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LXRX logoLexicon Pharmaceuticals, Inc.(LXRX)Earnings, Financials & Key Ratios

LXRX•NASDAQ
$1.60
$678M mkt cap·Price updated May 6, 2026
SectorHealthcareIndustryBiotechnologySub-IndustryMetabolic and Obesity Therapies
AboutLexicon Pharmaceuticals, Inc., a biopharmaceutical company, focuses on the discovery, development, and commercialization of pharmaceutical products. Its orally-delivered small molecule drug candidates under development comprise Sotagliflozin that completed Phase III clinical trials for the for the treatment of heart failure and type 1 diabetes; and LX9211, which is in Phase II clinical development for the treatment of neuropathic pain. The company has strategic collaboration and license agreements with Bristol-Myers Squibb Company, and Genentech, Inc. Lexicon Pharmaceuticals, Inc. was incorporated in 1995 and is headquartered in The Woodlands, Texas.Show more
  • Revenue$50M+60.2%
  • EBITDA-$48M+75.4%
  • Net Income-$50M+74.9%
  • EPS (Diluted)-0.14+77.8%
  • Gross Margin99.45%+1.5%
  • EBITDA Margin-96.96%+84.7%
  • Operating Margin-98.21%+84.5%
  • Net Margin-101.08%+84.3%
  • ROE-39.72%+76.3%
  • ROIC-22.7%+72.0%
  • Debt/Equity0.58-22.1%
  • Interest Coverage-5.87+50.6%
Technical→

LXRX Key Insights

Lexicon Pharmaceuticals, Inc. (LXRX) fundamental analysis — strengths, weaknesses & financial health based on data analysis

✓Strengths

  • ✓High quality earnings: Operating CF exceeds net income
  • ✓Strong 5Y sales CAGR of 15.7%

✗Weaknesses

  • ✗Negative free cash flow
  • ✗Shares diluted 13.4% in last year
  • ✗Low asset turnover indicates capital-intensive operations

* These insights are generated automatically based on available financial data. Please conduct your own research before making investment decisions.

LXRX Price & Volume

Lexicon Pharmaceuticals, Inc. (LXRX) stock price & volume — 10-year historical chart

Loading chart...

LXRX Growth Metrics

Lexicon Pharmaceuticals, Inc. (LXRX) revenue, earnings & EPS growth — 3, 5 & 10-year CAGR

Revenue CAGR

10 Years-9.15%
5 Years15.72%
3 Years610.25%
TTM60.24%

Profit CAGR

10 Years-
5 Years-
3 Years-
TTM74.88%

EPS CAGR

10 Years-
5 Years-
3 Years-
TTM78.3%

Return on Capital

10 Years-42.34%
5 Years-67.7%
3 Years-67.98%
Last Year-23.44%

LXRX Recent Earnings

Lexicon Pharmaceuticals, Inc. (LXRX) EPS & revenue vs analyst estimates — last 4 quarters

Full history →
●Beat EPS 8/12 qtrs (67%)●Beat Revenue 4/12 qtrs (33%)
Q2 2026Latest
Mar 5, 2026
EPS
$0.04
Est $0.07
+42.9%
Revenue
$5M
Est $3M
+74.8%
Q4 2025
Nov 6, 2025
EPS
$0.04
Est $0.07
+42.9%
Revenue
$14M
Est $3M
+351.4%
Q3 2025
Aug 6, 2025
EPS
$0.01
Est $0.08
+112.5%
Revenue
$29M
Est $6M
+396.7%
Q2 2025
May 13, 2025
EPS
$0.07
Est $0.10
+30.0%
Revenue
$1M
Est $1M
-3.4%
QuarterDateEPS (Act vs Est)Revenue (Act vs Est)
Q2 2026LatestMar 5, 2026
$0.04vs $0.07+42.9%
$5Mvs $3M+74.8%
Q4 2025Nov 6, 2025
$0.04vs $0.07+42.9%
$14Mvs $3M+351.4%
Q3 2025Aug 6, 2025
$0.01vs $0.08+112.5%
$29Mvs $6M+396.7%
Q2 2025May 13, 2025
$0.07vs $0.10+30.0%
$1Mvs $1M-3.4%
Based on last 12 quarters of dataView full earnings history →

LXRX Peer Comparison

Lexicon Pharmaceuticals, Inc. (LXRX) competitors in Metabolic and Obesity Therapies — business model, growth, and fundamentals comparison

Select Columns
Stock Universe
Valuation
Growth
Profitability
Financial Health
Dividends & Buybacks
Price Performance
Technical
Fundamentals ($)
Sector-Specific
CompanyMarket CapStock PriceP/E Ratio (TTM)Revenue Growth 1YNet MarginReturn on Equity (ROE)FCF YieldDebt / Equity
ARDX logoARDXArdelyx, Inc.Direct Competitor1.74B7.10-27.3122.09%-13.58%-38.11%1.27
CORT logoCORTCorcept Therapeutics IncorporatedDirect Competitor5.6B52.1563.6012.79%6.23%7.5%0.01
INVA logoINVAInnoviva, Inc.Direct Competitor1.91B22.526.8218.52%118.91%46.47%0.23
PTGX logoPTGXProtagonist Therapeutics, Inc.Direct Competitor6.63B103.97-50.72-89.41%-6.48%-17.76%0.02
ACAD logoACADACADIA Pharmaceuticals Inc.Direct Competitor3.68B21.489.3811.87%36.49%41.9%0.04
AGIO logoAGIOAgios Pharmaceuticals, Inc.Product Competitor1.6B26.98-3.7948.03%-6.4%-34.11%0.05
FOLD logoFOLDAmicus Therapeutics, Inc.Product Competitor4.47B14.49-80.5032.29%-2.35%-6.1%2.29
RARE logoRAREUltragenyx Pharmaceutical Inc.Product Competitor2.55B25.93-4.4520.13%-91.03%-6.08%

Compare LXRX vs Peers

Lexicon Pharmaceuticals, Inc. (LXRX) vs competitors — business, growth, and fundamentals comparison against the closest industry rivals.

Closest Rival

vs ARDX

Most directly comparable listed peer for LXRX.

Scale Benchmark

vs LLY

Larger-name benchmark to compare LXRX against a more recognizable public peer.

Peer Set

Compare Top 5

vs ARDX, CORT, INVA, PTGX

LXRX Income Statement

Lexicon Pharmaceuticals, Inc. (LXRX) annual income statement — 10-year revenue, gross profit & net income history

10Y historyFree accessUpdated daily
Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Sales/Revenue90.33M63.21M322.07M24M298K139K1.2M31.08M49.8M
Revenue Growth %8.4%-30.03%409.54%-92.55%-98.76%-53.36%766.19%2481.48%60.24%
Cost of Goods Sold1.9M2.49M3.23M1.93M55.05M52.52M58.97M616K274K
COGS % of Revenue2.1%3.94%1%8.04%18471.81%37781.29%4898.01%1.98%0.55%
Gross Profit
88.44M▲ 0%
60.72M▼ 31.3%
318.84M▲ 425.1%
22.07M▼ 93.1%
-54.75M▼ 348.1%
-52.38M▲ 4.3%
-57.77M▼ 10.3%
30.46M▲ 152.7%
49.53M▲ 62.6%
Gross Margin %97.9%96.06%99%91.96%-18371.81%-37681.29%-4798.01%98.02%99.45%
Gross Profit Growth %209.67%-31.34%425.12%-93.08%-348.11%4.33%-10.29%152.74%62.58%
Operating Expenses223.02M164M177.4M69.87M32.34M48.38M113.98M227.58M98.44M
OpEx % of Revenue246.88%259.45%55.08%291.17%10853.02%34807.91%9466.94%732.22%197.66%
Selling, General & Admin66.2M63.75M56.84M47.23M000131.9M37.32M
SG&A % of Revenue73.29%100.86%17.65%196.83%---424.38%74.93%
Research & Development156.81M100.24M91.92M153.62M55.05M52.82M58.89M84.48M61.12M
R&D % of Revenue173.59%158.59%28.54%640.22%18471.81%37997.12%4890.95%271.81%122.73%
Other Operating Expenses1.95M028.64M-130.99M-22.7M-4.43M55.09M11.2M0
Operating Income
-136.68M▲ 0%
-103.28M▲ 24.4%
141.44M▲ 237.0%
-47.8M▼ 133.8%
-87.09M▼ 82.2%
-100.76M▼ 15.7%
-171.75M▼ 70.5%
-197.12M▼ 14.8%
-48.91M▲ 75.2%
Operating Margin %-151.3%-163.39%43.92%-199.21%-29224.83%-72489.21%-14264.95%-634.2%-98.21%
Operating Income Growth %0.35%24.44%236.95%-133.79%-82.2%-15.7%-70.45%-14.77%75.19%
EBITDA-133.28M-99.6M145.1M-44.87M-86.8M-100.33M-171.2M-196.58M-48.29M
EBITDA Margin %-147.54%-157.57%45.05%-186.98%-29126.85%-72182.01%-14218.94%-632.49%-96.96%
EBITDA Growth %1.34%25.27%245.69%-130.92%-93.46%-15.59%-70.63%-14.83%75.44%
D&A (Non-Cash Add-back)3.4M3.68M3.65M2.93M292K427K554K534K621K
EBIT-128.67M-99.77M144.79M-44.03M-87.09M-100.46M-170.31M-184.82M-48.91M
Net Interest Income-5.03M-17.27M-17.33M-11.78M-668K-1.18M-5.37M-3.29M-1.43M
Interest Income1.95M3.51M3.35M2.77M134K1.6M7.73M12.29M6.91M
Interest Expense6.98M20.78M20.68M14.54M802K2.78M13.1M15.58M8.34M
Other Income/Expense-5.03M-17.27M-17.33M-10.77M-668K-1.18M-5.37M-3.29M-1.43M
Pretax Income
-141.71M▲ 0%
-120.55M▲ 14.9%
124.12M▲ 203.0%
-58.57M▼ 147.2%
-87.76M▼ 49.8%
-101.94M▼ 16.2%
-177.12M▼ 73.7%
-200.4M▼ 13.1%
-50.34M▲ 74.9%
Pretax Margin %-156.87%-190.71%38.54%-244.11%-29448.99%-73341.01%-14710.88%-644.78%-101.08%
Income Tax-12.66M0-6.01M000000
Effective Tax Rate %8.93%0%-4.85%0%0%0%0%0%0%
Net Income
-129.05M▲ 0%
-120.55M▲ 6.6%
130.13M▲ 208.0%
-58.57M▼ 145.0%
-87.76M▼ 49.8%
-101.94M▼ 16.2%
-177.12M▼ 73.7%
-200.4M▼ 13.1%
-50.34M▲ 74.9%
Net Margin %-142.86%-190.71%40.4%-244.11%-29448.99%-73341.01%-14710.88%-644.78%-101.08%
Net Income Growth %8.75%6.59%207.95%-145.01%-49.82%-16.16%-73.74%-13.15%74.88%
Net Income (Continuing)-122.99M-120.55M130.13M-58.57M-87.76M-101.94M-177.12M-200.4M-50.34M
Discontinued Operations000000000
Minority Interest000000000
EPS (Diluted)
-1.23▲ 0%
-1.14▲ 7.3%
1.11▲ 197.4%
-0.63▼ 156.8%
-0.61▲ 3.2%
-0.62▼ 1.6%
-0.80▼ 29.0%
-0.63▲ 21.3%
-0.14▲ 77.8%
EPS Growth %9.56%7.32%197.37%-156.76%3.17%-1.64%-29.03%21.25%77.78%
EPS (Basic)-1.23-1.141.23-0.63-0.61-0.62-0.80-0.63-0.14
Diluted Shares Outstanding105.24M105.83M116.75M110.84M145.65M165.73M221.13M320.03M363.05M
Basic Shares Outstanding105.12M105.74M106.22M110.84M145.65M165.73M221.13M320.03M363.05M
Dividend Payout Ratio---------

LXRX Balance Sheet

Lexicon Pharmaceuticals, Inc. (LXRX) balance sheet — assets, liabilities & shareholders' equity

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Total Current Assets322M173.32M337.75M157.72M88.92M140.87M176.55M246.19M101.89M
Cash & Short-Term Investments310.79M160.05M271.66M152.28M86.74M138.36M170.03M237.96M96.23M
Cash Only310.79M160.05M36.11M126.26M64.06M46.34M22.46M66.66M34.33M
Short-Term Investments00235.55M26.01M22.68M92.01M147.56M171.3M61.9M
Accounts Receivable4.83M5.92M56.53M395K14K28K1.01M3.47M2.38M
Days Sales Outstanding19.534.2164.076.0117.1573.53306.1940.7917.47
Inventory1.95M4.68M4.24M000381K231K281K
Days Inventory Outstanding374.42685.75479.32---2.36136.88374.32
Other Current Assets4.43M2.67M0002.48M5.13M4.53M3M
Total Non-Current Assets114.54M110.81M79.96M46.07M47.99M53.43M52.88M52.23M83.09M
Property, Plant & Equipment17.69M15.87M14.05M295K3.44M8.48M7.51M7.32M9.18M
Fixed Asset Turnover5.11x3.98x22.93x81.34x0.09x0.02x0.16x4.25x5.42x
Goodwill44.54M44.54M44.54M44.54M44.54M44.54M44.54M44.54M44.54M
Intangible Assets51.88M50.12M19.72M000000
Long-Term Investments-4.88M-4.51M0000000
Other Non-Current Assets429K285K1.66M1.23M0412K828K368K29.37M
Total Assets
436.54M▲ 0%
284.14M▼ 34.9%
417.71M▲ 47.0%
203.79M▼ 51.2%
136.91M▼ 32.8%
194.3M▲ 41.9%
229.43M▲ 18.1%
298.42M▲ 30.1%
184.99M▼ 38.0%
Asset Turnover0.21x0.22x0.77x0.12x0.00x0.00x0.01x0.10x0.27x
Asset Growth %-8.22%-34.91%47.01%-51.21%-32.82%41.92%18.08%30.07%-38.01%
Total Current Liabilities124.13M36.75M65.34M46.81M22.12M23.17M31.55M45.25M20.87M
Accounts Payable38.76M12.05M12.18M5.47M9.15M10.39M14.39M14.8M3.08M
Days Payables Outstanding7.45K1.77K1.38K1.03K60.6972.2589.068.77K4.11K
Short-Term Debt14.09M1.11M11.01M11.65M00006.24M
Deferred Revenue (Current)40.1M3.4M0000000
Other Current Liabilities252K-1.06M9.64M6.2M5.71M3.66M9.59M14.71M11.55M
Current Ratio2.59x4.72x5.17x3.37x4.02x6.08x5.60x5.44x4.88x
Quick Ratio2.58x4.59x5.10x3.37x4.02x6.08x5.58x5.44x4.87x
Cash Conversion Cycle-7.06K-1.05K-832.34---219.49-8.59K-3.72K
Total Non-Current Liabilities260.31M273.79M235.27M611K1.19M54M104.77M107.22M56.58M
Long-Term Debt231.58M243.89M234.17M0048.58M99.51M100.3M49.41M
Capital Lease Obligations001.1M611K1.19M5.42M5.26M6.92M6.59M
Deferred Tax Liabilities6.01M6.01M0000000
Other Non-Current Liabilities292K238K000000582K
Total Liabilities384.44M310.54M300.61M47.42M23.31M77.17M136.32M152.47M77.45M
Total Debt245.67M245M246.84M12.81M2.28M55.29M106.06M108.4M62.24M
Net Debt-65.12M84.95M210.73M-113.45M-61.79M8.95M83.6M41.74M27.91M
Debt / Equity4.72x-2.11x0.08x0.02x0.47x1.14x0.74x0.58x
Debt / EBITDA--1.70x------
Net Debt / EBITDA--1.45x------
Interest Coverage-18.42x-4.80x7.00x-3.03x-108.59x-36.14x-13.00x-11.86x-5.87x
Total Equity
52.1M▲ 0%
-1.47B▼ 2924.4%
117.1M▲ 108.0%
156.37M▲ 33.5%
113.59M▼ 27.4%
117.12M▲ 3.1%
93.11M▼ 20.5%
145.95M▲ 56.8%
107.54M▼ 26.3%
Equity Growth %-66.9%-2924.42%107.96%33.54%-27.36%3.11%-20.5%56.75%-26.32%
Book Value per Share0.50-13.911.001.410.780.710.420.460.30
Total Shareholders' Equity52.1M-1.47B117.1M156.37M113.59M117.12M93.11M145.95M107.54M
Common Stock106K106K106K142K150K189K245K363K366K
Retained Earnings-1.38B-1.47B-1.34B-1.4B-1.49B-1.59B-1.77B-1.97B-2.02B
Treasury Stock-1.9M-2.88M-3.82M-4.84M-7.52M-2.06M-2.88M-4.62M-5.19M
Accumulated OCI-222K-12K84K-6K-10K-428K31K119K30K
Minority Interest000000000

LXRX Cash Flow Statement

Lexicon Pharmaceuticals, Inc. (LXRX) cash flow — operating, investing & free cash flow history

Line itemDec'17Dec'18Dec'19Dec'20Dec'21Dec'22Dec'23Dec'24Dec'25
Cash from Operations-185.39M-148.61M113.81M-142.97M-87.02M-88.85M-161.9M-178.78M-67.85M
Operating CF Margin %-205.23%-235.1%35.34%-595.83%-29200.34%-63921.58%-13446.59%-575.21%-136.24%
Operating CF Growth %-5.56%19.84%176.58%-225.62%39.14%-2.11%-82.21%-10.43%62.05%
Net Income-129.05M-120.55M130.13M-58.57M-87.76M-101.94M-177.12M-200.4M-50.34M
Depreciation & Amortization3.4M3.68M3.65M2.93M292K427K554K534K621K
Stock-Based Compensation9.47M11.7M14.22M13.27M10.58M11.52M14.34M13.5M12.52M
Deferred Taxes-12.66M0-6.01M-110K49K0000
Other Non-Cash Items2.7M1.34M30.1M-131.57M54K744K-2.33M-6.65M-3.75M
Working Capital Changes-59.26M-44.77M-58.29M31.08M-10.23M402K2.66M14.24M-26.89M
Change in Receivables166K-1.1M-50.61M53.23M381K-14K-982K-2.46M1.09M
Change in Inventory-1.95M-2.73M437K345K00-381K150K-50K
Change in Payables-7.17M-18.86M20.1M-20.97M-14.16M76K6.45M14.8M-30.22M
Cash from Investing50.52M169.58M-155.85M380.76M2.11M-71.08M-49.94M-15.38M113.02M
Capital Expenditures-228K-95K-70K-87K-1.22M-1.33M-470K-1.03M0
CapEx % of Revenue0.25%0.15%0.02%0.36%409.73%953.96%39.04%3.32%-
Acquisitions00155.78M11.01M-3.33M69.75M000
Investments---------
Other Investing50.75M169.67M-155.78M160.38M3.33M-69.75M09.3M3.71M
Cash from Financing149.93M-2.24M-2.23M-147.64M22.71M142.21M187.96M238.35M-48.5M
Debt Issued (Net)143.63M-2M-1.28M-216.58M-11.7M48.87M49.96M0-48M
Equity Issued (Net)6.31M-240K-941K-1.03M34.41M-864K138M239.59M73K
Dividends Paid000000000
Share Repurchases-1.68M-972K-941K-1.03M-2.67M-864K-824K-1.73M0
Other Financing00069.97M094.2M0-1.24M-572K
Net Change in Cash
15.06M▲ 0%
18.73M▲ 24.3%
-44.27M▼ 336.4%
90.15M▲ 303.6%
-62.2M▼ 169.0%
-17.72M▲ 71.5%
-23.88M▼ 34.8%
44.19M▲ 285.1%
-3.33M▼ 107.5%
Free Cash Flow
-185.62M▲ 0%
-148.7M▲ 19.9%
113.74M▲ 176.5%
-143.06M▼ 225.8%
-88.24M▲ 38.3%
-90.18M▼ 2.2%
-162.37M▼ 80.1%
-179.81M▼ 10.7%
-67.85M▲ 62.3%
FCF Margin %-205.48%-235.25%35.31%-596.19%-29610.07%-64875.54%-13485.63%-578.52%-136.24%
FCF Growth %-5.55%19.89%176.49%-225.78%38.32%-2.2%-80.05%-10.74%62.27%
FCF per Share-1.76-1.410.97-1.29-0.61-0.54-0.73-0.56-0.19
FCF Conversion (FCF/Net Income)1.44x1.23x0.87x2.44x0.99x0.87x0.91x0.89x1.35x
Interest Paid000000000
Taxes Paid000000000

LXRX Key Ratios

Lexicon Pharmaceuticals, Inc. (LXRX) financial ratios — P/E, ROE, debt and 30+ core market and balance-sheet ratios

Metric2016201720182019202020212022202320242025
Return on Equity (ROE)-63.81%-123.2%-111.13%-42.84%-65.01%-88.37%-168.5%-167.66%-39.72%
Return on Invested Capital (ROIC)---32.36%-19.34%-137.91%-84.97%-85.09%-81.14%-22.7%
Gross Margin-96.76%97.9%96.06%99%91.96%-18371.81%-37681.29%-4798.01%98.02%99.45%
Net Margin-169.71%-142.86%-190.71%40.4%-244.11%-29448.99%-73341.01%-14710.88%-644.78%-101.08%
Debt / Equity0.64x4.72x-2.11x0.08x0.02x0.47x1.14x0.74x0.58x
Interest Coverage-19.02x-18.42x-4.80x7.00x-3.03x-108.59x-36.14x-13.00x-11.86x-5.87x
FCF Conversion1.24x1.44x1.23x0.87x2.44x0.99x0.87x0.91x0.89x1.35x
Revenue Growth-35.9%8.4%-30.03%409.54%-92.55%-98.76%-53.36%766.19%2481.48%60.24%

LXRX SEC Filings & Documents

Lexicon Pharmaceuticals, Inc. (LXRX) SEC filings — annual & quarterly reports (10-K, 10-Q)

8-K Announcements

6
Material company update

Apr 30, 2026·SEC

Material company update

Mar 5, 2026·SEC

Material company update

Feb 2, 2026·SEC

10-K Annual Reports

3
FY 2026

Mar 5, 2026·SEC

FY 2025

Mar 7, 2025·SEC

FY 2024

Mar 25, 2024·SEC

10-Q Quarterly Reports

6
FY 2025

Nov 6, 2025·SEC

FY 2025

Aug 6, 2025·SEC

FY 2025

May 14, 2025·SEC

LXRX Frequently Asked Questions

Lexicon Pharmaceuticals, Inc. (LXRX) stock FAQ — growth, dividends, profitability & financials explained

Growth & Financials

Lexicon Pharmaceuticals, Inc. (LXRX) reported $49.8M in revenue for fiscal year 2025. This represents a 960% increase from $4.7M in 1999.

Lexicon Pharmaceuticals, Inc. (LXRX) grew revenue by 60.2% over the past year. This is strong growth.

Lexicon Pharmaceuticals, Inc. (LXRX) reported a net loss of $50.3M for fiscal year 2025.

Dividend & Returns

Lexicon Pharmaceuticals, Inc. (LXRX) has a return on equity (ROE) of -39.7%. Negative ROE indicates the company is unprofitable.

Lexicon Pharmaceuticals, Inc. (LXRX) had negative free cash flow of $67.9M in fiscal year 2025, likely due to heavy capital investments.

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Lexicon Pharmaceuticals, Inc. (LXRX) financial analysis — history, returns, DCA and operating performance tools

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