Lexicon Pharmaceuticals, Inc. (LXRX) Stock Price History

Historical prices from 2000 to 2026

$1.79-0.07 (-3.49%)close Sep 25

Returns

1M: -23.3%
3M: -21.6%
YTD: +57.5%
1Y: +34.0%
3Y: +19.2%
5Y: -19.6%

ATH$344.75Jul 2000-99.5%

ATL$0.28Mar 2025pre-split

Avg Vol (50D)2.8M/ day

52-Week Range$1.10 — $2.68

LowCurrent: $1.79High

Loading 10-year price history...

LXRX Historical Performance

1 YearTotal Return

+34.0%

Price: +34.0%

3 YearsTotal Return

+69.3%

CAGR: +19.2%

Price: +69.3%

5 YearsTotal Return

-66.4%

CAGR: -19.6%

Price: -66.4%

YTD

+57.5%

LXRX Annual Returns

Year-by-year price performance · 2002–2026

Best+106.7%2015

Worst-57.7%2002

Up years9/25

2002-57.7%

2003+14.4%

2004+28.3%

2005-50.7%

2006-5.2%

2007-17.9%

2008-54.1%

2009+18.1%

2010-16.8%

2011-14.0%

2012+76.8%

2013-24.4%

2014-49.2%

2015+106.7%

2016+5.2%

2017-30.4%

2018-34.4%

2019-39.9%

2020-16.4%

2021+11.9%

2022-50.9%

2023-23.1%

2024-53.6%

2025+48.0%

2026+102.6%

2002 annual price return: -57.7%
2003 annual price return: +14.4%
2004 annual price return: +28.3%
2005 annual price return: -50.7%
2006 annual price return: -5.2%
2007 annual price return: -17.9%
2008 annual price return: -54.1%
2009 annual price return: +18.1%
2010 annual price return: -16.8%
2011 annual price return: -14.0%
2012 annual price return: +76.8%
2013 annual price return: -24.4%
2014 annual price return: -49.2%
2015 annual price return: +106.7%
2016 annual price return: +5.2%
2017 annual price return: -30.4%
2018 annual price return: -34.4%
2019 annual price return: -39.9%
2020 annual price return: -16.4%
2021 annual price return: +11.9%
2022 annual price return: -50.9%
2023 annual price return: -23.1%
2024 annual price return: -53.6%
2025 annual price return: +48.0%
2026 annual price return: +102.6%

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LXRX Stock Price Trajectory (2000–2026)

As of September 26, 2026, Lexicon Pharmaceuticals, Inc. (LXRX) trades at $1.80, representing a +34.0% return over the past year. The stock has delivered a -66.4% total return over five years (-19.6% CAGR), reflecting challenging market conditions.

The stock reached its all-time high of $344.75 on July 21, 2000. From this peak, LXRX has corrected -99.5%, currently trading 2% below its 200-day moving average, suggesting potential weakness.

When compared to Healthcare sector peers ARDX (-42.6% 1Y), CORT (+40.3% 1Y), and INVA (+11.7% 1Y), LXRX has underperformed the peer group average. Compare LXRX vs ARDX →

LXRX Historical Price Data · from 2000

Rows 1–50 of 6,656

Date	Open	High	Low	Close	Volume	Change %
2026-09-25	1.88	1.93	1.77	1.79	3.01M	-3.49%
2026-09-24	2.05	2.06	1.85	1.86	4.44M	-9.71%
2026-09-23	2.17	2.17	2.02	2.06	3.17M	-5.50%
2026-09-22	2.05	2.19	2.02	2.18	3.95M	+6.86%
2026-09-21	2.02	2.04	2.01	2.04	1.35M	-0.49%
2026-09-18	2.04	2.06	1.99	2.05	7.43M	+0.74%
2026-09-17	2.05	2.11	2.02	2.04	2.23M	+0.74%
2026-09-16	2.01	2.06	2.00	2.02	2.15M	+0.50%
2026-09-15	1.98	2.02	1.89	2.01	2.51M	+1.52%
2026-09-14	2.01	2.01	1.94	1.98	1.77M	-1.00%
2026-09-11	2.05	2.06	1.95	2.00	3.06M	-0.99%
2026-09-10	2.11	2.14	2.01	2.02	2.60M	-6.05%
2026-09-09	2.23	2.23	2.13	2.15	2.03M	-3.59%
2026-09-08	2.21	2.25	2.19	2.23	1.57M	-0.45%
2026-09-04	2.25	2.25	2.21	2.24	1.04M	-0.88%
2026-09-03	2.25	2.27	2.23	2.26	1.51M	+0.89%
2026-09-02	2.23	2.26	2.19	2.24	2.33M	+2.28%
2026-09-01	2.24	2.27	2.17	2.19	1.99M	-2.67%
2026-08-31	2.25	2.29	2.19	2.25	6.65M	-1.75%
2026-08-28	2.31	2.31	2.27	2.29	2.68M	-1.29%
2026-08-27	2.30	2.34	2.29	2.32	1.62M	+0.43%
2026-08-26	2.32	2.33	2.29	2.31	1.19M	-1.28%
2026-08-25	2.34	2.37	2.34	2.34	1.82M	+0.86%
2026-08-24	2.32	2.35	2.30	2.32	1.68M	+0.87%
2026-08-21	2.19	2.31	2.19	2.30	3.19M	+5.50%
2026-08-20	2.40	2.40	2.17	2.18	4.75M	-9.54%
2026-08-19	2.46	2.48	2.39	2.41	1.78M	-0.41%
2026-08-18	2.33	2.44	2.33	2.42	2.90M	+3.42%
2026-08-17	2.31	2.39	2.29	2.34	3.53M	+0.86%
2026-08-14	2.32	2.34	2.27	2.32	1.76M	-0.85%
2026-08-13	2.37	2.39	2.32	2.34	2.32M	-0.43%
2026-08-12	2.41	2.46	2.35	2.35	2.57M	-3.29%
2026-08-11	2.42	2.45	2.31	2.43	3.03M	+1.25%
2026-08-10	2.45	2.49	2.38	2.40	2.70M	-2.83%
2026-08-07	2.44	2.48	2.29	2.47	3.09M	+4.66%
2026-08-06	1.96	2.44	1.96	2.36	4.89M	-3.67%
2026-08-05	2.52	2.52	2.40	2.45	3.97M	-1.61%
2026-08-04	2.33	2.52	2.32	2.49	3.91M	+6.87%
2026-08-03	2.29	2.34	2.22	2.33	2.05M	+0.87%
2026-07-31	2.32	2.35	2.25	2.31	2.77M	-1.28%
2026-07-30	2.32	2.40	2.29	2.34	2.46M	+0.86%
2026-07-29	2.38	2.42	2.29	2.32	2.48M	-0.85%
2026-07-28	2.24	2.35	2.17	2.34	2.68M	+4.93%
2026-07-27	2.30	2.38	2.16	2.23	2.96M	-2.62%
2026-07-24	2.30	2.35	2.24	2.29	1.68M	-0.43%
2026-07-23	2.21	2.35	2.19	2.30	2.71M	+2.22%
2026-07-22	2.36	2.37	2.19	2.25	3.60M	-5.46%
2026-07-21	2.33	2.40	2.26	2.38	2.35M	+2.15%
2026-07-20	2.40	2.42	2.26	2.33	3.10M	-2.51%
2026-07-17	2.22	2.40	2.19	2.39	2.43M	+6.70%

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DCF models, multiple analysis, and analyst estimates.

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10-year return with dividends reinvested.

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Peer Comparison

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LXRX — Frequently Asked Questions

Quick answers to the most common questions about buying LXRX stock.

How has LXRX stock performed recently?

LXRX returned +34.0% over the past year, beating its 5-year annualized CAGR of -19.6%. The stock trades below its 200-day moving average, confirming the uptrend.

What is LXRX's all-time high price?

Lexicon Pharmaceuticals, Inc. reached $344.75 on 2000-07-21. The 52-week high is $2.68. Current 1-year return of +34.0% places the stock closer to historical peaks.

Where can I download LXRX historical price data?

This page provides LXRX daily OHLCV data with 50-day MA, 200-day MA, and RSI indicators. Data spans 2000-2026, downloadable in CSV format.

LXRX Stock Price Trajectory (2000–2026)

When compared to Healthcare sector peers ARDX (-42.6% 1Y), CORT (+40.3% 1Y), and INVA (+11.7% 1Y), LXRX has underperformed the peer group average. Compare LXRX vs ARDX →

Date

Open

High

Low

Volume

Change %

2026-09-25

1.88

1.93

1.77

1.79

3.01M

-3.49%

2026-09-24

2.05

2.06

1.85

1.86

4.44M

-9.71%

2026-09-23

2.17

2.02

2.06

3.17M

-5.50%

2026-09-22

2.05

2.19

2.02

2.18

3.95M

+6.86%

2026-09-21

2.02

2.04

2.01

2.04

1.35M

-0.49%

2026-09-18

2.04

2.06

1.99

2.05

7.43M

+0.74%

2026-09-17

2.05

2.11

2.02

2.04

2.23M

+0.74%

2026-09-16

2.01

2.06

2.00

2.02

2.15M

+0.50%

2026-09-15

1.98

2.02

1.89

2.01

2.51M

+1.52%

2026-09-14

2.01

1.94

1.98

1.77M

-1.00%

2026-09-11

2.05

2.06

1.95

2.00

3.06M

-0.99%

2026-09-10

2.11

2.14

2.01

2.02

2.60M

-6.05%

2026-09-09

2.23

2.13

2.15

2.03M

-3.59%

2026-09-08

2.21

2.25

2.19

2.23

1.57M

-0.45%

2026-09-04

2.25

2.21

2.24

1.04M

-0.88%

2026-09-03

2.25

2.27

2.23

2.26

1.51M

+0.89%

2026-09-02

2.23

2.26

2.19

2.24

2.33M

+2.28%

2026-09-01

2.24

2.27

2.17

2.19

1.99M

-2.67%

2026-08-31

2.25

2.29

2.19

2.25

6.65M

-1.75%

2026-08-28

2.31

2.27

2.29

2.68M

-1.29%

2026-08-27

2.30

2.34

2.29

2.32

1.62M

+0.43%

2026-08-26

2.32

2.33

2.29

2.31

1.19M

-1.28%

2026-08-25

2.34

2.37

2.34

1.82M

+0.86%

2026-08-24

2.32

2.35

2.30

2.32

1.68M

+0.87%

2026-08-21

2.19

2.31

2.19

2.30

3.19M

+5.50%

2026-08-20

2.40

2.17

2.18

4.75M

-9.54%

2026-08-19

2.46

2.48

2.39

2.41

1.78M

-0.41%

2026-08-18

2.33

2.44

2.33

2.42

2.90M

+3.42%

2026-08-17

2.31

2.39

2.29

2.34

3.53M

+0.86%

2026-08-14

2.32

2.34

2.27

2.32

1.76M

-0.85%

2026-08-13

2.37

2.39

2.32

2.34

2.32M

-0.43%

2026-08-12

2.41

2.46

2.35

2.57M

-3.29%

2026-08-11

2.42

2.45

2.31

2.43

3.03M

+1.25%

2026-08-10

2.45

2.49

2.38

2.40

2.70M

-2.83%

2026-08-07

2.44

2.48

2.29

2.47

3.09M

+4.66%

2026-08-06

1.96

2.44

1.96

2.36

4.89M

-3.67%

2026-08-05

2.52

2.40

2.45

3.97M

-1.61%

2026-08-04

2.33

2.52

2.32

2.49

3.91M

+6.87%

2026-08-03

2.29

2.34

2.22

2.33

2.05M

+0.87%

2026-07-31

2.32

2.35

2.25

2.31

2.77M

-1.28%

2026-07-30

2.32

2.40

2.29

2.34

2.46M

+0.86%

2026-07-29

2.38

2.42

2.29

2.32

2.48M

-0.85%

2026-07-28

2.24

2.35

2.17

2.34

2.68M

+4.93%

2026-07-27

2.30

2.38

2.16

2.23

2.96M

-2.62%

2026-07-24

2.30

2.35

2.24

2.29

1.68M

-0.43%

2026-07-23

2.21

2.35

2.19

2.30

2.71M

+2.22%

2026-07-22

2.36

2.37

2.19

2.25

3.60M

-5.46%

2026-07-21

2.33

2.40

2.26

2.38

2.35M

+2.15%

2026-07-20

2.40

2.42

2.26

2.33

3.10M

-2.51%

2026-07-17

2.22

2.40

2.19

2.39

2.43M

+6.70%

Lexicon Pharmaceuticals, Inc. (LXRX) Stock Price History

LXRX Historical Performance

LXRX Annual Returns

Download Historical Data

LXRX Stock Price Trajectory (2000–2026)

LXRX Historical Price Data · from 2000

LXRX Chart Terminal

Live Breakouts Feed

Intrinsic Valuation

Historical Returns

Peer Comparison

Lexicon Pharmaceuticals, Inc. (LXRX) Stock Price History

LXRX Historical Performance

LXRX Annual Returns

Download Historical Data

LXRX Stock Price Trajectory (2000–2026)

LXRX Historical Price Data · from 2000

LXRX Chart Terminal

Live Breakouts Feed

Intrinsic Valuation

Historical Returns

Peer Comparison