Lexicon Pharmaceuticals, Inc. (LXRX) P/E Ratio History
Deep ValueTrading at -15.4x · 0th percentile of 5-year range · Significant discount to historical valuation · Data 2019–2021
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P/E Ratio Analysis
As of June 23, 2026, Lexicon Pharmaceuticals, Inc. (LXRX) trades at a price-to-earnings ratio of -15.4x, with a stock price of $2.15 and trailing twelve-month earnings per share of $-0.07.
The current P/E is 342% below its 5-year average of 6.4x. Over the past five years, LXRX's P/E has ranged from a low of 2.2x to a high of 11.9x, placing the current valuation at the 0th percentile of its historical range.
Compared to the Healthcare sector median P/E of 22.1x, LXRX trades at a 169% discount to its sector peers. The sector includes 233 companies with P/E ratios ranging from 0.0x to 194.5x.
Relative to the broader market, LXRX trades at a notable discount to the S&P 500 median P/E of 24.3x. Investors should consider the company's growth prospects, competitive position, and earnings quality when evaluating whether the current valuation is justified.
For a comprehensive intrinsic value estimate using discounted cash flow analysis, see our LXRX DCF Valuation Calculator →
Note: P/E ratio is just one valuation metric. It does not account for balance sheet strength, cash flow quality, or growth sustainability. Always conduct comprehensive due diligence before making investment decisions.
LXRX Cross-Benchmark Valuation
How does the current P/E compare to sector peers and the broader market?
LXRX P/E vs Peers
Metabolic and Obesity Therapies peers sorted by market cap
| Company | Market Cap | P/E Ratio | PEG Ratio | EPS Growth (1Y) |
|---|---|---|---|---|
| $9B | 97.2 | - | -33% | |
| $2B | 6.9Lowest | 0.66Best | +817%Best | |
| $4B | 9.6 | - | +68% |
Lower P/E can signal a discount or weaker growth expectations; PEG adds growth context.
LXRX Historical P/E Data (2019–2021)
Quarterly P/E ratios calculated from closing price and TTM EPS
| Quarter | Period End | Price | TTM EPS | P/E Ratio | vs Avg |
|---|---|---|---|---|---|
| FY2021 Q2 | Jun 30 2021 | $4.59 | $0.39 | 11.9x | +87% |
| FY2020 Q2 | - | $2.00 | $0.19 | 10.5x | +66% |
| FY2020 Q1 | - | $1.95 | $0.62 | 3.1x | -51% |
| FY2019 Q4 | - | $4.15 | $1.04 | 4.0x | -37% |
| FY2019 Q3 | Sep 30 2019 | $3.01 | $1.36 | 2.2x | -65% |
Average P/E for displayed period: 6.4x
Intrinsic Valuation
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Historical Returns
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DCA Calculator
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Peer Comparison
Compare growth, multiples, and margins vs sector.
LXRX — Frequently Asked Questions
Quick answers to the most common questions about buying LXRX stock.
What is LXRX's P/E ratio?
Lexicon Pharmaceuticals, Inc. (LXRX) trailing twelve-month P/E ratio is -15.4x, based on TTM diluted EPS of $-0.07. The 5-year average P/E is 6.4x and the historical range spans 2.2x to 11.9x.
Is LXRX stock overvalued or undervalued?
LXRX trades at -15.4x P/E, below its 5-year average of 6.4x. At the 0th percentile of its historical range (2.2x–11.9x), the stock is priced at a discount to its own history.
Is LXRX stock expensive?
No, LXRX is not expensive on a historical basis. The current P/E of -15.4x is below the 5-year average of 6.4x and sits at the 0th percentile of its valuation range.
What is LXRX's historical P/E range?
Over the past 5 years, LXRX's P/E ratio has ranged from 2.2x to 11.9x, with a median of 4.0x and an average of 6.4x. The current P/E of -15.4x places the stock at the 0th percentile of this range. Full historical data spans 2019–2021.
How does LXRX's P/E compare to the S&P 500?
LXRX trades at -15.4x P/E versus the S&P 500 median of 24.3x. The 163% discount to the market suggests lower growth expectations or perceived higher risk.
How does LXRX's valuation compare to Healthcare peers?
Lexicon Pharmaceuticals, Inc. P/E of -15.4x compares to the Healthcare sector median of 22.1x. The discount suggests lower growth expectations, weaker margins, or higher perceived risk relative to peers. See the peer comparison table on this page for ticker-by-ticker P/E and PEG.
What is LXRX's PEG ratio?
LXRX PEG ratio is N/A, based on a P/E of -15.4x and EPS growth of 77.8%. PEG normalises P/E by growth and helps compare stocks with different earnings trajectories.
What is LXRX's earnings yield?
LXRX earnings yield is N/A, the inverse of its -15.4x P/E ratio. Earnings yield represents the percentage of each dollar invested that the company earns. It can be compared directly to bond yields to assess relative attractiveness of stocks versus fixed income.