2026 13F market value
Share of total reported institutional value in IRD held by the largest 10 / 25 filers.
| # | Institution | Shares Held | Market Value | QoQ Change | Ownership % | % of Fund |
|---|---|---|---|---|---|---|
| 1 | Caligan Partners LP | 6.1M | $27.6M | β | 0.699% | 1.92% |
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 6.0M | $27.4M | +445.7% | 0.694% | 0.04% |
| 3 | BIOS Capital Management, LP | 3.7M | $16.8M | 0.0% | 0.424% | 31.70% |
| 4 | BALYASNY ASSET MANAGEMENT LLC | 2.7M | $12.4M | 0.0% | 0.313% | 0.04% |
| 5 | MILLENNIUM MANAGEMENT LLC | 2.6M | $12.0M | +31.4% | 0.303% | 0.01% |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | 2.4M | $11.1M | β | 0.282% | 0.00% |
| 7 | MARSHALL WACE, LLP | 2.3M | $10.5M | +1367.4% | 0.266% | 0.01% |
| 8 | Boxer Capital Management, LLC | 2.3M | $10.2M | β | 0.259% | 1.34% |
| 9 | ADAR1 Capital Management, LLC | 1.8M | $8.4M | +4522.5% | 0.213% | 0.53% |
| 10 | PERCEPTIVE ADVISORS LLC | 1.8M | $8.4M | -57.6% | 0.211% | 0.17% |
| 11 | Nantahala Capital Management, LLC | 1.7M | $7.7M | -64.8% | 0.194% | 0.39% |
| 12 | Woodline Partners LP | 1.4M | $6.2M | β | 0.156% | 0.02% |
| 13 | BOOTHBAY FUND MANAGEMENT, LLC | 1.2M | $5.4M | β | 0.137% | 0.14% |
| 14 | FARALLON CAPITAL MANAGEMENT LLC | 1.0M | $4.5M | β | 0.115% | 0.03% |
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 905K | $4.1M | +265.1% | 0.104% | 0.00% |
| 16 | Bleichroeder LP | 737K | $3.4M | 0.0% | 0.085% | 0.58% |
| 17 | Mink Brook Asset Management LLC | 591K | $2.7M | -64.5% | 0.068% | 1.50% |
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 538K | $2.5M | +6.6% | 0.062% | 0.00% |
| 19 | Trails Edge Capital Partners, LP | 500K | $2.3M | β | 0.057% | 0.52% |
| 20 | Opaleye Management Inc. | 1.1M | $2.3M | 0.0% | 0.129% | 0.30% |
| 21 | AMERIPRISE FINANCIAL INC | 388K | $1.8M | β | 0.045% | 0.00% |
| 22 | GOLDMAN SACHS GROUP INC | 327K | $1.5M | β | 0.038% | 0.00% |
| 23 | GREAT POINT PARTNERS LLC | 324K | $1.5M | β | 0.037% | 0.36% |
| 24 | VANGUARD FIDUCIARY TRUST CO | 282K | $1.3M | β | 0.032% | 0.00% |
| 25 | UBS Group AG | 258K | $1.2M | +186.9% | 0.030% | 0.00% |
denotes a marquee investor (Buffett, Burry, ARK, Tiger Global, Pershing Square, Baupost and other widely-followed managers). β% of Fundβ shows how much of that investorβs total 13F portfolio is invested in IRD β a direct measure of their conviction.
Filings activity in IRD during Q1 2026, grouped by how each filer changed its position.
Institutions that opened a new IRD position in Q1 2026
Institutions that fully closed their IRD position in Q1 2026
8 quarters of 13F filings Β· Ξ columns show change vs prior quarter
| Quarter | Inst. Holders | Ξ Holders | Ownership % | Ξ Ownership | Total 13F Value | Ξ Value |
|---|---|---|---|---|---|---|
| Q1 2026 | 78 | +32% | 5.78% | +4.19 pp | $203M | +263% |
| Q4 2025 | 59 | +23% | 1.59% | +0.70 pp | $56M | +78% |
| Q3 2025 | 48 | +9.1% | 0.89% | +0.42 pp | $31M | +92% |
| Q2 2025 | 44 | 4.3% | 0.47% | +0.05 pp | $16M | +12% |
| Q1 2025 | 46 | +9.5% | 0.42% | +0.25 pp | $15M | +146% |
| Q4 2024 | 42 | +11% | 0.17% | +0.08 pp | $6M | +88% |
| Q3 2024 | 38 | +5.6% | 0.09% | 0.03 pp | $3M | 23% |
| Q2 2024 | 36 | β | 0.12% | β | $4M | β |
Source: SEC 13F institutional filings. Ownership % requires market cap data and will show once linked. Ξ columns compare to the immediately prior filed quarter.
Quick answers to the most common questions about buying IRD stock.
Based on Q1 2026 13F filings, institutional ownership of Opus Genetics, Inc. stands at 5.8%, held across 78 reporting institutions.
Caligan Partners LP is the largest reported institutional holder of IRD, with approximately 6,075,028 shares worth $0.03B as of Q1 2026.
Yes β 2 widely-followed marquee investors appear among the top 25 institutional holders of IRD, including MILLENNIUM MANAGEMENT LLC, SUSQUEHANNA INTERNATIONAL GROUP, LLP.
Our composite Smart Money Score for IRD is 73 out of 100 (Bullish). It combines net institutional buying activity, ownership shift, marquee investor presence, and holder-count growth.
27 institutions opened new positions in IRD during Q1 2026, while 8 fully exited. 42 added to existing positions and 7 trimmed.
IRD institutional ownership rose by 4.19 percentage points quarter-over-quarter, with a net change of +19 holders.
The top 10 institutions account for 71.3% of all reported 13F value in IRD, and the top 25 account for 95.0%.
All data is sourced from SEC Form 13F filings, which institutional investment managers with at least $100M in assets are required to file each quarter. We process every 13F filing from EDGAR and recompute the aggregates after each cycle. Insider transactions are sourced from Form 4 filings.
Opus Genetics, Inc. (IRD) Institutional Ownership