The firm maintains a persistent negative free cash flow trajectory, evidenced by a $1.9 million deficit in 2026Q1 that highlights the structural inability to generate internal liquidity.
| Metric | TTM | Dec'25 | Dec'24 | Dec'23 | Dec'22 | Dec'21 | Dec'20 | Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 | Dec'08 | Dec'07 | Dec'06 | Dec'05 |
|---|
| Cash from Operations | -4.33M | -3.07M | -3.16M | -4.29M | -4.61M | -4.14M | -2.13M | -1.67M | -1.51M | -1.41M | -1.68M | -2.18M | -1.64M | -1.18M | -1.21M | -1.36M | -936.39K | -638.44K | -597.69K | -702.87K | -443.45K | -32.87K |
| Operating CF Margin % | - | - | - | - | - | - | - | - | - | - | - | -1090.56% | - | - | - | - | - | - | - | - | - | - |
| Operating CF Growth % | -260.16% | 2.97% | 26.29% | 6.91% | -11.32% | -94.37% | -27.31% | -10.79% | -7% | 15.81% | 23.09% | -33.36% | -38.59% | 2.13% | 11.32% | -45.2% | -46.67% | -6.82% | 14.96% | -58.5% | -1249.15% | - |
| Net Income | -7.27M | -6.01M | -3.59M | -5.09M | -6.31M | -6.73M | -3.26M | -2.44M | -2.13M | -1.81M | -2.13M | -2.85M | -2.77M | -1.37M | -3.58M | -2.07M | -880.25K | -1.55M | -1.27M | -1.65M | -488.08K | -32.87K |
| Depreciation & Amortization | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 128 | 615 | 592 | 462 | 0 |
| Stock-Based Compensation | 1.46M | 1.56M | 418.42K | 773.2K | 1.55M | 2.6M | 1.25M | 748.65K | 785.61K | 70.69K | 287.16K | 549.7K | 946.17K | 119.25K | 1.02M | 204.9K | 160.71K | 745.98K | 571.05K | 890.44K | 0 | 0 |
| Deferred Taxes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -571.05K | -890.44K | 0 | 0 |
| Other Non-Cash Items | 1.16M | 966.09K | 0 | 0 | 0 | 0 | 0 | 0 | 902.43K | -81.74K | 87.16K | 205.77K | 437.11K | 119.25K | 1.47M | 200.82K | 67.22K | 132.93K | 571.05K | 941.28K | 97.4K | 0 |
| Working Capital Changes | 269.66K | 412.88K | 3.01K | 20.56K | 154.76K | -13.44K | -117.88K | 17.54K | -163.52K | 325.54K | 170.13K | -84.49K | -252.64K | 75.49K | -117.01K | 302.58K | -284.08K | 33.85K | 102.17K | 3.75K | -53.23K | 0 |
| Change in Receivables | 0 | 0 | 0 | 0 | 0 | 0 | 14.37K | -14.37K | 0 | 0 | 200K | -200K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Inventory | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 14.37K | 0 | 0 | 35.12K | 12.59K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Change in Payables | -6.51K | 0 | -73.55K | 0 | 2.32K | 35.67K | 46.74K | -51.66K | -116.82K | 152.44K | 519 | 36.54K | 14.76K | 27.36K | -28.93K | 81K | -55.2K | -24.94K | 34.74K | 41.95K | 0 | 0 |
| Cash from Investing | -3.2M | -3.17M | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 104.09K | 109.6K | -207.56K | 0 | 345K | 1.25M | -1.58M | -25K | 0 | -272 | -498 | 0 |
| Capital Expenditures | -24.86K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -272 | -498 | 0 |
| CapEx % of Revenue | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Acquisitions | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Investments | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Other Investing | -95.1K | -95.1K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 104 | 109.6K | -208 | 0 | 345 | 1.25M | -1.09M | -25K | 0 | -272 | 0 | 0 |
| Cash from Financing | 9.4M | 10.31M | 0 | 3.14M | 5.14M | 3.9M | 4.6M | 0 | 4.48M | 2.52M | 1.75M | 2.05M | 1.41M | 2.5M | 2.5M | 5K | 1.09M | 2.2M | 100K | 531.57K | 1.12M | 37.5K |
| Debt Issued (Net) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.09M | 1.11M | 100K | 0 | 0 | 0 |
| Equity Issued (Net) | 9.4M | 10.31M | 0 | 3.14M | 5.14M | 3.69M | 4.6M | 0 | 4.5M | 2.5M | 1.75M | 1.75M | 0 | 0 | 0 | 0 | 0 | -112.95K | 0 | 531.57K | 969.37K | 25K |
| Dividends Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -2K | -2K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share Repurchases | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -112.95K | 0 | -118.68K | -214.52K | 0 |
| Other Financing | 0 | 0 | 0 | 6.32K | 0 | 207.63K | 0 | 0 | -21.7K | 18K | 0 | 304.39K | 1.41M | 2.5M | 2.5M | 5K | 0 | 1.2M | 0 | 0 | 149.27K | 12.5K |
| Net Change in Cash | 1.87M | 4.07M | -3.16M | -1.15M | 529.65K | -245.52K | 2.47M | -1.67M | 2.97M | 1.11M | 174.65K | -19.13K | -430.61K | -1.18M | 1.64M | -104.79K | -1.42M | 1.53M | -497.69K | -171.57K | 674.69K | 4.63K |
| Free Cash Flow | -4.36M | -3.07M | -3.16M | -4.29M | -4.61M | -4.14M | -2.13M | -1.67M | -1.51M | -1.41M | -1.68M | -2.18M | -1.64M | -1.18M | -1.21M | -1.36M | -936.39K | -638.44K | -597.69K | -703.14K | -443.95K | -32.87K |
| FCF Margin % | - | - | - | - | - | - | - | - | - | - | - | -1090.56% | - | - | - | - | - | - | - | - | - | - |
| FCF Growth % | -48.05% | 2.97% | 26.29% | 6.91% | -11.32% | -94.37% | -27.31% | -10.79% | -7% | 15.81% | 23.09% | -33.36% | -38.59% | 2.13% | 11.32% | -45.2% | -46.67% | -6.82% | 15% | -58.38% | -1250.66% | - |
| FCF per Share | -0.40 | -0.06 | -1.41 | -2.24 | -2.92 | -3.07 | -1.89 | -1.50 | -1.54 | -1.52 | -2.10 | -2.80 | -2.21 | -1.70 | -1.86 | -0.00 | -0.00 | -0.00 | -0.00 | -0.00 | -0.00 | -0.00 |
| FCF Conversion (FCF/Net Income) | 0.60x | 0.51x | 0.88x | 0.84x | 0.73x | 0.62x | 0.65x | 0.69x | 0.71x | 0.78x | 0.79x | 0.76x | 0.59x | 0.86x | 336.86x | 0.66x | 1.06x | 0.41x | 0.47x | 0.43x | 0.91x | 1.00x |
| Interest Paid | 0 | 0 | 0 | 16.23K | 0 | 7.41K | 3.67K | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Taxes Paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Limited cash runway
As reported in financial statements, LIXT's operating cash flow to net income ratio fluctuated significantly, reaching 0.95 in 2026Q1, which suggests that the company's reported losses are closely tracking actual cash outflows rather than being obscured by non-cash accounting adjustments or significant accrual-based distortions.
The alignment between net income and operating cash flow indicates that the company's burn is primarily driven by tangible operational expenses rather than accounting artifacts. Investors should monitor this relationship, as any future decoupling could signal the introduction of complex non-cash items that might mask the underlying clinical trial burn rate.
Based on LIXT's reported figures, the company has maintained a consistent negative free cash flow trajectory, with the 2026Q1 deficit of $1.9 million highlighting the structural inability of the current research-heavy business model to generate internal liquidity to support its ongoing clinical development programs.
The persistent negative FCF confirms that the firm remains entirely dependent on external capital markets to fund its operations. This trajectory suggests that without a major licensing event or partnership, the company will continue to face significant pressure on its cash reserves as clinical trial costs escalate.
According to recent SEC filings, LIXT utilized stock-based compensation reaching $821.3K in 2025Q3, a non-cash expense that effectively serves as a hidden financing mechanism to preserve limited cash reserves while simultaneously diluting the equity value held by existing shareholders in this capital-constrained environment.
While SBC does not impact the immediate cash burn, it represents a significant cost of capital that is often overlooked in headline cash flow metrics. Analysts should interpret this as a necessary trade-off for talent retention, though it warrants further investigation regarding the long-term impact on share count and future earnings per share.
Data from the most recent quarterly reports indicates that working capital changes have remained negligible, with a $101.9K outflow in 2026Q1, suggesting that the company lacks the operational scale or commercial inventory cycles that typically drive meaningful working capital fluctuations in more mature industrial entities.
The lack of significant working capital movement confirms that the company's cash flow is almost entirely dictated by R&D and administrative spending. Investors should not expect working capital to provide any relief or additional liquidity, as the firm's operational structure remains focused on early-stage clinical development.
Quick answers to the most common questions about buying LIXT stock.
Lixte Biotechnology Holdings, Inc. (LIXT) generated $-3.1M in net cash from operating activities in 2025. This reflects the cash generated directly from core business operations.
Lixte Biotechnology Holdings, Inc. (LIXT) reported negative free cash flow of $3.1M in 2025, indicating capital requirements exceeded cash from operations.
Lixte Biotechnology Holdings, Inc. (LIXT) spent $0.0M on capital expenditures in 2025. CapEx represents the cash invested in physical assets like property, plant, and equipment to maintain or grow the business.